Journal of Antimicrobial Chemotherapy

Editorial:

F. Baquero, R. Bax, and I. Phillips

Antibiotic clinical trials revisited
J. Antimicrob. Chemother. 2000 46: 651-652; doi:10.1093/jac/46.5.651 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Leading articles:

Elizabeth H. Price, John de Louvois, and M. Rella Workman

Antibiotics for Salmonella meningitis in children
J. Antimicrob. Chemother. 2000 46: 653-655; doi:10.1093/jac/46.5.653 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews:

Joseph P. McGowan and Sanjiv S. Shah

Prevention of perinatal HIV transmission during pregnancy
J. Antimicrob. Chemother. 2000 46: 657-668; doi:10.1093/jac/46.5.657 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

David H. Wright, Gigi H. Brown, Marnie L. Peterson, and John C. Rotschafer

Application of fluoroquinolone pharmacodynamics
J. Antimicrob. Chemother. 2000 46: 669-683; doi:10.1093/jac/46.5.669 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Laurent Bélec, Carol Tevi-Benissan, Anne Bianchi, Sylvie Cotigny, Maria Beumont-Mauviel, Ali Si-Mohamed, and Jean-Elie Malkin

In vitro inactivation of Chlamydia trachomatis and of a panel of DNA (HSV-2, CMV, adenovirus, BK virus) and RNA (RSV, enterovirus) viruses by the spermicide benzalkonium chloride
J. Antimicrob. Chemother. 2000 46: 685-693; doi:10.1093/jac/46.5.685 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Matthew B. Avison, Pannika Niumsup, Timothy R. Walsh, and Peter M. Bennett

Aeromonas hydrophila AmpH and CepH ß-lactamases: derepressed expression in mutants of Escherichia coli lacking creB
J. Antimicrob. Chemother. 2000 46: 695-702; doi:10.1093/jac/46.5.695 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Thierry Naas, Farida Benaoudia, Sandrine Massuard, and Patrice Nordmann

Integron-located VEB-1 extended-spectrum ß-lactamase gene in a Proteus mirabilis clinical isolate from Vietnam
J. Antimicrob. Chemother. 2000 46: 703-711; doi:10.1093/jac/46.5.703 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Patrick Butaye, Luc A. Devriese, and Freddy Haesebrouck

Influence of different medium components on the in vitro activity of the growth-promoting antibiotic flavomycin against enterococci
J. Antimicrob. Chemother. 2000 46: 713-716; doi:10.1093/jac/46.5.713 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

K. Lagrou, W. E. Peetermans, M. Jorissen, J. Verhaegen, J. Van Damme, and J. Van Eldere

Subinhibitory concentrations of erythromycin reduce pneumococcal adherence to respiratory epithelial cells in vitro
J. Antimicrob. Chemother. 2000 46: 717-723; doi:10.1093/jac/46.5.717 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alexander A. Firsov, Irene Yu. Lubenko, Sergey N. Vostrov, Olga V. Kononenko, Stephen H. Zinner, and Yury A. Portnoy

Comparative pharmacodynamics of moxifloxacin and levofloxacin in an in vitro dynamic model: prediction of the equivalent AUC/MIC breakpoints and equiefficient doses
J. Antimicrob. Chemother. 2000 46: 725-732; doi:10.1093/jac/46.5.725 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Simon Delacher, Hartmut Derendorf, Ursula Hollenstein, Martin Brunner, Christian Joukhadar, Sabine Hofmann, Apostoulos Georgopoulos, Hans Georg Eichler, and Markus Müller

A combined in vivo pharmacokinetic–in vitro pharmacodynamic approach to simulate target site pharmacodynamics of antibiotics in humans
J. Antimicrob. Chemother. 2000 46: 733-739; doi:10.1093/jac/46.5.733 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Charlotta Edlund, Gunnar Alván, Lisbeth Barkholt, Françoise Vacheron, and Carl Erik Nord

Pharmacokinetics and comparative effects of telithromycin (HMR 3647) and clarithromycin on the oropharyngeal and intestinal microflora
J. Antimicrob. Chemother. 2000 46: 741-749; doi:10.1093/jac/46.5.741 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Luigi Goffi, Federico Mocchegiani, Alessandra Riva, Giorgio Scalise, and Vittorio Saba

Efficacy of polycationic peptides in preventing vascular graft infection due to Staphylococcus epidermidis
J. Antimicrob. Chemother. 2000 46: 751-756; doi:10.1093/jac/46.5.751 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Bart Wolf, Luis C. Rey, Sylvain Brisse, Luciano B. Moreira, Dana Milatovic, Andre Fleer, John J. Roord, and Jan Verhoef

Molecular epidemiology of penicillin-resistant Streptococcus pneumoniae colonizing children with community-acquired pneumonia and children attending day-care centres in Fortaleza, Brazil
J. Antimicrob. Chemother. 2000 46: 757-765; doi:10.1093/jac/46.5.757 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Juan J. Granizo, Lorenzo Aguilar, Julio Casal, César García-Rey, Rafael Dal-Ré, and Fernando Baquero

Streptococcus pneumoniae resistance to erythromycin and penicillin in relation to macrolide and ß-lactam consumption in Spain (1979–1997)
J. Antimicrob. Chemother. 2000 46: 767-773; doi:10.1093/jac/46.5.767 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Richard H. Drew, John R. Perfect, Latha Srinath, Elisabeth Kurkimilis, Michael Dowzicky, George H. Talbot, and for the Synercid Emergency-Use Study Group

Treatment of methicillin-resistant Staphylococcus aureus infections with quinupristin–dalfopristin in patients intolerant of or failing prior therapy
J. Antimicrob. Chemother. 2000 46: 775-784; doi:10.1093/jac/46.5.775 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Christiane Werckenthin and Stefan Schwarz

Molecular analysis of the translational attenuator of a constitutively expressed erm(A) gene from Staphylococcus intermedius
J. Antimicrob. Chemother. 2000 46: 785-788; doi:10.1093/jac/46.5.785 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Janne Kataja, Pentti Huovinen, The Macrolide Resistance Study Group, and Helena Seppälä

Erythromycin resistance genes in group A streptococci of different geographical origins
J. Antimicrob. Chemother. 2000 46: 789-792; doi:10.1093/jac/46.5.789 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Dong H. Kwon, Jeremy A. Peña, Michael S. Osato, James G. Fox, David Y. Graham, and James Versalovic

Frameshift mutations in rdxA and metronidazole resistance in North American Helicobacter pylori isolates
J. Antimicrob. Chemother. 2000 46: 793-796; doi:10.1093/jac/46.5.793 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hiroki Okamoto, Shuichi Miyazaki, Kazuhiro Tateda, Yoshikazu Ishii, and Keizo Yamaguchi

Comparative in vitro activity of telithromycin (HMR 3647), three macrolides, amoxycillin, cefdinir and levofloxacin against Gram-positive clinical isolates in Japan
J. Antimicrob. Chemother. 2000 46: 797-802; doi:10.1093/jac/46.5.797 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Peter H. J. van der Voort, René W. M. van der Hulst, Durk F. Zandstra, Arie van der Ende, Alfons A. M. Geraedts, and Guido N. J. Tytgat

In vitro susceptibility of Helicobacter pylori to, and in vivo suppression by, antimicrobials used in selective decontamination of the digestive tract
J. Antimicrob. Chemother. 2000 46: 803-805; doi:10.1093/jac/46.5.803 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Giacometti, O. Cirioni, M. S. Del Prete, F. Barchiesi, A. Mataloni Paggi, E. Petrelli, and G. Scalise

Comparative activities of polycationic peptides and clinically used antimicrobial agents against multidrug-resistant nosocomial isolates of Acinetobacter baumannii
J. Antimicrob. Chemother. 2000 46: 807-810; doi:10.1093/jac/46.5.807 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jean-Marc Rolain, Max Maurin, and Didier Raoult

Bactericidal effect of antibiotics on Bartonella and Brucella spp.: clinical implications
J. Antimicrob. Chemother. 2000 46: 811-814; doi:10.1093/jac/46.5.811 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael A. Petrou and David C. Shanson

Susceptibility of Cryptococcus neoformans by the NCCLS microdilution and Etest methods using five defined media
J. Antimicrob. Chemother. 2000 46: 815-818; doi:10.1093/jac/46.5.815 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

V. Lemée, I. Zaharia, G. Nevez, M. Rabodonirina, P. Brasseur, J. J. Ballet, and L. Favennec

Metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France
J. Antimicrob. Chemother. 2000 46: 819-821; doi:10.1093/jac/46.5.819 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Cheng-Xu Liu, Naoki Kato, Kunitomo Watanabe, Tadashi Sakata, and Tsutomu Kaneko

Impact of a new quinolone, DU-6859a, and two oral carbapenems, CS-834 and L-084, on the rat and mouse caecal microflora
J. Antimicrob. Chemother. 2000 46: 823-826; doi:10.1093/jac/46.5.823 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. L. Joly-Guillou, M. Wolff, R. Farinotti, A. Bryskier, and C. Carbon

In vivo activity of levofloxacin alone or in combination with imipenem or amikacin in a mouse model of Acinetobacter baumannii pneumonia
J. Antimicrob. Chemother. 2000 46: 827-830; doi:10.1093/jac/46.5.827 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

E. Ghelardi, A. Tavanti, F. Celandroni, A. Lupetti, C. Blandizzi, E. Boldrini, M. Campa, and S. Senesi

Effect of a novel mucoadhesive polysaccharide obtained from tamarind seeds on the intraocular penetration of gentamicin and ofloxacin in rabbits
J. Antimicrob. Chemother. 2000 46: 831-834; doi:10.1093/jac/46.5.831 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wei Shen Lim, Sarah Gander, Roger G. Finch, and John T. Macfarlane

A novel method for collecting and detecting amoxycillin in urine: a tool for testing antibiotic compliance in the community
J. Antimicrob. Chemother. 2000 46: 835-837; doi:10.1093/jac/46.5.835 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Satoru Nagashima, Osamu Kozawa, Takanobu Otsuka, Ken-ichi Kohno, Masahiko Minamoto, Masahiro Yokokawa, Mitsutaka Kanamaru, and Toshihiko Uematsu

Pharmacokinetics of a parenteral carbapenem, biapenem, in patients with end-stage renal disease and influence of haemodialysis
J. Antimicrob. Chemother. 2000 46: 839-842; doi:10.1093/jac/46.5.839 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Fausto de Lalla, Roberto Nicolin, and Luca Lazzarini

Safety and efficacy of recombinant granulocyte colony-stimulating factor as an adjunctive therapy for Streptococcus pneumoniae meningitis in non-neutropenic adult patients: a pilot study
J. Antimicrob. Chemother. 2000 46: 843-846; doi:10.1093/jac/46.5.843 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

James B. Kahn

Quinolone-induced QT interval prolongation: a not-so-unexpected class effect
J. Antimicrob. Chemother. 2000 46: 847-848; doi:10.1093/jac/46.5.847 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

George W. Sundin

Examination of base pair variants of the strA–strB streptomycin resistance genes from bacterial pathogens of humans, animals and plants
J. Antimicrob. Chemother. 2000 46: 848-849; doi:10.1093/jac/46.5.848 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

J. C. Graham, J. A. Phillips, O. M. Murphy, A. M. Kearns, F. K. Gould, and R. Freeman

Use of Mastalex to detect methicillin resistance in coagulase-negative staphylococci
J. Antimicrob. Chemother. 2000 46: 850; doi:10.1093/jac/46.5.850 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

J. M. Andrews and for the BSAC Working Party on Sensitivity Testing

Effect of medium composition on the MIC breakpoint for gentamicin
J. Antimicrob. Chemother. 2000 46: 851-852; doi:10.1093/jac/46.5.851 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

J. M. T. Hamilton-Miller and S. Shah

Activity of the tea component epicatechin gallate and analogues against methicillin-resistant Staphylococcus aureus
J. Antimicrob. Chemother. 2000 46: 852-853; doi:10.1093/jac/46.5.852 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

C. E. J. van Rensburg, A. van Straten, and J. Dekker

An in vitro investigation of the antimicrobial activity of oxifulvic acid
J. Antimicrob. Chemother. 2000 46: 853-854; doi:10.1093/jac/46.5.853 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Ralf René Reinert, Adnan Al-Lahham, Sebastian Lemmen, and Rudolf Lütticken

In vitro activity of gatifloxacin against Streptococcus pneumoniae isolates in Germany
J. Antimicrob. Chemother. 2000 46: 854-856; doi:10.1093/jac/46.5.854 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

A. Carricajo, N. Fonsale, A. C. Vautrin, and G. Aubert

In vitro activity of ß-lactams against gentamicin-susceptible and gentamicin-resistant Staphylococcus aureus
J. Antimicrob. Chemother. 2000 46: 856-858; doi:10.1093/jac/46.5.856 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

A. Doménech-Sánchez, A. Pascual, A. I. Suárez, D. Alvarez, V. J. Benedí, and L. Martínez-Martínez

Activity of nine antimicrobial agents against clinical isolates of Klebsiella pneumoniae producing extended-spectrum ß-lactamases and deficient or not in porins
J. Antimicrob. Chemother. 2000 46: 858-860; doi:10.1093/jac/46.5.858 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

E. J. Threlfall, J. A. Skinner, A. Graham, L. R. Ward, and H. R. Smith

Resistance to ceftriaxone and cefotaxime in non-typhoidal Salmonella enterica in England and Wales, 1998–99
J. Antimicrob. Chemother. 2000 46: 860-862; doi:10.1093/jac/46.5.860 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

G. Kumarasinghe, C. Chow, and P. A. Tambyah

The emergence of resistance to levofloxacin before clinical use in a university hospital in Singapore
J. Antimicrob. Chemother. 2000 46: 862-863; doi:10.1093/jac/46.5.862 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book reviews:

R. A. Howe

Quality Assurance: Principles and Practice in the Microbiology Laboratory: J. J. S. Snell, D. F. J. Brown & C. Roberts, Eds. Public Health Laboratory Service, UK, 2000. ISBN 0-091144-452, £25.00.
J. Antimicrob. Chemother. 2000 46: 865; doi:10.1093/jac/46.5.865 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

A. P. Fraise

Baillière's Clinical Infectious Diseases: International Practice and Research, Antibiotic Resistance, Vol. 5, no. 2: R. G. Finch and R. J. Williams, Eds. Baillière Tindall, London, 1999. ISSN 1071-6564, £31.00.
J. Antimicrob. Chemother. 2000 46: 865-866; doi:10.1093/jac/46.5.865-a [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Dr Robert Wilson

Cytokines in Pulmonary Disease; Infection and Inflammation. Lung Biology in Health and Disease Volume 141: Steve Nelson & Thomas R. Martin, Eds. Marcel Dekker Inc., New York, Basel, 2000. ISBN 0-8247-1931-X, £121.00.
J. Antimicrob. Chemother. 2000 46: 866-867; doi:10.1093/jac/46.5.866 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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