Journal of Antimicrobial Chemotherapy

Appreciation:

Dr Martin John Wood
J. Antimicrob. Chemother. 2003 51: 479; doi:10.1093/jac/dkg197 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Leading articles:

Man-Fung Yuen and Ching-Lung Lai

Current and future antiviral agents for chronic hepatitis B
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 481-485; doi:10.1093/jac/dkg122 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Samuel S. Lee and Ayman A. Abdo

Predicting antiviral treatment response in chronic hepatitis C: how accurate and how soon?
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 487-491; doi:10.1093/jac/dkg135 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Patrick G. Hoggard and Andrew Owen

The mechanisms that control intracellular penetration of the HIV protease inhibitors
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 493-496; doi:10.1093/jac/dkg137 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews:

Grit Ackermann and Arne C. Rodloff

Drugs of the 21st century: telithromycin (HMR 3647)—the first ketolide
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 497-511; doi:10.1093/jac/dkg123 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Valérie Letscher-Bru and Raoul Herbrecht

Caspofungin: the first representative of a new antifungal class
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 513-521; doi:10.1093/jac/dkg117 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

K. Straker, M. Wootton, A. M. Simm, P. M. Bennett, A. P. MacGowan, and T. R. Walsh

Cefuroxime resistance in non-ß-lactamase Haemophilus influenzae is linked to mutations in ftsI
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 523-530; doi:10.1093/jac/dkg107 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ahmed El Zoeiby, François Sanschagrin, André Darveau, Jean-Robert Brisson, and Roger C. Levesque

Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 531-543; doi:10.1093/jac/dkg010 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shirley Yang, Sonia Rahmati Clayton, and E. Lynn Zechiedrich

Relative contributions of the AcrAB, MdfA and NorE efflux pumps to quinolone resistance in Escherichia coli
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 545-556; doi:10.1093/jac/dkg126 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

C. A. Arias, J. Peña, D. Panesso, and P. Reynolds

Role of the transmembrane domain of the VanT serine racemase in resistance to vancomycin in Enterococcus gallinarum BM4174
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 557-564; doi:10.1093/jac/dkg128 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Felipe Fernández-Cuenca, Luis Martínez-Martínez, Mª Carmen Conejo, Juan A. Ayala, Evelio J. Perea, and Alvaro Pascual

Relationship between ß-lactamase production, outer membrane protein and penicillin-binding protein profiles on the activity of carbapenems against clinical isolates of Acinetobacter baumannii
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 565-574; doi:10.1093/jac/dkg097 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. Fraud, A. C. Hann, J.-Y. Maillard, and A. D. Russell

Effects of ortho-phthalaldehyde, glutaraldehyde and chlorhexidine diacetate on Mycobacterium chelonae and Mycobacterium abscessus strains with modified permeability
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 575-584; doi:10.1093/jac/dkg099 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hans Gollwitzer, Karim Ibrahim, Henriette Meyer, Wolfram Mittelmeier, Raymonde Busch, and Axel Stemberger

Antibacterial poly(D,L-lactic acid) coating of medical implants using a biodegradable drug delivery technology
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 585-591; doi:10.1093/jac/dkg105 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Stephen R. Davis, Rosemary Perrie, and Rafael Apitz-Castro

The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum)
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 593-597; doi:10.1093/jac/dkg144 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Grit Ackermann, Angelika Degner, Stuart H. Cohen, Joseph Silva, Jr, and Arne C. Rodloff

Prevalence and association of macrolide–lincosamide– streptogramin B (MLS_B) resistance with resistance to moxifloxacin in Clostridium difficile
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 599-603; doi:10.1093/jac/dkg112 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gioia S. Babini, Meifang Yuan, Lucinda M. C. Hall, and David M. Livermore

Variable susceptibility to piperacillin/tazobactam amongst Klebsiella spp. with extended-spectrum ß-lactamases
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 605-612; doi:10.1093/jac/dkg114 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Upton, S. Lang, and H. Heffernan

Mupirocin and Staphylococcus aureus: a recent paradigm of emerging antibiotic resistance
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 613-617; doi:10.1093/jac/dkg127 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hee-Jeong Yun, Sang Won Lee, Gyu Man Yoon, Su Yeon Kim, Sooyoung Choi, Yeong Seon Lee, Eung-Chil Choi, and Sunghoon Kim

Prevalence and mechanisms of low- and high-level mupirocin resistance in staphylococci isolated from a Korean hospital
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 619-623; doi:10.1093/jac/dkg140 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Amani El Kholy, Hadia Baseem, Geraldine S. Hall, Gary W. Procop, and David L. Longworth

Antimicrobial resistance in Cairo, Egypt 1999–2000: a survey of five hospitals
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 625-630; doi:10.1093/jac/dkg101 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Katsutoshi Yamasaki, Masaru Komatsu, Tomonari Yamashita, Koichi Shimakawa, Toshiro Ura, Hisaaki Nishio, Kaori Satoh, Ryoudou Washidu, Shohiro Kinoshita, and Masanori Aihara

Production of CTX-M-3 extended-spectrum ß-lactamase and IMP-1 metallo ß-lactamase by five Gram-negative bacilli: survey of clinical isolates from seven laboratories collected in 1998 and 2000, in the Kinki region of Japan
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 631-638; doi:10.1093/jac/dkg103 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ian A. Critchley, Deborah C. Draghi, Daniel F. Sahm, Clyde Thornsberry, Mark E. Jones, and James A. Karlowsky

Activity of daptomycin against susceptible and multidrug-resistant Gram-positive pathogens collected in the SECURE study (Europe) during 2000–2001
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 639-649; doi:10.1093/jac/dkg130 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nariné Baririan, Hugues Chanteux, Eric Viaene, Hélène Servais, and Paul M. Tulkens

Stability and compatibility study of cefepime in comparison with ceftazidime for potential administration by continuous infusion under conditions pertinent to ambulatory treatment of cystic fibrosis patients and to administration in intensive care units
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 651-658; doi:10.1093/jac/dkg134 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Annette Lubasch, Stefan Lück, Hartmut Lode, Harald Mauch, Joachim Lorenz, Pal Bölcskei, Tobias Welte, and the COPD study group

Optimizing ceftazidime pharmacodynamics in patients with acute exacerbation of severe chronic bronchitis
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 659-664; doi:10.1093/jac/dkg111 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jacob Strahilevitz, Avram Lev, Itzchak Levi, Eduard Fridman, and Ethan Rubinstein

Experimental pneumococcal pleural empyema model: the effect of moxifloxacin
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 665-669; doi:10.1093/jac/dkg094 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Romuald Bellmann, Petra Egger, Walter Gritsch, Rosa Bellmann-Weiler, Michael Joannidis, Nicole Kaneider, Stefan Dunzendorfer, and Christian J. Wiedermann

Amphotericin B lipid formulations in critically ill patients on continuous veno-venous haemofiltration
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 671-681; doi:10.1093/jac/dkg139 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nana Thrane, Charlotte Olesen, Henrik Carl Schønheyder, and Henrik Toft Sørensen

Socioeconomic factors and prescription of antibiotics in 0- to 2-year-old Danish children
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 683-689; doi:10.1093/jac/dkg118 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. Van Kerkhoven, W. E. Peetermans, L. Verbist, and J. Verhaegen

Breakthrough pneumococcal bacteraemia in patients treated with clarithromycin or oral ß-lactams
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 691-696; doi:10.1093/jac/dkg116 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

G. Gopal Rao, C. S. Mahankali Rao, and I. Starke

Clostridium difficile-associated diarrhoea in patients with community-acquired lower respiratory infection being treated with levofloxacin compared with ß-lactam-based therapy
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 697-701; doi:10.1093/jac/dkg115 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Ireena Dutta and Peter E. Reynolds

The vanC-3 vancomycin resistance gene cluster of Enterococcus flavescens CCM 439
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 703-706; doi:10.1093/jac/dkg131 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

H. E. Jones, N. P. Brenwald, K. A. Owen, and M. J. Gill

A multidrug efflux phenotype mutant of Streptococcus pyogenes
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 707-710; doi:10.1093/jac/dkg121 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ellen Smith Moland, Nancy D. Hanson, Vicki L. Herrera, Jennifer A. Black, Thomas J. Lockhart, Ashfaque Hossain, Judith A. Johnson, Richard V. Goering, and Kenneth S. Thomson

Plasmid-mediated, carbapenem-hydrolysing ß-lactamase, KPC-2, in Klebsiella pneumoniae isolates
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 711-714; doi:10.1093/jac/dkg124 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Emilio Pérez-Trallero, José M. Marimón, Alberto Gonzalez, and Luis Iglesias

Spain¹⁴-5 international multiresistant Streptococcus pneumoniae clone resistant to fluoroquinolones and other families of antibiotics
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 715-719; doi:10.1093/jac/dkg106 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

I. Milazzo, G. Blandino, F. Caccamo, R. Musumeci, G. Nicoletti, and A. Speciale

Faropenem, a new oral penem: antibacterial activity against selected anaerobic and fastidious periodontal isolates
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 721-725; doi:10.1093/jac/dkg120 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Andrews, D. Honeybourne, G. Jevons, M. Boyce, R. Wise, A. Bello, and D. Gajjar

Concentrations of garenoxacin in plasma, bronchial mucosa, alveolar macrophages and epithelial lining fluid following a single oral 600 mg dose in healthy adult subjects
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 727-730; doi:10.1093/jac/dkg110 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. J. Dancer, A. Robb, A. Crawford, and D. Morrison

Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 731-735; doi:10.1093/jac/dkg143 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

S. Pattharachayakul, M. M. Neuhauser, J. P. Quinn, and S. L. Pendland

Extended-spectrum ß-lactamase (ESBL)-producing Klebsiella pneumoniae: activity of single versus combination agents
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 737-739; doi:10.1093/jac/dkg119 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Richard W. Ellis

Mu50 glycopeptide-resistant Staphylococcus aureus: the case of the missing penicillinase
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 739-740; doi:10.1093/jac/dkg132 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

J. R. Greig

Quinolone resistance in Campylobacter
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 740-742; doi:10.1093/jac/dkg125 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Nadege Bourgeois, Jean-Claude Ghnassia, and Florence Doucet-Populaire

In vitro activity of fluoroquinolones against erythromycin-susceptible and -resistant Bordetella pertussis
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 742-743; doi:10.1093/jac/dkg145 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Grit Ackermann, Daniela Adler, and Arne C. Rodloff

In vitro activity of linezolid against Clostridium difficile
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 743-745; doi:10.1093/jac/dkg113 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

A. P. Johnson, M. Warner, H. Malnick, and D. M. Livermore

Activity of the oxazolidinones AZD2563 and linezolid against Corynebacterium jeikeium and other Corynebacterium spp.
JAC Advance Access published on February 11, 2003
J. Antimicrob. Chemother. 2003 51: 745-747; doi:10.1093/jac/dkg129 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

L. J. Haddow, M. Chandra Sekhar, V. Hajela, and G. Gopal Rao

Spontaneous Achilles tendon rupture in patients treated with levofloxacin
JAC Advance Access published on January 28, 2003
J. Antimicrob. Chemother. 2003 51: 747-748; doi:10.1093/jac/dkg081 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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