Journal of Antimicrobial Chemotherapy

Leading articles

Get checked abstract Roger Finch and Mike Sharland

18 November and beyond: observations on the EU Antibiotic Awareness Day
JAC Advance Access published on February 17, 2009
J. Antimicrob. Chemother. 2009 63: 633-635; doi:10.1093/jac/dkp039 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Brian Wells Pence

The impact of mental health and traumatic life experiences on antiretroviral treatment outcomes for people living with HIV/AIDS
JAC Advance Access published on January 18, 2009
J. Antimicrob. Chemother. 2009 63: 636-640; doi:10.1093/jac/dkp006 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original research

Get checked abstract Po-Liang Lu, Michel Doumith, David M. Livermore, Tyen-Po Chen, and Neil Woodford

Diversity of carbapenem resistance mechanisms in Acinetobacter baumannii from a Taiwan hospital: spread of plasmid-borne OXA-72 carbapenemase
JAC Advance Access published on January 31, 2009
J. Antimicrob. Chemother. 2009 63: 641-647; doi:10.1093/jac/dkn553 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Nicole Wueppenhorst, Hans-Peter Stueger, Manfred Kist, and Erik Glocker

Identification and molecular characterization of triple- and quadruple-resistant Helicobacter pylori clinical isolates in Germany
JAC Advance Access published on February 3, 2009
J. Antimicrob. Chemother. 2009 63: 648-653; doi:10.1093/jac/dkp003 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Ørjan Samuelsen, Umaer Naseer, Ståle Tofteland, Dag Harald Skutlaberg, Annette Onken, Reidar Hjetland, Arnfinn Sundsfjord, and Christian G. Giske

Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 654-658; doi:10.1093/jac/dkp018 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Michel Doumith, Matthew J. Ellington, David M. Livermore, and Neil Woodford

Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK
JAC Advance Access published on February 20, 2009
J. Antimicrob. Chemother. 2009 63: 659-667; doi:10.1093/jac/dkp029 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Anna Fenosa, Ester Fusté, Lidia Ruiz, Patricia Veiga-Crespo, Teresa Vinuesa, Victor Guallar, Tomas G. Villa, and Miguel Viñas

Role of TolC in Klebsiella oxytoca resistance to antibiotics
JAC Advance Access published on February 24, 2009
J. Antimicrob. Chemother. 2009 63: 668-674; doi:10.1093/jac/dkp027 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Avelina Espinosa, George Perdrizet, Guillermo Paz-y-Miño C., Regine Lanfranchi, and Monichan Phay

Effects of iron depletion on Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) and trophozoite growth: implications for antiamoebic therapy
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 675-678; doi:10.1093/jac/dkp015 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Pearl M. Swe, Gregory M. Cook, John R. Tagg, and Ralph W. Jack

Mode of action of dysgalacticin: a large heat-labile bacteriocin
JAC Advance Access published on February 12, 2009
J. Antimicrob. Chemother. 2009 63: 679-686; doi:10.1093/jac/dkn552 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Christian Oefner, Monica Bandera, Andreas Haldimann, Heike Laue, Henk Schulz, Seema Mukhija, Sandro Parisi, Laurent Weiss, Sergio Lociuro, and Glenn E. Dale

Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity
JAC Advance Access published on February 11, 2009
J. Antimicrob. Chemother. 2009 63: 687-698; doi:10.1093/jac/dkp024 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract R. Skov, R. Smyth, A. Yusof, A. Karlsson, K. Mills, N. Frimodt-Moller, and G. Kahlmeter

Effects of temperature on the detection of methicillin resistance in Staphylococcus aureus using cefoxitin disc diffusion testing with Iso-Sensitest agar
JAC Advance Access published on February 18, 2009
J. Antimicrob. Chemother. 2009 63: 699-703; doi:10.1093/jac/dkp019 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Susanna K. P. Lau, Gilman K. M. Wong, Rosana W. S. Poon, Leo C. K. Lee, Kit-wah Leung, Cindy W. S. Tse, Pak-Leung Ho, Tak-Lun Que, Patrick C. Y. Woo, and Kwok-Yung Yuen

Susceptibility patterns of clinical and fish isolates of Laribacter hongkongensis: comparison of the Etest, disc diffusion and broth microdilution methods
JAC Advance Access published on February 6, 2009
J. Antimicrob. Chemother. 2009 63: 704-708; doi:10.1093/jac/dkp010 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Xiaohua Yang, Andrew Nguyen, Dan Qiu, and Benjamin J. Luft

In vitro activity of tigecycline against multiple strains of Borrelia burgdorferi
JAC Advance Access published on January 31, 2009
J. Antimicrob. Chemother. 2009 63: 709-712; doi:10.1093/jac/dkn551 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract David M. Livermore, Shazad Mushtaq, Marina Warner, and Neil Woodford

Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci
JAC Advance Access published on January 22, 2009
J. Antimicrob. Chemother. 2009 63: 713-715; doi:10.1093/jac/dkp002 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Ronald N. Jones, Gary J. Moet, Helio S. Sader, Rodrigo E. Mendes, and Mariana Castanheira

TR-700 in vitro activity against and resistance mutation frequencies among Gram-positive pathogens
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 716-720; doi:10.1093/jac/dkp021 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract E. De Vecchi, L. Nicola, F. Ossola, and L. Drago

In vitro selection of resistance in Streptococcus pneumoniae at in vivo fluoroquinolone concentrations
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 721-727; doi:10.1093/jac/dkp020 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract M. I. Gillham, S. Sundaram, C. R. Laughton, C. S. Haworth, D. Bilton, and J. E. Foweraker

Variable antibiotic susceptibility in populations of Pseudomonas aeruginosa infecting patients with bronchiectasis
JAC Advance Access published on February 4, 2009
J. Antimicrob. Chemother. 2009 63: 728-732; doi:10.1093/jac/dkp007 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Anno de Jong, Robin Bywater, Pascal Butty, Erik Deroover, Kevin Godinho, Ulrich Klein, Hervé Marion, Shabbir Simjee, Katelijne Smets, Valérie Thomas, Michel Vallé, and Aileen Wheadon

A pan-European survey of antimicrobial susceptibility towards human-use antimicrobial drugs among zoonotic and commensal enteric bacteria isolated from healthy food-producing animals
JAC Advance Access published on February 20, 2009
J. Antimicrob. Chemother. 2009 63: 733-744; doi:10.1093/jac/dkp012 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Klas I. Udekwu, Nicholas Parrish, Peter Ankomah, Fernando Baquero, and Bruce R. Levin

Functional relationship between bacterial cell density and the efficacy of antibiotics
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 745-757; doi:10.1093/jac/dkn554 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Ellen N. Kersh, Wei Luo, Debra R. Adams, James Mitchell, J. Gerardo Garcia-Lerma, Sal Butera, Tom Folks, and Ron Otten

Evaluation of the lymphocyte trafficking drug FTY720 in SHIV_SF162P3-infected rhesus macaques
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 758-762; doi:10.1093/jac/dkp008 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Sharath S. Hegde, Stacey Difuntorum, Robert Skinner, Justin Trumbull, and Kevin M. Krause

Efficacy of telavancin against glycopeptide-intermediate Staphylococcus aureus in the neutropenic mouse bacteraemia model
JAC Advance Access published on January 20, 2009
J. Antimicrob. Chemother. 2009 63: 763-766; doi:10.1093/jac/dkp001 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Isabel Spriet, Pieter Annaert, Philippe Meersseman, Greet Hermans, Wouter Meersseman, Rene Verbesselt, and Ludo Willems

Pharmacokinetics of caspofungin and voriconazole in critically ill patients during extracorporeal membrane oxygenation
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 767-770; doi:10.1093/jac/dkp026 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Audrey Lecaillet, Marie-Noëlle Mallet, Didier Raoult, and Jean-Marc Rolain

Therapeutic impact of the correlation of doxycycline serum concentrations and the decline of phase I antibodies in Q fever endocarditis
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 771-774; doi:10.1093/jac/dkp013 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract N. C. Gordon and D. W. Wareham

A review of clinical and microbiological outcomes following treatment of infections involving multidrug-resistant Acinetobacter baumannii with tigecycline
JAC Advance Access published on January 21, 2009
J. Antimicrob. Chemother. 2009 63: 775-780; doi:10.1093/jac/dkn555 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jesús Rodríguez-Baño, Juan Alcalá, Jose Miguel Cisneros, Fabio Grill, Antonio Oliver, Juan Pablo Horcajada, Teresa Tórtola, Beatriz Mirelis, Gemma Navarro, María Cuenca, María Esteve, Carmen Peña, Ana C. Llanos, Rafael Cantón, and Alvaro Pascual

Escherichia coli producing SHV-type extended-spectrum β-lactamase is a significant cause of community-acquired infection
JAC Advance Access published on February 17, 2009
J. Antimicrob. Chemother. 2009 63: 781-784; doi:10.1093/jac/dkp028 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Philippe Montravers, Alain Lepape, Luc Dubreuil, Rémy Gauzit, Yves Pean, Daniel Benchimol, and Hervé Dupont

Clinical and microbiological profiles of community-acquired and nosocomial intra-abdominal infections: results of the French prospective, observational EBIIA study
JAC Advance Access published on February 5, 2009
J. Antimicrob. Chemother. 2009 63: 785-794; doi:10.1093/jac/dkp005 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Isabelle Malet, Olivier Delelis, Cathia Soulie, Marc Wirden, Luba Tchertanov, Philippe Mottaz, Gilles Peytavin, Christine Katlama, Jean-François Mouscadet, Vincent Calvez, and Anne-Genevieve Marcelin

Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients
JAC Advance Access published on February 16, 2009
J. Antimicrob. Chemother. 2009 63: 795-804; doi:10.1093/jac/dkp014 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Gertraud Regula, Kay Torriani, Beat Gassner, Flurina Stucki, and Cedric R. Müntener

Prescription patterns of antimicrobials in veterinary practices in Switzerland
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 805-811; doi:10.1093/jac/dkp009 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Ulrich S. Jensen, Line Skjøt-Rasmussen, Stefan S. Olsen, Niels Frimodt-Møller, and Anette M. Hammerum on behalf of the DANRES Study Group

Consequences of increased antibacterial consumption and change in pattern of antibacterial use in Danish hospitals
JAC Advance Access published on February 24, 2009
J. Antimicrob. Chemother. 2009 63: 812-815; doi:10.1093/jac/dkp043 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Marc H. Scheetz, Maureen K. Bolon, Michael Postelnick, Gary A. Noskin, and Todd A. Lee

Cost-effectiveness analysis of an antimicrobial stewardship team on bloodstream infections: a probabilistic analysis
JAC Advance Access published on February 6, 2009
J. Antimicrob. Chemother. 2009 63: 816-825; doi:10.1093/jac/dkp004 [Abstract] [Full Text] [PDF] [Request Permissions]  

Research letters

Maria Daskalaki, Joaquin R. Otero, and Fernando Chaves

Molecular characterization of resistance to mupirocin in methicillin-resistant Staphylococcus aureus isolates in a tertiary hospital in Spain
JAC Advance Access published on February 17, 2009
J. Antimicrob. Chemother. 2009 63: 826-828; doi:10.1093/jac/dkp025 [Extract] [Full Text] [PDF] [Request Permissions]  

Maria Giannouli, Federica Tomasone, Antonella Agodi, Haluk Vahaboglu, Ziad Daoud, Maria Triassi, Athanassios Tsakris, and Raffaele Zarrilli

Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii strains in intensive care units of multiple Mediterranean hospitals
JAC Advance Access published on February 17, 2009
J. Antimicrob. Chemother. 2009 63: 828-830; doi:10.1093/jac/dkp032 [Extract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

S. M. Naqvi, C. Jenkins, T. D. McHugh, and I. Balakrishnan

Identification of the qnr family in Enterobacteriaceae in clinical practice
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 830-832; doi:10.1093/jac/dkp011 [Extract] [Full Text] [PDF] [Request Permissions]  

Hector Rodriguez-Villalobos, Alina Cardentey-Reyes, Christine Thiroux, Claire Nonhoff, and Marc J. Struelens

Comparison of four commercial methods for determining temocillin susceptibility of Escherichia coli
JAC Advance Access published on February 17, 2009
J. Antimicrob. Chemother. 2009 63: 832-834; doi:10.1093/jac/dkp035 [Extract] [Full Text] [PDF] [Request Permissions]  

Nichola E. Duddy, Caroline B. Moore, Susan J. Howard, and David W. Denning

In vitro susceptibility of non-Aspergillus allergenic fungal species to azoles
JAC Advance Access published on February 15, 2009
J. Antimicrob. Chemother. 2009 63: 834-836; doi:10.1093/jac/dkp023 [Extract] [Full Text] [PDF] [Request Permissions]  

P. L. Ho, Vincent C. Cheng, and K. H. Chow

Decreasing prevalence of levofloxacin-resistant Streptococcus pneumoniae in Hong Kong, 2001 to 2007
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 836-838; doi:10.1093/jac/dkp038 [Extract] [Full Text] [PDF] [Request Permissions]  

Simon D. Baines, Rachael O'Connor, Grace Huscroft, Katie Saxton, Jane Freeman, and Mark H. Wilcox

Mecillinam: a low-risk antimicrobial agent for induction of Clostridium difficile infection in an in vitro human gut model
JAC Advance Access published on February 11, 2009
J. Antimicrob. Chemother. 2009 63: 838-839; doi:10.1093/jac/dkp017 [Extract] [Full Text] [PDF] [Request Permissions]  

Martin Kolditz, Jakob Bickhardt, Wolfgang Matthiessen, Olaf Holotiuk, Gert Höffken, and Dirk Koschel

Medical management of pulmonary actinomycosis: data from 49 consecutive cases
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 839-841; doi:10.1093/jac/dkp016 [Extract] [Full Text] [PDF] [Request Permissions]  

Geetha Ramachandran, Karunaianantham Ramesh, Agibothu K. Hemanth Kumar, Ishaan Jagan, Mahalingam Vasantha, Chandrasekaran Padmapriyadarsini, Gopalan Narendran, Sikhamani Rajasekaran, and Soumya Swaminathan

Association of high T allele frequency of CYP2B6 G516T polymorphism among ethnic south Indian HIV-infected patients with elevated plasma efavirenz and nevirapine
JAC Advance Access published on February 13, 2009
J. Antimicrob. Chemother. 2009 63: 841-843; doi:10.1093/jac/dkp033 [Extract] [Full Text] [PDF] [Request Permissions]  

Eugenia Ch Yiannakopoulou

Methodological issues regarding safety evaluation in randomized controlled trials of the effectiveness of antibiotic prophylaxis for the prevention of post-operative wound infection: systematic review
JAC Advance Access published on February 24, 2009
J. Antimicrob. Chemother. 2009 63: 843-845; doi:10.1093/jac/dkp030 [Extract] [Full Text] [PDF] [Request Permissions]  

Letters to the Editor

Piero Baglioni

Comment on: Urinary tract infection in hospitalized elderly patients in the United Kingdom: the importance of making an accurate diagnosis in the post broad-spectrum antibiotic era
JAC Advance Access published on February 3, 2009
J. Antimicrob. Chemother. 2009 63: 846; doi:10.1093/jac/dkp022 [Extract] [Full Text] [PDF] [Request Permissions]  

G. Gopal Rao and Mehool Patel

Urinary tract infection in hospitalized elderly patients in the United Kingdom: the importance of making an accurate diagnosis in the post broad-spectrum antibiotic era—authors' response
JAC Advance Access published on February 17, 2009
J. Antimicrob. Chemother. 2009 63: 846-847; doi:10.1093/jac/dkp040 [Extract] [Full Text] [PDF] [Request Permissions]  

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