Journal of Antimicrobial Chemotherapy

Leading articles:

Marc D. Cubbon and Robert G. Masterton

New quinolones—a fresh answer to the pneumococcus
J. Antimicrob. Chemother. 2000 46: 869-872; doi:10.1093/jac/46.6.869 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

The 1999 Garrod Lecture:

Alasdair Geddes

Infection in the twenty-first century: predictions and postulates
J. Antimicrob. Chemother. 2000 46: 873-877; doi:10.1093/jac/46.6.873 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Matthew B. Avison, Charlotte J. von Heldreich, Catherine S. Higgins, Peter M. Bennett, and Timothy R. Walsh

A TEM-2 ß-lactamase encoded on an active Tn1-like transposon in the genome of a clinical isolate of Stenotrophomonas maltophilia
J. Antimicrob. Chemother. 2000 46: 879-884; doi:10.1093/jac/46.6.879 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Xian-Zhi Li, Nicole Barré, and Keith Poole

Influence of the MexA-MexB-OprM multidrug efflux system on expression of the MexC-MexD-OprJ and MexE-MexF-OprN multidrug efflux systems in Pseudomonas aeruginosa
J. Antimicrob. Chemother. 2000 46: 885-893; doi:10.1093/jac/46.6.885 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Van Thi Bao Cao, Guillaume Arlet, Britt-Marie Ericsson, Ann Tammelin, Patrice Courvalin, and Thierry Lambert

Emergence of imipenem resistance in Klebsiella pneumoniae owing to combination of plasmid-mediated CMY-4 and permeability alteration
J. Antimicrob. Chemother. 2000 46: 895-900; doi:10.1093/jac/46.6.895 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Atsushi Nakamura, Masayoshi Hosoda, Takashi Kato, Yasuo Yamada, Makoto Itoh, Katsunori Kanazawa, and Hiroshi Nouda

Combined effects of meropenem and aminoglycosides on Pseudomonas aeruginosa in vitro
J. Antimicrob. Chemother. 2000 46: 901-904; doi:10.1093/jac/46.6.901 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

E. Giovanetti, M. P. Montanari, F. Marchetti, and P. E. Varaldo

In vitro activity of ketolides telithromycin and HMR 3004 against Italian isolates of Streptococcus pyogenes and Streptococcus pneumoniae with different erythromycin susceptibility
J. Antimicrob. Chemother. 2000 46: 905-908; doi:10.1093/jac/46.6.905 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kensuke Nagai, Todd A. Davies, Bonifacio E. Dewasse, Glenn A. Pankuch, Michael R. Jacobs, and Peter C. Appelbaum

In vitro development of resistance to ceftriaxone, cefprozil and azithromycin in Streptococcus pneumoniae
J. Antimicrob. Chemother. 2000 46: 909-915; doi:10.1093/jac/46.6.909 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Bernadette Murugasu-Oei and Thomas Dick

Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG
J. Antimicrob. Chemother. 2000 46: 917-919; doi:10.1093/jac/46.6.917 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Murli Purswani, Susan Eckert, Harman Arora, Rosemary Johann-Liang, and Gary J. Noel

The effect of three broad-spectrum antimicrobials on mononuclear cell responses to encapsulated bacteria: evidence for down-regulation of cytokine mRNA transcription by trovafloxacin
J. Antimicrob. Chemother. 2000 46: 921-929; doi:10.1093/jac/46.6.921 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

C. J. Henwood, D. M. Livermore, A. P. Johnson, D. James, M. Warner, A. Gardiner, and The Linezolid Study Group

Susceptibility of Gram-positive cocci from 25 UK hospitals to antimicrobial agents including linezolid
J. Antimicrob. Chemother. 2000 46: 931-940; doi:10.1093/jac/46.6.931 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. M. T. Hamilton-Miller and Saroj Shah

Patterns of phenotypic resistance to the macrolide-lincosamide-ketolide-streptogramin group of antibiotics in staphylococci
J. Antimicrob. Chemother. 2000 46: 941-949; doi:10.1093/jac/46.6.941 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeannette N. Pham, Sydney M. Bell, Liliane Martin, and Elisabeth Carniel

The ß-lactamases and ß-lactam antibiotic susceptibility of Yersinia enterocolitica
J. Antimicrob. Chemother. 2000 46: 951-957; doi:10.1093/jac/46.6.951 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Juan J. Granizo, Lorenzo Aguilar, Julio Casal, Rafael Dal-Ré, and Fernando Baquero

Streptococcus pyogenes resistance to erythromycin in relation to macrolide consumption in Spain (1986–1997)
J. Antimicrob. Chemother. 2000 46: 959-964; doi:10.1093/jac/46.6.959 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jacques Breuil, Anne Brisabois, Isabelle Casin, Laurence Armand-Lefèvre, Sylvine Frémy, and Ekkehard Collatz

Antibiotic resistance in salmonellae isolated from humans and animals in France: comparative data from 1994 and 1997
J. Antimicrob. Chemother. 2000 46: 965-971; doi:10.1093/jac/46.6.965 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Helle Krogh Johansen, Thøger Gorm Jensen, Ram Benny Dessau, Bettina Lundgren, and Niels Frimodt-Møller

Antagonism between penicillin and erythromycin against Streptococcus pneumoniae in vitro and in vivo
J. Antimicrob. Chemother. 2000 46: 973-980; doi:10.1093/jac/46.6.973 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Philippe Cottagnoud, Cynthia M. Gerber, F. Acosta, Marianne Cottagnoud, Klaus Neftel, and Martin G. Täuber

Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model
J. Antimicrob. Chemother. 2000 46: 981-985; doi:10.1093/jac/46.6.981 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Eliette Touati, Maurice Hofnung, Jean-Michel Thiberge, Valérie Michel, Agnès Labigne, and Peter J. Jenks

Short-term infection with Helicobacter pylori and 1 week exposure to metronidazole does not enhance gastric mutation frequency in transgenic mice
J. Antimicrob. Chemother. 2000 46: 987-992; doi:10.1093/jac/46.6.987 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

B. Hamel, N. Mottet, M. Audran, P. Costa, and F. Bressolle

Pharmacokinetics of enoxacin and its oxometabolite after multiple oral dosing and penetration into prostatic tissue
J. Antimicrob. Chemother. 2000 46: 993-996; doi:10.1093/jac/46.6.993 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. I. Aller, E. Martín-Mazuelos, M. J. Gutiérrez, S. Bernal, M. Chávez, and F. J. Recio

Comparison of the Etest and microdilution method for antifungal susceptibility testing of Cryptococcus neoformans to four antifungal agents
J. Antimicrob. Chemother. 2000 46: 997-1000; doi:10.1093/jac/46.6.997 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michel Laverdière, Coleman Rotstein, Eric J. Bow, Robin S. Roberts, Stratis Ioannou, Danielle Carr, Narguess Moghaddam, and The Canadian Fluconazole Study Group

Impact of fluconazole prophylaxis on fungal colonization and infection rates in neutropenic patients
J. Antimicrob. Chemother. 2000 46: 1001-1008; doi:10.1093/jac/46.6.1001 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

R. Edwards and P. N. Read

Expression of the carbapenemase gene (cfiA) in Bacteroides fragilis
J. Antimicrob. Chemother. 2000 46: 1009-1012; doi:10.1093/jac/46.6.1009 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. Pournaras, A. Tsakris, M.-F. I. Palepou, A. Papa, J. Douboyas, A. Antoniadis, and N. Woodford

Pheromone responses and high-level aminoglycoside resistance of conjugative plasmids of Enterococcus faecalis from Greece
J. Antimicrob. Chemother. 2000 46: 1013-1016; doi:10.1093/jac/46.6.1013 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. M. Andrews, T. M. A. Weller, J. P. Ashby, R. M. Walker, and R. Wise

The in vitro activity of ABT773, a new ketolide antimicrobial agent
J. Antimicrob. Chemother. 2000 46: 1017-1022; doi:10.1093/jac/46.6.1017 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. Fernández-Roblas, F. Cabria, J. Esteban, J. C. López, I. Gadea, and F. Soriano

In vitro activity of gemifloxacin (SB-265805) compared with 14 other antimicrobials against intestinal pathogens
J. Antimicrob. Chemother. 2000 46: 1023-1027; doi:10.1093/jac/46.6.1023 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Cabrita, M. Oleastro, R. Matos, A. Manhente, J. Cabral, R. Barros, A. I. Lopes, P. Ramalho, B. C. Neves, and A. S. Guerreiro

Features and trends in Helicobacter pylori antibiotic resistance in Lisbon area, Portugal (1990–1999)
J. Antimicrob. Chemother. 2000 46: 1029-1031; doi:10.1093/jac/46.6.1029 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nikolaus O. A. Palmer, Michael V. Martin, Rosemary Pealing, and Robert S. Ireland

An analysis of antibiotic prescriptions from general dental practitioners in England
J. Antimicrob. Chemother. 2000 46: 1033-1035; doi:10.1093/jac/46.6.1033 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Ansgar Schulte and Peter Heisig

In vitro activity of gemifloxacin and five other fluoroquinolones against defined isogenic mutants of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus
J. Antimicrob. Chemother. 2000 46: 1037-1038; doi:10.1093/jac/46.6.1037 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

E. D. Platsouka, H. Dimopoulou, V. Miriagou, and O. Paniara

The first clinical isolates of Enterococcus faecium with the VanA phenotype in a tertiary Greek hospital
J. Antimicrob. Chemother. 2000 46: 1039-1040; doi:10.1093/jac/46.6.1039 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

A. Tsakris, E. Papadimitriou, J. Douboyas, and A. Antoniadis

Emergence of teicoplanin-resistant Staphylococcus haemolyticus clinical isolates in Greece
J. Antimicrob. Chemother. 2000 46: 1040-1041; doi:10.1093/jac/46.6.1040 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

A. Mavroidi, A. Tsakris, E. Tzelepi, S. Pournaras, V. Loukova, and L. S. Tzouvelekis

Carbapenem-hydrolysing VIM-2 metallo- ß-lactamase in Pseudomonas aeruginosa from Greece
J. Antimicrob. Chemother. 2000 46: 1041-1043; doi:10.1093/jac/46.6.1041 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

L. O. White and J. Sunderland

Laboratory implications of incorrectly taken blood samples for antibiotic assay
J. Antimicrob. Chemother. 2000 46: 1043-1044; doi:10.1093/jac/46.6.1043 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Dimitrios P. Kontoyiannis and Gregory S. May

-Aminolaevulinic acid modulates the resistance to fluconazole in a hem1 mutant of Saccharomyces cerevisiae
J. Antimicrob. Chemother. 2000 46: 1044-1046; doi:10.1093/jac/46.6.1044 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book reviews:

K. N. Ward

Human Virology: A Text for Students of Medicine, Dentistry and Microbiology, 2nd edn: L. Collier and J. Oxford. Oxford University Press, Oxford, UK, and New York, NY, USA, 2000. ISBN 0-19-262820-8. £24.95.
J. Antimicrob. Chemother. 2000 46: 1047; doi:10.1093/jac/46.6.1047 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

I. G. Charles

DNA Vaccines. Methods and Protocols: Douglas B. Lowrie and Robert G. Whalen, Eds. Humana Press, Totowa, NJ, USA, 2000. ISBN 0-89603-580-8. £72.50.
J. Antimicrob. Chemother. 2000 46: 1047-1048; doi:10.1093/jac/46.6.1047-a [Extract] [FREE Full Text] [PDF] [Request Permissions]  

S. W. B. Newsom

Wellcome Witnesses to Twentieth Century Medicine. Volume 6. Post Penicillin Antibiotics: From Acceptance to Resistance?: E. M. Tansey and L. A. Reynolds, Eds. The Wellcome Trust, London, UK, 2000. ISBN 1-841290-12-2. £5.00.
J. Antimicrob. Chemother. 2000 46: 1048-1049; doi:10.1093/jac/46.6.1048 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Errata:

R. J. Boon, T. H. Bacon, H. L. Robey, T. J. Coleman, A. Connolly, P. Crosson, and S. L. Sacks

Antiviral susceptibilities of herpes simplex virus from immunocompetent subjects with recurrent herpes labialis: a UK-based survey
J. Antimicrob. Chemother. 2000 46: 1051. [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Robin J. Bywater and Mark W. Casewell

An assessment of the impact of antibiotic resistance in different bacterial species and of the contribution of animal sources to resistance in human infections
J. Antimicrob. Chemother. 2000 46: 1052. [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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