Journal of Antimicrobial Chemotherapy

Leading articles:

Shirit Einav and Jeffrey S. Glenn

Prenylation inhibitors: a novel class of antiviral agents
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 883-886; doi:10.1093/jac/dkg490 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Melissa M. Herbst and Richard B. Pyles

Immunostimulatory CpG treatment for genital HSV-2 infections
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 887-889; doi:10.1093/jac/dkg481 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

John P. Moore and Robin J. Shattock

Preventing HIV-1 sexual transmission—not sexy enough science, or no benefit to the bottom line?
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 890-892; doi:10.1093/jac/dkh011 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews:

Antina Barger, Christine Fuhst, and Bernd Wiedemann

Pharmacological indices in antibiotic therapy
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 893-898; doi:10.1093/jac/dkg482 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

E. C. Nelson, Heidi Segal, and B. Gay Elisha

Outer membrane protein alterations and bla_TEM-1 variants: their role in ß-lactam resistance in Klebsiella pneumoniae
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 899-903; doi:10.1093/jac/dkg486 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Monique Chéron, Caroline Petit, Jacques Bolard, and François Gaboriau

Heat-induced reformulation of amphotericin B-deoxycholate favours drug uptake by the macrophage-like cell line J774
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 904-910; doi:10.1093/jac/dkg455 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shigeharu Oie, Toshinari Uematsu, Akihiro Sawa, Hidekazu Mizuno, Masaaki Tomita, Shiro Ishida, Yoshiro Okano, and Akira Kamiya

In vitro effects of combinations of antipseudomonal agents against seven strains of multidrug-resistant Pseudomonas aeruginosa
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 911-914; doi:10.1093/jac/dkg478 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wilfredo G. Veloira, Philip Domenico, John J. LiPuma, Jonathan M. Davis, Ellen Gurzenda, and Jeffrey A. Kazzaz

In vitro activity and synergy of bismuth thiols and tobramycin against Burkholderia cepacia complex
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 915-919; doi:10.1093/jac/dkg471 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Futoshi Higa, Noriko Arakaki, Masao Tateyama, Michio Koide, Takashi Shinzato, Kazuyoshi Kawakami, and Atsushi Saito

In vitro and in vivo activity of olamufloxacin (HSR-903) against Legionella spp.
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 920-924; doi:10.1093/jac/dkh001 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rosy Reynolds, Jemma Shackcloth, David Felmingham, and Alasdair MacGowan on behalf of the BSAC Extended Working Party on Respiratory Resistance Surveillance

Comparison of BSAC agar dilution and NCCLS broth microdilution MIC methods for in vitro susceptibility testing of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis: the BSAC Respiratory Resistance Surveillance Programme
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 925-930; doi:10.1093/jac/dkg462 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rosy Reynolds, Jemma Shackcloth, David Felmingham, and Alasdair MacGowan on behalf of the BSAC Extended Working Party on Respiratory Resistance Surveillance

Antimicrobial susceptibility of lower respiratory tract pathogens in Great Britain and Ireland 1999–2001 related to demographic and geographical factors: the BSAC Respiratory Resistance Surveillance Programme
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 931-943; doi:10.1093/jac/dkg461 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. Canton, M. Morosini, M. C. Enright, and I. Morrissey

Worldwide incidence, molecular epidemiology and mutations implicated in fluoroquinolone-resistant Streptococcus pneumoniae: data from the global PROTEKT surveillance programme
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 944-952; doi:10.1093/jac/dkg465 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. P. Johnson, C. L. Sheppard, S. J. Harnett, A. Birtles, T. Harrison, N. P. Brenwald, M. J. Gill, R. A. Walker, D. M. Livermore, and R. C. George

Emergence of a fluoroquinolone-resistant strain of Streptococcus pneumoniae in England
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 953-960; doi:10.1093/jac/dkg469 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

José Campos, Federico Román, María Pérez-Vázquez, Belén Aracil, Jesús Oteo, Emilia Cercenado, and the Spanish Study Group for H. influenzae type f

Antibiotic resistance and clinical significance of Haemophilus influenzae type f
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 961-966; doi:10.1093/jac/dkh004 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Isabel Jado, Rubens López, Ernesto García, Asunción Fenoll, Julio Casal, and Pedro García on behalf of the Spanish Pneumococcal Infection Study Network

Phage lytic enzymes as therapy for antibiotic-resistant Streptococcus pneumoniae infection in a murine sepsis model
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 967-973; doi:10.1093/jac/dkg485 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shyh-ming Tsao, Cheng-chin Hsu, and Mei-chin Yin

Garlic extract and two diallyl sulphides inhibit methicillin-resistant Staphylococcus aureus infection in BALB/cA mice
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 974-980; doi:10.1093/jac/dkg476 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rajesh Pandey, Anjali Sharma, A. Zahoor, Sadhna Sharma, G. K. Khuller, and B. Prasad

Poly (DL-lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 981-986; doi:10.1093/jac/dkg477 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jian Li, Kingsley Coulthard, Robert Milne, Roger L. Nation, Steven Conway, Daniel Peckham, Christine Etherington, and John Turnidge

Steady-state pharmacokinetics of intravenous colistin methanesulphonate in patients with cystic fibrosis
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 987-992; doi:10.1093/jac/dkg468 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

John Philpott-Howard, Andrew Burroughs, Neil Fisher, Mark Hastings, Christopher Kibbler, David Mutimer, David Patch, Nancy Rolando, Jim Wade, Julia Wendon, and John O’Grady

Piperacillin–tazobactam versus ciprofloxacin plus amoxicillin in the treatment of infective episodes after liver transplantation
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 993-1000; doi:10.1093/jac/dkg463 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Antimicrobial practice:

Elias Zintzaras and John P. A. Ioannidis

Modelling of escalating outpatient antibiotic expenditures
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 1001-1004; doi:10.1093/jac/dkg464 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

G. Kahlmeter, P. Menday, and O. Cars

Non-hospital antimicrobial usage and resistance in community-acquired Escherichia coli urinary tract infection
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 1005-1010; doi:10.1093/jac/dkg488 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Susana Cruchaga, María Pérez-Vázquez, Federico Román, and José Campos

Molecular basis of rifampicin resistance in Haemophilus influenzae
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 1011-1014; doi:10.1093/jac/dkh008 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

John Heritage, Philip A. Chambers, Caroline Tyndall, and E. Stephen Buescher

SHV-34: an extended-spectrum ß-lactamase encoded by an epidemic plasmid
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 1015-1017; doi:10.1093/jac/dkh017 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vlatka Matic, Bülent Bozdogan, Michael R. Jacobs, Kimiko Ubukata, and Peter C. Appelbaum

Contribution of ß-lactamase and PBP amino acid substitutions to amoxicillin/clavulanate resistance in ß-lactamase-positive, amoxicillin/clavulanate-resistant Haemophilus influenzae
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 1018-1021; doi:10.1093/jac/dkg474 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Malin Grape, Lars Sundström, and Göran Kronvall

Sulphonamide resistance gene sul3 found in Escherichia coli isolates from human sources
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 1022-1024; doi:10.1093/jac/dkg473 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tao Lu and Karl Drlica

In vitro activity of C-8-methoxy fluoroquinolones against mycobacteria when combined with anti-tuberculosis agents
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 1025-1028; doi:10.1093/jac/dkg480 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Eric Hernandez, Monique Girardet, Francoise Ramisse, Dominique Vidal, and Jean-Didier Cavallo

Antibiotic susceptibilities of 94 isolates of Yersinia pestis to 24 antimicrobial agents
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 1029-1031; doi:10.1093/jac/dkg484 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

María Teresa Martín, Joan Gavaldà, Pedro López, Xavier Gomis, José Luís Ramírez, Dolors Rodríguez, Oscar Len, Queralt Jordano, Isabel Ruiz, Marta Rosal, Benito Almirante, and Albert Pahissa

Efficacy of high doses of liposomal amphotericin B in the treatment of experimental aspergillosis
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 1032-1034; doi:10.1093/jac/dkh003 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Antti J. Hakanen, Mirva Lehtopolku, Anja Siitonen, Pentti Huovinen, and Pirkko Kotilainen

Multidrug resistance in Campylobacter jejuni strains collected from Finnish patients during 1995–2000
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 1035-1039; doi:10.1093/jac/dkg489 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

David M. Livermore, Tom Nichols, Theresa L. Lamagni, Nicola Potz, Rosy Reynolds, and Georgia Duckworth

Ciprofloxacin-resistant Escherichia coli from bacteraemias in England; increasingly prevalent and mostly from men
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 1040-1042; doi:10.1093/jac/dkg479 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Kayode K. Ojo, Corinna Kehrenberg, H. Akin Odelola, and Stefan Schwarz

Structural analysis of the tetracycline resistance gene region of a small multiresistance plasmid from uropathogenic Escherichia coli isolated in Nigeria
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 1043-1044; doi:10.1093/jac/dkh005 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

A. J. Smith and M. S. Jackson

Susceptibility of viridans group streptococci isolated from dento-alveolar infections to eight antimicrobial agents
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 1045-1046; doi:10.1093/jac/dkg487 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

A. Tsakris, C. Tsioni, S. Pournaras, S. Polyzos, A. N. Maniatis, and D. Sofianou

Spread of low-level carbapenem-resistant Acinetobacter baumannii clones in a tertiary care Greek hospital
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 1046-1047; doi:10.1093/jac/dkg470 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Laura Piccoli, Monica Larosa, and Federico Marchetti

Time–kill curves as a tool for targeting ceftazidime serum concentration during continuous infusion
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 1047-1048; doi:10.1093/jac/dkg467 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Giuseppe V. L. De Socio, Maurizio Fiorio, and Giuliano Stagni

AmBisome administration for Candida albicans shunt infections
JAC Advance Access published on October 29, 2003
J. Antimicrob. Chemother. 2003 52: 1048-1049; doi:10.1093/jac/dkg475 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Harri Hemilä

Vitamin C and SARS coronavirus
JAC Advance Access published on November 12, 2003
J. Antimicrob. Chemother. 2003 52: 1049-1050; doi:10.1093/jac/dkh002 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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