Journal of Antimicrobial Chemotherapy

Editorial:

F. C. Odds

Synergy, antagonism, and what the chequerboard puts between them
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 1; doi:10.1093/jac/dkg301 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Leading articles:

Nancy D. Hanson

AmpC ß-lactamases: what do we need to know for the future?
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 2-4; doi:10.1093/jac/dkg284 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

K. Kümmerer

Significance of antibiotics in the environment
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 5-7; doi:10.1093/jac/dkg293 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Noboru Uchide and Kunio Ohyama

Antiviral function of pyrrolidine dithiocarbamate against influenza virus: the inhibition of viral gene replication and transcription
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 8-10; doi:10.1093/jac/dkg282 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews:

Karl Drlica

The mutant selection window and antimicrobial resistance
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 11-17; doi:10.1093/jac/dkg269 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jane Finlay, Linda Miller, and James A. Poupard

A review of the antimicrobial activity of clavulanate
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 18-23; doi:10.1093/jac/dkg286 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

I. García, A. Pascual, S. Ballesta, C. del Castillo, and E. J. Perea

Accumulation and activity of cethromycin (ABT-773) within human polymorphonuclear leucocytes
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 24-28; doi:10.1093/jac/dkg290 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. Bonnet, C. Recule, R. Baraduc, C. Chanal, D. Sirot, C. De Champs, and J. Sirot

Effect of D240G substitution in a novel ESBL CTX-M-27
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 29-35; doi:10.1093/jac/dkg256 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Roberto Melano, Alejandra Corso, Alejandro Petroni, Daniela Centrón, Betina Orman, Adriana Pereyra, Noemí Moreno, and Marcelo Galas

Multiple antibiotic-resistance mechanisms including a novel combination of extended-spectrum ß-lactamases in a Klebsiella pneumoniae clinical strain isolated in Argentina
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 36-42; doi:10.1093/jac/dkg281 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Agnès Aubouy, Sayeh Jafari, Virginie Huart, Florence Migot-Nabias, Justice Mayombo, Rémy Durand, Mohamed Bakary, Jacques Le Bras, and Philippe Deloron

DHFR and DHPS genotypes of Plasmodium falciparum isolates from Gabon correlate with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine–pyrimethamine treatment efficacy
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 43-49; doi:10.1093/jac/dkg294 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

María-Isabel Morosini, Rafael Cantón, Elena Loza, Rosa del Campo, Felisa Almaraz, and Fernando Baquero

Streptococcus pyogenes isolates with characterized macrolide resistance mechanisms in Spain: in vitro activities of telithromycin and cethromycin
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 50-55; doi:10.1093/jac/dkg303 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ying Zhang, Hao Zhang, and Zhonghe Sun

Susceptibility of Mycobacterium tuberculosis to weak acids
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 56-60; doi:10.1093/jac/dkg287 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tao Lu, Xilin Zhao, Xinying Li, Glen Hansen, Joseph Blondeau, and Karl Drlica

Effect of chloramphenicol, erythromycin, moxifloxacin, penicillin and tetracycline concentration on the recovery of resistant mutants of Mycobacterium smegmatis and Staphylococcus aureus
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 61-64; doi:10.1093/jac/dkg268 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Roxana G. Vitale, Jacques F. G. M. Meis, Johan W. Mouton, and Paul E. Verweij

Evaluation of the post-antifungal effect (PAFE) of amphotericin B and nystatin against 30 zygomycetes using two different media
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 65-70; doi:10.1093/jac/dkg285 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yee-Chun Chen, Shan-Chwen Chang, Kwen-Tay Luh, and Wei-Chuan Hsieh

Stable susceptibility of Candida blood isolates to fluconazole despite increasing use during the past 10 years
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 71-77; doi:10.1093/jac/dkg275 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

John F. Wilson, Alan C. Davis, and Caroline M. Tobin

Evaluation of commercial assays for vancomycin and aminoglycosides in serum: a comparison of accuracy and precision based on external quality assessment
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 78-82; doi:10.1093/jac/dkg296 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

George G. Zhanel, Mel DeCorby, Ayman Noreddin, Chris Mendoza, Andrew Cumming, Kim Nichol, Aleksandra Wierzbowski, and Daryl J. Hoban

Pharmacodynamic activity of azithromycin against macrolide-susceptible and -resistant Streptococcus pneumoniae simulating clinically achievable free serum, epithelial lining fluid and middle ear fluid concentrations
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 83-88; doi:10.1093/jac/dkg278 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Pierre Vaudaux, Patrice Francois, Carmelo Bisognano, Dongmei Li, Daniel P. Lew, and Jacques Schrenzel

Comparative efficacy of daptomycin and vancomycin in the therapy of experimental foreign body infection due to Staphylococcus aureus
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 89-95; doi:10.1093/jac/dkg277 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jane Freeman, Fiona J. O’Neill, and Mark H. Wilcox

Effects of cefotaxime and desacetylcefotaxime upon Clostridium difficile proliferation and toxin production in a triple-stage chemostat model of the human gut
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 96-102; doi:10.1093/jac/dkg267 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Begoña Brime, Paloma Frutos, Pilar Bringas, Ana Nieto, M. Paloma Ballesteros, and Gloria Frutos

Comparative pharmacokinetics and safety of a novel lyophilized amphotericin B lecithin-based oil–water microemulsion and amphotericin B deoxycholate in animal models
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 103-109; doi:10.1093/jac/dkg266 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Ziya Cibali Acikgoz, Safiye Gocer, and Serdar Tuncer

Macrolide resistance determinants of group A streptococci in Ankara, Turkey
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 110-112; doi:10.1093/jac/dkg300 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Guido Werner, Ingo Klare, Friedrich-Bernhard Spencker, and Wolfgang Witte

Intra-hospital dissemination of quinupristin/dalfopristin- and vancomycin-resistant Enterococcus faecium in a paediatric ward of a German hospital
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 113-115; doi:10.1093/jac/dkg305 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Timothy R. Walsh, Mark A. Toleman, Waleria Hryniewicz, Peter M. Bennett, and Ronald N. Jones

Evolution of an integron carrying bla_VIM-2 in Eastern Europe: report from the SENTRY Antimicrobial Surveillance Program
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 116-119; doi:10.1093/jac/dkg299 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Maria M. Theron, Marais N. Janse van Rensburg, and Lynda J. Chalkley

Penicillin-binding proteins involved in high-level piperacillin resistance in Veillonella spp.
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 120-122; doi:10.1093/jac/dkg297 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. S. Richter, D. E. Kealey, C. T. Murray, K. P. Heilmann, S. L. Coffman, and G. V. Doern

The in vitro activity of daptomycin against Staphylococcus aureus and Enterococcus species
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 123-127; doi:10.1093/jac/dkg288 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gunnar Kahlmeter and Paul Menday

Cross-resistance and associated resistance in 2478 Escherichia coli isolates from the Pan-European ECO·SENS Project surveying the antimicrobial susceptibility of pathogens from uncomplicated urinary tract infections
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 128-131; doi:10.1093/jac/dkg280 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Juan Carlos Rodríguez, Elia Sirvent, José María López-Lozano, and Gloria Royo

Criteria of time and antibiotic susceptibility in the elimination of duplicates when calculating resistance frequencies
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 132-134; doi:10.1093/jac/dkg298 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Julie Sunderland, Andrew M. Lovering, Caroline M. Tobin, Alasdair P. MacGowan, John M. Roe, and Anne A. Delsol

Determination by HPLC of chlortetracycline in pig faeces
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 135-137; doi:10.1093/jac/dkg279 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Emilia Cercenado, Sonia Cercenado, Juan A. Gómez, and Emilio Bouza

In vitro activity of tigecycline (GAR-936), a novel glycylcycline, against vancomycin-resistant enterococci and staphylococci with diminished susceptibility to glycopeptides
JAC Advance Access published on June 12, 2003
J. Antimicrob. Chemother. 2003 52: 138-139; doi:10.1093/jac/dkg289 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Soraya S. Andrade, Ronald N. Jones, Ana C. Gales, and Helio S. Sader

Increasing prevalence of antimicrobial resistance among Pseudomonas aeruginosa isolates in Latin American medical centres: 5 year report of the SENTRY Antimicrobial Surveillance Program (1997–2001)
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 140-141; doi:10.1093/jac/dkg270 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Rohini J. Manuel, Gee Yen Shin, N. Farrag, and Richard Holliman

Endemic carbapenem-resistant Acinetobacter baumannii in a London hospital
JAC Advance Access published on May 29, 2003
J. Antimicrob. Chemother. 2003 52: 141-142; doi:10.1093/jac/dkg276 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book review:

Probiotics and Prebiotics: Where Are We Going?
J. Antimicrob. Chemother. 2003 52: 143; doi:10.1093/jac/dkg283 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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