Journal of Antimicrobial Chemotherapy

Leading articles:

Denise Paulsen, Robert Elston, Wendy Snowden, Margaret Tisdale, and Lisa Ross

Differentiation of genotypic resistance profiles for amprenavir and lopinavir, a valuable aid for choice of therapy in protease inhibitor-experienced HIV-1-infected subjects
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 319-323; doi:10.1093/jac/dkg392 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews:

Fausto Baldanti and Giuseppe Gerna

Human cytomegalovirus resistance to antiviral drugs: diagnosis, monitoring and clinical impact
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 324-330; doi:10.1093/jac/dkg354 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

David M. Livermore, Armine M. Sefton, and Geoffrey M. Scott

Properties and potential of ertapenem
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 331-344; doi:10.1093/jac/dkg375 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Fiona Walsh, Joanne Willcock, and Sebastian Amyes

High-level telithromycin resistance in laboratory-generated mutants of Streptococcus pneumoniae
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 345-353; doi:10.1093/jac/dkg348 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Ford, E. R. Meaden, P. G. Hoggard, M. Dalton, P. Newton, I. Williams, S. H. Khoo, and D. J. Back

Effect of protease inhibitor-containing regimens on lymphocyte multidrug resistance transporter expression
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 354-358; doi:10.1093/jac/dkg381 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vera Hommer, Jutta Eichholz, and Franz Petry

Effect of antiretroviral protease inhibitors alone, and in combination with paromomycin, on the excystation, invasion and in vitro development of Cryptosporidium parvum
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 359-364; doi:10.1093/jac/dkg357 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Estrella Martín-Mazuelos, Javier Pemán, Anastasio Valverde, Mónica Chaves, M. Carmen Serrano, and Emilia Cantón

Comparison of the Sensititre YeastOne colorimetric antifungal panel and Etest with the NCCLS M38-A method to determine the activity of amphotericin B and itraconazole against clinical isolates of Aspergillus spp.
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 365-370; doi:10.1093/jac/dkg384 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Astrid Buxbaum, Sabine Forsthuber, Wolfgang Graninger, and Apostolos Georgopoulos

Comparative activity of telithromycin against typical community-acquired respiratory pathogens
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 371-374; doi:10.1093/jac/dkg359 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alessandra Arzese, Barbara Skerlavaj, Linda Tomasinsig, Renato Gennaro, and Margherita Zanetti

Antimicrobial activity of SMAP-29 against the Bacteroides fragilis group and clostridia
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 375-381; doi:10.1093/jac/dkg372 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

George G. Zhanel, Nancy M. Laing, Kim A. Nichol, Lorraine P. Palatnick, Ayman Noreddin, Tamiko Hisanaga, Jack L. Johnson, the NAVRESS Group, and Daryl J. Hoban

Antibiotic activity against urinary tract infection (UTI) isolates of vancomycin-resistant enterococci (VRE): results from the 2002 North American Vancomycin Resistant Enterococci Susceptibility Study (NAVRESS)
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 382-388; doi:10.1093/jac/dkg352 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Trupti A. Gaonkar and Shanta M. Modak

Comparison of microbial adherence to antiseptic and antibiotic central venous catheters using a novel agar subcutaneous infection model
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 389-396; doi:10.1093/jac/dkg361 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nagaraju R. Poola, Michelle Kalis, Fotios M. Plakogiannis, and David R. Taft

Characterization of pentamidine excretion in the isolated perfused rat kidney
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 397-404; doi:10.1093/jac/dkg341 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Prachi K. Dandekar, Pamela R. Tessier, Peter Williams, Charlie H. Nightingale, and David P. Nicolau

Pharmacodynamic profile of daptomycin against Enterococcus species and methicillin-resistant Staphylococcus aureus in a murine thigh infection model
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 405-411; doi:10.1093/jac/dkg337 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nilton Lincopan, Elsa M. Mamizuka, and Ana M. Carmona-Ribeiro

In vivo activity of a novel amphotericin B formulation with synthetic cationic bilayer fragments
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 412-418; doi:10.1093/jac/dkg383 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. S. Espuelas, P. Legrand, M. A. Campanero, M. Appel, M. Chéron, C. Gamazo, G. Barratt, and J. M. Irache

Polymeric carriers for amphotericin B: in vitro activity, toxicity and therapeutic efficacy against systemic candidiasis in neutropenic mice
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 419-427; doi:10.1093/jac/dkg351 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Martin J. Becker, Siem de Marie, Marcel H. A. M. Fens, Henri A. Verbrugh, and Irma A. J. M. Bakker-Woudenberg

Effect of amphotericin B treatment on kinetics of cytokines and parameters of fungal load in neutropenic rats with invasive pulmonary aspergillosis
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 428-434; doi:10.1093/jac/dkg367 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Paul G. Ambrose, Sujata M. Bhavnani, Brenda B. Cirincione, Marion Piedmonte, and Thaddeus H. Grasela

Gatifloxacin and the elderly: pharmacokinetic–pharmacodynamic rationale for a potential age-related dose reduction
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 435-440; doi:10.1093/jac/dkg370 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alejandro G. Schijman, Jaime Altcheh, Juan M. Burgos, Miguel Biancardi, Margarita Bisio, Mariano J. Levin, and Héctor Freilij

Aetiological treatment of congenital Chagas’ disease diagnosed and monitored by the polymerase chain reaction
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 441-449; doi:10.1093/jac/dkg338 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mark H. Gotfried, Larry H. Danziger, and Keith A. Rodvold

Steady-state plasma and bronchopulmonary characteristics of clarithromycin extended-release tablets in normal healthy adult subjects
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 450-456; doi:10.1093/jac/dkg355 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Joseph A. Paladino, Jenna L. Sunderlin, Alan Forrest, and Jerome J. Schentag

Characterization of the onset and consequences of pneumonia due to fluoroquinolone-susceptible or -resistant Pseudomonas aeruginosa
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 457-463; doi:10.1093/jac/dkg342 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Fernando Laguna, Sebastián Videla, Manuel E. Jiménez-Mejías, Guillem Sirera, Julián Torre-Cisneros, Esteban Ribera, Dolores Prados, Bonaventura Clotet, Mariano Sust, Rogelio López-Vélez, and Jorge Alvar

Amphotericin B lipid complex versus meglumine antimoniate in the treatment of visceral leishmaniasis in patients infected with HIV: a randomized pilot study
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 464-468; doi:10.1093/jac/dkg356 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael W. Dunne, Thomas Latiolais, Barnett Lewis, Bruce Pistorius, Gerald Bottenfield, William H. Moore, Anne Garrett, Tracy D. Stewart, Jeffrey Aoki, Craig Spiegel, David Boettger, and Anne Shemer

Randomized, double-blind study of the clinical efficacy of 3 days of azithromycin compared with co-amoxiclav for the treatment of acute otitis media
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 469-472; doi:10.1093/jac/dkg358 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Roly D. Gosling, Leonid Heifets, and Stephen H. Gillespie

A multicentre comparison of a novel surrogate marker for determining the specific potency of anti-tuberculosis drugs
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 473-476; doi:10.1093/jac/dkg345 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Anna Ribera, Ignasi Roca, Joaquim Ruiz, Isidre Gibert, and Jordi Vila

Partial characterization of a transposon containing the tet(A) determinant in a clinical isolate of Acinetobacter baumannii
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 477-480; doi:10.1093/jac/dkg344 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. L. Peterson, J. C. Rotschafer, and L. J. V. Piddock

Plasmid-mediated complementation of gyrA and gyrB in fluoroquinolone-resistant Bacteroides fragilis
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 481-484; doi:10.1093/jac/dkg368 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Portillo, M. J. Gastañares, F. Ruiz-Larrea, and C. Torres

Clonal diversity among erythromycin-resistant ß-haemolytic Streptococcus isolates in La Rioja, Spain
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 485-488; doi:10.1093/jac/dkg347 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Beatriz Guerra, Ernst Junker, Andreas Schroeter, Burkhard Malorny, Simone Lehmann, and Reiner Helmuth

Phenotypic and genotypic characterization of antimicrobial resistance in German Escherichia coli isolates from cattle, swine and poultry
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 489-492; doi:10.1093/jac/dkg362 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kyungwon Lee, Dongeun Yong, Jong Hwa Yum, Ho Hoon Kim, and Yunsop Chong

Diversity of TEM-52 extended-spectrum ß-lactamase-producing non-typhoidal Salmonella isolates in Korea
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 493-496; doi:10.1093/jac/dkg385 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Naoyuki Miyashita, Hiroshi Fukano, Koichiro Yoshida, Yoshihito Niki, and Toshiharu Matsushima

In vitro activity of cethromycin, a novel antibacterial ketolide, against Chlamydia pneumoniae
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 497-499; doi:10.1093/jac/dkg371 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Laura J. V. Piddock, M. M. Johnson, and Mark A. Webber

Activity of faropenem and imipenem for ciprofloxacin-resistant bacteria
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 500-502; doi:10.1093/jac/dkg373 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mark W. Garrison

Comparative antimicrobial activity of levofloxacin and ciprofloxacin against Streptococcus pneumoniae
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 503-506; doi:10.1093/jac/dkg380 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

L. P. Randall, A. M. Ridley, S. W. Cooles, M. Sharma, A. R. Sayers, L. Pumbwe, D. G. Newell, L. J. V. Piddock, and M. J. Woodward

Prevalence of multiple antibiotic resistance in 443 Campylobacter spp. isolated from humans and animals
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 507-510; doi:10.1093/jac/dkg379 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Habib M. Alloush, Vyvyan Salisbury, Roger J. Lewis, and Alasdair P. MacGowan

Pharmacodynamics of linezolid in a clinical isolate of Streptococcus pneumoniae genetically modified to express lux genes
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 511-513; doi:10.1093/jac/dkg334 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Joan Gavaldà, Pedro López Onrubia, María Teresa Martín Gómez, Xavier Gomis, José Luis Ramírez, Oscar Len, Dolors Rodríguez, Manuel Crespo, Isabel Ruíz, and Albert Pahissa

Efficacy of ampicillin combined with ceftriaxone and gentamicin in the treatment of experimental endocarditis due to Enterococcus faecalis with no high-level resistance to aminoglycosides
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 514-517; doi:10.1093/jac/dkg360 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sutep Jaruratanasirikul and Somchai Sriwiriyajan

Comparison of the pharmacodynamics of meropenem in healthy volunteers following administration by intermittent infusion or bolus injection
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 518-521; doi:10.1093/jac/dkg378 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

James R. Bebb, Nathalie Bailey-Flitter, Dlawer Ala’Aldeen, and John C. Atherton

Mastic gum has no effect on Helicobacter pylori load in vivo
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 522-523; doi:10.1093/jac/dkg366 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Eric L. Nuermberger and William R. Bishai

Significance of macrolide resistance in Streptococcus pneumoniae
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 524-525; doi:10.1093/jac/dkg349 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

J. Verhaegen, W. Peetermans, and L. Verbist

Reply
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 525; doi:10.1093/jac/dkg350 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

J. M. Andrews, J. P. Ashby, G. Jevons, and R. Wise

Determination of in vitro susceptibility to ABT-492 by BSAC standardized methodology
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 526-527; doi:10.1093/jac/dkg328 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Lynn B. Duffy, Donna M. Crabb, Xue Bing, and Ken B. Waites

Bactericidal activity of levofloxacin against Mycoplasma pneumoniae
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 527-528; doi:10.1093/jac/dkg365 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Shazad Mushtaq, Neil Woodford, Nicola Potz, and David M. Livermore

Detection of CTX-M-15 extended-spectrum ß-lactamase in the United Kingdom
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 528-529; doi:10.1093/jac/dkg353 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Mireille van Westreenen, Armand Paauw, Ad C. Fluit, Sylvain Brisse, Willemien van Dijk, and Jan Verhoef

Occurrence and spread of SHV extended-spectrum ß-lactamase-producing Klebsiella pneumoniae isolates in Curaçao
JAC Advance Access published on August 13, 2003
J. Antimicrob. Chemother. 2003 52: 530-532; doi:10.1093/jac/dkg382 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

J. H. T. Wagenvoort, D. M. T. Burgers, T. H. C. Wagenvoort, and E. Burgers

Absence of vancomycin-resistant enterococci (VRE) in companion dogs in the conurbation of Parkstad Limburg, The Netherlands
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 532; doi:10.1093/jac/dkg374 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Jorge Cepeda, Samantha Hayman, Tony Whitehouse, Christopher C. Kibbler, David Livermore, Mervyn Singer, and A. Peter R. Wilson

Teicoplanin resistance in methicillin-resistant Staphylococcus aureus in an intensive care unit
JAC Advance Access published on July 29, 2003
J. Antimicrob. Chemother. 2003 52: 533-534; doi:10.1093/jac/dkg369 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Errata:

Vera Hommer, Jutta Eichholz, and Franz Petry

Effect of antiretroviral protease inhibitors alone, and in combination with paromomycin, on the excystation, invasion and in vitro development of Cryptosporidium parvum
J. Antimicrob. Chemother. 2003 52: 535; doi:10.1093/jac/dkg436 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

David Honeybourne, Caroline Tobin, Gail Jevons, Jenny Andrews, and Richard Wise

Intrapulmonary penetration of linezolid
J. Antimicrob. Chemother. 2003 52: 536; doi:10.1093/jac/dkg435 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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