Journal of Antimicrobial Chemotherapy

Leading articles:

Scott D. Mills

The role of genomics in antimicrobial discovery
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 749-752; doi:10.1093/jac/dkg178 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Glen A. Coburn and Bryan R. Cullen

siRNAs: a new wave of RNA-based therapeutics
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 753-756; doi:10.1093/jac/dkg166 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Gabriela Stiegler and Hermann Katinger

Therapeutic potential of neutralizing antibodies in the treatment of HIV-1 infection
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 757-759; doi:10.1093/jac/dkg172 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews:

Peter Karayiannis

Hepatitis B virus: old, new and future approaches to antiviral treatment
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 761-785; doi:10.1093/jac/dkg163 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Isabelle Plante, Daniela Centrón, and Paul H. Roy

An integron cassette encoding erythromycin esterase, ere(A), from Providencia stuartii
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 787-790; doi:10.1093/jac/dkg169 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Steven D. Mahlen, Stacey S. Morrow, Baha Abdalhamid, and Nancy D. Hanson

Analyses of ampC gene expression in Serratia marcescens reveal new regulatory properties
JAC Advance Access published on February 25, 2003
J. Antimicrob. Chemother. 2003 51: 791-802; doi:10.1093/jac/dkg133 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Xian-Zhi Li, Li Zhang, Geoffrey A. McKay, and Keith Poole

Role of the acetyltransferase AAC(6')-Iz modifying enzyme in aminoglycoside resistance in Stenotrophomonas maltophilia
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 803-811; doi:10.1093/jac/dkg148 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tomoyuki Kuwasaki, Masasi Hatta, Hiroaki Takeuchi, and Hiroshi Takaku

Inhibition of human immunodeficiency virus 1 replication in vitro by a self-stabilized oligonucleotide with 2'-O-methyl-guanosine-uridine quadruplex motifs
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 813-819; doi:10.1093/jac/dkg174 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neil J. Marshall, Ryszard Andruszkiewicz, Sona Gupta, Slawomir Milewski, and John W. Payne

Structure–activity relationships for a series of peptidomimetic antimicrobial prodrugs containing glutamine analogues
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 821-831; doi:10.1093/jac/dkg170 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

B. J. Fennell, S. Carolan, G. R. Pettit, and A. Bell

Effects of the antimitotic natural product dolastatin 10, and related peptides, on the human malarial parasite Plasmodium falciparum
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 833-841; doi:10.1093/jac/dkg151 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Andrea Giacometti, Oscar Cirioni, Maria Simona Del Prete, Barbara Skerlavaj, Raffaella Circo, Margherita Zanetti, and Giorgio Scalise

In vitro effect on Cryptosporidium parvum of short-term exposure to cathelicidin peptides
JAC Advance Access published on February 25, 2003
J. Antimicrob. Chemother. 2003 51: 843-847; doi:10.1093/jac/dkg149 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jan C. Droste, Hassan A. Jeraj, Alan MacDonald, and Ken Farrington

Stability and in vitro efficacy of antibiotic–heparin lock solutions potentially useful for treatment of central venous catheter-related sepsis
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 849-855; doi:10.1093/jac/dkg179 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Cédric Jacqueline, Jocelyne Caillon, Virginie Le Mabecque, Anne-Françoise Miègeville, Pierre-Yves Donnio, Denis Bugnon, and Gilles Potel

In vitro activity of linezolid alone and in combination with gentamicin, vancomycin or rifampicin against methicillin-resistant Staphylococcus aureus by time–kill curve methods
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 857-864; doi:10.1093/jac/dkg160 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ingo Stock, Sonja Burak, Kimberley Jane Sherwood, Thomas Grüger, and Bernd Wiedemann

Natural antimicrobial susceptibilities of strains of ‘unusual’ Serratia species: S. ficaria, S. fonticola, S. odorifera, S. plymuthica and S. rubidaea
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 865-885; doi:10.1093/jac/dkg156 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Orsolya Dobay, Ferenc Rozgonyi, Edit Hajdú, Erzsébet Nagy, Márta Knausz, and Sebastian G. B. Amyes

Antibiotic susceptibility and serotypes of Streptococcus pneumoniae isolates from Hungary
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 887-893; doi:10.1093/jac/dkg171 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. M. Ling, A. W. Lam, E. W. Chan, and A. F. Cheng

What have we learnt from community-acquired infections in Hong Kong?
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 895-904; doi:10.1093/jac/dkg167 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sheryl A. Zelenitsky, Robert E. Ariano, Harris Iacovides, Siyao Sun, and Godfrey K. M. Harding

AUC_0–t/MIC is a continuous index of fluoroquinolone exposure and predictive of antibacterial response for Streptococcus pneumoniae in an in vitro infection model
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 905-911; doi:10.1093/jac/dkg152 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

P. A. Warn, G. Morrissey, J. Morrissey, and D. W. Denning

Activity of micafungin (FK463) against an itraconazole-resistant strain of Aspergillus fumigatus and a strain of Aspergillus terreus demonstrating in vivo resistance to amphotericin B
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 913-919; doi:10.1093/jac/dkg185 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Peter J. Nelson, Vivette D. D’Agati, Jean-Michel Gries, Jose-Ramon Suarez, and Irwin H. Gelman

Amelioration of nephropathy in mice expressing HIV-1 genes by the cyclin-dependent kinase inhibitor flavopiridol
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 921-929; doi:10.1093/jac/dkg175 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Qurrat-ul-Ain, Sadhna Sharma, G. K. Khuller, and S. K. Garg

Alginate-based oral drug delivery system for tuberculosis: pharmacokinetics and therapeutic effects
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 931-938; doi:10.1093/jac/dkg165 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Romano Danesi, Antonella Lupetti, Cecilia Barbara, Emilia Ghelardi, Antonio Chella, Tecla Malizia, Sonia Senesi, Carlo Alberto Angeletti, Mario Del Tacca, and Mario Campa

Comparative distribution of azithromycin in lung tissue of patients given oral daily doses of 500 and 1000 mg
JAC Advance Access published on February 25, 2003
J. Antimicrob. Chemother. 2003 51: 939-945; doi:10.1093/jac/dkg138 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Charles M. Fogarty, Shigeru Kohno, Patricia Buchanan, Michel Aubier, and Malik Baz

Community-acquired respiratory tract infections caused by resistant pneumococci: clinical and bacteriological efficacy of the ketolide telithromycin
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 947-955; doi:10.1093/jac/dkg153 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ping-Yu Lee, Wen-Neng Chang, Cheng-Hsien Lu, Mei-Wen Lin, Ben-Chung Cheng, Chun-Chih Chien, Chin-Jung Chang, and Hsueh-Wen Chang

Clinical features and in vitro antimicrobial susceptibilities of community-acquired Klebsiella pneumoniae meningitis in Taiwan
JAC Advance Access published on February 25, 2003
J. Antimicrob. Chemother. 2003 51: 957-962; doi:10.1093/jac/dkg158 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Joshua P. Metlay, Brian L. Strom, and David A. Asch

Prior antimicrobial drug exposure: a risk factor for trimethoprim–sulfamethoxazole-resistant urinary tract infections
JAC Advance Access published on February 25, 2003
J. Antimicrob. Chemother. 2003 51: 963-970; doi:10.1093/jac/dkg146 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Federico Pea, Loris Brollo, Pierluigi Viale, Federica Pavan, and Mario Furlanut

Teicoplanin therapeutic drug monitoring in critically ill patients: a retrospective study emphasizing the importance of a loading dose
JAC Advance Access published on February 25, 2003
J. Antimicrob. Chemother. 2003 51: 971-975; doi:10.1093/jac/dkg147 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neil M. Ferguson, Susan Mallett, Helen Jackson, Noel Roberts, and Penelope Ward

A population-dynamic model for evaluating the potential spread of drug-resistant influenza virus infections during community-based use of antivirals
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 977-990; doi:10.1093/jac/dkg136 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Yuji Morita, Takeshi Murata, Takehiko Mima, Sumiko Shiota, Teruo Kuroda, Tohru Mizushima, Naomasa Gotoh, Takeshi Nishino, and Tomofusa Tsuchiya

Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 991-994; doi:10.1093/jac/dkg173 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Stephanie A. Chisholm and Robert J. Owen

Mutations in Helicobacter pylori rdxA gene sequences may not contribute to metronidazole resistance
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 995-999; doi:10.1093/jac/dkg192 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yolanda Sáenz, Myriam Zarazaga, Laura Briñas, Fernanda Ruiz-Larrea, and Carmen Torres

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 1001-1005; doi:10.1093/jac/dkg168 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Danièle Meunier, Sylvie Baucheron, Elisabeth Chaslus-Dancla, Jean-Louis Martel, and Axel Cloeckaert

Florfenicol resistance in Salmonella enterica serovar Newport mediated by a plasmid related to R55 from Klebsiella pneumoniae
JAC Advance Access published on February 25, 2003
J. Antimicrob. Chemother. 2003 51: 1007-1009; doi:10.1093/jac/dkg141 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mi-Jeong Kim, Hee-Jeong Yun, Jin-Wook Kang, Sunghoon Kim, Jin-Hwan Kwak, and Eung-Chil Choi

In vitro development of resistance to a novel fluoroquinolone, DW286, in methicillin-resistant Staphylococcus aureus clinical isolates
JAC Advance Access published on February 25, 2003
J. Antimicrob. Chemother. 2003 51: 1011-1016; doi:10.1093/jac/dkg162 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Agostinho Cruz, M. Isaura Sousa, Zaida Azeredo, Emilia Leite, J. C. Figueiredo de Sousa, and Miguel Cabral

Isolation, excystation and axenization of Giardia lamblia isolates: in vitro susceptibility to metronidazole and albendazole
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 1017-1020; doi:10.1093/jac/dkg150 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Christiane Atteke, Jérôme Mezui Me Ndong, Agnès Aubouy, Lucien Maciejewski, Jacques Brocard, Jacques Lébibi, and Philippe Deloron

In vitro susceptibility to a new antimalarial organometallic analogue, ferroquine, of Plasmodium falciparum isolates from the Haut-Ogooué region of Gabon
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 1021-1024; doi:10.1093/jac/dkg161 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Margaret R. Hammerschlag, Tamara Reznik, Patricia M. Roblin, Julio Ramirez, James Summersgill, and Stanley Bukofzer

Microbiological efficacy of ABT-773 (cethromycin) for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae
JAC Advance Access published on February 25, 2003
J. Antimicrob. Chemother. 2003 51: 1025-1028; doi:10.1093/jac/dkg154 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

N. Bruinsma, P. M. G. Filius, A. E. van den Bogaard, S. Nys, J. Degener, H. Ph. Endtz, and E. E. Stobberingh

Hospitalization, a risk factor for antibiotic-resistant Escherichia coli in the community?
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 1029-1032; doi:10.1093/jac/dkg164 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brendan W. Mason, Anthony J. Howard, and John T. Magee

Fusidic acid resistance in community isolates of methicillin-susceptible Staphylococcus aureus and fusidic acid prescribing
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 1033-1036; doi:10.1093/jac/dkg190 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Luis Martínez-Martínez, Alvaro Pascual, Isabel García, John Tran, and George A. Jacoby

Interaction of plasmid and host quinolone resistance
JAC Advance Access published on February 25, 2003
J. Antimicrob. Chemother. 2003 51: 1037-1039; doi:10.1093/jac/dkg157 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

George Sakoulas, Howard S. Gold, Lata Venkataraman, Robert C. Moellering, Jr, Mary Jane Ferraro, and George M. Eliopoulos

Introduction of erm(C) into a linezolid- and methicillin-resistant Staphylococcus aureus does not restore linezolid susceptibility
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 1039-1041; doi:10.1093/jac/dkg194 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

C. M. Tobin, J. Sunderland, A. M. Lovering, and A. P. MacGowan

A high performance liquid chromatography (HPLC) assay for linezolid in continuous ambulatory peritoneal dialysis fluid (CAPDF)
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 1041-1042; doi:10.1093/jac/dkg177 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Patricia Sánchez, Uyen Le, and José L. Martínez

The efflux pump inhibitor Phe-Arg-ß-naphthylamide does not abolish the activity of the Stenotrophomonas maltophilia SmeDEF multidrug efflux pump
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 1042-1045; doi:10.1093/jac/dkg181 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

T. J. Young, G. P. Oliver, D. Pryde, M. Perros, and T. Parkinson

Antifungal activity of selective serotonin reuptake inhibitors attributed to non-specific cytotoxicity
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 1045-1047; doi:10.1093/jac/dkg184 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Rachel Gorman and Catherine C. Adley

Nalidixic acid-resistant strains of Salmonella showing decreased susceptibility to fluoroquinolones in the mid-west region of the Republic of Ireland
JAC Advance Access published on February 25, 2003
J. Antimicrob. Chemother. 2003 51: 1047-1049; doi:10.1093/jac/dkg159 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

S. Uzunovic-Kamberovic

Antibiotic susceptibility of Campylobacter jejuni and Campylobacter coli human isolates from Bosnia and Herzegovina
JAC Advance Access published on February 25, 2003
J. Antimicrob. Chemother. 2003 51: 1049-1051; doi:10.1093/jac/dkg142 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Stéphane Carryn, Françoise Van Bambeke, Marie-Paule Mingeot-Leclercq, and Paul M. Tulkens

Activity of ß-lactams (ampicillin, meropenem), gentamicin, azithromycin and moxifloxacin against intracellular Listeria monocytogenes in a 24 h THP-1 human macrophage model
JAC Advance Access published on March 13, 2003
J. Antimicrob. Chemother. 2003 51: 1051-1052; doi:10.1093/jac/dkg189 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book reviews:

Antimalarial Chemotherapy. Mechanisms of Action, Resistance and New Directions in Drug Discovery
J. Antimicrob. Chemother. 2003 51: 1053; doi:10.1093/jac/dkg183 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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