Journal of Antimicrobial Chemotherapy

Leading articles:

F. Goldstein

The potential clinical impact of low-level antibiotic resistance in Staphylococcus aureus
JAC Advance Access published on October 26, 2006
J. Antimicrob. Chemother. 2007 59: 1-4; doi:10.1093/jac/dkl429 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Systematic review:

Anat Gafter-Gvili, Mical Paul, Abigail Fraser, and Leonard Leibovici

Effect of quinolone prophylaxis in afebrile neutropenic patients on microbial resistance: systematic review and meta-analysis
JAC Advance Access published on October 30, 2006
J. Antimicrob. Chemother. 2007 59: 5-22; doi:10.1093/jac/dkl425 [Abstract] [Full Text] [PDF] [Request Permissions]  

Original articles:

Yvonne Agersø and Andreas Petersen

The tetracycline resistance determinant Tet 39 and the sulphonamide resistance gene sulII are common among resistant Acinetobacter spp. isolated from integrated fish farms in Thailand
JAC Advance Access published on November 9, 2006
J. Antimicrob. Chemother. 2007 59: 23-27; doi:10.1093/jac/dkl419 [Abstract] [Full Text] [PDF] [Request Permissions]  

Dewan S. Billal, Daniel P. Fedorko, S. Steve Yan, Muneki Hotomi, Keiji Fujihara, Nancy Nelson, and Noboru Yamanaka

In vitro induction and selection of fluoroquinolone-resistant mutants of Streptococcus pyogenes strains with multiple emm types
JAC Advance Access published on October 25, 2006
J. Antimicrob. Chemother. 2007 59: 28-34; doi:10.1093/jac/dkl428 [Abstract] [Full Text] [PDF] [Request Permissions]  

Lisa J. Moore, Andrea M. Gilbey, Christopher G. Dowson, Alison C. Pridmore, Steven K. Dower, and Robert C. Read

Proinflammatory activation of Toll-like receptor-2 during exposure of penicillin-resistant Streptococcus pneumoniae to ß-lactam antibiotics
JAC Advance Access published on October 31, 2006
J. Antimicrob. Chemother. 2007 59: 35-42; doi:10.1093/jac/dkl442 [Abstract] [Full Text] [PDF] [Request Permissions]  

Paul F. Seaman, Dietmar Ochs, and Martin J. Day

Small-colony variants: a novel mechanism for triclosan resistance in methicillin-resistant Staphylococcus aureus
JAC Advance Access published on October 31, 2006
J. Antimicrob. Chemother. 2007 59: 43-50; doi:10.1093/jac/dkl450 [Abstract] [Full Text] [PDF] [Request Permissions]  

Rong Liu, Karim Abid, John Pichardo, Valerio Pazienza, Paul Ingravallo, Rong Kong, Sony Agrawal, Stephane Bogen, Anil Saksena, Kuo-Chi Cheng, Andrew Prongay, F. George Njoroge, Bahige M. Baroudy, and Francesco Negro

In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease
JAC Advance Access published on December 5, 2006
J. Antimicrob. Chemother. 2007 59: 51-58; doi:10.1093/jac/dkl455 [Abstract] [Full Text] [PDF] [Request Permissions]  

Naoko Takahashi, Kazuyuki Ishihara, Tetsuo Kato, and Katsuji Okuda

Susceptibility of Actinobacillus actinomycetemcomitans to six antibiotics decreases as biofilm matures
JAC Advance Access published on November 20, 2006
J. Antimicrob. Chemother. 2007 59: 59-65; doi:10.1093/jac/dkl452 [Abstract] [Full Text] [PDF] [Request Permissions]  

Lucas D. Tilley, Brett L. Mellbye, Susan E. Puckett, Patrick. L. Iversen, and Bruce L. Geller

Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose–response in mice infected with Escherichia coli
JAC Advance Access published on October 31, 2006
J. Antimicrob. Chemother. 2007 59: 66-73; doi:10.1093/jac/dkl444 [Abstract] [Full Text] [PDF] [Request Permissions]  

Isabel Herrmann, Markus Kellert, Annette Spreer, Joachim Gerber, Helmut Eiffert, Marco Prinz, and Roland Nau

Minocycline delays but does not attenuate the course of experimental autoimmune encephalomyelitis in Streptococcus pneumoniae-infected mice
JAC Advance Access published on November 1, 2006
J. Antimicrob. Chemother. 2007 59: 74-79; doi:10.1093/jac/dkl446 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jan Balzarini, Dominique Schols, Kristel Van Laethem, Erik De Clercq, Dana Hocková, Milina Masojidkova, and Antonin Holy

Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines
JAC Advance Access published on November 22, 2006
J. Antimicrob. Chemother. 2007 59: 80-86; doi:10.1093/jac/dkl454 [Abstract] [Full Text] [PDF] [Request Permissions]  

Salvador Vergara, Juan Macías, José A. Mira, José A. García-García, Nicolás Merchante, José del Valle, Laila Abdel-Kader, Fernando Lozano, Jesús M. Gómez-Mateos, and Juan A. Pineda

Low-level liver enzyme elevations during HAART are not associated with liver fibrosis progression among HIV/HCV-coinfected patients
JAC Advance Access published on November 9, 2006
J. Antimicrob. Chemother. 2007 59: 87-91; doi:10.1093/jac/dkl447 [Abstract] [Full Text] [PDF] [Request Permissions]  

Rafaëlla F. A. L'homme, Tim Dijkema, Adilia Warris, Andre J. A. M. van der Ven, Diana M. Gibb, and David M. Burger

Pharmacokinetics of two generic fixed-dose combinations for HIV-infected children (Pedimune Baby & Pedimune Junior) are similar to the branded products in healthy adults
JAC Advance Access published on October 28, 2006
J. Antimicrob. Chemother. 2007 59: 92-96; doi:10.1093/jac/dkl445 [Abstract] [Full Text] [PDF] [Request Permissions]  

Brief reports:

Petra Lüthje and Stefan Schwarz

Molecular analysis of constitutively expressed erm(C) genes selected in vitro in the presence of the non-inducers pirlimycin, spiramycin and tylosin
JAC Advance Access published on November 3, 2006
J. Antimicrob. Chemother. 2007 59: 97-101; doi:10.1093/jac/dkl459 [Abstract] [Full Text] [PDF] [Request Permissions]  

Neil Woodford, Suganya Reddy, Elizabeth J. Fagan, Robert L. R. Hill, Katie L. Hopkins, Mary E. Kaufmann, James Kistler, Marie-France I. Palepou, Rachel Pike, M. Elaina Ward, John Cheesbrough, and David M. Livermore

Wide geographic spread of diverse acquired AmpC ß-lactamases among Escherichia coli and Klebsiella spp. in the UK and Ireland
JAC Advance Access published on November 16, 2006
J. Antimicrob. Chemother. 2007 59: 102-105; doi:10.1093/jac/dkl456 [Abstract] [Full Text] [PDF] [Request Permissions]  

Neil Woodford, Mary E. Kaufmann, Edi Karisik, and John W. Hartley

Molecular epidemiology of multiresistant Escherichia coli isolates from community-onset urinary tract infections in Cornwall, England
JAC Advance Access published on November 6, 2006
J. Antimicrob. Chemother. 2007 59: 106-109; doi:10.1093/jac/dkl435 [Abstract] [Full Text] [PDF] [Request Permissions]  

R. Hope, N. A. C. Potz, M. Warner, E. J. Fagan, E. Arnold, and D. M. Livermore

Efficacy of practised screening methods for detection of cephalosporin-resistant Enterobacteriaceae
JAC Advance Access published on November 6, 2006
J. Antimicrob. Chemother. 2007 59: 110-113; doi:10.1093/jac/dkl431 [Abstract] [Full Text] [PDF] [Request Permissions]  

Saima Salahuddin, Dik J. Kok, and Noor N.-P. Buchholz

Influence of body temperature on indinavir crystallization under loop of Henle conditions
JAC Advance Access published on November 9, 2006
J. Antimicrob. Chemother. 2007 59: 114-117; doi:10.1093/jac/dkl436 [Abstract] [Full Text] [PDF] [Request Permissions]  

Mary C. Long, Paula W. Allan, Mei-Zhen Luo, Mao-Chin Liu, Alan C. Sartorelli, and William B. Parker

Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth
JAC Advance Access published on November 3, 2006
J. Antimicrob. Chemother. 2007 59: 118-121; doi:10.1093/jac/dkl448 [Abstract] [Full Text] [PDF] [Request Permissions]  

Sabrina Bouyer, Christine Imbert, Gyslaine Daniault, Estelle Cateau, and Marie-Hélène Rodier

Effect of caspofungin on trophozoites and cysts of three species of Acanthamoeba
JAC Advance Access published on October 31, 2006
J. Antimicrob. Chemother. 2007 59: 122-124; doi:10.1093/jac/dkl451 [Abstract] [Full Text] [PDF] [Request Permissions]  

M. Ann S. McMahon, Ian S. Blair, John E. Moore, and David A. McDowell

Habituation to sub-lethal concentrations of tea tree oil (Melaleuca alternifolia) is associated with reduced susceptibility to antibiotics in human pathogens
JAC Advance Access published on October 28, 2006
J. Antimicrob. Chemother. 2007 59: 125-127; doi:10.1093/jac/dkl443 [Abstract] [Full Text] [PDF] [Request Permissions]  

Anton Y. Peleg, Brian A. Potoski, Rhonda Rea, Jennifer Adams, Jigme Sethi, Blair Capitano, Shahid Husain, Eun J. Kwak, Sunil V. Bhat, and David L. Paterson

Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary report
JAC Advance Access published on November 1, 2006
J. Antimicrob. Chemother. 2007 59: 128-131; doi:10.1093/jac/dkl441 [Abstract] [Full Text] [PDF] [Request Permissions]  

Ingrid Wybo, Denis Piérard, Inge Verschraegen, Marijke Reynders, Kristof Vandoorslaer, Geert Claeys, Michel Delmée, Youri Glupczynski, Bart Gordts, Margaretha Ieven, Pierrette Melin, Marc Struelens, Jan Verhaegen, and Sabine Lauwers

Third Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria
JAC Advance Access published on November 9, 2006
J. Antimicrob. Chemother. 2007 59: 132-139; doi:10.1093/jac/dkl458 [Abstract] [Full Text] [PDF] [Request Permissions]  

Carlos Bantar, Gabriela Alcazar, Diego Franco, Francisco Salamone, Eduardo Vesco, Teodoro Stieben, Florencia Obaid, Alejandro Fiorillo, Mariano Izaguirre, and María Eugenia Oliva

Are laboratory-based antibiograms reliable to guide the selection of empirical antimicrobial treatment in patients with hospital-acquired infections?
JAC Advance Access published on October 31, 2006
J. Antimicrob. Chemother. 2007 59: 140-143; doi:10.1093/jac/dkl434 [Abstract] [Full Text] [PDF] [Request Permissions]  

George G. Zhanel, Sheldon Derkatch, Nancy Laing, Ayman M. Noreddin, and Daryl J. Hoban

Pharmacodynamic activity of ertapenem versus penicillin-susceptible and penicillin-non-susceptible Streptococcus pneumoniae using an in vitro model
JAC Advance Access published on November 1, 2006
J. Antimicrob. Chemother. 2007 59: 144-147; doi:10.1093/jac/dkl433 [Abstract] [Full Text] [PDF] [Request Permissions]  

James E. Moon, Robert G. Rivard, Matthew E. Griffith, Roseanne A. Ressner, Suzanne McCall, Raven E. Reitstetter, Duane R. Hospenthal, and Clinton K. Murray

Effect of timing and duration of azithromycin therapy of leptospirosis in a hamster model
JAC Advance Access published on November 16, 2006
J. Antimicrob. Chemother. 2007 59: 148-151; doi:10.1093/jac/dkl453 [Abstract] [Full Text] [PDF] [Request Permissions]  

Larissa Grigoryan, Johannes G. M. Burgerhof, Flora M. Haaijer-Ruskamp, John E. Degener, Reginald Deschepper, Dominique L. Monnet, Antonella Di Matteo, Elizabeth A. Scicluna, Ana-Claudia Bara, Cecilia Stålsby Lundborg, Joan Birkin, and on behalf of the SAR group

Is self-medication with antibiotics in Europe driven by prescribed use?
JAC Advance Access published on November 22, 2006
J. Antimicrob. Chemother. 2007 59: 152-156; doi:10.1093/jac/dkl457 [Abstract] [Full Text] [PDF] [Request Permissions]  

Correspondence:

Matthew J. Ellington and Neil Woodford

Comment on: Quinolone resistance determinant qnrA3 in clinical isolates of Salmonella in 2000–2005 in Hong Kong
JAC Advance Access published on October 24, 2006
J. Antimicrob. Chemother. 2007 59: 157; doi:10.1093/jac/dkl437 [Extract] [Full Text] [PDF] [Request Permissions]  

Govindarajan Rajagopalan, Robin Patel, Srini V. Kaveri, and Chella S. David

Comment on: Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation
JAC Advance Access published on October 28, 2006
J. Antimicrob. Chemother. 2007 59: 157-159; doi:10.1093/jac/dkl430 [Extract] [Full Text] [PDF] [Request Permissions]  

Shiranee Sriskandan

Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation—author's response
JAC Advance Access published on December 1, 2006
J. Antimicrob. Chemother. 2007 59: 159-160; doi:10.1093/jac/dkl462 [Extract] [Full Text] [PDF] [Request Permissions]  

S. Latifi-Navid, F. Siavoshi, F. Safari, R. Malekzadeh, and S. Massarrat

Antimicrobial effectiveness of ketoconazole against metronidazole-resistant Helicobacter pylori isolates from Iranian dyspeptic patients
JAC Advance Access published on November 3, 2006
J. Antimicrob. Chemother. 2007 59: 160-161; doi:10.1093/jac/dkl449 [Extract] [Full Text] [PDF] [Request Permissions]  

Andrew Berrington

Hospital antibiotic prescribing data require careful local interpretation
JAC Advance Access published on October 24, 2006
J. Antimicrob. Chemother. 2007 59: 162-163; doi:10.1093/jac/dkl440 [Extract] [Full Text] [PDF] [Request Permissions]  

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