Journal of Antimicrobial Chemotherapy

Leading articles:

Kenneth S. Thomson

Minimizing quinolone resistance: are the new agents more or less likely to cause resistance?
J. Antimicrob. Chemother. 2000 45: 719-723; doi:10.1093/jac/45.6.719 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

S. Esposito

Outpatient parenteral treatment of bacterial infections: the Italian model as an international trend?
J. Antimicrob. Chemother. 2000 45: 724-727; doi:10.1093/jac/45.6.724 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Working Party Report:

Management of herpes virus infections following transplantation
J. Antimicrob. Chemother. 2000 45: 729-748; doi:10.1093/jac/45.6.729 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Review:

Nina Singh

Invasive mycoses in organ transplant recipients: controversies in prophylaxis and management
J. Antimicrob. Chemother. 2000 45: 749-755; doi:10.1093/jac/45.6.749 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

For debate:

I. M. Gould

Towards a common susceptibility testing method?
J. Antimicrob. Chemother. 2000 45: 757-762; doi:10.1093/jac/45.6.757 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Krzysztof Trzcinski, Ben S. Cooper, Waleria Hryniewicz, and Christopher G. Dowson

Expression of resistance to tetracyclines in strains of methicillin-resistant Staphylococcus aureus
J. Antimicrob. Chemother. 2000 45: 763-770; doi:10.1093/jac/45.6.763 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Akihiro Kaneko, Jiro Sasaki, Mitsunobu Shimadzu, Akiko Kanayama, Takeshi Saika, and Intetsu Kobayashi

Comparison of gyrA and parC mutations and resistance levels among fluoroquinolone-resistant isolates and laboratory-derived mutants of oral streptococci
J. Antimicrob. Chemother. 2000 45: 771-775; doi:10.1093/jac/45.6.771 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

H. M. Palmer, J. P. Leeming, and A. Turner

A multiplex polymerase chain reaction to differentiate ß-lactamase plasmids of Neisseria gonorrhoeae
J. Antimicrob. Chemother. 2000 45: 777-782; doi:10.1093/jac/45.6.777 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

N. Caroff, E. Espaze, D. Gautreau, H. Richet, and A. Reynaud

Analysis of the effects of –42 and –32 ampC promoter mutations in clinical isolates of Escherichia coli hyperproducing AmpC
J. Antimicrob. Chemother. 2000 45: 783-788; doi:10.1093/jac/45.6.783 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

T. Maira-Litrán, David G. Allison, and P. Gilbert

An evaluation of the potential of the multiple antibiotic resistance operon (mar) and the multidrug efflux pump acrAB to moderate resistance towards ciprofloxacin in Escherichia coli biofilms
J. Antimicrob. Chemother. 2000 45: 789-795; doi:10.1093/jac/45.6.789 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Marguerite Fines and Roland Leclercq

Activity of linezolid against Gram-positive cocci possessing genes conferring resistance to protein synthesis inhibitors
J. Antimicrob. Chemother. 2000 45: 797-802; doi:10.1093/jac/45.6.797 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Albert Musafija, Jacob Ramon, Yuri Shtelman, Gila Yoseph, Bina Rubinovitz, Shlomo Segev, and Ethan Rubinstein

Trans-epithelial intestinal elimination of moxifloxacin in rabbits
J. Antimicrob. Chemother. 2000 45: 803-805; doi:10.1093/jac/45.6.803 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yoshinao Kobayashi, Masayoshi Doi, Hiroshi Nagata, Tadatoshi Kubota, Masaharu Kume, and Kazuhisa Murakami

The 7-methoxy substituent in cephem or oxacephem antibiotics enhances in vivo anti-Helicobacter felis activity in mice after oral administration
J. Antimicrob. Chemother. 2000 45: 807-811; doi:10.1093/jac/45.6.807 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

P. Russell, S. M. Eley, J. Ellis, M. Green, D. L. Bell, D. J. Kenny, and R. W. Titball

Comparison of efficacy of ciprofloxacin and doxycycline against experimental melioidosis and glanders
J. Antimicrob. Chemother. 2000 45: 813-818; doi:10.1093/jac/45.6.813 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. S. S. Araújo, O. A. Martins-Filho, M. E. S. Pereira, and Z. Brener

A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease
J. Antimicrob. Chemother. 2000 45: 819-824; doi:10.1093/jac/45.6.819 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alana M. Thackray and Hugh J. Field

Further evidence from a murine infection model that famciclovir interferes with the establishment of HSV-1 latent infections
J. Antimicrob. Chemother. 2000 45: 825-833; doi:10.1093/jac/45.6.825 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

I. Harding, A. P. MacGowan, L. O. White, E. S. R. Darley, and V. Reed

Teicoplanin therapy for Staphylococcus aureus septicaemia: relationship between pre-dose serum concentrations and outcome
J. Antimicrob. Chemother. 2000 45: 835-841; doi:10.1093/jac/45.6.835 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Zoran Erjavec, Hilly G. de Vries-Hospers, Marianne Laseur, Ruud M. Halie, and Simon Daenen

A prospective, randomized, double-blinded, placebo-controlled trial of empirical teicoplanin in febrile neutropenia with persistent fever after imipenem monotherapy
J. Antimicrob. Chemother. 2000 45: 843-849; doi:10.1093/jac/45.6.843 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Charles M. Fogarty, Robert B. Bettis, Timothy J. Griffin, Constance H. Keyserling, Mary Anne Nemeth, and Kenneth J. Tack

Comparison of a 5 day regimen of cefdinir with a 10 day regimen of cefprozil for treatment of acute exacerbations of chronic bronchitis
J. Antimicrob. Chemother. 2000 45: 851-858; doi:10.1093/jac/45.6.851 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

F. A. Sirgel, P. R. Donald, J. Odhiambo, W. Githui, K. C. Umapathy, C. N. Paramasivan, C. M. Tam, K. M. Kam, C. W. Lam, K. M. Sole, and D. A. Mitchison

A multicentre study of the early bactericidal activity of anti-tuberculosis drugs
J. Antimicrob. Chemother. 2000 45: 859-870; doi:10.1093/jac/45.6.859 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

James A. Karlowsky, Geetika Verma, George G. Zhanel, and Daryl J. Hoban

Presence of ROB-1 ß-lactamase correlates with cefaclor resistance among recent isolates of Haemophilus influenzae
J. Antimicrob. Chemother. 2000 45: 871-875; doi:10.1093/jac/45.6.871 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Matthew B. Avison, Peter M. Bennett, and Timothy R. Walsh

ß-Lactamase expression in Plesiomonas shigelloides
J. Antimicrob. Chemother. 2000 45: 877-880; doi:10.1093/jac/45.6.877 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Fatima H. M'Zali, Aroonwadee Chanawong, Kevin G. Kerr, David Birkenhead, and Peter M. Hawkey

Detection of extended-spectrum ß-lactamases in members of the family Enterobacteriaceae: comparison of the MAST DD test, the double disc and the Etest ESBL
J. Antimicrob. Chemother. 2000 45: 881-885; doi:10.1093/jac/45.6.881 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

O. Chesneau, A. Morvan, and N. El Solh

Retrospective screening for heterogeneous vancomycin resistance in diverse Staphylococcus aureus clones disseminated in French hospitals
J. Antimicrob. Chemother. 2000 45: 887-890; doi:10.1093/jac/45.6.887 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Franz-Josef Schmitz, Ralf Sadurski, Angela Kray, Mechthild Boos, Roland Geisel, Karl Köhrer, Jan Verhoef, and Ad C. Fluit

Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals
J. Antimicrob. Chemother. 2000 45: 891-894; doi:10.1093/jac/45.6.891 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Guillermo Saurina, John M. Quale, Vivek M. Manikal, Elise Oydna, and David Landman

Antimicrobial resistance in Enterobacteriaceae in Brooklyn, NY: epidemiology and relation to antibiotic usage patterns
J. Antimicrob. Chemother. 2000 45: 895-898; doi:10.1093/jac/45.6.895 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

John C. Christenson, E. Kent Korgenski, and Judy A. Daly

In vitro activity of meropenem, imipenem, cefepime and ceftazidime against Pseudomonas aeruginosa isolates from cystic fibrosis patients
J. Antimicrob. Chemother. 2000 45: 899-901; doi:10.1093/jac/45.6.899 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. Taylor-Robinson and P. M. Furr

Observations on the antibiotic treatment of experimentally induced mycoplasmal infections in mice
J. Antimicrob. Chemother. 2000 45: 903-907; doi:10.1093/jac/45.6.903 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Greg Simmons, Nicholas Jones, and Lester Calder

Equivalence of ceftriaxone and rifampicin in eliminating nasopharyngeal carriage of serogroup B Neisseria meningitidis
J. Antimicrob. Chemother. 2000 45: 909-911; doi:10.1093/jac/45.6.909 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Antimicrobial practice:

I. M. Gould and B. Jappy

Trends in hospital antimicrobial prescribing after 9 years of stewardship
J. Antimicrob. Chemother. 2000 45: 913-917; doi:10.1093/jac/45.6.913-a [Abstract] [FREE Full Text] [Request Permissions]  

Correspondence:

Richard Wise and Ian Phillips

Towards a common susceptibility testing method?
J. Antimicrob. Chemother. 2000 45: 919-920; doi:10.1093/jac/45.6.919 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

L. Bjerager, R. Skov, and N. Frimodt-Møller

In vitro study of the susceptibility of Escherichia coli to mecillinam
J. Antimicrob. Chemother. 2000 45: 920-921; doi:10.1093/jac/45.6.920 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Franz-Josef Schmitz, Ralf Sadurski, Jan Verhoef, Dana Milatovic, and Ad C. Fluit

Typing of 154 clinical isolates of Stenotrophomonas maltophilia by pulsed-field gel electrophoresis and determination of the in vitro susceptibilities of these strains to 28 antibiotics
J. Antimicrob. Chemother. 2000 45: 921-923; doi:10.1093/jac/45.6.921 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Geert Claeys, Gerda Verschraegen, Thierry de Baere, and Mario Vaneechoutte

PER-1 ß-lactamase-producing Pseudomonas aeruginosa in an intensive care unit
J. Antimicrob. Chemother. 2000 45: 924-925; doi:10.1093/jac/45.6.924 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

John D. Turnidge

Quantifying the impact of resistance for prescribers and drug developers—a function of natural resolution rates
J. Antimicrob. Chemother. 2000 45: 925-926; doi:10.1093/jac/45.6.925 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

E. S. R. Darley, A. P. MacGowan, R. A. Howe, and C. M. Tobin

Clinafloxacin serum concentrations in a patient on continuous veno-venous haemofiltration
J. Antimicrob. Chemother. 2000 45: 927-928; doi:10.1093/jac/45.6.927 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

F. Persat, P. E. Schwartzbrod, J. Troncy, Q. Timour, A. Maul, M. A. Piens, and S. Picot

Abnormalities in liver enzymes during simultaneous therapy with itraconazole and amphotericin B in leukaemic patients
J. Antimicrob. Chemother. 2000 45: 928-929; doi:10.1093/jac/45.6.928 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

A. J. Matute, C. A. M. Schurink, and I. M. Hoepelman

Is a 5 day course of azithromycin enough for infections caused by Legionella pneumophila?
J. Antimicrob. Chemother. 2000 45: 930-931; doi:10.1093/jac/45.6.930 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book reviews:

David A. Cook

Laboratory-Acquired Infections: History, Incidence, Causes and Preventions, 4th edn
J. Antimicrob. Chemother. 2000 45: 933; doi:10.1093/jac/45.6.933 [Extract] [FREE Full Text] [Request Permissions]  

Robert S. Heyderman

Therapies for Viral Hepatitis
J. Antimicrob. Chemother. 2000 45: 933; doi:10.1093/jac/45.6.933-a [Extract] [FREE Full Text] [Request Permissions]  

Emma C. M. Williamson

Aspergillus fumigatus. Biology, Clinical Aspects and Molecular Approaches to Pathogenicity (Contributions to Microbiology Series, Volume 2)
J. Antimicrob. Chemother. 2000 45: 934; doi:10.1093/jac/45.6.934 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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