Journal of Antimicrobial Chemotherapy

Leading articles:

J. Gerardo García-Lerma and Walid Heneine

Rapid biochemical assays for phenotypic drug resistance testing of HIV-1
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 771-774; doi:10.1093/jac/dkg005 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Gunnar Kahlmeter and Derek F. J. Brown

Resistance surveillance studies—comparability of results and quality assurance of methods
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 775-777; doi:10.1093/jac/dkg041 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews:

Luis M. Schang

Cyclin-dependent kinases as cellular targets for antiviral drugs
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 779-792; doi:10.1093/jac/dkf227 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Osmond J. D’Cruz and Fatih M. Uckun

Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07)
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 793-803; doi:10.1093/jac/dkg001 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Itzhak Brook

Microbiology of polymicrobial abscesses and implications for therapy
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 805-810; doi:10.1093/jac/dkg009 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

P. David Rogers, Margaret M. Pearson, John D. Cleary, Donna C. Sullivan, and Stanley W. Chapman

Differential expression of genes encoding immunomodulatory proteins in response to amphotericin B in human mononuclear cells identified by cDNA microarray analysis
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 811-817; doi:10.1093/jac/dkf234 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tien Tze Lim, Geoffrey W. Coombs, and Warren B. Grubb

Genetic organization of mecA and mecA-regulatory genes in epidemic methicillin-resistant Staphylococcus aureus from Australia and England
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 819-824; doi:10.1093/jac/dkf238 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rajan P. Adhikari, Gregory M. Cook, Iain Lamont, Selwyn Lang, Helen Heffernan, and John M. B. Smith

Phenotypic and molecular characterization of community occurring, Western Samoan phage pattern methicillin-resistant Staphylococcus aureus
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 825-831; doi:10.1093/jac/dkf242 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Glenn W. Kaatz, Varsha V. Moudgal, and Susan M. Seo

Identification and characterization of a novel efflux-related multidrug resistance phenotype in Staphylococcus aureus
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 833-838; doi:10.1093/jac/dkf224 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. J. O’Neill, J. M. Bostock, A. Morais Moita, and I. Chopra

Antimicrobial activity and mechanisms of resistance to cephalosporin P1, an antibiotic related to fusidic acid
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 839-848; doi:10.1093/jac/dkf248 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Takeshi Okamoto, Hironori Yoshiyama, Teruko Nakazawa, In-Dal Park, Myung-Woong Chang, Hideo Yanai, Kiwamu Okita, and Mutsunori Shirai

A change in PBP1 is involved in amoxicillin resistance of clinical isolates of Helicobacter pylori
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 849-856; doi:10.1093/jac/dkf140 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michelle L. Embleton, Sean P. Nair, Barry D. Cookson, and Michael Wilson

Selective lethal photosensitization of methicillin-resistant Staphylococcus aureus using an IgG–tin (IV) chlorin e6 conjugate
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 857-864; doi:10.1093/jac/dkf209 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tamara Matysiak-Budnik, Martine Heyman, Céline Candalh, Denis Lethuaire, and Francis Mégraud

In vitro transfer of clarithromycin and amoxicillin across the epithelial barrier: effect of Helicobacter pylori
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 865-872; doi:10.1093/jac/dkf219 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yngvar Tveten, Andrew Jenkins, and Bjørn-Erik Kristiansen

A fusidic acid-resistant clone of Staphylococcus aureus associated with impetigo bullosa is spreading in Norway
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 873-876; doi:10.1093/jac/dkf217 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. Simjee, D. G. White, J. Meng, D. D. Wagner, S. Qaiyumi, S. Zhao, J. R. Hayes, and P. F. McDermott

Prevalence of streptogramin resistance genes among Enterococcus isolates recovered from retail meats in the Greater Washington DC area
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 877-882; doi:10.1093/jac/dkf236 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ernesto Fattorusso, Silvia Parapini, Claudio Campagnuolo, Nicoletta Basilico, Orazio Taglialatela-Scafati, and Donatella Taramelli

Activity against Plasmodium falciparum of cycloperoxide compounds obtained from the sponge Plakortis simplex
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 883-888; doi:10.1093/jac/dkg008 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Koki Nagayama, Yoshitoshi Iwamura, Toshiyuki Shibata, Izumi Hirayama, and Takashi Nakamura

Bactericidal activity of phlorotannins from the brown alga Ecklonia kurome
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 889-893; doi:10.1093/jac/dkf222 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vittorio Sambri, Antonella Marangoni, Lorenzo Giacani, Renato Gennaro, Rossella Murgia, Roberto Cevenini, and Marina Cinco

Comparative in vitro activity of five cathelicidin-derived synthetic peptides against Leptospira, Borrelia and Treponema pallidum
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 895-902; doi:10.1093/jac/dkf220 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Irini Lazou Ahrén, Eva Karlsson, Arne Forsgren, and Kristian Riesbeck

Comparison of the antibacterial activities of ampicillin, ciprofloxacin, clarithromycin, telithromycin and quinupristin/dalfopristin against intracellular non-typeable Haemophilus influenzae
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 903-906; doi:10.1093/jac/dkf221 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. M. T. Hamilton-Miller and Saroj Shah

Activity of ketolide ABT-773 (cethromycin) against erythromycin-resistant Streptococcus pneumoniae: correlation with extended MLSK phenotypes
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 907-913; doi:10.1093/jac/dkf237 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ronald N. Jones, Lalitagauri M. Deshpande, Alan H. Mutnick, and Douglas J. Biedenbach

In vitro evaluation of BAL9141, a novel parenteral cephalosporin active against oxacillin-resistant staphylococci
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 915-932; doi:10.1093/jac/dkf249 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. A. John, C. Pletch, and Z. Hussain

In vitro activity of quinupristin/dalfopristin, linezolid, telithromycin and comparator antimicrobial agents against 13 species of coagulase-negative staphylococci
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 933-938; doi:10.1093/jac/dkf241 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rose Jung, Susan L. Pendland, and Steven J. Martin

Combined bactericidal activity of perfluorooctyl bromide and aminoglycosides against Pseudomonas aeruginosa
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 939-944; doi:10.1093/jac/dkf226 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Oteo, J. Campos, F. Baquero, and Spanish members of the European Antimicrobial Resistance Surveillance System (EARSS)

Antibiotic resistance in 1962 invasive isolates of Escherichia coli in 27 Spanish hospitals participating in the European Antimicrobial Resistance Surveillance System (2001)
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 945-952; doi:10.1093/jac/dkf255 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. Bronzwaer, U. Buchholz, P. Courvalin, J. Snell, G. Cornaglia, A. de Neeling, H. Aubry-Damon, J. Degener, and EARSS participants

Comparability of antimicrobial susceptibility test results from 22 European countries and Israel: an external quality assurance exercise of the European Antimicrobial Resistance Surveillance System (EARSS) in collaboration with the United Kingdom National External Quality Assurance Scheme (UK NEQAS)
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 953-964; doi:10.1093/jac/dkf231 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

K. P. Shannon and G. L. French

Validation of the NCCLS proposal to use results only from the first isolate of a species per patient in the calculation of susceptibility frequencies
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 965-969; doi:10.1093/jac/dkf225 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shuichi Miyazaki, Toshihiko Fujikawa, Intetsu Kobayashi, Tetsuya Matsumoto, Kazuhiro Tateda, and Keizo Yamaguchi

The in vitro and in vivo antibacterial characterization of vancomycin and linezolid against vancomycin-susceptible and -resistant enterococci
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 971-974; doi:10.1093/jac/dkf245 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Oliver Kayser, W. Ray Waters, Keith M. Woods, Steve J. Upton, Janet S. Keithly, Hartmut Laatsch, and Albrecht F. Kiderlen

Evaluation of in vitro and in vivo activity of benzindazole-4,9-quinones against Cryptosporidium parvum
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 975-980; doi:10.1093/jac/dkf199 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Olgica Djurkovic-Djakovic, Vladimir Milenkovic, Aleksandra Nikolic, Branko Bobic, and Jelica Grujic

Efficacy of atovaquone combined with clindamycin against murine infection with a cystogenic (Me49) strain of Toxoplasma gondii
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 981-987; doi:10.1093/jac/dkf251 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alberto Vaccheri, Lars Bjerrum, Davide Resi, Ulf Bergman, and Nicola Montanaro

Antibiotic prescribing in general practice: striking differences between Italy (Ravenna) and Denmark (Funen)
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 989-997; doi:10.1093/jac/dkf239 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Francesco Barchiesi, Monia Maracci, Brunella Radi, Daniela Arzeni, Isabella Baldassarri, Andrea Giacometti, and Giorgio Scalise

Point prevalence, microbiology and fluconazole susceptibility patterns of yeast isolates colonizing the oral cavities of HIV-infected patients in the era of highly active antiretroviral therapy
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 999-1002; doi:10.1093/jac/dkf233 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jesús Fortún, Teresa M. Coque, Pilar Martín-Dávila, Leonor Moreno, Rafael Cantón, Elena Loza, Fernando Baquero, and Santiago Moreno

Risk factors associated with ampicillin resistance in patients with bacteraemia caused by Enterococcus faecium
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 1003-1009; doi:10.1093/jac/dkf216 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hisham M. Ziglam, David R. Baldwin, Ian Daniels, Jenny M. Andrews, and Roger G. Finch

Rifampicin concentrations in bronchial mucosa, epithelial lining fluid, alveolar macrophages and serum following a single 600 mg oral dose in patients undergoing fibre-optic bronchoscopy
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 1011-1015; doi:10.1093/jac/dkf214 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Pamela A. Moise, Alan Forrest, Mary C. Birmingham, and Jerome J. Schentag

The efficacy and safety of linezolid as treatment for Staphylococcus aureus infections in compassionate use patients who are intolerant of, or who have failed to respond to, vancomycin
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 1017-1026; doi:10.1093/jac/dkf215 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Cristina Gil-Lamaignere, Emmanuel Roilides, Avgi Maloukou, Irene Georgopoulou, George Petrikkos, and Thomas J. Walsh

Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 1027-1030; doi:10.1093/jac/dkf198 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Laurent Poirel, Marek Gniadkowski, and Patrice Nordmann

Biochemical analysis of the ceftazidime-hydrolysing extended-spectrum ß-lactamase CTX-M-15 and of its structurally related ß-lactamase CTX-M-3
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 1031-1034; doi:10.1093/jac/dkf240 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Teresa M. Coque, Rob Willems, Rafael Cantón, Rosa Del Campo, and Fernando Baquero

High occurrence of esp among ampicillin-resistant and vancomycin-susceptible Enterococcus faecium clones from hospitalized patients
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 1035-1038; doi:10.1093/jac/dkf229 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. D. Cavallo, P. Plesiat, G. Couetdic, F. Leblanc, R. Fabre, and Groupe d’Etude de la Résistance de Pseudomonas aeruginosa aux Bêtalactamines (GERPB)

Mechanisms of ß-lactam resistance in Pseudomonas aeruginosa: prevalence of OprM-overproducing strains in a French multicentre study (1997)
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 1039-1043; doi:10.1093/jac/dkf186 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Douglas N. Fish, Michael K. Choi, and Rose Jung

Synergic activity of cephalosporins plus fluoroquinolones against Pseudomonas aeruginosa with resistance to one or both drugs
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 1045-1049; doi:10.1093/jac/dkf211 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Zhi-Qing Hu, Wei-Hua Zhao, Yoshiyuki Yoda, Nozomi Asano, Yukihiko Hara, and Tadakatsu Shimamura

Additive, indifferent and antagonistic effects in combinations of epigallocatechin gallate with 12 non-ß-lactam antibiotics against methicillin-resistant Staphylococcus aureus
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 1051-1054; doi:10.1093/jac/dkf250 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jesús Oteo-Iglesias, Juan-Ignacio Alós, and José-Luis Gómez-Garcés

Increase in resistance to new fluoroquinolones from 1998 to 2001 in the Bacteroides fragilis group
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 1055-1057; doi:10.1093/jac/dkf230 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lorenzo Drago, Elena De Vecchi, Alessandra Lombardi, Lucia Nicola, Marilena Valli, and Maria Rita Gismondo

Bactericidal activity of levofloxacin, gatifloxacin, penicillin, meropenem and rokitamycin against Bacillus anthracis clinical isolates
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 1059-1063; doi:10.1093/jac/dkg006 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jolanta Krzyszton-Russjan, Marek Gniadkowski, Hanna Polowniak-Pracka, Elzbieta Hagmajer, and Waleria Hryniewicz

The first Staphylococcus aureus isolates with reduced susceptibility to vancomycin in Poland
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 1065-1069; doi:10.1093/jac/dkf252 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Peter A. Warn, Andrew Sharp, Graham Morrissey, and David W. Denning

In vivo activity of micafungin in a persistently neutropenic murine model of disseminated infection caused by Candida tropicalis
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 1071-1074; doi:10.1093/jac/dkf247 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

L. M. Chiu, A. M. Menhinick, P. W. Johnson, and G. W. Amsden

Pharmacokinetics of intravenous azithromycin and ceftriaxone when administered alone and concurrently to healthy volunteers
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 1075-1079; doi:10.1093/jac/dkg003 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Marta Boffito, Pierluigi Carriero, Laura Trentini, Riccardo Raiteri, Stefano Bonora, Alessandro Sinicco, Helen E. Reynolds, Patrick G. Hoggard, David J. Back, and Giovanni Di Perri

Pharmacokinetics of saquinavir co-administered with cimetidine
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 1081-1084; doi:10.1093/jac/dkf232 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Douglas Steinke, Alistair Emslie-Smith, Paul Boyle, Hilary Kay Young, George Macfarlane, and Peter Davey

A population study of first exposure to community antibacterials in children and the suitability of routine urine samples for study of the acquisition of drug resistance
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 1085-1088; doi:10.1093/jac/dkf223 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Rohini J. Manuel, Andrew Tuck, Andrew Lowes, and Ann Pallett

Detection of teicoplanin resistance in UK EMRSA-17 strains
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 1089-1090; doi:10.1093/jac/dkf213 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

E. Petinaki, F. Kontos, and A. N. Maniatis

Emergence of two oxacillin-susceptible mecA-positive Staphylococcus aureus clones in a Greek hospital
JAC Advance Access published on November 1, 2002
J. Antimicrob. Chemother. 2002 50: 1090-1091; doi:10.1093/jac/dkf235 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Kevin J. Towner, Thekli Gee, and Tim Boswell

An unwanted import to the UK: a carbapenem-resistant clinical isolate of Acinetobacter baumannii producing metallo-ß-lactamase
JAC Advance Access published on November 18, 2002
J. Antimicrob. Chemother. 2002 50: 1092-1093; doi:10.1093/jac/dkg012 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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