Journal of Antimicrobial Chemotherapy

Leading articles:

Kurt G. Naber and Wolfgang Weidner

Chronic prostatitis—an infectious disease?
J. Antimicrob. Chemother. 2000 46: 157-161; doi:10.1093/jac/46.2.157 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews:

Alasdair MacGowan, Chris Rogers, and Karen Bowker

The use of in vitro pharmacodynamic models of infection to optimize fluoroquinolone dosing regimens
J. Antimicrob. Chemother. 2000 46: 163-170; doi:10.1093/jac/46.2.163 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

A. Vermes, H.-J. Guchelaar, and J. Dankert

Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions
J. Antimicrob. Chemother. 2000 46: 171-179; doi:10.1093/jac/46.2.171 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Kyoko Hayashi, Kiwamu Kawahara, Chieko Nakai, Ushio Sankawa, Haruo Seto, and Toshimitsu Hayashi

Evaluation of (1R,2R)-1-(5'-methylfur-3'-yl)propane-1,2,3-triol, a sphydrofuran derivative isolated from a Streptomyces species, as an anti-herpesvirus drug
J. Antimicrob. Chemother. 2000 46: 181-189; doi:10.1093/jac/46.2.181 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Dimitrios P. Kontoyiannis

Modulation of fluconazole sensitivity by the interaction of mitochondria and Erg3p in Saccharomyces cerevisiae
J. Antimicrob. Chemother. 2000 46: 191-197; doi:10.1093/jac/46.2.191 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Dimitrios P. Kontoyiannis

Efflux-mediated resistance to fluconazole could be modulated by sterol homeostasis in Saccharomyces cerevisiae
J. Antimicrob. Chemother. 2000 46: 199-203; doi:10.1093/jac/46.2.199 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

E. Anne Eady, Patricia Coates, Jeremy I. Ross, A. Hamid Ratyal, and Jonathan H. Cove

Antibiotic resistance patterns of aerobic coryneforms and furazolidone-resistant Gram-positive cocci from the skin surface of the human axilla and fourth toe cleft
J. Antimicrob. Chemother. 2000 46: 205-213; doi:10.1093/jac/46.2.205 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Helga Schumacher, Jens Scheibel, and Jens Kjølseth Møller

Cross-resistance patterns among clinical isolates of Klebsiella pneumoniae with decreased susceptibility to cefuroxime
J. Antimicrob. Chemother. 2000 46: 215-221; doi:10.1093/jac/46.2.215 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

W. Goettsch, W. van Pelt, N. Nagelkerke, M. G. R. Hendrix, A. G. M. Buiting, P. L. Petit, L. J. M. Sabbe, A. J. A. van Griethuysen, and A. J. de Neeling

Increasing resistance to fluoroquinolones in Escherichia coli from urinary tract infections in The Netherlands
J. Antimicrob. Chemother. 2000 46: 223-228; doi:10.1093/jac/46.2.223 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Elias K. Manavathu, Jessica L. Cutright, David Loebenberg, and Pranatharthi H. Chandrasekar

A comparative study of the in vitro susceptibilities of clinical and laboratory-selected resistant isolates of Aspergillus spp. to amphotericin B, itraconazole, voriconazole and posaconazole (SCH 56592)
J. Antimicrob. Chemother. 2000 46: 229-234; doi:10.1093/jac/46.2.229 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Marc J. Schultz, Peter Speelman, C. Erik Hack, Wim A. Buurman, Sander J. H. van Deventer, and Tom van der Poll

Intravenous infusion of erythromycin inhibits CXC chemokine production, but augments neutrophil degranulation in whole blood stimulated with Streptococcus pneumoniae
J. Antimicrob. Chemother. 2000 46: 235-240; doi:10.1093/jac/46.2.235 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

V. Tullio, A. M. Cuffini, A. Bonino, A. Ianni Palarchio, J. Roana, N. Mandras, V. Rossi, and N. A. Carlone

Influence of a new fluoroquinolone, AF3013 (the active metabolite of prulifloxacin), on macrophage functions against Klebsiella pneumoniae: an in vitro comparison with pefloxacin
J. Antimicrob. Chemother. 2000 46: 241-247; doi:10.1093/jac/46.2.241 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Cynthia M. Gerber, Luis Tovar, Marianne Cottagnoud, Klaus A. Neftel, Martin G. Täuber, and Philippe Cottagnoud

Grepafloxacin against penicillin-resistant pneumococci in the rabbit meningitis model
J. Antimicrob. Chemother. 2000 46: 249-253; doi:10.1093/jac/46.2.249 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Margaret M. Wasilewski, Michael G. Wilson, Gregory D. Sides, and Jennifer L. Stotka

Comparative efficacy of 5 days of dirithromycin and 7 days of erythromycin in skin and soft tissue infections
J. Antimicrob. Chemother. 2000 46: 255-262; doi:10.1093/jac/46.2.255 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mohammad A. Hossain, Shigefumi Maesaki, Mohammed S. Razzaque, Kazunori Tomono, Takashi Taguchi, and Shigeru Kohno

Attenuation of nephrotoxicity by a novel lipid nanosphere (NS-718) incorporating amphotericin B
J. Antimicrob. Chemother. 2000 46: 263-268; doi:10.1093/jac/46.2.263 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

A. J. Theron, C. Feldman, and R. Anderson

Investigation of the anti-inflammatory and membrane-stabilizing potential of spiramycin in vitro
J. Antimicrob. Chemother. 2000 46: 269-271; doi:10.1093/jac/46.2.269 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Santiago Hernández-Allés, María del Carmen Conejo, Alvaro Pascual, Juan M. Tomás, Vicente Javier Benedí, and Luis Martínez-Martínez

Relationship between outer membrane alterations and susceptibility to antimicrobial agents in isogenic strains of Klebsiella pneumoniae
J. Antimicrob. Chemother. 2000 46: 273-277; doi:10.1093/jac/46.2.273 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mercedes Berlanga and Miguel Viñas

Salicylate induction of phenotypic resistance to quinolones in Serratia marcescens
J. Antimicrob. Chemother. 2000 46: 279-282; doi:10.1093/jac/46.2.279 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

José Elías García Sánchez, Natalia García Sáenz, Manuel Rodríguez Rincón, Ignacio Trujillano Martín, Enrique García Sánchez, and María José Fresnadillo Martínez

Susceptibility of Helicobacter pylori to mupirocin, oxazolidinones, quinupristin/dalfopristin and new quinolones
J. Antimicrob. Chemother. 2000 46: 283-285; doi:10.1093/jac/46.2.283 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

I. Ikäheimo, H. Syrjälä, J. Karhukorpi, R. Schildt, and M. Koskela

In vitro antibiotic susceptibility of Francisella tularensis isolated from humans and animals
J. Antimicrob. Chemother. 2000 46: 287-290; doi:10.1093/jac/46.2.287 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Markus Ruhnke, Andrea Schmidt-Westhausen, and Joachim Morschhäuser

Development of simultaneous resistance to fluconazole in Candida albicans and Candida dubliniensis in a patient with AIDS
J. Antimicrob. Chemother. 2000 46: 291-295; doi:10.1093/jac/46.2.291 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Marisol Goñi-Urriza, Lionel Pineau, Michèle Capdepuy, Christine Roques, Pierre Caumette, and Claudine Quentin

Antimicrobial resistance of mesophilic Aeromonas spp. isolated from two European rivers
J. Antimicrob. Chemother. 2000 46: 297-301; doi:10.1093/jac/46.2.297 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Laura J. V. Piddock, V. Ricci, K. Stanley, and K. Jones

Activity of antibiotics used in human medicine for Campylobacter jejuni isolated from farm animals and their environment in Lancashire, UK
J. Antimicrob. Chemother. 2000 46: 303-306; doi:10.1093/jac/46.2.303 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. A. Seaton, D. T. Steinke, G. Phillips, T. MacDonald, and P. G. Davey

Community antibiotic therapy, hospitalization and subsequent respiratory tract isolation of Haemophilus influenzae resistant to amoxycillin: a nested case–control study
J. Antimicrob. Chemother. 2000 46: 307-309; doi:10.1093/jac/46.2.307 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kyriaki Kanellakopoulou, Nearchos Galanakis, Evangelos J. Giamarellos-Bourboulis, Christos Rifiotis, Konstantinos Papakostas, Andreas Andreopoulos, Eleftherios Dounis, Panagiotis Karagianakos, and Helen Giamarellou

Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a biodegradable system of lactic acid polymer releasing pefloxacin
J. Antimicrob. Chemother. 2000 46: 311-314; doi:10.1093/jac/46.2.311 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Emmanuelle Sampol, Alexis Jacquet, Marc Viggiano, Victor Bernini, Jean-Claude Manelli, Bruno Lacarelle, and Alain Durand

Plasma, urine and skin pharmacokinetics of cefepime in burns patients
J. Antimicrob. Chemother. 2000 46: 315-317; doi:10.1093/jac/46.2.315 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

B. Allegranzi, A. Cazzadori, G. Di Perri, S. Bonora, M. Berti, L. Franchino, A. Biglino, A. Cipriani, and E. Concia

Concentrations of single-dose meropenem (1 g iv) in bronchoalveolar lavage and epithelial lining fluid
J. Antimicrob. Chemother. 2000 46: 319-322; doi:10.1093/jac/46.2.319 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Joseph M. Blondeau

Reply
J. Antimicrob. Chemother. 2000 46: 323; doi:10.1093/jac/46.2.323 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

R. J. Boon, T. H. Bacon, H. L. Robey, T. J. Coleman, A Connolly, P. Crosson, and S. L. Sacks

Antiviral susceptibilities of herpes simplex virus from immunocompetent subjects with recurrent herpes labialie: a UK-based survey
J. Antimicrob. Chemother. 2000 46: 324-325; doi:10.1093/jac/46.2.324 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Ágoston Ghidán, Csaba Jeney, Csaba L. Maródi, Károly Csiszár, and Ferenc Rozgonyi

PCR detection of the vanA gene in a vancomycin-resistant Enterococcus faecalis clinical isolate from Hungary
J. Antimicrob. Chemother. 2000 46: 325-327; doi:10.1093/jac/46.2.325 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Derek F. J. Brown, Jenny Andrews, Anna King, and Alasdair P. MacGowan

Detection of extended-spectrum ß-lactamases with Etest and double-disc potentiation methods
J. Antimicrob. Chemother. 2000 46: 327-328; doi:10.1093/jac/46.2.327 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

M. A. O. Lewis, C. L. Pankhurst, C. W. I. Douglas, M. V. Martin, E. G. Absi, P. B. Bishop, and S. A. Jones

Assessment of the Etest method for detection of penicillin resistance in acute suppurative oral infection
J. Antimicrob. Chemother. 2000 46: 328-330; doi:10.1093/jac/46.2.328 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Thomas Gottlieb and Candice Wolfson

Comparison of the MICs of cefepime for extended-spectrum ß-lactamase-producing and non-extended-spectrum ß-lactamase-producing strains of Enterobacter cloacae
J. Antimicrob. Chemother. 2000 46: 330-332; doi:10.1093/jac/46.2.330 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Hiroshige Mikamo, Yin Xiang Hua, Yasumasa Sato, Yoh Hayasaki, and Teruhiko Tamaya

In vitro antibacterial activities of telithromycin, a new ketolide, against bacteria causing infections in obstetric and gynaecological patients
J. Antimicrob. Chemother. 2000 46: 332-334; doi:10.1093/jac/46.2.332 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

J. L. Muñoz Bellido, F. J. Sánchez Hernández, M. N. Gutiérrez Zufiaurre, and J. A. García-Rodríguez

In vitro activity of newer fluoroquinolones against Stenotrophomonas maltophilia
J. Antimicrob. Chemother. 2000 46: 334-335; doi:10.1093/jac/46.2.334 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Nico Caggiano and Ian Chopra

Inhibition of staphylococcal growth by fusidic acid prevents production of volatile metabolites
J. Antimicrob. Chemother. 2000 46: 335-336; doi:10.1093/jac/46.2.335 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Isabel Pujol, Carmen Aguilar, Josepa Gené, and Josep Guarro

In vitro antifungal susceptibility of Alternaria spp. and Ulocladium spp.
J. Antimicrob. Chemother. 2000 46: 337-338; doi:10.1093/jac/46.2.337 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Frank-Michael C. Müller, Michael Weig, Joanne Peter, and Thomas J. Walsh

Azole cross-resistance to ketoconazole, fluconazole, itraconazole and voriconazole in clinical Candida albicans isolates from HIV-infected children with oropharyngeal candidosis
J. Antimicrob. Chemother. 2000 46: 338-341; doi:10.1093/jac/46.2.338 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

V. S. Amato, A. C. Nicodemo, J. G. Amato, M. Boulos, and V. Amato Neto

Mucocutaneous leishmaniasis associated with HIV infection treated successfully with liposomal amphotericin B (AmBisome)
J. Antimicrob. Chemother. 2000 46: 341-342; doi:10.1093/jac/46.2.341 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book reviews:

R. C. Spencer

Mandell, Douglas and Bennett's Principles and Practice of Infectious Disease 5th Edn (two volumes)
J. Antimicrob. Chemother. 2000 46: 343; doi:10.1093/jac/46.2.343 [Extract] [FREE Full Text] [Request Permissions]  

Geoffrey L. Ridgway

New Macrolides, Azalides and Streptogramins in Clinical Practice
J. Antimicrob. Chemother. 2000 46: 343; doi:10.1093/jac/46.2.343-a [Extract] [FREE Full Text] [Request Permissions]  

R. C. Spencer

Chemical and Biological Terrorism: Research and Development to Improve Civilian Medical Response
J. Antimicrob. Chemother. 2000 46: 344-345; doi:10.1093/jac/46.2.344 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

R. C. Spencer

Resurgent/emergent Infectious Diseases. British Medical Bulletin Vol. 54 No. 3
J. Antimicrob. Chemother. 2000 46: 345; doi:10.1093/jac/46.2.345 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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