Journal of Antimicrobial Chemotherapy

Leading articles

Get checked abstract Christopher McGuigan and Jan Balzarini

FV100 as a new approach for the possible treatment of varicella-zoster virus infection
JAC Advance Access published on August 13, 2009
J. Antimicrob. Chemother. 2009 64: 671-673; doi:10.1093/jac/dkp294 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Jake Dunning and Mark Nelson

Novel strategies to treat antiretroviral-naive HIV-infected patients
JAC Advance Access published on July 29, 2009
J. Antimicrob. Chemother. 2009 64: 674-679; doi:10.1093/jac/dkp239 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original research

Get checked abstract Shenghui Cui, Jingyun Li, Changqin Hu, Shaohong Jin, Fengqin Li, Yunchang Guo, Lu Ran, and Yue Ma

Isolation and characterization of methicillin-resistant Staphylococcus aureus from swine and workers in China
JAC Advance Access published on August 14, 2009
J. Antimicrob. Chemother. 2009 64: 680-683; doi:10.1093/jac/dkp275 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Håvard Valvatne, Heidi Syre, Martijn Kross, Ruth Stavrum, Ti Ti, Sabai Phyu, and Harleen M. S. Grewal

Isoniazid and rifampicin resistance-associated mutations in Mycobacterium tuberculosis isolates from Yangon, Myanmar: implications for rapid molecular testing
JAC Advance Access published on August 26, 2009
J. Antimicrob. Chemother. 2009 64: 694-701; doi:10.1093/jac/dkp292 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Nicola C. Elviss, Lisa K. Williams, Frieda Jørgensen, Stephanie A. Chisholm, Andrew J. Lawson, Craig Swift, Robert J. Owen, Deborah J. Griggs, Maggie M. Johnson, Tom J. Humphrey, and Laura J. V. Piddock

Amoxicillin therapy of poultry flocks: effect upon the selection of amoxicillin-resistant commensal Campylobacter spp.
JAC Advance Access published on August 4, 2009
J. Antimicrob. Chemother. 2009 64: 702-711; doi:10.1093/jac/dkp277 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jesús Oteo, Beatriz Orden, Verónica Bautista, Oscar Cuevas, Margarita Arroyo, Rocío Martínez-Ruiz, María Pérez-Vázquez, Marta Alcaraz, Silvia García-Cobos, and José Campos

CTX-M-15-producing urinary Escherichia coli O25b-ST131-phylogroup B2 has acquired resistance to fosfomycin
JAC Advance Access published on August 11, 2009
J. Antimicrob. Chemother. 2009 64: 712-717; doi:10.1093/jac/dkp288 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Inna Chmelnitsky, Orit Hermesh, Shiri Navon-Venezia, Jacob Strahilevitz, and Yehuda Carmeli

Detection of aac(6')-Ib-cr in KPC-producing Klebsiella pneumoniae isolates from Tel Aviv, Israel
JAC Advance Access published on August 4, 2009
J. Antimicrob. Chemother. 2009 64: 718-722; doi:10.1093/jac/dkp272 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract L. F. Mataseje, J. Xiao, S. Kost, L.-K. Ng, K. Doré, M. R. Mulvey, and on behalf of the Canadian Public Health Laboratory Network (CPHLN)

Characterization of Canadian cefoxitin-resistant non-typhoidal Salmonella isolates, 2005–06
JAC Advance Access published on July 27, 2009
J. Antimicrob. Chemother. 2009 64: 723-730; doi:10.1093/jac/dkp249 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Arif Al-Hamad, Mathew Upton, and James Burnie

Molecular cloning and characterization of SmrA, a novel ABC multidrug efflux pump from Stenotrophomonas maltophilia
JAC Advance Access published on July 29, 2009
J. Antimicrob. Chemother. 2009 64: 731-734; doi:10.1093/jac/dkp271 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Nicola Ooi, Keith Miller, Joanne Hobbs, William Rhys-Williams, William Love, and Ian Chopra

XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity
JAC Advance Access published on August 18, 2009
J. Antimicrob. Chemother. 2009 64: 735-740; doi:10.1093/jac/dkp299 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Donald F. Smee, Brett L. Hurst, Hiroyuki Egawa, Kazumi Takahashi, Takumi Kadota, and Yousuke Furuta

Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells
JAC Advance Access published on July 29, 2009
J. Antimicrob. Chemother. 2009 64: 741-746; doi:10.1093/jac/dkp274 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Anissa Daliry, Patrícia B. Da Silva, Cristiane F. Da Silva, Marcos Meuser Batista, Solange L. De Castro, Richard R. Tidwell, and Maria de Nazaré C. Soeiro

In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi
JAC Advance Access published on August 11, 2009
J. Antimicrob. Chemother. 2009 64: 747-750; doi:10.1093/jac/dkp290 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Autumn S. Downey, Thaddeus K. Graczyk, and David J. Sullivan

In vitro activity of pyrvinium pamoate against Entamoeba histolytica and Giardia intestinalis using radiolabelled thymidine incorporation and an SYBR Green I-based fluorescence assay
JAC Advance Access published on August 18, 2009
J. Antimicrob. Chemother. 2009 64: 751-754; doi:10.1093/jac/dkp296 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Gabriel Mircus, Shelly Hagag, Emma Levdansky, Haim Sharon, Yona Shadkchan, Itamar Shalit, and Nir Osherov

Identification of novel cell wall destabilizing antifungal compounds using a conditional Aspergillus nidulans protein kinase C mutant
JAC Advance Access published on July 31, 2009
J. Antimicrob. Chemother. 2009 64: 755-763; doi:10.1093/jac/dkp270 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Lan Yan, Miaohai Li, Yongbing Cao, Pinghui Gao, Yingying Cao, Yan Wang, and Yuanying Jiang

The alternative oxidase of Candida albicans causes reduced fluconazole susceptibility
JAC Advance Access published on August 5, 2009
J. Antimicrob. Chemother. 2009 64: 764-773; doi:10.1093/jac/dkp273 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Antima Gupta, Sanjib Bhakta, Subir Kundu, Manish Gupta, Brahm S. Srivastava, and Ranjana Srivastava

Fast-growing, non-infectious and intracellularly surviving drug-resistant Mycobacterium aurum: a model for high-throughput antituberculosis drug screening
JAC Advance Access published on August 4, 2009
J. Antimicrob. Chemother. 2009 64: 774-781; doi:10.1093/jac/dkp279 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Elke Feese and Reza A. Ghiladi

Highly efficient in vitro photodynamic inactivation of Mycobacterium smegmatis
JAC Advance Access published on August 6, 2009
J. Antimicrob. Chemother. 2009 64: 782-785; doi:10.1093/jac/dkp278 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Thomas Schön, Pontus Juréen, Christian G. Giske, Erja Chryssanthou, Erik Sturegård, Jim Werngren, Gunnar Kahlmeter, Sven E. Hoffner, and Kristian A. Ängeby

Evaluation of wild-type MIC distributions as a tool for determination of clinical breakpoints for Mycobacterium tuberculosis
JAC Advance Access published on July 23, 2009
J. Antimicrob. Chemother. 2009 64: 786-793; doi:10.1093/jac/dkp262 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Maria de Lourdes Shikama, Regina Ruivo Ferro E. Silva, Maria Conceição Martins, Carmen Maria Saraiva Giampaglia, Rosângela Siqueira Oliveira, Rosmari F. A. M. Silva, Paula Ferro E. Silva, Maria Alice da Silva Telles, Anandi Martin, and Juan Carlos Palomino

Rapid detection of resistant tuberculosis by nitrate reductase assay performed in three settings in Brazil
JAC Advance Access published on August 11, 2009
J. Antimicrob. Chemother. 2009 64: 794-796; doi:10.1093/jac/dkp284 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Maneesh Paul-Satyaseela, Shakti Singh Solanki, Devarajan Sathishkumar, Thirunavukkarasu Bharani, Vijayan Magesh, and Sriram Rajagopal

In vitro antibacterial activities of a novel oxazolidinone, OCID0050
JAC Advance Access published on August 18, 2009
J. Antimicrob. Chemother. 2009 64: 797-800; doi:10.1093/jac/dkp300 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Elke Peeters, Hans J. Nelis, and Tom Coenye

In vitro activity of ceftazidime, ciprofloxacin, meropenem, minocycline, tobramycin and trimethoprim/sulfamethoxazole against planktonic and sessile Burkholderia cepacia complex bacteria
JAC Advance Access published on July 23, 2009
J. Antimicrob. Chemother. 2009 64: 801-809; doi:10.1093/jac/dkp253 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Kamel Alhanout, Jean-Michel Brunel, Didier Raoult, and Jean-Marc Rolain

In vitro antibacterial activity of aminosterols against multidrug-resistant bacteria from patients with cystic fibrosis
JAC Advance Access published on August 7, 2009
J. Antimicrob. Chemother. 2009 64: 810-814; doi:10.1093/jac/dkp281 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Maria V. Smirnova, Sergey N. Vostrov, Elena V. Strukova, Svetlana A. Dovzhenko, Michael B. Kobrin, Yury A. Portnoy, Stephen H. Zinner, and Alexander A. Firsov

The impact of duration of antibiotic exposure on bacterial resistance predictions using in vitro dynamic models
JAC Advance Access published on August 11, 2009
J. Antimicrob. Chemother. 2009 64: 815-820; doi:10.1093/jac/dkp287 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Robert Sauermann, Richard Schwameis, Manfred Fille, Maria Luciana Camuz Ligios, and Markus Zeitlinger

Cerebrospinal fluid impairs antimicrobial activity of fosfomycin in vitro
JAC Advance Access published on July 21, 2009
J. Antimicrob. Chemother. 2009 64: 821-823; doi:10.1093/jac/dkp261 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract George G. Zhanel, Patricia J. Baudry, Franil Tailor, Lauren Cox, Daryl J. Hoban, and James A. Karlowsky

Determination of the pharmacodynamic activity of clinically achievable tigecycline serum concentrations against clinical isolates of Escherichia coli with extended-spectrum β-lactamases, AmpC β-lactamases and reduced susceptibility to carbapenems using an in vitro model
JAC Advance Access published on July 29, 2009
J. Antimicrob. Chemother. 2009 64: 824-828; doi:10.1093/jac/dkp254 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jared L. Crandon, Aryun Kim, and David P. Nicolau

Comparison of tigecycline penetration into the epithelial lining fluid of infected and uninfected murine lungs
JAC Advance Access published on August 19, 2009
J. Antimicrob. Chemother. 2009 64: 837-839; doi:10.1093/jac/dkp301 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Kazuro Ikawa, Kenichi Nomura, Norifumi Morikawa, Kayo Ikeda, and Masafumi Taniwaki

Assessment of micafungin regimens by pharmacokinetic–pharmacodynamic analysis: a dosing strategy for Aspergillus infections
JAC Advance Access published on August 21, 2009
J. Antimicrob. Chemother. 2009 64: 840-844; doi:10.1093/jac/dkp298 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Miguel Genebat, Ezequiel Ruiz-Mateos, Juan A. León, Alejandro González-Serna, Ildefonso Pulido, Inmaculada Rivas, Sara Ferrando-Martínez, Berta Sánchez, Ma Ángeles Muñoz-Fernández, and Manuel Leal

Correlation between the Trofile^® test and virological response to a short-term maraviroc exposure in HIV-infected patients
JAC Advance Access published on August 11, 2009
J. Antimicrob. Chemother. 2009 64: 845-849; doi:10.1093/jac/dkp293 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Sumit Mohan, Manasvi Jaitly, Velvie A. Pogue, and Jen-Tse Cheng

Influence of concomitant prednisolone on trimethoprim-associated hyperkalaemia
JAC Advance Access published on August 4, 2009
J. Antimicrob. Chemother. 2009 64: 850-852; doi:10.1093/jac/dkp280 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Julie Bruce, Fiona M. MacKenzie, Barry Cookson, Jill Mollison, Jos W. M. van der Meer, Vladimir Krcmery, and Ian M. Gould on behalf of the ARPAC Steering Group

Antibiotic stewardship and consumption: findings from a pan-European hospital study
JAC Advance Access published on August 12, 2009
J. Antimicrob. Chemother. 2009 64: 853-860; doi:10.1093/jac/dkp268 [Abstract] [Full Text] [PDF] [Request Permissions]  

Research letters

Marianne Gunell, Antti J. Hakanen, Jari Jalava, Pentti Huovinen, and Monica Österblad

Hidden qnrB12 gene in a Finnish faecal microbiota isolate from 1994
JAC Advance Access published on August 19, 2009
J. Antimicrob. Chemother. 2009 64: 861-862; doi:10.1093/jac/dkp304 [Extract] [Full Text] [PDF] [Request Permissions]  

Alicia Coelho, Beatriz Mirelis, Carles Alonso-Tarrés, María Nieves Larrosa, Elisenda Miró, Raquel Clivillé Abad, Rosa María Bartolomé, Mireia Castañer, Guillem Prats, James R. Johnson, Ferran Navarro, and Juan José González-López

Detection of three stable genetic clones of CTX-M-15-producing Klebsiella pneumoniae in the Barcelona metropolitan area, Spain
JAC Advance Access published on July 22, 2009
J. Antimicrob. Chemother. 2009 64: 862-864; doi:10.1093/jac/dkp264 [Extract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Dearbháile Morris, Fiona Boyle, Victoria Buckley, Li Xu, Belinda Hanahoe, Peter Hawkey, and Martin Cormican

CTX-M enzymes are the predominant extended-spectrum β-lactamases produced by Enterobacteriaceae in Ireland
JAC Advance Access published on August 21, 2009
J. Antimicrob. Chemother. 2009 64: 864-866; doi:10.1093/jac/dkp297 [Extract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Thierry Naas, Chafia Bentchouala, Sandra Lima, Abdesselam Lezzar, Farida Smati, Jean-Michel Scheftel, and Patrice Nordmann

Plasmid-mediated 16S rRNA methylases among extended-spectrum-β-lactamase-producing Salmonella enterica Senftenberg isolates from Algeria
JAC Advance Access published on August 21, 2009
J. Antimicrob. Chemother. 2009 64: 866-868; doi:10.1093/jac/dkp312 [Extract] [Full Text] [PDF] [Request Permissions]  

Francis F. Arhin, Ingrid Sarmiento, Thomas R. Parr, Jr, and Gregory Moeck

Comparative in vitro activity of oritavancin against Staphylococcus aureus strains that are resistant, intermediate or heteroresistant to vancomycin
JAC Advance Access published on August 4, 2009
J. Antimicrob. Chemother. 2009 64: 868-870; doi:10.1093/jac/dkp286 [Extract] [Full Text] [PDF] [Request Permissions]  

S. Aathithan and G. L. French

Organic solvent tolerance and fluoroquinolone resistance in Klebsiella pneumoniae clinical isolates
JAC Advance Access published on August 13, 2009
J. Antimicrob. Chemother. 2009 64: 870-871; doi:10.1093/jac/dkp295 [Extract] [Full Text] [PDF] [Request Permissions]  

H. Khachi, R. O'Connell, D. Ladenheim, and C. Orkin

Pharmacokinetic interactions between rifabutin and lopinavir/ritonavir in HIV-infected patients with mycobacterial co-infection
JAC Advance Access published on July 22, 2009
J. Antimicrob. Chemother. 2009 64: 871-873; doi:10.1093/jac/dkp263 [Extract] [Full Text] [PDF] [Request Permissions]  

Antonio Di Biagio, Raffaella Rosso, Marco Siccardi, Antonio D'Avolio, Stefano Bonora, and Claudio Viscoli

Lack of interaction between raltegravir and cyclosporin in an HIV-infected liver transplant recipient
JAC Advance Access published on July 29, 2009
J. Antimicrob. Chemother. 2009 64: 874-875; doi:10.1093/jac/dkp269 [Extract] [Full Text] [PDF] [Request Permissions]  

C. Y. William Tong, Jane E. Mullen, and Terry Wong

Early hepatitis B virological rebound on entecavir through selection of lamivudine-associated mutations
JAC Advance Access published on August 11, 2009
J. Antimicrob. Chemother. 2009 64: 875-877; doi:10.1093/jac/dkp283 [Extract] [Full Text] [PDF] [Request Permissions]  

Isabel Spriet, Lien Delaere, Katrien Lagrou, Willy E. Peetermans, Johan Maertens, and Ludo Willems

Intraocular penetration of voriconazole and caspofungin in a patient with fungal endophthalmitis
JAC Advance Access published on August 14, 2009
J. Antimicrob. Chemother. 2009 64: 877-878; doi:10.1093/jac/dkp306 [Extract] [Full Text] [PDF] [Request Permissions]  

Letters to the Editor

Giovanni Sotgiu, Christoph Lange, Morgan D'Arcy Richardson, Alberto Matteelli, Rosella Centis, Barbara Eker, Gunar Guenther, Antonio Spanevello, and Giovanni Battista Migliori for the TBNET

Comment on: Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis
JAC Advance Access published on August 3, 2009
J. Antimicrob. Chemother. 2009 64: 879-883; doi:10.1093/jac/dkp265 [Extract] [Full Text] [PDF] [Request Permissions]  

Won-Jung Koh and Tae Sun Shim

Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis—authors' response
JAC Advance Access published on August 3, 2009
J. Antimicrob. Chemother. 2009 64: 883-884; doi:10.1093/jac/dkp276 [Extract] [Full Text] [PDF] [Request Permissions]  

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