Journal of Antimicrobial Chemotherapy

Leading articles

Get checked abstract Luz Martin-Carbonero and Vincent Soriano

New paradigms for treating hepatitis B in HIV/hepatitis B virus co-infected patients
JAC Advance Access published on January 19, 2010
J. Antimicrob. Chemother. 2010 65: 379-382; doi:10.1093/jac/dkp492 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Jose M. Gatell

When and why to start antiretroviral therapy?
JAC Advance Access published on January 12, 2010
J. Antimicrob. Chemother. 2010 65: 383-385; doi:10.1093/jac/dkp487 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Satyajit Das

Risk of cardiovascular disease in HIV-infected patients
JAC Advance Access published on December 21, 2009
J. Antimicrob. Chemother. 2010 65: 386-389; doi:10.1093/jac/dkp460 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews

Get checked abstract Waldemar Gottardi and Markus Nagl

N-chlorotaurine, a natural antiseptic with outstanding tolerability
JAC Advance Access published on January 6, 2010
J. Antimicrob. Chemother. 2010 65: 399-409; doi:10.1093/jac/dkp466 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Simon Cronin and Pranatharthi H. Chandrasekar

Safety of triazole antifungal drugs in patients with cancer
JAC Advance Access published on December 24, 2009
J. Antimicrob. Chemother. 2010 65: 410-416; doi:10.1093/jac/dkp464 [Abstract] [Full Text] [PDF] [Request Permissions]  

Original research

Get checked abstract Mercedes Armand-Ugón, Gemma Moncunill, Emmanuel Gonzalez, MariaPau Mena, Ester Ballana, Bonaventura Clotet, and José A. Esté

Different selection patterns of resistance and cross-resistance to HIV-1 agents targeting CCR5
JAC Advance Access published on January 12, 2010
J. Antimicrob. Chemother. 2010 65: 417-424; doi:10.1093/jac/dkp482 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Filippo Canducci, Maria Chiara Marinozzi, Michela Sampaolo, Enzo Boeri, Vincenzo Spagnuolo, Nicola Gianotti, Antonella Castagna, Stefania Paolucci, Fausto Baldanti, Adriano Lazzarin, and Massimo Clementi

Genotypic/phenotypic patterns of HIV-1 integrase resistance to raltegravir
JAC Advance Access published on January 7, 2010
J. Antimicrob. Chemother. 2010 65: 425-433; doi:10.1093/jac/dkp477 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Sandrine Reigadas, Marie-Line Andréola, Linda Wittkop, Ophélie Cosnefroy, Guerric Anies, Patricia Recordon-Pinson, Rodolphe Thiébaut, Bernard Masquelier, and Hervé Fleury

Evolution of 2-long terminal repeat (2-LTR) episomal HIV-1 DNA in raltegravir-treated patients and in in vitro infected cells
JAC Advance Access published on January 5, 2010
J. Antimicrob. Chemother. 2010 65: 434-437; doi:10.1093/jac/dkp473 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Marielle Karine Bouyou-Akotet, Denise Patricia Mawili-Mboumba, Tanguy de Dieu Tchantchou, and Maryvonne Kombila

High prevalence of sulfadoxine/pyrimethamine-resistant alleles of Plasmodium falciparum isolates in pregnant women at the time of introduction of intermittent preventive treatment with sulfadoxine/pyrimethamine in Gabon
JAC Advance Access published on January 6, 2010
J. Antimicrob. Chemother. 2010 65: 438-441; doi:10.1093/jac/dkp467 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Robert L. R. Hill, Angela M. Kearns, James Nash, Sarah E. North, Rachel Pike, Timothy Newson, Neil Woodford, Richard Calver, and David M. Livermore

Linezolid-resistant ST36 methicillin-resistant Staphylococcus aureus associated with prolonged linezolid treatment in two paediatric cystic fibrosis patients
JAC Advance Access published on January 20, 2010
J. Antimicrob. Chemother. 2010 65: 442-445; doi:10.1093/jac/dkp494 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Matthew J. Ellington, Russell Hope, David M. Livermore, Angela M. Kearns, Katherine Henderson, Barry D. Cookson, Andrew Pearson, and Alan P. Johnson

Decline of EMRSA-16 amongst methicillin-resistant Staphylococcus aureus causing bacteraemias in the UK between 2001 and 2007
JAC Advance Access published on December 24, 2009
J. Antimicrob. Chemother. 2010 65: 446-448; doi:10.1093/jac/dkp448 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract David Orr, Paul Wilkinson, Laura Moyce, Siobhan Martin, Robert George, and Bruno Pichon

Incidence and epidemiology of levofloxacin resistance in Streptococcus pneumoniae: experience from a tertiary referral hospital in England
JAC Advance Access published on December 17, 2009
J. Antimicrob. Chemother. 2010 65: 449-452; doi:10.1093/jac/dkp463 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jiyong Yang, Yanping Luo, Jingyun Li, Yue Ma, Changqin Hu, Shaohong Jin, Liyan Ye, and Shenghui Cui

Characterization of clinical Escherichia coli isolates from China containing transferable quinolone resistance determinants
JAC Advance Access published on January 7, 2010
J. Antimicrob. Chemother. 2010 65: 453-459; doi:10.1093/jac/dkp478 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Rikke Lind Jørgensen, Jesper Boye Nielsen, Alice Friis-Møller, Hans Fjeldsøe-Nielsen, and Kristian Schønning

Prevalence and molecular characterization of clinical isolates of Escherichia coli expressing an AmpC phenotype
JAC Advance Access published on January 22, 2010
J. Antimicrob. Chemother. 2010 65: 460-464; doi:10.1093/jac/dkp484 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Juliëtte A. Severin, Ni Made Mertaniasih, Kuntaman Kuntaman, Endang S. Lestari, Marijam Purwanta, Nicole Lemmens-Den Toom, D. Offra Duerink, Usman Hadi, Alex van Belkum, Henri A. Verbrugh, Wil H. Goessens, and on behalf of the study group ‘Antimicrobial Resistance in Indonesia: Prevalence and Prevention’ (AMRIN)

Molecular characterization of extended-spectrum β-lactamases in clinical Escherichia coli and Klebsiella pneumoniae isolates from Surabaya, Indonesia
JAC Advance Access published on January 6, 2010
J. Antimicrob. Chemother. 2010 65: 465-469; doi:10.1093/jac/dkp471 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Héctor Toledo and Remigio López-Solís

Tetracycline resistance in Chilean clinical isolates of Helicobacter pylori
JAC Advance Access published on December 24, 2009
J. Antimicrob. Chemother. 2010 65: 470-473; doi:10.1093/jac/dkp457 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Carlos Juan, Laura Zamorano, Ana Mena, Sebastián Albertí, Jose Luis Pérez, and Antonio Oliver

Metallo-β-lactamase-producing Pseudomonas putida as a reservoir of multidrug resistance elements that can be transferred to successful Pseudomonas aeruginosa clones
JAC Advance Access published on January 12, 2010
J. Antimicrob. Chemother. 2010 65: 474-478; doi:10.1093/jac/dkp491 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Michael Hornsey, Matthew J. Ellington, Michel Doumith, Sue Hudson, David M. Livermore, and Neil Woodford

Tigecycline resistance in Serratia marcescens associated with up-regulation of the SdeXY-HasF efflux system also active against ciprofloxacin and cefpirome
JAC Advance Access published on January 5, 2010
J. Antimicrob. Chemother. 2010 65: 479-482; doi:10.1093/jac/dkp475 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract N. C. Gordon and D. W. Wareham

Novel variants of the Smqnr family of quinolone resistance genes in clinical isolates of Stenotrophomonas maltophilia
JAC Advance Access published on January 12, 2010
J. Antimicrob. Chemother. 2010 65: 483-489; doi:10.1093/jac/dkp476 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Caroline Dallenne, Anaelle Da Costa, Dominique Decré, Christine Favier, and Guillaume Arlet

Development of a set of multiplex PCR assays for the detection of genes encoding important β-lactamases in Enterobacteriaceae
JAC Advance Access published on January 12, 2010
J. Antimicrob. Chemother. 2010 65: 490-495; doi:10.1093/jac/dkp498 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Swati Mandal, Mahendra Maharjan, Sarman Singh, Mitali Chatterjee, and Rentala Madhubala

Assessing aquaglyceroporin gene status and expression profile in antimony-susceptible and -resistant clinical isolates of Leishmania donovani from India
JAC Advance Access published on January 12, 2010
J. Antimicrob. Chemother. 2010 65: 496-507; doi:10.1093/jac/dkp468 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Karin Seifert, Patricia Escobar, and Simon L. Croft

In vitro activity of anti-leishmanial drugs against Leishmania donovani is host cell dependent
JAC Advance Access published on January 20, 2010
J. Antimicrob. Chemother. 2010 65: 508-511; doi:10.1093/jac/dkp500 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Britta Stadelmann, Sabrina Scholl, Joachim Müller, and Andrew Hemphill

Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure–activity relationship of thiazolides against Echinococcus multilocularis metacestodes
JAC Advance Access published on January 19, 2010
J. Antimicrob. Chemother. 2010 65: 512-519; doi:10.1093/jac/dkp490 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Xiuhong Wang, Xilin Zhao, Muhammad Malik, and Karl Drlica

Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death
JAC Advance Access published on January 12, 2010
J. Antimicrob. Chemother. 2010 65: 520-524; doi:10.1093/jac/dkp486 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Nuria Fernández-Hidalgo, Joan Gavaldà, Benito Almirante, María-Teresa Martín, Pedro López Onrubia, Xavier Gomis, and Albert Pahissa

Evaluation of linezolid, vancomycin, gentamicin and ciprofloxacin in a rabbit model of antibiotic-lock technique for Staphylococcus aureus catheter-related infection
JAC Advance Access published on January 18, 2010
J. Antimicrob. Chemother. 2010 65: 525-530; doi:10.1093/jac/dkp499 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Tineke Lauwaet, Yolanda Andersen, Liesbeth Van de Ven, Lars Eckmann, and Frances D. Gillin

Rapid detachment of Giardia lamblia trophozoites as a mechanism of antimicrobial action of the isoflavone formononetin
JAC Advance Access published on January 12, 2010
J. Antimicrob. Chemother. 2010 65: 531-534; doi:10.1093/jac/dkp501 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Pavel Gershkovich, Ellen K. Wasan, Olena Sivak, Raymond Li, Xiaohua Zhu, Karl A. Werbovetz, Richard R. Tidwell, John G. Clement, Sheila J. Thornton, and Kishor M. Wasan

Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice
JAC Advance Access published on December 21, 2009
J. Antimicrob. Chemother. 2010 65: 535-537; doi:10.1093/jac/dkp465 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract C. T. M. M. de Kanter, E. P. H. Colbers, Q. Fillekes, A. Hoitsma, and D. M. Burger

Pharmacokinetics of two generic co-formulations of lopinavir/ritonavir for HIV-infected children: a pilot study of paediatric Lopimune versus the branded product in healthy adult volunteers
JAC Advance Access published on January 7, 2010
J. Antimicrob. Chemother. 2010 65: 538-542; doi:10.1093/jac/dkp472 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Eugenia Vispo, Alvaro Mena, Ivana Maida, Francisco Blanco, Mateo Cordoba, Pablo Labarga, Sonia Rodriguez-Novoa, Elena Álvarez, Inmaculada Jimenez-Nacher, and Vincent Soriano

Hepatic safety profile of raltegravir in HIV-infected patients with chronic hepatitis C
JAC Advance Access published on December 23, 2009
J. Antimicrob. Chemother. 2010 65: 543-547; doi:10.1093/jac/dkp446 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Vincent Soriano, Amanda Mocroft, Lars Peters, Juergen Rockstroh, Francisco Antunes, Nikolai Kirkby, Stephane de Wit, Antonella d'Arminio Monforte, Robert Flisiak, and Jens Lundgren on behalf of EuroSIDA

Predictors of hepatitis B virus genotype and viraemia in HIV-infected patients with chronic hepatitis B in Europe
JAC Advance Access published on January 5, 2010
J. Antimicrob. Chemother. 2010 65: 548-555; doi:10.1093/jac/dkp479 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract M. A. Valantin, R. Bittar, P. de Truchis, D. Bollens, L. Slama, P. Giral, D. Bonnefont-Rousselot, P. Pétour, C. Aubron-Olivier, D. Costagliola, C. Katlama, and on behalf of the TOTEM trial group

Switching the nucleoside reverse transcriptase inhibitor backbone to tenofovir disoproxil fumarate + emtricitabine promptly improves triglycerides and low-density lipoprotein cholesterol in dyslipidaemic patients
JAC Advance Access published on January 6, 2010
J. Antimicrob. Chemother. 2010 65: 556-561; doi:10.1093/jac/dkp462 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract M. Ortega, F. Marco, A. Soriano, M. Almela, J. A. Martínez, C. Pitart, and J. Mensa

Candida spp. bloodstream infection: influence of antifungal treatment on outcome
JAC Advance Access published on January 18, 2010
J. Antimicrob. Chemother. 2010 65: 562-568; doi:10.1093/jac/dkp495 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Evelyne Van Gastel, Michiel Costers, Willy E. Peetermans, Marc J. Struelens, and on behalf of the Hospital Medicine Working Group of the Belgian Antibiotic Policy Coordination Committee

Nationwide implementation of antibiotic management teams in Belgian hospitals: a self-reporting survey
JAC Advance Access published on January 6, 2010
J. Antimicrob. Chemother. 2010 65: 576-580; doi:10.1093/jac/dkp470 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Research letters

Silpak Biswas, Ricardo G. Maggi, Mark G. Papich, and Edward B. Breitschwerdt

Molecular mechanisms of Bartonella henselae resistance to azithromycin, pradofloxacin and enrofloxacin
JAC Advance Access published on December 18, 2009
J. Antimicrob. Chemother. 2010 65: 581-582; doi:10.1093/jac/dkp459 [Extract] [Full Text] [PDF] [Request Permissions]  

Sebastian Guenther, Mirjam Grobbel, Janine Beutlich, Beatriz Guerra, Rainer G. Ulrich, Lothar H. Wieler, and Christa Ewers

Detection of pandemic B2-O25-ST131 Escherichia coli harbouring the CTX-M-9 extended-spectrum β-lactamase type in a feral urban brown rat (Rattus norvegicus)
JAC Advance Access published on January 12, 2010
J. Antimicrob. Chemother. 2010 65: 582-584; doi:10.1093/jac/dkp496 [Extract] [Full Text] [PDF] [Request Permissions]  

Guo-Bao Tian, Jemelyn Garcia, Jennifer M. Adams-Haduch, Jennifer P. Evangelista, Raul V. Destura, Hong-Ning Wang, and Yohei Doi

CTX-M as the predominant extended-spectrum β-lactamases among Enterobacteriaceae in Manila, Philippines
JAC Advance Access published on January 6, 2010
J. Antimicrob. Chemother. 2010 65: 584-586; doi:10.1093/jac/dkp480 [Extract] [Full Text] [PDF] [Request Permissions]  

Shazad Mushtaq and David M. Livermore

AmpC induction by ceftaroline
JAC Advance Access published on January 19, 2010
J. Antimicrob. Chemother. 2010 65: 586-588; doi:10.1093/jac/dkp493 [Extract] [Full Text] [PDF] [Request Permissions]  

Angelino Julio Cariello, Gabriela Freitas Pereira de Souza, Annette Silva Foronda, Maria Cecília Zorat Yu, Ana Luisa Hofling-Lima, and Marcelo Ganzarolli de Oliveira

In vitro amoebicidal activity of S-nitrosoglutathione and S-nitroso-N-acetylcysteine against trophozoites of Acanthamoeba castellanii
JAC Advance Access published on January 19, 2010
J. Antimicrob. Chemother. 2010 65: 588-591; doi:10.1093/jac/dkp485 [Extract] [Full Text] [PDF] [Request Permissions]  

Sonia Borbone, Floriana Campanile, Dafne Bongiorno, and Stefania Stefani

In vitro bactericidal activity of ceftobiprole against hospital- and community-associated methicillin-resistant Staphylococcus aureus
JAC Advance Access published on January 18, 2010
J. Antimicrob. Chemother. 2010 65: 591-594; doi:10.1093/jac/dkp483 [Extract] [Full Text] [PDF] [Request Permissions]  

Christiane Gaudreau, René Lecours, Johanne Ismaïl, Simon Gagnon, Louise Jetté, and Michel Roger

Prosthetic hip joint infection with a Streptococcus agalactiae isolate not susceptible to penicillin G and ceftriaxone
JAC Advance Access published on December 18, 2009
J. Antimicrob. Chemother. 2010 65: 594-595; doi:10.1093/jac/dkp458 [Extract] [Full Text] [PDF] [Request Permissions]  

Massimiliano Lanzafame, Andrew Hill, Emanuela Lattuada, Andrea Calcagno, and Stefano Bonora

Raltegravir: is a 400 mg once-daily dose enough?
JAC Advance Access published on January 12, 2010
J. Antimicrob. Chemother. 2010 65: 595-597; doi:10.1093/jac/dkp488 [Extract] [Full Text] [PDF] [Request Permissions]  

Letter to the Editor

F. J. Cooke, R. Matar, W. Lawson, S. H. Aliyu, and A. Holmes

Comment on: Antibiotic stewardship—more education and regulation not more availability?
JAC Advance Access published on January 6, 2010
J. Antimicrob. Chemother. 2010 65: 598; doi:10.1093/jac/dkp481 [Extract] [Full Text] [PDF] [Request Permissions]  

Erratum

Pavel Gershkovich, Ellen K. Wasan, Molly Lin, Olena Sivak, Carlos G. Leon, John G. Clement, and Kishor M. Wasan

Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation
JAC Advance Access published on January 6, 2010
J. Antimicrob. Chemother. 2010 65: 599; doi:10.1093/jac/dkp474 [Extract] [Full Text] [PDF] [Request Permissions]  

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