Journal of Antimicrobial Chemotherapy

Leading articles:

T. M. A. Weller and C. E. Jamieson

The expanding role of the antibiotic pharmacist
JAC Advance Access published on June 16, 2004
J. Antimicrob. Chemother. 2004 54: 295-298; doi:10.1093/jac/dkh327 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Philip J. Budge and Barney S. Graham

Inhibition of respiratory syncytial virus by RhoA-derived peptides: implications for the development of improved antiviral agents targeting heparin-binding viruses
JAC Advance Access published on July 14, 2004
J. Antimicrob. Chemother. 2004 54: 299-302; doi:10.1093/jac/dkh355 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Heiner C. Bucher, James Young, and Manuel Battegay

Protease inhibitor-sparing simplified maintenance therapy: a need for perspective
JAC Advance Access published on July 21, 2004
J. Antimicrob. Chemother. 2004 54: 303-305; doi:10.1093/jac/dkh379 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Garrod Lecture:

Richard Wise

The relentless rise of resistance?
JAC Advance Access published on July 1, 2004
J. Antimicrob. Chemother. 2004 54: 306-310; doi:10.1093/jac/dkh340 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews:

K. Kümmerer

Resistance in the environment
JAC Advance Access published on June 23, 2004
J. Antimicrob. Chemother. 2004 54: 311-320; doi:10.1093/jac/dkh325 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Luca Guardabassi, Stefan Schwarz, and David H. Lloyd

Pet animals as reservoirs of antimicrobial-resistant bacteria: Review
JAC Advance Access published on July 14, 2004
J. Antimicrob. Chemother. 2004 54: 321-332; doi:10.1093/jac/dkh332 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael L. Greenberg and Nick Cammack

Resistance to enfuvirtide, the first HIV fusion inhibitor
JAC Advance Access published on July 1, 2004
J. Antimicrob. Chemother. 2004 54: 333-340; doi:10.1093/jac/dkh330 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Lilian Pumbwe, Luke P. Randall, Martin J. Woodward, and Laura J. V. Piddock

Expression of the efflux pump genes cmeB, cmeF and the porin gene porA in multiple-antibiotic-resistant Campylobacter jejuni
JAC Advance Access published on June 16, 2004
J. Antimicrob. Chemother. 2004 54: 341-347; doi:10.1093/jac/dkh331 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Virginia C. Gould, Aki Okazaki, Robin A. Howe, and Matthew B. Avison

Analysis of sequence variation among smeDEF multi drug efflux pump genes and flanking DNA from defined 16S rRNA subgroups of clinical Stenotrophomonas maltophilia isolates
JAC Advance Access published on July 14, 2004
J. Antimicrob. Chemother. 2004 54: 348-353; doi:10.1093/jac/dkh367 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael R. Mulvey, David A. Boyd, Lorea Baker, Oksana Mykytczuk, E. M. F. Reis, M. D. Asensi, D. P. Rodrigues, and Lai-King Ng

Characterization of a Salmonella enterica serovar Agona strain harbouring a class 1 integron containing novel OXA-type ß-lactamase (bla_OXA-53) and 6'-N-aminoglycoside acetyltransferase genes [aac(6')-I30]
JAC Advance Access published on July 1, 2004
J. Antimicrob. Chemother. 2004 54: 354-359; doi:10.1093/jac/dkh347 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rajan P. Adhikari, Georgina C. Scales, Kere Kobayashi, John M. B. Smith, Brigitte Berger-Bächi, and Gregory M. Cook

Vancomycin-induced deletion of the methicillin resistance gene mecA in Staphylococcus aureus
JAC Advance Access published on July 8, 2004
J. Antimicrob. Chemother. 2004 54: 360-363; doi:10.1093/jac/dkh350 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Glenn W. Kaatz and Susan M. Seo

Effect of substrate exposure and other growth condition manipulations on norA expression
JAC Advance Access published on July 1, 2004
J. Antimicrob. Chemother. 2004 54: 364-369; doi:10.1093/jac/dkh341 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Caroline E. Codling, Brian V. Jones, Eshwar Mahenthiralingam, A. Denver Russell, and Jean-Yves Maillard

Identification of genes involved in the susceptibility of Serratia marcescens to polyquaternium-1
JAC Advance Access published on July 1, 2004
J. Antimicrob. Chemother. 2004 54: 370-375; doi:10.1093/jac/dkh351 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Katherine S. Barker, Sarah Crisp, Nathan Wiederhold, Russell E. Lewis, Bart Bareither, James Eckstein, Robert Barbuch, Martin Bard, and P. David Rogers

Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans
JAC Advance Access published on June 16, 2004
J. Antimicrob. Chemother. 2004 54: 376-385; doi:10.1093/jac/dkh336 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Chelsea J. Longbottom, Christine F. Carson, Katherine A. Hammer, Brian J. Mee, and Thomas V. Riley

Tolerance of Pseudomonas aeruginosa to Melaleuca alternifolia (tea tree) oil is associated with the outer membrane and energy-dependent cellular processes
JAC Advance Access published on July 14, 2004
J. Antimicrob. Chemother. 2004 54: 386-392; doi:10.1093/jac/dkh359 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mihaela Peric, Bülent Bozdogan, Chad Galderisi, Dan Krissinger, Terry Rager, and Peter C. Appelbaum

Inability of L22 ribosomal protein alteration to increase macrolide MICs in the absence of efflux mechanism in Haemophilus influenzae HMC-S
JAC Advance Access published on July 8, 2004
J. Antimicrob. Chemother. 2004 54: 393-400; doi:10.1093/jac/dkh364 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sachin Sharma, Priya Ramnani, and J. S. Virdi

Detection and assay of ß-lactamases in clinical and non-clinical strains of Yersinia enterocolitica biovar 1A
JAC Advance Access published on July 21, 2004
J. Antimicrob. Chemother. 2004 54: 401-405; doi:10.1093/jac/dkh365 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Enno Stürenburg, Alexandra Kühn, Dietrich Mack, and Rainer Laufs

A novel extended-spectrum ß-lactamase CTX-M-23 with a P167T substitution in the active-site omega loop associated with ceftazidime resistance
JAC Advance Access published on June 16, 2004
J. Antimicrob. Chemother. 2004 54: 406-409; doi:10.1093/jac/dkh334 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alain Bonnefoy, Claudine Dupuis-Hamelin, Valérie Steier, Carole Delachaume, Catherine Seys, Thérèse Stachyra, Monique Fairley, Michèle Guitton, and Maxime Lampilas

In vitro activity of AVE1330A, an innovative broad-spectrum non-ß-lactam ß-lactamase inhibitor
JAC Advance Access published on July 14, 2004
J. Antimicrob. Chemother. 2004 54: 410-417; doi:10.1093/jac/dkh358 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Irith Wiegand and Sonja Burak

Effect of inoculum density on susceptibility of Plesiomonas shigelloides to cephalosporins
JAC Advance Access published on June 23, 2004
J. Antimicrob. Chemother. 2004 54: 418-423; doi:10.1093/jac/dkh322 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Athamna, M. Athamna, N. Abu-Rashed, B. Medlej, D. J. Bast, and E. Rubinstein

Selection of Bacillus anthracis isolates resistant to antibiotics
JAC Advance Access published on June 17, 2004
J. Antimicrob. Chemother. 2004 54: 424-428; doi:10.1093/jac/dkh258 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Patrícia Antunes, Jorge Machado, João Carlos Sousa, and Luísa Peixe

Dissemination amongst humans and food products of animal origin of a Salmonella typhimurium clone expressing an integron-borne OXA-30 ß-lactamase
JAC Advance Access published on July 8, 2004
J. Antimicrob. Chemother. 2004 54: 429-434; doi:10.1093/jac/dkh333 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nicola C. Elviss, Robert J. Owen, Jacqueline Xerry, A. Mark Walker, and Kenneth Davies

Helicobacter pylori antibiotic resistance patterns and genotypes in adult dyspeptic patients from a regional population in North Wales
JAC Advance Access published on July 8, 2004
J. Antimicrob. Chemother. 2004 54: 435-440; doi:10.1093/jac/dkh343 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. El-Zimaity, A. M. Kearns, S. J. Dawson, S. Price, and G. A. J. Harrison

Survey, characterization and susceptibility to fusidic acid of Staphylococcus aureus in the Carmarthen area
JAC Advance Access published on July 21, 2004
J. Antimicrob. Chemother. 2004 54: 441-446; doi:10.1093/jac/dkh373 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sunjoo Kim and Nam Yong Lee

Epidemiology and antibiotic resistance of group A streptococci isolated from healthy schoolchildren in Korea
JAC Advance Access published on July 21, 2004
J. Antimicrob. Chemother. 2004 54: 447-450; doi:10.1093/jac/dkh363 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Dongeun Yong, Tae Sook Kim, Jong Rak Choi, Jong Hwa Yum, Kyungwon Lee, Yunsop Chong, Hee-Bok Oh, Tiffany Shultz, and John W. Tapsall

Epidemiological characteristics and molecular basis of fluoroquinolone-resistant Neisseria gonorrhoeae strains isolated in Korea and nearby countries
JAC Advance Access published on July 1, 2004
J. Antimicrob. Chemother. 2004 54: 451-455; doi:10.1093/jac/dkh345 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Olivier Lortholary, Agnès Charlemagne, Frédéric Bastides, Patrick Chevalier, Annick Datry, Marie-France Gonzalves, Gérard Michel, Patrick Tilleul, Benoît Veber, and Raoul Herbrecht

A multicentre pharmacoepidemiological study of therapeutic practices in invasive fungal infections in France during 1998–1999
JAC Advance Access published on July 1, 2004
J. Antimicrob. Chemother. 2004 54: 456-464; doi:10.1093/jac/dkh348 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

César García-Rey, Asunción Fenoll, Lorenzo Aguilar, and Julio Casal

Effect of social and climatological factors on antimicrobial use and Streptococcus pneumoniae resistance in different provinces in Spain
JAC Advance Access published on July 21, 2004
J. Antimicrob. Chemother. 2004 54: 465-471; doi:10.1093/jac/dkh375 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hein P. Stallmann, Christopher Faber, Antonius L. J. J. Bronckers, Arie V. Nieuw Amerongen, and Paul I. J. M. Wuisman

Osteomyelitis prevention in rabbits using antimicrobial peptide hLF1-11- or gentamicin-containing calcium phosphate cement
JAC Advance Access published on July 1, 2004
J. Antimicrob. Chemother. 2004 54: 472-476; doi:10.1093/jac/dkh346 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Steve Hernandez, Gloria M. Gonzalez, Dora I. McCarthy, Arnaldo Lopes Colombo, Laura K. Najvar, Rosie Bocanegera, and John R. Graybill

Alternatives to amphotericin B for Candida rugosa infection
JAC Advance Access published on June 23, 2004
J. Antimicrob. Chemother. 2004 54: 477-480; doi:10.1093/jac/dkh335 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vicenç Falcó, Benito Almirante, Queralt Jordano, Laura Calonge, Oscar del Valle, Carles Pigrau, Ana María Planes, Joan Gavaldà, and Albert Pahissa

Influence of penicillin resistance on outcome in adult patients with invasive pneumococcal pneumonia: is penicillin useful against intermediately resistant strains?
JAC Advance Access published on June 23, 2004
J. Antimicrob. Chemother. 2004 54: 481-488; doi:10.1093/jac/dkh338 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sung-Han Kim, Wan-Beom Park, Ki-Deok Lee, Cheol-In Kang, Ji-Whan Bang, Hong-Bin Kim, Eui-Chong Kim, Myoung-don Oh, and Kang-Won Choe

Outcome of inappropriate initial antimicrobial treatment in patients with methicillin-resistant Staphylococcus aureus bacteraemia
JAC Advance Access published on July 14, 2004
J. Antimicrob. Chemother. 2004 54: 489-497; doi:10.1093/jac/dkh366 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Adil Isaac, Stephen Taylor, Patricia Cane, Erasmus Smit, Sarah E. Gibbons, David J. White, Susan M. Drake, Saye Khoo, and David J. Back

Lopinavir/ritonavir combined with twice-daily 400 mg indinavir: pharmacokinetics and pharmacodynamics in blood, CSF and semen
JAC Advance Access published on July 14, 2004
J. Antimicrob. Chemother. 2004 54: 498-502; doi:10.1093/jac/dkh357 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

L. Waters, J. Stebbing, R. Jones, C. Michailidis, S. Sawleshwarkar, S. Mandalia, M. Bower, M. Nelson, and B. Gazzard

A comparison of the CD4 response to antiretroviral regimens in patients commencing therapy with low CD4 counts
JAC Advance Access published on June 16, 2004
J. Antimicrob. Chemother. 2004 54: 503-507; doi:10.1093/jac/dkh329 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Joan R. Badia, Dolors Soy, Maria Adrover, Miquel Ferrer, Maria Sarasa, Antonio Alarcón, Carles Codina, and Antoni Torres

Disposition of instilled versus nebulized tobramycin and imipenem in ventilated intensive care unit (ICU) patients
JAC Advance Access published on June 23, 2004
J. Antimicrob. Chemother. 2004 54: 508-514; doi:10.1093/jac/dkh326 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Guy Tellier, Michael S. Niederman, Roomi Nusrat, Manish Patel, and Bruce Lavin

Clinical and bacteriological efficacy and safety of 5 and 7 day regimens of telithromycin once daily compared with a 10 day regimen of clarithromycin twice daily in patients with mild to moderate community-acquired pneumonia
JAC Advance Access published on July 21, 2004
J. Antimicrob. Chemother. 2004 54: 515-523; doi:10.1093/jac/dkh356 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Antimicrobial practice:

Agnès Sommet, Catherine Sermet, Pierre Yves Boëlle, Muriel Tafflet, Claire Bernède, and Didier Guillemot

No significant decrease in antibiotic use from 1992 to 2000, in the French community
JAC Advance Access published on July 8, 2004
J. Antimicrob. Chemother. 2004 54: 524-528; doi:10.1093/jac/dkh342 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Chris Curtis, John Marriott, and Chris Langley

Development of a prescribing indicator for objective quantification of antibiotic usage in secondary care
JAC Advance Access published on July 21, 2004
J. Antimicrob. Chemother. 2004 54: 529-533; doi:10.1093/jac/dkh362 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Brief reports:

C. M. Yates, M. C. Pearce, M. E. J. Woolhouse, and S. G. B. Amyes

High frequency transfer and horizontal spread of apramycin resistance in calf faecal Escherichia coli
JAC Advance Access published on July 1, 2004
J. Antimicrob. Chemother. 2004 54: 534-537; doi:10.1093/jac/dkh353 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. M. Rolain, M. N. Mallet, P. E. Fournier, and D. Raoult

Real-time PCR for universal antibiotic susceptibility testing
JAC Advance Access published on July 1, 2004
J. Antimicrob. Chemother. 2004 54: 538-541; doi:10.1093/jac/dkh324 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lorenzo Drago, Elena De Vecchi, Lucia Nicola, Alberto Colombo, and Maria Rita Gismondo

Selection of resistance of telithromycin against Haemophilus influenzae, Moraxella catarrhalis and streptococci in comparison with macrolides
JAC Advance Access published on June 23, 2004
J. Antimicrob. Chemother. 2004 54: 542-545; doi:10.1093/jac/dkh339 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kareen I. Batarseh

Anomaly and correlation of killing in the therapeutic properties of silver (I) chelation with glutamic and tartaric acids
JAC Advance Access published on July 8, 2004
J. Antimicrob. Chemother. 2004 54: 546-548; doi:10.1093/jac/dkh349 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Julian G. Hurdle, Alex J. O'Neill, and Ian Chopra

Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections
JAC Advance Access published on July 8, 2004
J. Antimicrob. Chemother. 2004 54: 549-552; doi:10.1093/jac/dkh352 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sigrun Eick, Andrea Schmitt, Svea Sachse, Karl-Hermann Schmidt, and Wolfgang Pfister

In vitro antibacterial activity of fluoroquinolones against Porphyromonas gingivalis strains
JAC Advance Access published on July 1, 2004
J. Antimicrob. Chemother. 2004 54: 553-556; doi:10.1093/jac/dkh354 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kenneth S. Thomson and Ellen Smith Moland

CS-023 (R-115685), a novel carbapenem with enhanced in vitro activity against oxacillin-resistant staphylococci and Pseudomonas aeruginosa
JAC Advance Access published on June 16, 2004
J. Antimicrob. Chemother. 2004 54: 557-562; doi:10.1093/jac/dkh328 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Borann Sar, Didier Monchy, Mich Vann, Chantary Keo, Jean Louis Sarthou, and Yves Buisson

Increasing in vitro resistance to fluconazole in Cryptococcus neoformans Cambodian isolates: April 2000 to March 2002
JAC Advance Access published on July 14, 2004
J. Antimicrob. Chemother. 2004 54: 563-565; doi:10.1093/jac/dkh361 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Magdalena E. Sobieszczyk, E. Yoko Furuya, Christine M. Hay, Preeti Pancholi, Phyllis Della-Latta, Scott M. Hammer, and Christine J. Kubin

Combination therapy with polymyxin B for the treatment of multidrug-resistant Gram-negative respiratory tract infections
JAC Advance Access published on July 21, 2004
J. Antimicrob. Chemother. 2004 54: 566-569; doi:10.1093/jac/dkh369 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Hein P. Stallmann, Chris Faber, and Paul I. J. M. Wuisman

Response to: Release of gentamicin and vancomycin from temporary human hip spacers in two-stage revision of infected arthroplasty
JAC Advance Access published on June 23, 2004
J. Antimicrob. Chemother. 2004 54: 570; doi:10.1093/jac/dkh226 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

E. Bertazzoni Minelli, A. Benini, B. Magnan, and P. Bartolozzi

Reply
JAC Advance Access published on June 23, 2004
J. Antimicrob. Chemother. 2004 54: 570-571; doi:10.1093/jac/dkh344 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Corinna Kehrenberg, Jürgen Mumme, Jürgen Wallmann, Jutta Verspohl, Regina Tegeler, Tilman Kühn, and Stefan Schwarz

Monitoring of florfenicol susceptibility among bovine and porcine respiratory tract pathogens collected in Germany during the years 2002 and 2003
JAC Advance Access published on July 14, 2004
J. Antimicrob. Chemother. 2004 54: 572-574; doi:10.1093/jac/dkh371 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Spyros Pournaras, Alexandros Ikonomidis, Ioulia Kristo, Athanassios Tsakris, and Antonios N. Maniatis

CTX-M enzymes are the most common extended-spectrum ß-lactamases among Escherichia coli in a tertiary Greek hospital
JAC Advance Access published on June 23, 2004
J. Antimicrob. Chemother. 2004 54: 574-575; doi:10.1093/jac/dkh323 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Matteo Bassetti, Francesca Bisio, Antonio Di Biagio, Ivana Pierri, Manuela Balocco, Ornella Soro, Mario Cruciani, and Dante Bassetti

Trichosporon asahii infection treated with caspofungin combined with liposomal amphotericin B
JAC Advance Access published on July 1, 2004
J. Antimicrob. Chemother. 2004 54: 575-577; doi:10.1093/jac/dkh337 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

I. B. Eltayeb, A. I. Awad, M. A. Elderbi, and S. A. Shadad

Effect of gum arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers
JAC Advance Access published on July 21, 2004
J. Antimicrob. Chemother. 2004 54: 577-578; doi:10.1093/jac/dkh372 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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