Journal of Antimicrobial Chemotherapy

Leading articles:

Helen Giamarellou

Prescribing guidelines for severe Pseudomonas infections
J. Antimicrob. Chemother. 2002 49: 229-233; doi:10.1093/jac/49.2.229 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Niels Høiby

New antimicrobials in the management of cystic fibrosis
J. Antimicrob. Chemother. 2002 49: 235-238; doi:10.1093/jac/49.2.235 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Georg Maschmeyer

New antifungal agents—treatment standards are beginning to grow old
J. Antimicrob. Chemother. 2002 49: 239-241; doi:10.1093/jac/49.2.239 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

The 2001 Garrod Lecture:

Paul D. Griffiths

The treatment of cytomegalovirus infection
J. Antimicrob. Chemother. 2002 49: 243-253; doi:10.1093/jac/49.2.243 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Matthew B. Avison, Peter M. Bennett, Robin A. Howe, and Timothy R. Walsh

Preliminary analysis of the genetic basis for vancomycin resistance in Staphylococcus aureus strain Mu50
J. Antimicrob. Chemother. 2002 49: 255-260; doi:10.1093/jac/49.2.255 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jungmin Kim, Haeng-Seop Shin, Sung-Yong Seol, and Dong-Taek Cho

Relationship between bla_SHV-12 and bla_SHV-2a in Korea
J. Antimicrob. Chemother. 2002 49: 261-267; doi:10.1093/jac/49.2.261 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sang Hee Lee, Jae Young Kim, Gyu Sang Lee, Seok Ho Cheon, Young Jun An, Seok Hoon Jeong, and Kye Joon Lee

Characterization of bla_CMY-11, an AmpC-type plasmid-mediated ß-lactamase gene in a Korean clinical isolate of Escherichia coli
J. Antimicrob. Chemother. 2002 49: 269-273; doi:10.1093/jac/49.2.269 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alessandro De Logu, Valentina Onnis, Barbara Saddi, Cenzo Congiu, Maria Laura Schivo, and Maria Teresa Cocco

Activity of a new class of isonicotinoylhydrazones used alone and in combination with isoniazid, rifampicin, ethambutol, para-aminosalicylic acid and clofazimine against Mycobacterium tuberculosis
J. Antimicrob. Chemother. 2002 49: 275-282; doi:10.1093/jac/49.2.275 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Franz-Josef Schmitz, Mechthild Boos, Susanne Mayer, Harold Jagusch, and Ad C. Fluit

Increased in vitro activity of the novel des-fluoro(6) quinolone BMS-284756 against genetically defined clinical isolates of Staphylococcus aureus
J. Antimicrob. Chemother. 2002 49: 283-287; doi:10.1093/jac/49.2.283 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. M. Livermore, M. Struelens, J. Amorim, F. Baquero, J. Bille, R. Canton, S. Henning, S. Gatermann, A. Marchese, H. Mittermayer, C. Nonhoff, K. J. Oakton, F. Praplan, H. Ramos, G. C. Schito, J. Van Eldere, J. Verhaegen, J. Verhoef, and M. R. Visser

Multicentre evaluation of the VITEK 2 Advanced Expert System for interpretive reading of antimicrobial resistance tests
J. Antimicrob. Chemother. 2002 49: 289-300; doi:10.1093/jac/49.2.289 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sarah Gander, Katy Hayward, and Roger Finch

An investigation of the antimicrobial effects of linezolid on bacterial biofilms utilizing an in vitro pharmacokinetic model
J. Antimicrob. Chemother. 2002 49: 301-308; doi:10.1093/jac/49.2.301 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Pei-Ching Shih and Ching-Tsan Huang

Effects of quorum-sensing deficiency on Pseudomonas aeruginosa biofilm formation and antibiotic resistance
J. Antimicrob. Chemother. 2002 49: 309-314; doi:10.1093/jac/49.2.309 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sébastien Vilain, Pascal Cosette, Guy-Alain Junter, and Thierry Jouenne

Phosphate deprivation is associated with high resistance to latamoxef of gel-entrapped, sessile-like Escherichia coli cells
J. Antimicrob. Chemother. 2002 49: 315-320; doi:10.1093/jac/49.2.315 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

G. Mozzi, P. Benelli, T. Bruzzese, M. R. Galmozzi, and A. Bonabello

The use of lipid emulsions for the iv administration of a new water soluble polyene antibiotic, SPK-843
J. Antimicrob. Chemother. 2002 49: 321-325; doi:10.1093/jac/49.2.321 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Philippe Cottagnoud, Fernando Acosta, Marianne Cottagnoud, and Martin G. Täuber

Cefepime is efficacious against penicillin- and quinolone-resistant pneumococci in experimental meningitis
J. Antimicrob. Chemother. 2002 49: 327-330; doi:10.1093/jac/49.2.327 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Yuste, I. Jado, A. Fenoll, L. Aguilar, M. J. Giménez, and J. Casal

ß-Lactam modification of the bacteraemic profile and its relationship with mortality in a pneumococcal mouse sepsis model
J. Antimicrob. Chemother. 2002 49: 331-335; doi:10.1093/jac/49.2.331 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Henri Portier, Jamila Filipecki, Philippe Weber, Gerard Goldfarb, Denis Lethuaire, and Jean-Pierre Chauvin

Five day clarithromycin modified release versus 10 day penicillin V for group A streptococcal pharyngitis: a multi-centre, open-label, randomized study
J. Antimicrob. Chemother. 2002 49: 337-344; doi:10.1093/jac/49.2.337 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. E. Lewis, D. J. Diekema, S. A. Messer, M. A. Pfaller, and M. E. Klepser

Comparison of Etest, chequerboard dilution and time–kill studies for the detection of synergy or antagonism between antifungal agents tested against Candida species
J. Antimicrob. Chemother. 2002 49: 345-351; doi:10.1093/jac/49.2.345 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

William R. Kirkpatrick, Sofia Perea, Brent J. Coco, and Thomas F. Patterson

Efficacy of ravuconazole (BMS-207147) in a guinea pig model of disseminated aspergillosis
J. Antimicrob. Chemother. 2002 49: 353-357; doi:10.1093/jac/49.2.353 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Matthew J. Lock, Nicola Thorley, Jeanette Teo, and Vincent C. Emery

Azidodeoxythymidine and didehydrodeoxythymidine as inhibitors and substrates of the human herpesvirus 8 thymidine kinase
J. Antimicrob. Chemother. 2002 49: 359-366; doi:10.1093/jac/49.2.359 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Véronique Leflon-Guibout, Géraldine Ternat, Beate Heym, and Marie-Hélène Nicolas-Chanoine

Exposure to co-amoxiclav as a risk factor for co-amoxiclav-resistant Escherichia coli urinary tract infection
J. Antimicrob. Chemother. 2002 49: 367-371; doi:10.1093/jac/49.2.367 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Véronique Leflon-Guibout, Stéphane Bonacorsi, Olivier Clermont, Géraldine Ternat, Beate Heym, and Marie-Hélène Nicolas-Chanoine

Pyelonephritis caused by multiple clones of Escherichia coli, susceptible and resistant to co-amoxiclav, after a 45 day course of co-amoxiclav
J. Antimicrob. Chemother. 2002 49: 373-377; doi:10.1093/jac/49.2.373 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ioanna Spyridaki, Anna Psaroulaki, Emmanouil Kokkinakis, Achilleas Gikas, and Yannis Tselentis

Mechanisms of resistance to fluoroquinolones in Coxiella burnetii
J. Antimicrob. Chemother. 2002 49: 379-382; doi:10.1093/jac/49.2.379 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Corinna Kehrenberg and Stefan Schwarz

Nucleotide sequence and organization of plasmid pMVSCS1 from Mannheimia varigena: identification of a multiresistance gene cluster
J. Antimicrob. Chemother. 2002 49: 383-386; doi:10.1093/jac/49.2.383 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Matthew B. Avison, Catherine S. Higgins, Peter J. Ford, Charlotte J. von Heldreich, Timothy R. Walsh, and Peter M. Bennett

Differential regulation of L1 and L2 ß-lactamase expression in Stenotrophomonas maltophilia
J. Antimicrob. Chemother. 2002 49: 387-389; doi:10.1093/jac/49.2.387 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Janine Landrygan, Peter A. James, Dawn Brooks, and Elizabeth M. Kubiak

Reproducibility of control organism zone diameters for batches of IsoSensitest agar manufactured from 1996 to 2000 using the BSAC disc susceptibility test method
J. Antimicrob. Chemother. 2002 49: 391-394; doi:10.1093/jac/49.2.391 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

N. Franceschini, B. Segatore, M. Perilli, S. Vessillier, L. Franchino, and G. Amicosante

Meropenem stability to ß-lactamase hydrolysis and comparative in vitro activity against several ß-lactamase-producing Gram-negative strains
J. Antimicrob. Chemother. 2002 49: 395-398; doi:10.1093/jac/49.2.395 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Peter C. Fuchs, Arthur L. Barry, and Steven D. Brown

In vitro activity of telithromycin against Streptococcus pneumoniae resistant to other antibiotics, including cefotaxime
J. Antimicrob. Chemother. 2002 49: 399-401; doi:10.1093/jac/49.2.399 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tanja Schülin

In vitro activity of the aerosolized agents colistin and tobramycin and five intravenous agents against Pseudomonas aeruginosa isolated from cystic fibrosis patients in southwestern Germany
J. Antimicrob. Chemother. 2002 49: 403-406; doi:10.1093/jac/49.2.403 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

H. Vorbach, C. Armbruster, B. Robibaro, A. Griesmacher, I. El Menyawi, H. Daxecker, M. Raab, and M. M. Müller

Endothelial cell compatibility of azithromycin and erythromycin
J. Antimicrob. Chemother. 2002 49: 407-409; doi:10.1093/jac/49.2.407 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Satoshi Takeshita, Yasuo Ono, Ken Kozuma, Masatoshi Suzuki, Yutaka Kawamura, Naoyuki Yokoyama, Taiji Furukawa, and Takaaki Isshiki

Modulation of oxidative burst of neutrophils by doxycycline in patients with acute myocardial infarction
J. Antimicrob. Chemother. 2002 49: 411-413; doi:10.1093/jac/49.2.411 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Susan Hadley, José A. Martinez, Laura McDermott, Barbara Rapino, and David R. Snydman

Real-time antifungal susceptibility screening aids management of invasive yeast infections in immunocompromised patients
J. Antimicrob. Chemother. 2002 49: 415-419; doi:10.1093/jac/49.2.415 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. D. Vaudaux and Y. Guex-Crosier

Rifabutin-induced cystoid macular oedema
J. Antimicrob. Chemother. 2002 49: 421-422; doi:10.1093/jac/49.2.421 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Ashraf A. F. Elsaghier, Hazel M. Aucken, Jeremy M. Hamilton-Miller, Stephen Shaw, and Christopher C. Kibbler

Resistance to teicoplanin developing during treatment of methicillin-resistant Staphylococcus aureus infection
J. Antimicrob. Chemother. 2002 49: 423-424; doi:10.1093/jac/49.2.423 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Eugénia Ferreira and Manuela Caniça

Invasive meningococci with reduced susceptibility to penicillin in Portugal
J. Antimicrob. Chemother. 2002 49: 424-425; doi:10.1093/jac/49.2.424 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Vicenza Di Modugno, Massimo Guerrini, Saroj Shah, and Jeremy Hamilton-Miller

Low level resistance to oleandomycin as a marker of ermA in staphylococci
J. Antimicrob. Chemother. 2002 49: 425-427; doi:10.1093/jac/49.2.425 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Stefano Rusconi, Elisabetta Bulgheroni, Simona La Seta Catamancio, Francesco Croce, Mirko Lo Cicero, Paola Citterio, and Massimo Galli

Accumulation of drug-related mutations in HIV-1 genome and virus replicative capacity in multi-drug failure subjects
J. Antimicrob. Chemother. 2002 49: 427-429; doi:10.1093/jac/49.2.427 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

M. I. Andersson and A. P. MacGowan

Trends in original research published from the United Kingdom in the antimicrobial literature
J. Antimicrob. Chemother. 2002 49: 429-430; doi:10.1093/jac/49.2.429 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book review:

Stuart C. Clarke

Meningococcal Disease: Methods and Protocols. Methods in Molecular Medicine: Andrew J. Pollard & Martin C. J. Maiden, Eds. Humana Press, Totowa, NJ, 2001. ISBN 0-89603-849-1. 728 pp.
J. Antimicrob. Chemother. 2002 49: 431; doi:10.1093/jac/49.2.431 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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