Journal of Antimicrobial Chemotherapy

Leading articles:

Francis P. Tally and Michael F. DeBruin

Development of daptomycin for Gram-positive infections
J. Antimicrob. Chemother. 2000 46: 523-526; doi:10.1093/jac/46.4.523 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Francis Martineau, François J. Picard, Louis Grenier, Paul H. Roy, Marc Ouellette, and Michel G. Bergeron

Multiplex PCR assays for the detection of clinically relevant antibiotic resistance genes in staphylococci isolated from patients infected after cardiac surgery
J. Antimicrob. Chemother. 2000 46: 527-534; doi:10.1093/jac/46.4.527 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. M. Andrews, F. J. Boswell, and R. Wise

Evaluation of the Oxoid Aura image system for measuring zones of inhibition with the disc diffusion technique
J. Antimicrob. Chemother. 2000 46: 535-540; doi:10.1093/jac/46.4.535 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mario Castelli, Monica Malagoli, Lucia Lupo, Sergio Roffia, Francesco Paolucci, Claudio Cermelli, Andrea Zanca, and Giosuè Baggio

Cytotoxicity and probable mechanism of action of sulphimidazole
J. Antimicrob. Chemother. 2000 46: 541-550; doi:10.1093/jac/46.4.541 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mark H. Wilcox, Warren Fawley, Jane Freeman, and Janet Brayson

In vitro activity of new generation fluoroquinolones against genotypically distinct and indistinguishable Clostridium difficile isolates
J. Antimicrob. Chemother. 2000 46: 551-556; doi:10.1093/jac/46.4.551 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Francesc Marco, Emilio Bouza, Juan García-de-Lomas, and Lorenzo Aguilar

Streptococcus pneumoniae in community-acquired respiratory tract infections in Spain: the impact of serotype and geographical, seasonal and clinical factors on its susceptibility to the most commonly prescribed antibiotics
J. Antimicrob. Chemother. 2000 46: 557-564; doi:10.1093/jac/46.4.557 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

N. Rastogi, K. S. Goh, M. Berchel, and A. Bryskier

Activity of rifapentine and its metabolite 25-O-desacetylrifapentine compared with rifampicin and rifabutin against Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis and M. bovis BCG
J. Antimicrob. Chemother. 2000 46: 565-570; doi:10.1093/jac/46.4.565 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Pascale Bemer-Melchior, André Bryskier, and Henri B. Drugeon

Comparison of the in vitro activities of rifapentine and rifampicin against Mycobacterium tuberculosis complex
J. Antimicrob. Chemother. 2000 46: 571-576; doi:10.1093/jac/46.4.571 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Oscar Cirioni, Andrea Giacometti, Francesco Barchiesi, and Giorgio Scalise

Inhibition of growth of Pneumocystis carinii by lactoferrins alone and in combination with pyrimethamine, clarithromycin and minocycline
J. Antimicrob. Chemother. 2000 46: 577-582; doi:10.1093/jac/46.4.577 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. Eick, W. Pfister, D. Fiedler, and E. Straube

Clindamycin promotes phagocytosis and intracellular killing of periodontopathogenic bacteria by crevicular granulocytes: an in vitro study
J. Antimicrob. Chemother. 2000 46: 583-588; doi:10.1093/jac/46.4.583 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hiromu Takemura, Hiroyuki Yamamoto, Hiroyuki Kunishima, Hideaki Ikejima, Takashi Hara, Keiji Kanemitsu, Shigemi Terakubo, Yoko Shoji, Mitsuo Kaku, and Jingoro Shimada

Evaluation of a human monocytic cell line THP-1 model for assay of the intracellular activities of antimicrobial agents against Legionella pneumophila
J. Antimicrob. Chemother. 2000 46: 589-594; doi:10.1093/jac/46.4.589 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hiroyuki Wakabayashi, Katsuhisa Uchida, Koji Yamauchi, Susumu Teraguchi, Hirotoshi Hayasawa, and Hideyo Yamaguchi

Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models
J. Antimicrob. Chemother. 2000 46: 595-602; doi:10.1093/jac/46.4.595 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kerstin Orrhage, Svante Sjöstedt, and Carl Erik Nord

Effect of supplements with lactic acid bacteria and oligofructose on the intestinal microflora during administration of cefpodoxime proxetil
J. Antimicrob. Chemother. 2000 46: 603-612; doi:10.1093/jac/46.4.603 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Teresa Alarcón, Diego Domingo, Nuria Prieto, and Manuel López-Brea

Clarithromycin resistance stability in Helicobacter pylori: influence of the MIC and type of mutation in the 23S rRNA
J. Antimicrob. Chemother. 2000 46: 613-616; doi:10.1093/jac/46.4.613 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ariane Deplano, Panayotis T. Tassios, Youri Glupczynski, Edmond Godfroid, and Marc J. Struelens

In vivo deletion of the methicillin resistance mec region from the chromosome of Staphylococcus aureus strains
J. Antimicrob. Chemother. 2000 46: 617-620; doi:10.1093/jac/46.4.617 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mardjan Arvand, Marlies Hoeck, Helmut Hahn, and Jutta Wagner

Antimicrobial resistance in Streptococcus pyogenes isolates in Berlin
J. Antimicrob. Chemother. 2000 46: 621-624; doi:10.1093/jac/46.4.621 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Joshua Howarth and David G. Lloyd

Simple 1,2-aminoalcohols as strain-specific antimalarial agents
J. Antimicrob. Chemother. 2000 46: 625-628; doi:10.1093/jac/46.4.625 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kenichiro Murakami, Kazuhiro Tateda, Tetsuya Matsumoto, Shuichi Miyazaki, and Keizo Yamaguchi

Efficacy of a novel tetracycline derivative, glycylcycline, against penicillin-resistant Streptococcus pneumoniae in a mouse model of pneumonia
J. Antimicrob. Chemother. 2000 46: 629-632; doi:10.1093/jac/46.4.629 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

N. Shetty and A. P. R. Wilson

Sitafloxacin in the treatment of patients with infections caused by vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus
J. Antimicrob. Chemother. 2000 46: 633-638; doi:10.1093/jac/46.4.633 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Jonathan Cooke

Trends in antimicrobial prescribing
J. Antimicrob. Chemother. 2000 46: 639; doi:10.1093/jac/46.4.639 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Hazel M. Aucken, Marina Warner, Mark Ganner, Alan P. Johnson, Judith F. Richardson, Barry D. Cookson, and David M. Livermore

Twenty months of screening for glycopeptide-intermediateStaphylococcus aureus
J. Antimicrob. Chemother. 2000 46: 639-640; doi:10.1093/jac/46.4.639-a [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Garfield A. Drummond and David R. Jenkins

Treatment protocols for community-acquired pneumonia: evidence-based must replace consensus-based
J. Antimicrob. Chemother. 2000 46: 640-641; doi:10.1093/jac/46.4.640 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Andrea Guyot, Matthew D. M. Rawlins, and Steve P. Barrett

Clarithromycin appears to be linked with Clostridium difficile-associated diarrhoea in the elderly
J. Antimicrob. Chemother. 2000 46: 642-643; doi:10.1093/jac/46.4.642 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Robin J. Bywater and Mark W. Casewell

An assessment of the impact of antibiotic resistance in different bacterial species and of the contribution of animal sources to resistance in human infections
J. Antimicrob. Chemother. 2000 46: 643-645; doi:10.1093/jac/46.4.643 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book review:

R. Jones

Laboratory Diagnosis of Viral Infections, 3rd edn
J. Antimicrob. Chemother. 2000 46: 647-648; doi:10.1093/jac/46.4.647 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Erratum:

Study group: Sebahat Aksaray, Basak Dokuzoguz, Engin Güvener, Mine Yücesoy, Nuran Yulug, Sesin Kocagöz, Serhat Ünal, Sila Çetin, Semra Çalangu, Murat Günaydin, Hakan Leblebicioglu, Saban Esen, Banu Bayar, Ayse Willke, Duygu Findik, Inci Tuncer, Bülent Baysal, Filiz Günseren, and Latife Mamikoglu

Surveillance of antimicrobial resistance among Gram-negative isolates from intensive care units in eight hospitals in Turkey
J. Antimicrob. Chemother. 2000 46: 649. [Extract] [FREE Full Text] [PDF] [Request Permissions]  

John D. Turnidge

Quantifying the impact of resistance for prescribers and drug developers—a function of natural resolution rates
J. Antimicrob. Chemother. 2000 46: 649; doi:10.1093/jac/46.4.649-a [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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