Journal of Antimicrobial Chemotherapy

Leading articles

Get checked abstract Peter Davey

The potential role of computerized decision support systems to improve empirical antibiotic prescribing
JAC Advance Access published on November 1, 2006
J. Antimicrob. Chemother. 2006 58: 1105-1106; doi:10.1093/jac/dkl438 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Review

Get checked abstract G. L. French

Bactericidal agents in the treatment of MRSA infections—the potential role of daptomycin
JAC Advance Access published on October 13, 2006
J. Antimicrob. Chemother. 2006 58: 1107-1117; doi:10.1093/jac/dkl393 [Abstract] [Full Text] [PDF] [Request Permissions]  

Original articles

Get checked abstract Arshnee Moodley, Marc Stegger, Arzu F. Bagcigil, Keith E. Baptiste, Anette Loeffler, David H. Lloyd, Nicola J. Williams, Nola Leonard, Yvonne Abbott, Robert Skov, and Luca Guardabassi

spa typing of methicillin-resistant Staphylococcus aureus isolated from domestic animals and veterinary staff in the UK and Ireland
JAC Advance Access published on October 9, 2006
J. Antimicrob. Chemother. 2006 58: 1118-1123; doi:10.1093/jac/dkl394 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Irene Rodríguez, M. Cruz Martín, M. Carmen Mendoza, and M. Rosario Rodicio

Class 1 and class 2 integrons in non-prevalent serovars of Salmonella enterica: structure and association with transposons and plasmids
JAC Advance Access published on October 20, 2006
J. Antimicrob. Chemother. 2006 58: 1124-1132; doi:10.1093/jac/dkl400 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Robert S. Barlow and Kari S. Gobius

Diverse class 2 integrons in bacteria from beef cattle sources
JAC Advance Access published on October 25, 2006
J. Antimicrob. Chemother. 2006 58: 1133-1138; doi:10.1093/jac/dkl423 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract R. Gaind, B. Paglietti, M. Murgia, R. Dawar, S. Uzzau, P. Cappuccinelli, M. Deb, P. Aggarwal, and S. Rubino

Molecular characterization of ciprofloxacin-resistant Salmonella enterica serovar Typhi and Paratyphi A causing enteric fever in India
JAC Advance Access published on October 28, 2006
J. Antimicrob. Chemother. 2006 58: 1139-1144; doi:10.1093/jac/dkl391 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Nick G. Coldham, Luke P. Randall, Laura J. V. Piddock, and Martin J. Woodward

Effect of fluoroquinolone exposure on the proteome of Salmonella enterica serovar Typhimurium
JAC Advance Access published on October 24, 2006
J. Antimicrob. Chemother. 2006 58: 1145-1153; doi:10.1093/jac/dkl413 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Meiguan Yan, Orhan Sahin, Jun Lin, and Qijing Zhang

Role of the CmeABC efflux pump in the emergence of fluoroquinolone-resistant Campylobacter under selection pressure
JAC Advance Access published on October 5, 2006
J. Antimicrob. Chemother. 2006 58: 1154-1159; doi:10.1093/jac/dkl412 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Sonja Löfmark, Cecilia Jernberg, Janet K. Jansson, and Charlotta Edlund

Clindamycin-induced enrichment and long-term persistence of resistant Bacteroides spp. and resistance genes
JAC Advance Access published on October 17, 2006
J. Antimicrob. Chemother. 2006 58: 1160-1167; doi:10.1093/jac/dkl420 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Elizabeth M. O'Shaughnessy, Joseph Meletiadis, Theodouli Stergiopoulou, Joanne P. Demchok, and Thomas J. Walsh

Antifungal interactions within the triple combination of amphotericin B, caspofungin and voriconazole against Aspergillus species
JAC Advance Access published on October 27, 2006
J. Antimicrob. Chemother. 2006 58: 1168-1176; doi:10.1093/jac/dkl392 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Alexander A. Firsov, Maria V. Smirnova, Irene Yu. Lubenko, Sergey N. Vostrov, Yury A. Portnoy, and Stephen H. Zinner

Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to daptomycin and vancomycin in an in vitro dynamic model
JAC Advance Access published on October 5, 2006
J. Antimicrob. Chemother. 2006 58: 1185-1192; doi:10.1093/jac/dkl387 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jennifer Keiser, Jürg Utzinger, Marcel Tanner, Yuxiang Dong, and Jonathan L. Vennerstrom

The synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica
JAC Advance Access published on October 5, 2006
J. Antimicrob. Chemother. 2006 58: 1193-1197; doi:10.1093/jac/dkl408 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Peter A. Warn, Andrew Sharp, Juan Mosquera, Jochen Spickermann, Anne Schmitt-Hoffmann, Markus Heep, and David W. Denning

Comparative in vivo activity of BAL4815, the active component of the prodrug BAL8557, in a neutropenic murine model of disseminated Aspergillus flavus
JAC Advance Access published on October 27, 2006
J. Antimicrob. Chemother. 2006 58: 1198-1207; doi:10.1093/jac/dkl396 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jacques Vouillamoz, Philippe Moreillon, Marlyse Giddey, and José M. Entenza

Efficacy of daptomycin in the treatment of experimental endocarditis due to susceptible and multidrug-resistant enterococci
JAC Advance Access published on October 9, 2006
J. Antimicrob. Chemother. 2006 58: 1208-1214; doi:10.1093/jac/dkl406 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Keith A. Rodvold, Mark H. Gotfried, Michael Cwik, Joan M. Korth-Bradley, Gary Dukart, and Evelyn J. Ellis-Grosse

Serum, tissue and body fluid concentrations of tigecycline after a single 100 mg dose
JAC Advance Access published on September 29, 2006
J. Antimicrob. Chemother. 2006 58: 1221-1229; doi:10.1093/jac/dkl403 [Abstract] [Full Text] [PDF] [Request Permissions]  

Antimicrobial practice

Get checked abstract H. J. Wickens and A. Jacklin

Impact of the Hospital Pharmacy Initiative for promoting prudent use of antibiotics in hospitals in England
JAC Advance Access published on October 9, 2006
J. Antimicrob. Chemother. 2006 58: 1230-1237; doi:10.1093/jac/dkl405 [Abstract] [Full Text] [PDF] [Supplementary data] [Request Permissions]  

Get checked abstract Mical Paul, Steen Andreassen, Evelina Tacconelli, Anders D. Nielsen, Nadja Almanasreh, Uwe Frank, Roberto Cauda, Leonard Leibovici, and on behalf of the TREAT Study Group

Improving empirical antibiotic treatment using TREAT, a computerized decision support system: cluster randomized trial
JAC Advance Access published on September 23, 2006
J. Antimicrob. Chemother. 2006 58: 1238-1245; doi:10.1093/jac/dkl372 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Brief reports

Get checked abstract Marina C. Costa, Francisco Esteves, Francisco Antunes, and Olga Matos

Genetic characterization of the dihydrofolate reductase gene of Pneumocystis jirovecii isolates from Portugal
JAC Advance Access published on October 12, 2006
J. Antimicrob. Chemother. 2006 58: 1246-1249; doi:10.1093/jac/dkl411 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Simona Bratu, Jyoti Gupta, and John Quale

Expression of the las and rhl quorum-sensing systems in clinical isolates of Pseudomonas aeruginosa does not correlate with efflux pump expression or antimicrobial resistance
JAC Advance Access published on October 9, 2006
J. Antimicrob. Chemother. 2006 58: 1250-1253; doi:10.1093/jac/dkl407 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Siamak P. Yazdankhah, Anette W. Åsli, Henning Sørum, Hanne Oppegaard, and Marianne Sunde

Fusidic acid resistance, mediated by fusB, in bovine coagulase-negative staphylococci
JAC Advance Access published on October 23, 2006
J. Antimicrob. Chemother. 2006 58: 1254-1256; doi:10.1093/jac/dkl418 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract V. M. Ensor, M. Shahid, J. T. Evans, and P. M. Hawkey

Occurrence, prevalence and genetic environment of CTX-M ß-lactamases in Enterobacteriaceae from Indian hospitals
JAC Advance Access published on October 28, 2006
J. Antimicrob. Chemother. 2006 58: 1260-1263; doi:10.1093/jac/dkl422 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Denise Drudy, Teresa Quinn, Rebecca O'Mahony, Lorraine Kyne, Peadar Ó'Gaora, and Séamus Fanning

High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile
JAC Advance Access published on October 3, 2006
J. Antimicrob. Chemother. 2006 58: 1264-1267; doi:10.1093/jac/dkl398 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Paul A. Wickman, Jennifer A. Black, Ellen Smith Moland, Kenneth S. Thomson, and Nancy D. Hanson

In vitro development of resistance to DX-619 and other quinolones in enterococci
JAC Advance Access published on October 24, 2006
J. Antimicrob. Chemother. 2006 58: 1268-1273; doi:10.1093/jac/dkl421 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Hafizah Y. Chenia, Balakrishna Pillay, and Dorsamy Pillay

Analysis of the mechanisms of fluoroquinolone resistance in urinary tract pathogens
JAC Advance Access published on October 13, 2006
J. Antimicrob. Chemother. 2006 58: 1274-1278; doi:10.1093/jac/dkl404 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Masato Touyama, Futoshi Higa, Chikara Nakasone, Takashi Shinzato, Morikazu Akamine, Shusaku Haranaga, Masao Tateyama, Isamu Nakasone, Nobuhisa Yamane, and Jiro Fujita

In vitro activity of sitafloxacin against clinical strains of Streptococcus pneumoniae with defined amino acid substitutions in QRDRs of gyrase A and topoisomerase IV
JAC Advance Access published on October 20, 2006
J. Antimicrob. Chemother. 2006 58: 1279-1282; doi:10.1093/jac/dkl427 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Xilin Zhao, Brian Quinn, Robert Kerns, and Karl Drlica

Bactericidal activity and target preference of a piperazinyl-cross-linked ciprofloxacin dimer with Staphylococcus aureus and Escherichia coli
JAC Advance Access published on September 26, 2006
J. Antimicrob. Chemother. 2006 58: 1283-1286; doi:10.1093/jac/dkl388 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Geert T. Ensing, Daniëlle Neut, Jim R. van Horn, Henny C. van der Mei, and Henk J. Busscher

The combination of ultrasound with antibiotics released from bone cement decreases the viability of planktonic and biofilm bacteria: an in vitro study with clinical strains
JAC Advance Access published on October 13, 2006
J. Antimicrob. Chemother. 2006 58: 1287-1290; doi:10.1093/jac/dkl402 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Christian T. Brandt, Niels Frimodt-Møller, Jens D. Lundgren, Michael Pedersen, Ian C. Skovsted, Ian J. Rowland, and Christian Østergaard

Evaluation of anti-pneumococcal capsular antibodies as adjunctive therapy in experimental pneumococcal meningitis
JAC Advance Access published on October 26, 2006
J. Antimicrob. Chemother. 2006 58: 1291-1294; doi:10.1093/jac/dkl401 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Marçal Mariné, Carolina Serena, F. Javier Pastor, and Josep Guarro

Combined antifungal therapy in a murine infection by Candida glabrata
JAC Advance Access published on September 29, 2006
J. Antimicrob. Chemother. 2006 58: 1295-1298; doi:10.1093/jac/dkl395 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Gerald Friedland, Saye Khoo, Christopher Jack, and Umesh Lalloo

Administration of efavirenz (600 mg/day) with rifampicin results in highly variable levels but excellent clinical outcomes in patients treated for tuberculosis and HIV
JAC Advance Access published on October 10, 2006
J. Antimicrob. Chemother. 2006 58: 1299-1302; doi:10.1093/jac/dkl399 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Sharon Hillier, Joanna Bell, Margaret Heginbothom, Zoë Roberts, Frank Dunstan, Anthony Howard, Brendan Mason, and Christopher C. Butler

When do general practitioners request urine specimens for microbiology analysis? The applicability of antibiotic resistance surveillance based on routinely collected data
JAC Advance Access published on October 24, 2006
J. Antimicrob. Chemother. 2006 58: 1303-1306; doi:10.1093/jac/dkl432 [Abstract] [Full Text] [PDF] [Request Permissions]  

Correspondence

Houssem Hmouda, Chaker Ben Salem, Kamel Bouraoui, and Letaief Jemni

Comment on: Bactericidal activity of orally available agents against methicillin-resistant Staphylococcus aureus
JAC Advance Access published on October 20, 2006
J. Antimicrob. Chemother. 2006 58: 1307; doi:10.1093/jac/dkl417 [Extract] [Full Text] [PDF] [Request Permissions]  

Anjum S. Kaka and Daniel M. Musher

Bactericidal activity of orally available agents against methicillin-resistant Staphylococcus aureus: authors' response
JAC Advance Access published on October 24, 2006
J. Antimicrob. Chemother. 2006 58: 1307-1308; doi:10.1093/jac/dkl439 [Extract] [Full Text] [PDF] [Request Permissions]  

Ashraf A. Khan, Chorng-Ming Cheng, Khanh T. Van, Christine Summage West, M. S. Nawaz, and S. A. Khan

Characterization of class 1 integron resistance gene cassettes in Salmonella enterica serovars Oslo and Bareily from imported seafood
JAC Advance Access published on October 26, 2006
J. Antimicrob. Chemother. 2006 58: 1308-1310; doi:10.1093/jac/dkl416 [Extract] [Full Text] [PDF] [Request Permissions]  

Daniela Costa, Patricia Poeta, Yolanda Sáenz, Laura Vinué, Beatriz Rojo-Bezares, Ahlem Jouini, Myriam Zarazaga, Jorge Rodrigues, and Carmen Torres

Detection of Escherichia coli harbouring extended-spectrum ß-lactamases of the CTX-M, TEM and SHV classes in faecal samples of wild animals in Portugal
JAC Advance Access published on October 5, 2006
J. Antimicrob. Chemother. 2006 58: 1311-1312; doi:10.1093/jac/dkl415 [Extract] [Full Text] [PDF] [Request Permissions]  

R. Hope, M. Warner, N. A. C. Potz, E. J. Fagan, D. James, and D. M. Livermore

Activity of tigecycline against ESBL-producing and AmpC-hyperproducing Enterobacteriaceae from South-East England
JAC Advance Access published on October 11, 2006
J. Antimicrob. Chemother. 2006 58: 1312-1314; doi:10.1093/jac/dkl414 [Extract] [Full Text] [PDF] [Request Permissions]  

Acknowledgement of referees

Acknowledgement of referees
J. Antimicrob. Chemother. 2006 58: 1315-1320; doi:10.1093/jac/dkl468 [Extract] [Full Text] [PDF] [Request Permissions]  

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