Journal of Antimicrobial Chemotherapy

Leading articles:

Caroline A. Sabin and Andrew N. Phillips

Treatment comparisons in HIV infection: the benefits and limitations of observational cohort studies
J. Antimicrob. Chemother. 2001 47: 371-375; doi:10.1093/jac/47.4.371 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Simon R. Clarke and Keith G. H. Dyke

Studies of the operator region of the Staphylococcus aureus ß-lactamase operon
J. Antimicrob. Chemother. 2001 47: 377-389; doi:10.1093/jac/47.4.377 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. Carmen Domínguez, Manuel de la Rosa, and M. Victoria Borobio

Application of a spectrophotometric method for the determination of post-antibiotic effect and comparison with viable counts in agar
J. Antimicrob. Chemother. 2001 47: 391-398; doi:10.1093/jac/47.4.391 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. Wootton, R. A. Howe, R. Hillman, T. R. Walsh, P. M. Bennett, and A. P. MacGowan

A modified population analysis profile (PAP) method to detect hetero-resistance to vancomycin in Staphylococcus aureus in a UK hospital
J. Antimicrob. Chemother. 2001 47: 399-403; doi:10.1093/jac/47.4.399 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

H. Endo, H. Yoshida, N. Ohmi, and S. Higuchi

Effects of lansoprazole, clarithromycin and pH gradient on uptake of [¹⁴C]amoxycillin into rat gastric tissue
J. Antimicrob. Chemother. 2001 47: 405-410; doi:10.1093/jac/47.4.405 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. P. Johnson, M. Warner, R. C. George, and D. M. Livermore

Activity of moxifloxacin against clinical isolates of Streptococcus pneumoniae from England and Wales
J. Antimicrob. Chemother. 2001 47: 411-415; doi:10.1093/jac/47.4.411 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

John R. Graybill and Rosie Bocanegra

Treatment alternatives for Mycobacterium kansasii
J. Antimicrob. Chemother. 2001 47: 417-420; doi:10.1093/jac/47.4.417 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

G. M. Joynt, J. Lipman, C. D. Gomersall, R. J. Young, E. L. Y. Wong, and T. Gin

The pharmacokinetics of once-daily dosing of ceftriaxone in critically ill patients
J. Antimicrob. Chemother. 2001 47: 421-429; doi:10.1093/jac/47.4.421 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

T. Gee, J. M. Andrews, J. P. Ashby, G. Marshall, and R. Wise

Pharmacokinetics and tissue penetration of gemifloxacin following a single oral dose
J. Antimicrob. Chemother. 2001 47: 431-434; doi:10.1093/jac/47.4.431 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

George G. Zhanel, Michael Walters, Nancy Laing, and Daryl J. Hoban

In vitro pharmacodynamic modelling simulating free serum concentrations of fluoroquinolones against multidrug-resistant Streptococcus pneumoniae
J. Antimicrob. Chemother. 2001 47: 435-440; doi:10.1093/jac/47.4.435 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Annemarie Ferwerda, Henriëtte A. Moll, Wim C. J. Hop, Jan M. Kouwenberg, Cecil V. Tjon Pian Gi, Simon G. F. Robben, and Ronald de Groot

Efficacy, safety and tolerability of 3 day azithromycin versus 10 day co-amoxiclav in the treatment of children with acute lower respiratory tract infections
J. Antimicrob. Chemother. 2001 47: 441-446; doi:10.1093/jac/47.4.441 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Yoshikuni Onodera, Mayumi Tanaka, and Kenichi Sato

Inhibitory activity of quinolones against DNA gyrase of Mycobacterium tuberculosis
J. Antimicrob. Chemother. 2001 47: 447-450; doi:10.1093/jac/47.4.447 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

William J. Suling and Joseph A. Maddry

Antimycobacterial activity of 1-deaza-7,8-dihydropteridine derivatives against Mycobacterium tuberculosis and Mycobacterium avium complex in vitro
J. Antimicrob. Chemother. 2001 47: 451-454; doi:10.1093/jac/47.4.451 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Thomas Butler, Robert W. Frenck, Raymond B. Johnson, and Rasik Khakhria

In vitro effects of azithromycin on Salmonella typhi: early inhibition by concentrations less than the MIC and reduction of MIC by alkaline pH and small inocula
J. Antimicrob. Chemother. 2001 47: 455-458; doi:10.1093/jac/47.4.455 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jae J. Kim, Rita Reddy, Miae Lee, Jong G. Kim, Fouad A. K. El-Zaatari, Michael S. Osato, David Y. Graham, and Dong H. Kwon

Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea
J. Antimicrob. Chemother. 2001 47: 459-461; doi:10.1093/jac/47.4.459 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

John E. Corkill, Luis E. Cuevas, Ricardo Q. Gurgel, Julie Greensill, and C. Anthony Hart

SHV-27, a novel cefotaxime-hydrolysing ß-lactamase, identified in Klebsiella pneumoniae isolates from a Brazilian hospital
J. Antimicrob. Chemother. 2001 47: 463-465; doi:10.1093/jac/47.4.463 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hannah M. Wexler, Eric Molitoris, Denise Molitoris, and Sydney M. Finegold

In vitro activity of telithromycin (HMR 3647) against 502 strains of anaerobic bacteria
J. Antimicrob. Chemother. 2001 47: 467-469; doi:10.1093/jac/47.4.467 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alain Bonnefoy and Pascal Le Priol

Antibacterial activity of telithromycin (HMR 3647) in relation to in vitro simulated human plasma kinetics
J. Antimicrob. Chemother. 2001 47: 471-473; doi:10.1093/jac/47.4.471 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Milan Cizman, Marko Pokorn, Katja Seme, Andreja Orazem, and Metka Paragi

The relationship between trends in macrolide use and resistance to macrolides of common respiratory pathogens
J. Antimicrob. Chemother. 2001 47: 475-477; doi:10.1093/jac/47.4.475 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

María-Jesús Rodríguez-Hernández, Lucila Cuberos, Cristina Pichardo, Francisco J. Caballero, Ignacio Moreno, M. Enrique Jiménez-Mejías, Andrés García-Curiel, and Jerónimo Pachón

Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains
J. Antimicrob. Chemother. 2001 47: 479-482; doi:10.1093/jac/47.4.479 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. M. Lovering, T. R. Walsh, G. C. Bannister, and A. P. MacGowan

The penetration of ceftriaxone and cefamandole into bone, fat and haematoma and relevance of serum protein binding to their penetration into bone
J. Antimicrob. Chemother. 2001 47: 483-486; doi:10.1093/jac/47.4.483 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Christine Armbruster, H. Vorbach, F. Steindl, and I. El Menyawi

Intracellular concentration of the HIV protease inhibitors indinavir and saquinavir in human endothelial cells
J. Antimicrob. Chemother. 2001 47: 487-490; doi:10.1093/jac/47.4.487 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Elias K. Manavathu, Jonathan R. Dimmock, Sarvesh C. Vashishtha, and P. H. Chandrasekar

Inhibition of H⁺-ATPase-mediated proton pumping in Cryptococcus neoformans by a novel conjugated styryl ketone
J. Antimicrob. Chemother. 2001 47: 491-494; doi:10.1093/jac/47.4.491 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Peter A. White and William D. Rawlinson

Current status of the aadA and dfr gene cassette families
J. Antimicrob. Chemother. 2001 47: 495-496; doi:10.1093/jac/47.4.495 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

B. Comuzzi, C. Arcelloni, R. Vaiani, and R. Paroni

Gentamicin diffusion in Mueller–Hinton agar plates from different manufacturers
J. Antimicrob. Chemother. 2001 47: 496-498; doi:10.1093/jac/47.4.496 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Nicole van den Braak, Alex van Belkum, Deborah Kreft, Henri Verbrugh, and Hubert Endtz

Dietary habits and gastrointestinal colonization by antibiotic resistant microorganisms
J. Antimicrob. Chemother. 2001 47: 498-500; doi:10.1093/jac/47.4.498 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Johan W. Mouton and Nieko Punt

Use of the t > MIC to choose between different dosing regimens of ß-lactam antibiotics
J. Antimicrob. Chemother. 2001 47: 500-501; doi:10.1093/jac/47.4.500 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Milan Cizman, Andreja Orazem, Veronika Krizan-Hergouth, and Jana Kolman

Correlation between increased consumption of fluoroquinolones in outpatients and resistance of Escherichia coli from urinary tract infections
J. Antimicrob. Chemother. 2001 47: 502; doi:10.1093/jac/47.4.502 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book reviews:

Tyrone Pitt

Methods in Molecular Biology. Volume 145. Bacterial Toxins. Methods and Protocols
J. Antimicrob. Chemother. 2001 47: 503; doi:10.1093/jac/47.4.503 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Alison Grant

Tickborne Infectious Diseases: Diagnosis and Management
J. Antimicrob. Chemother. 2001 47: 503-504; doi:10.1093/jac/47.4.503-a [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Geoffrey Pasvol

Infectious Diseases, 2nd edition
J. Antimicrob. Chemother. 2001 47: 504; doi:10.1093/jac/47.4.504 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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