Journal of Antimicrobial Chemotherapy

Leading articles:

Pentti Huovinen

Mathematical model—tell us the future!
JAC Advance Access published on June 21, 2005
J. Antimicrob. Chemother. 2005 56: 257-258; doi:10.1093/jac/dki230 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neil Woodford and Arnfinn Sundsfjord

Molecular detection of antibiotic resistance: when and where?
JAC Advance Access published on June 20, 2005
J. Antimicrob. Chemother. 2005 56: 259-261; doi:10.1093/jac/dki195 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Catherine Yates and Sebastian Amyes

Extended-spectrum ß-lactamases in non-typhoidal Salmonella spp. isolated in the UK are now a reality: why the late arrival?
JAC Advance Access published on July 6, 2005
J. Antimicrob. Chemother. 2005 56: 262-264; doi:10.1093/jac/dki237 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Gerardo García-Lerma

Diversity of thymidine analogue resistance genotypes among newly diagnosed HIV-1-infected persons
JAC Advance Access published on June 10, 2005
J. Antimicrob. Chemother. 2005 56: 265-269; doi:10.1093/jac/dki194 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kurt Vermeire and Dominique Schols

Cyclotriazadisulfonamides: promising new CD4-targeted anti-HIV drugs
JAC Advance Access published on June 24, 2005
J. Antimicrob. Chemother. 2005 56: 270-272; doi:10.1093/jac/dki208 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Susan S. Kaplan and Charles B. Hicks

Safety and antiviral activity of lopinavir/ritonavir-based therapy in human immunodeficiency virus type 1 (HIV-1) infection
JAC Advance Access published on June 30, 2005
J. Antimicrob. Chemother. 2005 56: 273-276; doi:10.1093/jac/dki209 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Edward Gershburg and Joseph S. Pagano

Epstein–Barr virus infections: prospects for treatment
JAC Advance Access published on July 8, 2005
J. Antimicrob. Chemother. 2005 56: 277-281; doi:10.1093/jac/dki240 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Andrew J. Lawson, Nicola C. Elviss, and Robert J. Owen

Real-time PCR detection and frequency of 16S rDNA mutations associated with resistance and reduced susceptibility to tetracycline in Helicobacter pylori from England and Wales
JAC Advance Access published on June 15, 2005
J. Antimicrob. Chemother. 2005 56: 282-286; doi:10.1093/jac/dki199 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

María Mateo, Juan-Ramón Maestre, Lorenzo Aguilar, Fabio Cafini, Pilar Puente, Paloma Sánchez, Luis Alou, María-José Giménez, and José Prieto

Genotypic versus phenotypic characterization, with respect to susceptibility and identification, of 17 clinical isolates of Staphylococcus lugdunensis
JAC Advance Access published on July 1, 2005
J. Antimicrob. Chemother. 2005 56: 287-291; doi:10.1093/jac/dki227 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

T. G. Winstanley, H. K. Parsons, M. A. Horstkotte, I. Sobottka, and E. Stürenburg

Phenotypic detection of ß-lactamase-mediated resistance to oxyimino-cephalosporins in Enterobacteriaceae: evaluation of the Mastascan Elite Expert System
JAC Advance Access published on June 21, 2005
J. Antimicrob. Chemother. 2005 56: 292-296; doi:10.1093/jac/dki203 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Luke P. Randall, Deborah J. Eaves, Sue W. Cooles, V. Ricci, Antony Buckley, Martin J. Woodward, and Laura J. V. Piddock

Fluoroquinolone treatment of experimental Salmonella enterica serovar Typhimurium DT104 infections in chickens selects for both gyrA mutations and changes in efflux pump gene expression
JAC Advance Access published on June 14, 2005
J. Antimicrob. Chemother. 2005 56: 297-306; doi:10.1093/jac/dki189 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sophie Brun, Frédéric Dalle, Patrick Saulnier, Gilles Renier, Alain Bonnin, Dominique Chabasse, and Jean-Philippe Bouchara

Biological consequences of petite mutations in Candida glabrata
JAC Advance Access published on June 15, 2005
J. Antimicrob. Chemother. 2005 56: 307-314; doi:10.1093/jac/dki200 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Maren Blickwede, Ralph Goethe, Christiane Wolz, Peter Valentin-Weigand, and Stefan Schwarz

Molecular basis of florfenicol-induced increase in adherence of Staphylococcus aureus strain Newman
JAC Advance Access published on June 27, 2005
J. Antimicrob. Chemother. 2005 56: 315-323; doi:10.1093/jac/dki233 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Iriana Carla Junqueira Zanin, Reginaldo Bruno Gonçalves, Aldo Brugnera Junior, Christopher Keith Hope, and Jonathan Pratten

Susceptibility of Streptococcus mutans biofilms to photodynamic therapy: an in vitro study
JAC Advance Access published on June 27, 2005
J. Antimicrob. Chemother. 2005 56: 324-330; doi:10.1093/jac/dki232 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nuno Cerca, Silvia Martins, Filipe Cerca, Kimberly K. Jefferson, Gerald B. Pier, Rosário Oliveira, and Joana Azeredo

Comparative assessment of antibiotic susceptibility of coagulase-negative staphylococci in biofilm versus planktonic culture as assessed by bacterial enumeration or rapid XTT colorimetry
JAC Advance Access published on June 24, 2005
J. Antimicrob. Chemother. 2005 56: 331-336; doi:10.1093/jac/dki217 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sarah Gander, Andrew Kinnaird, and Roger Finch

Telavancin: in vitro activity against staphylococci in a biofilm model
JAC Advance Access published on June 21, 2005
J. Antimicrob. Chemother. 2005 56: 337-343; doi:10.1093/jac/dki198 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Stephen H. Gillespie, Shreya Basu, Anne L. Dickens, Denise M. O'Sullivan, and Timothy D. McHugh

Effect of subinhibitory concentrations of ciprofloxacin on Mycobacterium fortuitum mutation rates
JAC Advance Access published on June 14, 2005
J. Antimicrob. Chemother. 2005 56: 344-348; doi:10.1093/jac/dki191 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

C. Betriu, E. Culebras, M. Gómez, I. Rodríguez-Avial, and J. J. Picazo

In vitro activity of tigecycline against Bacteroides species
JAC Advance Access published on June 10, 2005
J. Antimicrob. Chemother. 2005 56: 349-352; doi:10.1093/jac/dki197 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lorenzo Drago, Elena De Vecchi, Lucia Nicola, Loredana Tocalli, and Maria Rita Gismondo

In vitro selection of resistance in Pseudomonas aeruginosa and Acinetobacter spp. by levofloxacin and ciprofloxacin alone and in combination with ß-lactams and amikacin
JAC Advance Access published on June 20, 2005
J. Antimicrob. Chemother. 2005 56: 353-359; doi:10.1093/jac/dki204 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

K. P. Ittner, G. Roth, M. Gruber, M. Pawlik, and K. Taeger

Clearance of moxifloxacin during continuous haemofiltration (CVVHF) in vitro
JAC Advance Access published on June 27, 2005
J. Antimicrob. Chemother. 2005 56: 360-364; doi:10.1093/jac/dki205 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. Girard, S. M. Finegan, M. W. Dunne, and M. E. Lame

Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models
JAC Advance Access published on July 7, 2005
J. Antimicrob. Chemother. 2005 56: 365-371; doi:10.1093/jac/dki241 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Chuan-Chen Ho, Shih-Shen Lin, Ming-Yung Chou, Fang-Lung Chen, Chao-Chin Hu, Chung-Shih Chen, Guan-Yu Lu, and Chi-Chiang Yang

Effects of CAPE-like compounds on HIV replication in vitro and modulation of cytokines in vivo
JAC Advance Access published on July 7, 2005
J. Antimicrob. Chemother. 2005 56: 372-379; doi:10.1093/jac/dki244 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alan Winston, Mark Bloch, Andrew Carr, Janaki Amin, Patrick W. G. Mallon, John Ray, Debbie Marriott, David A. Cooper, and Sean Emery

Atazanavir trough plasma concentration monitoring in a cohort of HIV-1-positive individuals receiving highly active antiretroviral therapy
JAC Advance Access published on July 4, 2005
J. Antimicrob. Chemother. 2005 56: 380-387; doi:10.1093/jac/dki235 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Chonghua Li, Joseph L. Kuti, Charles H. Nightingale, Debra L. Mansfield, Adrian Dana, and David P. Nicolau

Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infection
JAC Advance Access published on July 7, 2005
J. Antimicrob. Chemother. 2005 56: 388-395; doi:10.1093/jac/dki243 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

J. M. Rolain and D. Raoult

Prediction of resistance to erythromycin in the genus Rickettsia by mutations in L22 ribosomal protein
JAC Advance Access published on July 4, 2005
J. Antimicrob. Chemother. 2005 56: 396-398; doi:10.1093/jac/dki242 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tomasz Hauschild, Petra Lüthje, and Stefan Schwarz

Staphylococcal tetracycline–MLS_B resistance plasmid pSTE2 is the product of an RS_A-mediated in vivo recombination
JAC Advance Access published on June 24, 2005
J. Antimicrob. Chemother. 2005 56: 399-402; doi:10.1093/jac/dki207 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Corinna Kehrenberg, Boudewijn Catry, Freddy Haesebrouck, Aart de Kruif, and Stefan Schwarz

tet(L)-mediated tetracycline resistance in bovine Mannheimia and Pasteurella isolates
JAC Advance Access published on June 21, 2005
J. Antimicrob. Chemother. 2005 56: 403-406; doi:10.1093/jac/dki210 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. J. Smith, V. Hall, B. Thakker, and C. G. Gemmell

Antimicrobial susceptibility testing of Actinomyces species with 12 antimicrobial agents
JAC Advance Access published on June 21, 2005
J. Antimicrob. Chemother. 2005 56: 407-409; doi:10.1093/jac/dki206 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Andrea Giacometti, Oscar Cirioni, Wojciech Kamysz, Carmela Silvestri, Maria Simona Del Prete, Alberto Licci, Giuseppina D'Amato, Jerzy Lukasiak, and Giorgio Scalise

In vitro activity of citropin 1.1 alone and in combination with clinically used antimicrobial agents against Rhodococcus equi
JAC Advance Access published on June 27, 2005
J. Antimicrob. Chemother. 2005 56: 410-412; doi:10.1093/jac/dki236 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Barbara W. Trautner, Richard A. Hull, and Rabih O. Darouiche

Colicins prevent colonization of urinary catheters
JAC Advance Access published on June 24, 2005
J. Antimicrob. Chemother. 2005 56: 413-415; doi:10.1093/jac/dki228 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. Oette, M. Kurowski, T. Feldt, A. Kroidl, A. Sagir, C. Vogt, M. Wettstein, and D. Häussinger

Impact of rosiglitazone treatment on the bioavailability of antiretroviral compounds in HIV-positive patients
JAC Advance Access published on June 27, 2005
J. Antimicrob. Chemother. 2005 56: 416-419; doi:10.1093/jac/dki234 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Huug J. van Duijn, Marijke M. Kuyvenhoven, François G. Schellevis, and Theo J. M. Verheij

Determinants of prescribing of second-choice antibiotics for upper and lower respiratory tract episodes in Dutch general practice
JAC Advance Access published on June 16, 2005
J. Antimicrob. Chemother. 2005 56: 420-422; doi:10.1093/jac/dki214 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

H. M. Ziglam, I. Elliott, V. Wilson, K. Hill, and D. Nathwani

Clinical audit of linezolid use in a large teaching hospital
JAC Advance Access published on June 9, 2005
J. Antimicrob. Chemother. 2005 56: 423-426; doi:10.1093/jac/dki185 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. T. Magee

The resistance ratchet: theoretical implications of cyclic selection pressure
JAC Advance Access published on June 21, 2005
J. Antimicrob. Chemother. 2005 56: 427-430; doi:10.1093/jac/dki229 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Correspondence:

J. T. Magee

Resistance ratchet effect: author's response
JAC Advance Access published on June 21, 2005
J. Antimicrob. Chemother. 2005 56: 431; doi:10.1093/jac/dki231 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Pramod M. Shah

Comment on: Guidelines for the antibiotic treatment of endocarditis in adults: report of the Working Party of the British Society for Antimicrobial Chemotherapy
JAC Advance Access published on June 9, 2005
J. Antimicrob. Chemother. 2005 56: 432; doi:10.1093/jac/dki187 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

John D. Perry on behalf of the Working Party of the British Society for Antimicrobial Chemotherapy

Endocarditis guidelines: authors' response
JAC Advance Access published on June 9, 2005
J. Antimicrob. Chemother. 2005 56: 432-433; doi:10.1093/jac/dki188 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Dominique L. Monnet, Christian T. Brandt, Margit S. Kaltoft, Line Bagger-Skjøt, Thomas L. Sørensen, Hans-Ulrik K. Nielsen, and Niels Frimodt-Møller

High prevalence of macrolide resistance: not in every country! [Comment on: Halpern et al. J Antimicrob Chemother 2005; 55: 748–57]
JAC Advance Access published on June 20, 2005
J. Antimicrob. Chemother. 2005 56: 433-434; doi:10.1093/jac/dki215 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Michael T. Halpern, Jordana K. Schmier, Carl Asche, Phillip W. Sarocco, and Lionel A. Mandell

Meta-analysis of bacterial resistance to macrolides—providing generalizable results: authors' response
JAC Advance Access published on July 8, 2005
J. Antimicrob. Chemother. 2005 56: 434-435; doi:10.1093/jac/dki247 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

K. E. Dingle, L. Clarke, and I. C. J. W. Bowler

Ciprofloxacin resistance among human Campylobacter isolates 1991–2004: an update
JAC Advance Access published on June 14, 2005
J. Antimicrob. Chemother. 2005 56: 435-437; doi:10.1093/jac/dki192 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

P. L. Ragunathan, C. Ison, and D. M. Livermore

Nalidixic acid-susceptible, ciprofloxacin-resistant Neisseria gonorrhoeae strain in the UK
JAC Advance Access published on June 20, 2005
J. Antimicrob. Chemother. 2005 56: 437; doi:10.1093/jac/dki201 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Maria-Cristina C. Brandileone, Silvana Tadeu Casagrande, Maria-Luiza L. S. Guerra, Rosemeire Cobo Zanella, Ana-Lucia S. Sgambatti de Andrade, and José-Luis Di Fabio

Increase in penicillin resistance of invasive Streptococcus pneumoniae in Brazil after 1999
JAC Advance Access published on June 21, 2005
J. Antimicrob. Chemother. 2005 56: 437-439; doi:10.1093/jac/dki196 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Thierry Naas, Abdesselam Lezzar, Chafia Bentchouala, Farida Smati, Jean-Michel Scheftel, Henri Monteil, and Patrice Nordmann

Multidrug-resistant Salmonella enterica serotype Senftenberg isolates producing CTX-M ß-lactamases from Constantine, Algeria
JAC Advance Access published on June 20, 2005
J. Antimicrob. Chemother. 2005 56: 439-440; doi:10.1093/jac/dki216 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Santiago Grau, José A. Morales-Molina, Javier Mateu-de Antonio, Mónica Marín-Casino, and Francisco Alvarez-Lerma

Linezolid: low pre-treatment platelet values could increase the risk of thrombocytopenia
JAC Advance Access published on June 14, 2005
J. Antimicrob. Chemother. 2005 56: 440-441; doi:10.1093/jac/dki202 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Emine Alp, Johannes G. van der Hoeven, Paul E. Verweij, Johan W. Mouton, and Andreas Voss

Duration of antibiotic treatment: are even numbers odd?
JAC Advance Access published on June 24, 2005
J. Antimicrob. Chemother. 2005 56: 441-442; doi:10.1093/jac/dki213 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book reviews:

Sally J. Cutler

Brucella: Molecular and Cellular Biology • I. Lopez-Goni and I. Moriyon, Eds. • Horizon Bioscience, Wymondham, UK, 2004. • ISBN 1-904933-04-1. £90.00, 432 pp.
J. Antimicrob. Chemother. 2005 56: 443-444; doi:10.1093/jac/dki211 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

A. A. Glynn

Penicillin Man: Alexander Fleming and the Antibiotic Revolution • K. Brown • Sutton Publishing, 2004. • ISBN 0-7509-3152-3. £20.00, 320 pp.
J. Antimicrob. Chemother. 2005 56: 444-445; doi:10.1093/jac/dki212 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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