Journal of Antimicrobial Chemotherapy

Leading articles

Get checked abstract Matthew S. Dryden, Jonathan Cooke, and Peter Davey

Antibiotic stewardship—more education and regulation not more availability?
JAC Advance Access published on September 2, 2009
J. Antimicrob. Chemother. 2009 64: 885-888; doi:10.1093/jac/dkp305 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Gavin D. Barlow on behalf of the BSAC Council

Swine flu and antibiotics
JAC Advance Access published on September 9, 2009
J. Antimicrob. Chemother. 2009 64: 889-894; doi:10.1093/jac/dkp313 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract F. Martin and G. P. Taylor

The safety of highly active antiretroviral therapy for the HIV-positive pregnant mother and her baby: is ‘the more the merrier’?
JAC Advance Access published on August 25, 2009
J. Antimicrob. Chemother. 2009 64: 895-900; doi:10.1093/jac/dkp303 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews

Get checked abstract Anne Maagaard and Dag Kvale

Mitochondrial toxicity in HIV-infected patients both off and on antiretroviral treatment: a continuum or distinct underlying mechanisms?
JAC Advance Access published on September 9, 2009
J. Antimicrob. Chemother. 2009 64: 901-909; doi:10.1093/jac/dkp316 [Abstract] [Full Text] [PDF] [Request Permissions]  

Systematic review

Get checked abstract A. M. M. Y. Li, C. D. Gomersall, G. Choi, Q. Tian, G. M. Joynt, and J. Lipman

A systematic review of antibiotic dosing regimens for septic patients receiving continuous renal replacement therapy: do current studies supply sufficient data?
JAC Advance Access published on August 25, 2009
J. Antimicrob. Chemother. 2009 64: 929-937; doi:10.1093/jac/dkp302 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Original research

Get checked abstract Esmeralda A. Soares, André F. Santos, Luis M. Gonzalez, Matthew S. Lalonde, Denis M. Tebit, Amilcar Tanuri, Eric J. Arts, and Marcelo A. Soares

Mutation T74S in HIV-1 subtype B and C proteases resensitizes them to ritonavir and indinavir and confers fitness advantage
JAC Advance Access published on August 26, 2009
J. Antimicrob. Chemother. 2009 64: 938-944; doi:10.1093/jac/dkp315 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Peter D. Dryer, Berkeley N. Limketkai, Christina M. Martin, Gang Ma, Kenneth E. Sherman, Lynn E. Taylor, Kenneth H. Mayer, Denise J. Jamieson, and Jason T. Blackard

Screening for hepatitis C virus non-nucleotide resistance mutations in treatment-naive women
JAC Advance Access published on September 18, 2009
J. Antimicrob. Chemother. 2009 64: 945-948; doi:10.1093/jac/dkp328 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Marie Doyle, Eva-Anne Feuerbaum, Keith R. Fox, Jason Hinds, David E. Thurston, and Peter W. Taylor

Response of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer
JAC Advance Access published on September 10, 2009
J. Antimicrob. Chemother. 2009 64: 949-959; doi:10.1093/jac/dkp325 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Mark S. Turner, Patiyan Andersson, Jan M. Bell, John D. Turnidge, Tegan Harris, and Philip M. Giffard

Plasmid-borne bla_SHV genes in Klebsiella pneumoniae are associated with strong promoters
JAC Advance Access published on September 12, 2009
J. Antimicrob. Chemother. 2009 64: 960-964; doi:10.1093/jac/dkp338 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Jessica M. A. Blair, Roberto M. La Ragione, Martin J. Woodward, and Laura J. V. Piddock

Periplasmic adaptor protein AcrA has a distinct role in the antibiotic resistance and virulence of Salmonella enterica serovar Typhimurium
JAC Advance Access published on September 10, 2009
J. Antimicrob. Chemother. 2009 64: 965-972; doi:10.1093/jac/dkp311 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Andrew M. Bailey, Chrystala Constantinidou, Al Ivens, Mark I. Garvey, Mark A. Webber, Nick Coldham, Jon L. Hobman, John Wain, Martin J. Woodward, and Laura J. V. Piddock

Exposure of Escherichia coli and Salmonella enterica serovar Typhimurium to triclosan induces a species-specific response, including drug detoxification
JAC Advance Access published on September 16, 2009
J. Antimicrob. Chemother. 2009 64: 973-985; doi:10.1093/jac/dkp320 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Cynthia Oxacelay, Ayla Ergani, Thierry Naas, and Patrice Nordmann

Rapid detection of CTX-M-producing Enterobacteriaceae in urine samples
JAC Advance Access published on September 10, 2009
J. Antimicrob. Chemother. 2009 64: 986-989; doi:10.1093/jac/dkp336 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract J. M. Sierra, M. Ortega, C. Tarragó, C. Albet, J. Vila, J. Terencio, and A. Guglietta

Decreased linezolid uptake in an in vitro-selected linezolid-resistant Staphylococcus epidermidis mutant
JAC Advance Access published on August 27, 2009
J. Antimicrob. Chemother. 2009 64: 990-992; doi:10.1093/jac/dkp309 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract M. Saint-Pierre-Chazalet, M. Ben Brahim, L. Le Moyec, C. Bories, M. Rakotomanga, and P. M. Loiseau

Membrane sterol depletion impairs miltefosine action in wild-type and miltefosine-resistant Leishmania donovani promastigotes
JAC Advance Access published on September 12, 2009
J. Antimicrob. Chemother. 2009 64: 993-1001; doi:10.1093/jac/dkp321 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Omar Janneh, Becky Chandler, Ruben Hartkoorn, Wai San Kwan, Claire Jenkinson, Sorcha Evans, David J. Back, Andrew Owen, and Saye H. Khoo

Intracellular accumulation of efavirenz and nevirapine is independent of P-glycoprotein activity in cultured CD4 T cells and primary human lymphocytes
JAC Advance Access published on September 11, 2009
J. Antimicrob. Chemother. 2009 64: 1002-1007; doi:10.1093/jac/dkp335 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract H. C. Steel, A. J. Theron, G. R. Tintinger, and R. Anderson

Posaconazole attenuates leukotriene B₄ release and uptake of calcium by chemoattractant-activated human neutrophils: a potential strategy to control neutrophil-mediated inflammation
JAC Advance Access published on September 10, 2009
J. Antimicrob. Chemother. 2009 64: 1008-1012; doi:10.1093/jac/dkp329 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Lucio Vera-Cabrera, Nelly A. Espinoza-González, Oliverio Welsh, Jorge Ocampo-Candiani, and Jorge Castro-Garza

Activity of novel oxazolidinones against Nocardia brasiliensis growing within THP-1 macrophages
JAC Advance Access published on August 26, 2009
J. Antimicrob. Chemother. 2009 64: 1013-1017; doi:10.1093/jac/dkp314 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Manju Y. Krishnan, Elizabeth J. B. Manning, and Michael T. Collins

Effects of interactions of antibacterial drugs with each other and with 6-mercaptopurine on in vitro growth of Mycobacterium avium subspecies paratuberculosis
JAC Advance Access published on September 16, 2009
J. Antimicrob. Chemother. 2009 64: 1018-1023; doi:10.1093/jac/dkp339 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Helio S. Sader, Ronald N. Jones, Kerri L. Rossi, and Michael J. Rybak

Occurrence of vancomycin-tolerant and heterogeneous vancomycin-intermediate strains (hVISA) among Staphylococcus aureus causing bloodstream infections in nine USA hospitals
JAC Advance Access published on September 10, 2009
J. Antimicrob. Chemother. 2009 64: 1024-1028; doi:10.1093/jac/dkp319 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract M. I. A. Rijnders, R. H. Deurenberg, M. L. L. Boumans, J. A. A. Hoogkamp-Korstanje, P. S. Beisser, E. E. Stobberingh, and on behalf of the Antibiotic Resistance Surveillance Group

Flucloxacillin, still the empirical choice for putative Staphylococcus aureus infections in intensive care units in the Netherlands
JAC Advance Access published on September 22, 2009
J. Antimicrob. Chemother. 2009 64: 1029-1034; doi:10.1093/jac/dkp337 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Sandrine Lemaire, Françoise Van Bambeke, Peter C. Appelbaum, and Paul M. Tulkens

Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines
JAC Advance Access published on September 16, 2009
J. Antimicrob. Chemother. 2009 64: 1035-1043; doi:10.1093/jac/dkp267 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Karen E. Bowker, Alan R. Noel, and Alasdair P. MacGowan

Comparative antibacterial effects of daptomycin, vancomycin and teicoplanin studied in an in vitro pharmacokinetic model of infection
JAC Advance Access published on September 16, 2009
J. Antimicrob. Chemother. 2009 64: 1044-1051; doi:10.1093/jac/dkp289 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Kathleen England, Christopher am Ende, Hao Lu, Todd J. Sullivan, Nicole L. Marlenee, Richard A. Bowen, Susan E. Knudson, Dennis L. Knudson, Peter J. Tonge, and Richard A. Slayden

Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia
JAC Advance Access published on September 4, 2009
J. Antimicrob. Chemother. 2009 64: 1052-1061; doi:10.1093/jac/dkp307 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract O. Murillo, M. E. Pachón, G. Euba, R. Verdaguer, M. Carreras, C. Cabellos, J. Cabo, F. Gudiol, and J. Ariza

Intracellular antimicrobial activity appearing as a relevant factor in antibiotic efficacy against an experimental foreign-body infection caused by Staphylococcus aureus
JAC Advance Access published on September 10, 2009
J. Antimicrob. Chemother. 2009 64: 1062-1066; doi:10.1093/jac/dkp326 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Feda' Emad Atta Ali, Guoying Cao, Anima Poudyal, Timo Vaara, Roger L. Nation, Martti Vaara, and Jian Li

Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration
JAC Advance Access published on September 10, 2009
J. Antimicrob. Chemother. 2009 64: 1067-1070; doi:10.1093/jac/dkp331 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Peter L. Anderson, Christina L. Aquilante, Edward M. Gardner, Julie Predhomme, Patrick McDaneld, Lane R. Bushman, Jia-Hua Zheng, Michelle Ray, and Samantha MaWhinney

Atazanavir pharmacokinetics in genetically determined CYP3A5 expressors versus non-expressors
JAC Advance Access published on August 26, 2009
J. Antimicrob. Chemother. 2009 64: 1071-1079; doi:10.1093/jac/dkp317 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Thanyawee Puthanakit, Jasper van der Lugt, Torsak Bunupuradah, Jintanat Ananworanich, Meena Gorowara, Chayapa Phasomsap, Thidarat Jupimai, Pitch Boonrak, Chitsanu Pancharoen, David Burger, and Kiat Ruxrungtham

Pharmacokinetics and 48 week efficacy of low-dose lopinavir/ritonavir in HIV-infected children
JAC Advance Access published on September 2, 2009
J. Antimicrob. Chemother. 2009 64: 1080-1086; doi:10.1093/jac/dkp322 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Marc Wirden, Anne Simon, Luminita Schneider, Roland Tubiana, Isabelle Malet, Hocine Ait-Mohand, Gilles Peytavin, Christine Katlama, Vincent Calvez, and Anne-Genevieve Marcelin

Raltegravir has no residual antiviral activity in vivo against HIV-1 with resistance-associated mutations to this drug
JAC Advance Access published on August 27, 2009
J. Antimicrob. Chemother. 2009 64: 1087-1090; doi:10.1093/jac/dkp310 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Michael C. Ober, Torsten Hoppe-Tichy, Jörg Köninger, Oliver Schunter, Hans-Günther Sonntag, Markus A. Weigand, Jens Encke, Carsten Gutt, and Stefanie Swoboda

Tissue penetration of moxifloxacin into human gallbladder wall in patients with biliary tract infections
JAC Advance Access published on September 4, 2009
J. Antimicrob. Chemother. 2009 64: 1091-1095; doi:10.1093/jac/dkp318 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Soumya Tiwari, H. S. Rehan, Jagdish Chandra, N. N. Mathur, and Varinder Singh

Efficacy and safety of a single daily dose of gentamicin in hospitalized Indian children: a quasi-randomized trial
JAC Advance Access published on September 16, 2009
J. Antimicrob. Chemother. 2009 64: 1096-1101; doi:10.1093/jac/dkp330 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Andrea Endimiani, John M. DePasquale, Sandra Forero, Federico Perez, Andrea M. Hujer, Daneshia Roberts-Pollack, Paul D. Fiorella, Nancy Pickens, Brandon Kitchel, Aida E. Casiano-Colón, Fred C. Tenover, and Robert A. Bonomo

Emergence of bla_KPC-containing Klebsiella pneumoniae in a long-term acute care hospital: a new challenge to our healthcare system
JAC Advance Access published on September 9, 2009
J. Antimicrob. Chemother. 2009 64: 1102-1110; doi:10.1093/jac/dkp327 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Richard Brindle and on behalf of Wessex Microbiologists

Has the publication of methicillin-resistant Staphylococcus aureus (MRSA) treatment guidelines increased the survival associated with MRSA bacteraemia?
JAC Advance Access published on September 10, 2009
J. Antimicrob. Chemother. 2009 64: 1111-1113; doi:10.1093/jac/dkp332 [Abstract] [Full Text] [PDF] [Request Permissions]  

Research letters

Patricia Dandache, Pamela A. Moise, Jose Orsini, Marisa Montecalvo, and George Sakoulas

Reduced biofilm production associated with increasing linezolid MICs among linezolid-resistant staphylococci
JAC Advance Access published on September 4, 2009
J. Antimicrob. Chemother. 2009 64: 1114-1115; doi:10.1093/jac/dkp324 [Extract] [Full Text] [PDF] [Request Permissions]  

Shigeru Fujimura, Hidenari Takane, Yoshihisa Nakano, and Akira Watanabe

In vitro synergy studies based on tazobactam/piperacillin against clinical isolates of metallo-β-lactamase-producing Pseudomonas aeruginosa
JAC Advance Access published on September 10, 2009
J. Antimicrob. Chemother. 2009 64: 1115-1116; doi:10.1093/jac/dkp333 [Extract] [Full Text] [PDF] [Request Permissions]  

A. M. Lovering and D. S. Reeves

Potentially dangerous misuse of the Hartford once-daily nomogram for gentamicin
JAC Advance Access published on August 31, 2009
J. Antimicrob. Chemother. 2009 64: 1117-1118; doi:10.1093/jac/dkp323 [Extract] [Full Text] [PDF] [Request Permissions]  

Letters to the Editor

Wing Wai Yew, Kwok Chiu Chang, and Chi Hung Chau

Comment on: Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis
JAC Advance Access published on August 8, 2009
J. Antimicrob. Chemother. 2009 64: 1119; doi:10.1093/jac/dkp291 [Extract] [Full Text] [PDF] [Request Permissions]  

Won-Jung Koh and Tae Sun Shim

Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis—authors' response
JAC Advance Access published on September 10, 2009
J. Antimicrob. Chemother. 2009 64: 1119-1120; doi:10.1093/jac/dkp344 [Extract] [Full Text] [PDF] [Request Permissions]  

Book review

Matthew Dryden

Oxford Handbook of Infectious Diseases and Microbiology
JAC Advance Access published on August 26, 2009
J. Antimicrob. Chemother. 2009 64: 1121; doi:10.1093/jac/dkp308 [Extract] [Full Text] [PDF] [Request Permissions]  

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