Journal of Antimicrobial Chemotherapy

Leading articles:

Johan W. Mouton, Michael N. Dudley, Otto Cars, Hartmut Derendorf, and George L. Drusano

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update
JAC Advance Access published on March 16, 2005
J. Antimicrob. Chemother. 2005 55: 601-607; doi:10.1093/jac/dki079 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Fabien Zoulim

Combination of nucleoside analogues in the treatment of chronic hepatitis B virus infection: lesson from experimental models
JAC Advance Access published on April 6, 2005
J. Antimicrob. Chemother. 2005 55: 608-611; doi:10.1093/jac/dki095 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Allison Martin and Patrick W. G. Mallon

Therapeutic approaches to combating lipoatrophy: do they work?
JAC Advance Access published on March 10, 2005
J. Antimicrob. Chemother. 2005 55: 612-615; doi:10.1093/jac/dki062 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews:

Bernard Vrijens and John Urquhart

Patient adherence to prescribed antimicrobial drug dosing regimens
JAC Advance Access published on March 16, 2005
J. Antimicrob. Chemother. 2005 55: 616-627; doi:10.1093/jac/dki066 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

For debate:

J. T. Magee, Margaret L. Heginbothom, and B. W. Mason

Finding a strategy: the case for co-operative research on resistance epidemiology
JAC Advance Access published on March 16, 2005
J. Antimicrob. Chemother. 2005 55: 628-633; doi:10.1093/jac/dki077 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Irene Galani, Maria Souli, Zoi Chryssouli, Konstantina Orlandou, and Helen Giamarellou

Characterization of a new integron containing bla_VIM-1 and aac(6')-IIc in an Enterobacter cloacae clinical isolate from Greece
JAC Advance Access published on March 10, 2005
J. Antimicrob. Chemother. 2005 55: 634-638; doi:10.1093/jac/dki073 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hee Young Kang, Young Sook Jeong, Jae Young Oh, Sung Ho Tae, Chul Hee Choi, Dong Chan Moon, Won Kil Lee, Yoo Chul Lee, Sung Yong Seol, Dong Taek Cho, and Je Chul Lee

Characterization of antimicrobial resistance and class 1 integrons found in Escherichia coli isolates from humans and animals in Korea
JAC Advance Access published on March 10, 2005
J. Antimicrob. Chemother. 2005 55: 639-644; doi:10.1093/jac/dki076 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vanessa M. S. Copping, Caroline J. Barelle, Bernhard Hube, Neil A. R. Gow, Alistair J. P. Brown, and Frank C. Odds

Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes
JAC Advance Access published on April 8, 2005
J. Antimicrob. Chemother. 2005 55: 645-654; doi:10.1093/jac/dki088 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Robin E. B. Lee, Teresa T. Liu, Katherine S. Barker, Richard E. Lee, and P. David Rogers

Genome-wide expression profiling of the response to ciclopirox olamine in Candida albicans
JAC Advance Access published on April 6, 2005
J. Antimicrob. Chemother. 2005 55: 655-662; doi:10.1093/jac/dki105 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hans-Christian Sigle, Sascha Thewes, Markus Niewerth, Hans Christian Korting, Monika Schäfer-Korting, and Bernhard Hube

Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans
JAC Advance Access published on March 24, 2005
J. Antimicrob. Chemother. 2005 55: 663-673; doi:10.1093/jac/dki089 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Denise M. O'Sullivan, Timothy D. McHugh, and Stephen H. Gillespie

Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution?
JAC Advance Access published on April 6, 2005
J. Antimicrob. Chemother. 2005 55: 674-679; doi:10.1093/jac/dki069 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Laurent Poirel, Claire Héritier, and Patrice Nordmann

Genetic and biochemical characterization of the chromosome-encoded class B ß-lactamases from Shewanella livingstonensis (SLB-1) and Shewanella frigidimarina (SFB-1)
JAC Advance Access published on March 16, 2005
J. Antimicrob. Chemother. 2005 55: 680-685; doi:10.1093/jac/dki065 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hong Zhang, Kazuya Morikawa, Toshiko Ohta, and Yusuke Kato

In vitro resistance to the CSß-type antimicrobial peptide ASABF- is conferred by overexpression of sigma factor sigB in Staphylococcus aureus
JAC Advance Access published on March 10, 2005
J. Antimicrob. Chemother. 2005 55: 686-691; doi:10.1093/jac/dki070 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alessandro De Logu, Manuela Saddi, Maria Cristina Cardia, Rita Borgna, Clara Sanna, Barbara Saddi, and Elias Maccioni

In vitro activity of 2-cyclohexylidenhydrazo-4-phenyl-thiazole compared with those of amphotericin B and fluconazole against clinical isolates of Candida spp. and fluconazole-resistant Candida albicans
JAC Advance Access published on March 16, 2005
J. Antimicrob. Chemother. 2005 55: 692-698; doi:10.1093/jac/dki084 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vincent H. Tam, Amy N. Schilling, and Michael Nikolaou

Modelling time–kill studies to discern the pharmacodynamics of meropenem
JAC Advance Access published on March 16, 2005
J. Antimicrob. Chemother. 2005 55: 699-706; doi:10.1093/jac/dki086 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sylvie Baucheron, Christian Mouline, Karine Praud, Elisabeth Chaslus-Dancla, and Axel Cloeckaert

TolC but not AcrB is essential for multidrug-resistant Salmonella enterica serotype Typhimurium colonization of chicks
JAC Advance Access published on April 6, 2005
J. Antimicrob. Chemother. 2005 55: 707-712; doi:10.1093/jac/dki091 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rama Falk, Moshe Hacham, Abraham Nyska, Julie F. Foley, Abraham J. Domb, and Itzhack Polacheck

Induction of interleukin-1ß, tumour necrosis factor- and apoptosis in mouse organs by amphotericin B is neutralized by conjugation with arabinogalactan
JAC Advance Access published on April 6, 2005
J. Antimicrob. Chemother. 2005 55: 713-720; doi:10.1093/jac/dki090 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Erjian Wang, Yves Bergeron, and Michel G. Bergeron

Ceftriaxone pharmacokinetics in interleukin-10-treated murine pneumococcal pneumonia
JAC Advance Access published on March 16, 2005
J. Antimicrob. Chemother. 2005 55: 721-726; doi:10.1093/jac/dki085 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nilton Lincopan, Elsa M. Mamizuka, and Ana M. Carmona-Ribeiro

Low nephrotoxicity of an effective amphotericin B formulation with cationic bilayer fragments
JAC Advance Access published on March 10, 2005
J. Antimicrob. Chemother. 2005 55: 727-734; doi:10.1093/jac/dki064 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

F. Jacobsen, A. Baraniskin, J. Mertens, D. Mittler, A. Mohammadi-Tabrisi, S. Schubert, M. Soltau, M. Lehnhardt, B. Behnke, S. Gatermann, H. U. Steinau, and L. Steinstraesser

Activity of histone H1.2 in infected burn wounds
JAC Advance Access published on March 16, 2005
J. Antimicrob. Chemother. 2005 55: 735-741; doi:10.1093/jac/dki067 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Luis Alou, Lorenzo Aguilar, David Sevillano, María-José Giménez, Beatriz Laguna, Olatz Echeverría, Antonio Carcas, Rubin Lubomirov, Julio Casal, and José Prieto

Effect of opsonophagocytosis mediated by specific antibodies on the co-amoxiclav serum bactericidal activity against Streptococcus pneumoniae after administration of a single oral dose of pharmacokinetically enhanced 2000/125 mg co-amoxiclav to healthy volunteers
JAC Advance Access published on March 10, 2005
J. Antimicrob. Chemother. 2005 55: 742-747; doi:10.1093/jac/dki071 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael T. Halpern, Jordana K. Schmier, Lia M. Snyder, Carl Asche, Phillip W. Sarocco, Bruce Lavin, Richard Nieman, and Lionel A. Mandell

Meta-analysis of bacterial resistance to macrolides
JAC Advance Access published on March 16, 2005
J. Antimicrob. Chemother. 2005 55: 748-757; doi:10.1093/jac/dki060 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. Cizman, T. Srovin, M. Pokorn, S. Cad Pecar, and S. Battelino

Analysis of the causes and consequences of decreased antibiotic consumption over the last 5 years in Slovenia
JAC Advance Access published on April 8, 2005
J. Antimicrob. Chemother. 2005 55: 758-763; doi:10.1093/jac/dki098 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Antimicrobial practice:

R. Andrew Seaton, E. Bell, Y. Gourlay, and L. Semple

Nurse-led management of uncomplicated cellulitis in the community: evaluation of a protocol incorporating intravenous ceftriaxone
JAC Advance Access published on March 16, 2005
J. Antimicrob. Chemother. 2005 55: 764-767; doi:10.1093/jac/dki092 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Dobryan M. Tracz, David A. Boyd, Louis Bryden, Romeo Hizon, Sandra Giercke, Paul Van Caeseele, and Michael R. Mulvey

Increase in ampC promoter strength due to mutations and deletion of the attenuator in a clinical isolate of cefoxitin-resistant Escherichia coli as determined by RT–PCR
JAC Advance Access published on March 10, 2005
J. Antimicrob. Chemother. 2005 55: 768-772; doi:10.1093/jac/dki074 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Corinna Kehrenberg and Stefan Schwarz

Plasmid-borne florfenicol resistance in Pasteurella multocida
JAC Advance Access published on April 6, 2005
J. Antimicrob. Chemother. 2005 55: 773-775; doi:10.1093/jac/dki102 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Geovana Brenner Michael, Marisa Cardoso, and Stefan Schwarz

Class 1 integron-associated gene cassettes in Salmonella enterica subsp. enterica serovar Agona isolated from pig carcasses in Brazil
JAC Advance Access published on March 10, 2005
J. Antimicrob. Chemother. 2005 55: 776-779; doi:10.1093/jac/dki081 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ricardo M. Santa-Rita, Renee Lira, Helene Santos Barbosa, Julio A. Urbina, and Solange L. de Castro

Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis
JAC Advance Access published on March 24, 2005
J. Antimicrob. Chemother. 2005 55: 780-784; doi:10.1093/jac/dki087 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sofía Ballesta, Isabel García, Evelio J. Perea, and Alvaro Pascual

Uptake and intracellular activity of voriconazole in human polymorphonuclear leucocytes
JAC Advance Access published on April 11, 2005
J. Antimicrob. Chemother. 2005 55: 785-787; doi:10.1093/jac/dki075 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gwladys Bertin, Nicaise Tuikue Ndam, Sayeh Jafari-Guemouri, Nadine Fievet, Emily Renart, Sokhna Sow, Jean-Yves Le Hesran, and Philippe Deloron

High prevalence of Plasmodium falciparum pfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal
JAC Advance Access published on April 6, 2005
J. Antimicrob. Chemother. 2005 55: 788-791; doi:10.1093/jac/dki097 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nathan P. Wiederhold, Elizabeth A. Coyle, Issam I. Raad, Randall A. Prince, and Russell E. Lewis

Antibacterial activity of linezolid and vancomycin in an in vitro pharmacodynamic model of Gram-positive catheter-related bacteraemia
JAC Advance Access published on April 6, 2005
J. Antimicrob. Chemother. 2005 55: 792-795; doi:10.1093/jac/dki106 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jin Sun, Tianhong Zhang, Feng Qiu, Yu Liu, Jingling Tang, Haihua Huang, and Zhonggui He

Impact of pharmaceutical dosage forms on the pharmacokinetics of roxithromycin in healthy human volunteers
JAC Advance Access published on March 10, 2005
J. Antimicrob. Chemother. 2005 55: 796-799; doi:10.1093/jac/dki082 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Maria Luisa Montes, Federico Pulido, Carlos Barros, Emilia Condes, Rafael Rubio, Concepción Cepeda, Fernando Dronda, Antonio Antela, José Sanz, Enrique Navas, Pilar Miralles, Juan Berenguer, Susana Pérez, Angeles Zapata, Juan J. González-García, Jose Ma Peña, J. J. Vázquez, and Jose R. Arribas

Lipid disorders in antiretroviral-naive patients treated with lopinavir/ritonavir-based HAART: frequency, characterization and risk factors
JAC Advance Access published on March 10, 2005
J. Antimicrob. Chemother. 2005 55: 800-804; doi:10.1093/jac/dki063 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

P. M. G. Filius, T. B. Y. Liem, P. D. van der Linden, R. Janknegt, S. Natsch, A. G. Vulto, and H. A. Verbrugh

An additional measure for quantifying antibiotic use in hospitals
JAC Advance Access published on April 6, 2005
J. Antimicrob. Chemother. 2005 55: 805-808; doi:10.1093/jac/dki093 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

C. Betriu, M. Gómez, I. Rodríguez-Avial, E. Culebras, and J. J. Picazo

In vitro activity of tigecycline against ampicillin-resistant Haemophilus influenzae isolates
JAC Advance Access published on March 24, 2005
J. Antimicrob. Chemother. 2005 55: 809-810; doi:10.1093/jac/dki096 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

V. Miriagou, E. Tzelepi, G. L. Daikos, P. T. Tassios, and L. S. Tzouvelekis

Panresistance in VIM-1-producing Klebsiella pneumoniae
JAC Advance Access published on March 16, 2005
J. Antimicrob. Chemother. 2005 55: 810-811; doi:10.1093/jac/dki080 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

E. Petinaki, I. Spiliopoulou, M. Maniati, and A. N. Maniatis

Emergence of Staphylococcus hominis strains expressing low-level resistance to quinupristin/dalfopristin in Greece
JAC Advance Access published on March 10, 2005
J. Antimicrob. Chemother. 2005 55: 811-812; doi:10.1093/jac/dki072 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

D. De Bels, A. Garcia-Filoso, M. Jeanmaire, T. Préseau, Y. Miendje, and J. Devriendt

Successful treatment with linezolid of septic shock secondary to methicillin-resistant Staphylococcus aureus arthritis
JAC Advance Access published on March 2, 2005
J. Antimicrob. Chemother. 2005 55: 812-813; doi:10.1093/jac/dki068 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book reviews:

Dr Rosemary Barnes

Pathogenic Fungi: Host Interactions and Emerging Strategies for Control
J. Antimicrob. Chemother. 2005 55: 814; doi:10.1093/jac/dki083 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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