Journal of Antimicrobial Chemotherapy

Leading articles

Get checked abstract Stephan Ludwig

Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy
JAC Advance Access published on May 6, 2009
J. Antimicrob. Chemother. 2009 64: 1-4; doi:10.1093/jac/dkp161 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Kay Seden, David Back, and Saye Khoo

Antiretroviral drug interactions: often unrecognized, frequently unavoidable, sometimes unmanageable
JAC Advance Access published on April 27, 2009
J. Antimicrob. Chemother. 2009 64: 5-8; doi:10.1093/jac/dkp152 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Review

Systematic review

Get checked abstract Evridiki K. Vouloumanou, Drosos E. Karageorgopoulos, Maria S. Kazantzi, Anastasios M. Kapaskelis, and Matthew E. Falagas

Antibiotics versus placebo or watchful waiting for acute otitis media: a meta-analysis of randomized controlled trials
JAC Advance Access published on May 19, 2009
J. Antimicrob. Chemother. 2009 64: 16-24; doi:10.1093/jac/dkp166 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Original research

Get checked abstract Nadine Sichtig, Saleta Sierra, Rolf Kaiser, Martin Däumer, Stefan Reuter, Eugen Schülter, Andre Altmann, Gerd Fätkenheuer, Ulf Dittmer, Herbert Pfister, and Stefan Esser

Evolution of raltegravir resistance during therapy
JAC Advance Access published on May 14, 2009
J. Antimicrob. Chemother. 2009 64: 25-32; doi:10.1093/jac/dkp153 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract J. Gerardo García-Lerma, Amanda McNulty, Cheryl Jennings, Diana Huang, Walid Heneine, and James W. Bremer

Rapid decline in the efficiency of HIV drug resistance genotyping from dried blood spots (DBS) and dried plasma spots (DPS) stored at 37°C and high humidity
JAC Advance Access published on April 29, 2009
J. Antimicrob. Chemother. 2009 64: 33-36; doi:10.1093/jac/dkp150 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Arabela Cuirolo, Konrad Plata, and Adriana E. Rosato

Development of homogeneous expression of resistance in methicillin-resistant Staphylococcus aureus clinical strains is functionally associated with a β-lactam-mediated SOS response
JAC Advance Access published on May 20, 2009
J. Antimicrob. Chemother. 2009 64: 37-45; doi:10.1093/jac/dkp164 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Syuntaro Kouda, Masaru Ohara, Makoto Onodera, Yoshihiro Fujiue, Megumi Sasaki, Tadahiro Kohara, Seiya Kashiyama, Shizue Hayashida, Toshie Harino, Takahiro Tsuji, Hideyuki Itaha, Naomasa Gotoh, Akio Matsubara, Tsuguru Usui, and Motoyuki Sugai

Increased prevalence and clonal dissemination of multidrug-resistant Pseudomonas aeruginosa with the bla_IMP-1 gene cassette in Hiroshima
JAC Advance Access published on April 27, 2009
J. Antimicrob. Chemother. 2009 64: 46-51; doi:10.1093/jac/dkp142 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract O. Peuchant, A. Ménard, H. Renaudin, M. Morozumi, K. Ubukata, C. M. Bébéar, and S. Pereyre

Increased macrolide resistance of Mycoplasma pneumoniae in France directly detected in clinical specimens by real-time PCR and melting curve analysis
JAC Advance Access published on May 9, 2009
J. Antimicrob. Chemother. 2009 64: 52-58; doi:10.1093/jac/dkp160 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract C. K. Hope, S. Packer, M. Wilson, and S. P. Nair

The inability of a bacteriophage to infect Staphylococcus aureus does not prevent it from specifically delivering a photosensitizer to the bacterium enabling its lethal photosensitization
JAC Advance Access published on May 2, 2009
J. Antimicrob. Chemother. 2009 64: 59-61; doi:10.1093/jac/dkp157 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Lucia Granieri, Oliver J. Miller, Andrew D. Griffiths, and Christoph A. Merten

A competition-based assay for the screening of species-specific antibiotics
JAC Advance Access published on April 28, 2009
J. Antimicrob. Chemother. 2009 64: 62-68; doi:10.1093/jac/dkp137 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract M. Casal, F. Rodríguez, B. Johnson, E. Garduno, F. Tubau, R. Ortiz de Lejarazu, A. Tenorio, M. J. Giménez, R. Bartolomé, C. Garcia-Rey, L. Aguilar, and N. García-Escribano

Influence of testing methodology on the tigecycline activity profile against presumably tigecycline-non-susceptible Acinetobacter spp.
JAC Advance Access published on May 17, 2009
J. Antimicrob. Chemother. 2009 64: 69-72; doi:10.1093/jac/dkp169 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Chih-Cheng Lai, Che-Kim Tan, Sheng Hsiang Lin, Chun-Hsing Liao, Chien-Hong Chou, Hsiao-Leng Hsu, Yu-Tsung Huang, and Po-Ren Hsueh

Comparative in vitro activities of nemonoxacin, doripenem, tigecycline and 16 other antimicrobials against Nocardia brasiliensis, Nocardia asteroides and unusual Nocardia species
JAC Advance Access published on April 27, 2009
J. Antimicrob. Chemother. 2009 64: 73-78; doi:10.1093/jac/dkp144 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract George R. Thompson, III, Nathan P. Wiederhold, Deanna A. Sutton, Annette Fothergill, and Thomas F. Patterson

In vitro activity of isavuconazole against Trichosporon, Rhodotorula, Geotrichum, Saccharomyces and Pichia species
JAC Advance Access published on April 30, 2009
J. Antimicrob. Chemother. 2009 64: 79-83; doi:10.1093/jac/dkp138 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Elisalva T. Guimarães, Milena S. Lima, Luana A. Santos, Ivone M. Ribeiro, Therezinha B. C. Tomassini, Ricardo Ribeiro dos Santos, Washington L. C. dos Santos, and Milena B. P. Soares

Activity of physalins purified from Physalis angulata in in vitro and in vivo models of cutaneous leishmaniasis
JAC Advance Access published on May 19, 2009
J. Antimicrob. Chemother. 2009 64: 84-87; doi:10.1093/jac/dkp170 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Rabih O. Darouiche, Mohammad D. Mansouri, Purushottam V. Gawande, and Srinivasa Madhyastha

Antimicrobial and antibiofilm efficacy of triclosan and DispersinB^® combination
JAC Advance Access published on May 14, 2009
J. Antimicrob. Chemother. 2009 64: 88-93; doi:10.1093/jac/dkp158 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract John F. Kokai-Kun, Tanya Chanturiya, and James J. Mond

Lysostaphin eradicates established Staphylococcus aureus biofilms in jugular vein catheterized mice
JAC Advance Access published on April 27, 2009
J. Antimicrob. Chemother. 2009 64: 94-100; doi:10.1093/jac/dkp145 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Pavel Gershkovich, Ellen K. Wasan, Molly Lin, Olena Sivak, Carlos G. Leon, John G. Clement, and Kishor M. Wasan

Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation
JAC Advance Access published on April 27, 2009
J. Antimicrob. Chemother. 2009 64: 101-108; doi:10.1093/jac/dkp140 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Massimiliano Fabbiani, Simona Di Giambenedetto, Laura Bracciale, Alessandra Bacarelli, Enzo Ragazzoni, Roberto Cauda, Pierluigi Navarra, and Andrea De Luca

Pharmacokinetic variability of antiretroviral drugs and correlation with virological outcome: 2 years of experience in routine clinical practice
JAC Advance Access published on April 27, 2009
J. Antimicrob. Chemother. 2009 64: 109-117; doi:10.1093/jac/dkp132 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Roland Landman, Catherine Capitant, Diane Descamps, Corine Chazallon, Gilles Peytavin, Christine Katlama, Gilles Pialoux, Michelle Bentata, Francoise Brun-Vézinet, Jean-Pierre Aboulker, Patrick Yéni, and on behalf of the ANRS 127 study group

Efficacy and safety of ritonavir-boosted dual protease inhibitor therapy in antiretroviral-naive HIV-1-infected patients: the 2IP ANRS 127 study
JAC Advance Access published on May 6, 2009
J. Antimicrob. Chemother. 2009 64: 118-125; doi:10.1093/jac/dkp146 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Pierre-Marie Girard, André Cabié, Christian Michelet, Renaud Verdon, Christine Katlama, Patrick Mercié, Laurence Morand-Joubert, Pascal Pétour, Françoise Monchecourt, Geneviève Chêne, Aldo Trylesinski, and on behalf of the COOL Study Team

A randomized trial of two-drug versus three-drug tenofovir-containing maintenance regimens in virologically controlled HIV-1 patients
JAC Advance Access published on April 29, 2009
J. Antimicrob. Chemother. 2009 64: 126-134; doi:10.1093/jac/dkp141 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Pierre Frange, Julie Galimand, Cécile Goujard, Christiane Deveau, Jade Ghosn, Christine Rouzioux, Laurence Meyer, and Marie-Laure Chaix

High frequency of X4/DM-tropic viruses in PBMC samples from patients with primary HIV-1 subtype-B infection in 1996–2007: the French ANRS CO06 PRIMO Cohort Study
JAC Advance Access published on May 2, 2009
J. Antimicrob. Chemother. 2009 64: 135-141; doi:10.1093/jac/dkp151 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jason A. Roberts, Carl M. J. Kirkpatrick, Michael S. Roberts, Thomas A. Robertson, Andrew J. Dalley, and Jeffrey Lipman

Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution
JAC Advance Access published on April 27, 2009
J. Antimicrob. Chemother. 2009 64: 142-150; doi:10.1093/jac/dkp139 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Stefan Krüger, Santiago Ewig, Jan Kunde, Alexa Hanschmann, Reinhard Marre, Norbert Suttorp, Tobias Welte, and on behalf of the CAPNETZ study group

C-terminal provasopressin (copeptin) in patients with community-acquired pneumonia—influence of antibiotic pre-treatment: results from the German competence network CAPNETZ
JAC Advance Access published on April 29, 2009
J. Antimicrob. Chemother. 2009 64: 159-162; doi:10.1093/jac/dkp148 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Annette S. Bukh, Henrik C. Schønheyder, Jeppe M. G. Emmersen, Mette Søgaard, Søren Bastholm, and Peter Roslev

Escherichia coli phylogenetic groups are associated with site of infection and level of antibiotic resistance in community-acquired bacteraemia: a 10 year population-based study in Denmark
JAC Advance Access published on May 8, 2009
J. Antimicrob. Chemother. 2009 64: 163-168; doi:10.1093/jac/dkp156 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Majdi N. Al-Hasan, Brian D. Lahr, Jeanette E. Eckel-Passow, and Larry M. Baddour

Antimicrobial resistance trends of Escherichia coli bloodstream isolates: a population-based study, 1998–2007
JAC Advance Access published on May 12, 2009
J. Antimicrob. Chemother. 2009 64: 169-174; doi:10.1093/jac/dkp162 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Vidya Mave, Julia Garcia-Diaz, Tareq Islam, and Rodrigo Hasbun

Vancomycin-resistant enterococcal bacteraemia: is daptomycin as effective as linezolid?
JAC Advance Access published on May 7, 2009
J. Antimicrob. Chemother. 2009 64: 175-180; doi:10.1093/jac/dkp154 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Elspeth Lamont, R. Andrew Seaton, Merran Macpherson, Lindsay Semple, Emma Bell, and Alison H. Thomson

Development of teicoplanin dosage guidelines for patients treated within an outpatient parenteral antibiotic therapy (OPAT) programme
JAC Advance Access published on May 2, 2009
J. Antimicrob. Chemother. 2009 64: 181-187; doi:10.1093/jac/dkp147 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Samuel Coenen, Arno Muller, Niels Adriaenssens, Vanessa Vankerckhoven, Erik Hendrickx, and Herman Goossens on behalf of the ESAC Project Group

European Surveillance of Antimicrobial Consumption (ESAC): outpatient parenteral antibiotic treatment in Europe
JAC Advance Access published on April 21, 2009
J. Antimicrob. Chemother. 2009 64: 200-205; doi:10.1093/jac/dkp135 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Research letters

Apostolos Liakopoulos, Charalambos Neocleous, Dimitra Klapsa, Maria Kanellopoulou, Iris Spiliopoulou, Kostas D. Mathiopoulos, Evangelos Papafrangas, and Efi Petinaki

A T2504A mutation in the 23S rRNA gene responsible for high-level resistance to linezolid of Staphylococcus epidermidis
JAC Advance Access published on May 9, 2009
J. Antimicrob. Chemother. 2009 64: 206-207; doi:10.1093/jac/dkp167 [Extract] [Full Text] [PDF] [Request Permissions]  

Rikke D. Bergenholtz, Mikael S. Jørgensen, Lars H. Hansen, Lars B. Jensen, and Henrik Hasman

Characterization of genetic determinants of extended-spectrum cephalosporinases (ESCs) in Escherichia coli isolates from Danish and imported poultry meat
JAC Advance Access published on May 19, 2009
J. Antimicrob. Chemother. 2009 64: 207-209; doi:10.1093/jac/dkp168 [Extract] [Full Text] [PDF] [Request Permissions]  

Ian Morrissey, Don Biek, and Regina Janes

ME1036, a novel carbapenem, with enhanced activity against clinical isolates causing bacteraemic community-acquired pneumonia
JAC Advance Access published on May 9, 2009
J. Antimicrob. Chemother. 2009 64: 209-210; doi:10.1093/jac/dkp163 [Extract] [Full Text] [PDF] [Request Permissions]  

Eliette Touati, Valérie Michel, Marta Correia, Luigi Menghini, Salvatore Genovese, Massimo Curini, and Francesco Epifano

Boropinic acid, a novel inhibitor of Helicobacter pylori stomach colonization
JAC Advance Access published on April 22, 2009
J. Antimicrob. Chemother. 2009 64: 210-211; doi:10.1093/jac/dkp136 [Extract] [Full Text] [PDF] [Request Permissions]  

Letters to the Editor

Karen Bush, George A. Jacoby, Gianfranco Amicosante, Robert A. Bonomo, Patricia Bradford, Giuseppe Cornaglia, Javier Garau, Helen Giamarellou, Vincent Jarlier, Luis Martinez-Martinez, Vivi Miriagou, Timothy Palzkill, Alvaro Pascual, Jesus Rodriguez-Baño, Gian Maria Rossolini, Wladimir Sougakoff, and Alkiviadis Vatopoulos

Comment on: Redefining extended-spectrum β-lactamases: balancing science and clinical need
JAC Advance Access published on March 24, 2009
J. Antimicrob. Chemother. 2009 64: 212-213; doi:10.1093/jac/dkp104 [Extract] [Full Text] [PDF] [Request Permissions]  

Christian G. Giske, Arnfinn S. Sundsfjord, Gunnar Kahlmeter, Neil Woodford, Patrice Nordmann, David L. Paterson, Rafael Cantón, and Timothy R. Walsh

Redefining extended-spectrum β-lactamases: balancing science and clinical need—authors’ response
JAC Advance Access published on April 29, 2009
J. Antimicrob. Chemother. 2009 64: 213-215; doi:10.1093/jac/dkp143 [Extract] [Full Text] [PDF] [Request Permissions]  

Massimiliano Lanzafame, Emanuela Lattuada, and Fabiana Corsini

Comment on: Unboosted fosamprenavir is associated with low drug exposure in HIV-infected patients with mild–moderate liver impairment resulting from HCV-related cirrhosis
JAC Advance Access published on March 24, 2009
J. Antimicrob. Chemother. 2009 64: 215-216; doi:10.1093/jac/dkp105 [Extract] [Full Text] [PDF] [Request Permissions]  

Francesca Gatti, Massimo Puoti, Paola Nasta, Saverio G. Parisi, and Giampiero Carosi

Unboosted fosamprenavir is associated with low drug exposure in HIV-infected patients with mild–moderate liver impairment resulting from HCV-related cirrhosis—authors’ response
JAC Advance Access published on April 29, 2009
J. Antimicrob. Chemother. 2009 64: 216; doi:10.1093/jac/dkp149 [Extract] [Full Text] [PDF] [Request Permissions]  

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