Journal of Antimicrobial Chemotherapy

Leading articles:

Susan M. Drake

NNRTIs—a new class of drugs for HIV
J. Antimicrob. Chemother. 2000 45: 417-420; doi:10.1093/jac/45.4.417 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Hitoshi Komatsuzawa, Kouji Ohta, Motoyuki Sugai, Tamaki Fujiwara, Philipp Glanzmann, Brigitte Berger-Bächi, and Hidekazu Suginaka

Tn551-mediated insertional inactivation of the fmtB gene encoding a cell wall-associated protein abolishes methicillin resistance in Staphylococcus aureus
J. Antimicrob. Chemother. 2000 45: 421-431; doi:10.1093/jac/45.4.421 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Xian-Zhi Li, Li Zhang, and Keith Poole

Interplay between the MexA-MexB-OprM multidrug efflux system and the outer membrane barrier in the multiple antibiotic resistance of Pseudomonas aeruginosa
J. Antimicrob. Chemother. 2000 45: 433-436; doi:10.1093/jac/45.4.433 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Joan Fung-Tomc, Beatrice Minassian, Benjamin Kolek, Thomas Washo, Elizabeth Huczko, and Daniel Bonner

In vitro antibacterial spectrum of a new broad-spectrum 8-methoxy fluoroquinolone, gatifloxacin
J. Antimicrob. Chemother. 2000 45: 437-446; doi:10.1093/jac/45.4.437 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

K. A. Saunders, J. Greenman, and C. McKenzie

Ecological effects of triclosan and triclosan monophosphate on defined mixed cultures of oral species grown in continuous culture
J. Antimicrob. Chemother. 2000 45: 447-452; doi:10.1093/jac/45.4.447 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Andrea Giacometti, Oscar Cirioni, Francesco Barchiesi, Fausto Ancarani, and Giorgio Scalise

Activity of nitazoxanide alone and in combination with azithromycin and rifabutin against Cryptosporidium parvum in cell culture
J. Antimicrob. Chemother. 2000 45: 453-456; doi:10.1093/jac/45.4.453 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Daniel F. Sahm, Mark E. Jones, Mary L. Hickey, David R. Diakun, Satish V. Mani, and Clyde Thornsberry

Resistance surveillance of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated in Asia and Europe, 1997–1998
J. Antimicrob. Chemother. 2000 45: 457-466; doi:10.1093/jac/45.4.457 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Delphine Girlich, Amal Karim, Laurent Poirel, Marie-Hélène Cavin, Christiane Verny, and Patrice Nordmann

Molecular epidemiology of an outbreak due to IRT-2 ß-lactamase-producing strains of Klebsiella pneumoniae in a geriatric department
J. Antimicrob. Chemother. 2000 45: 467-473; doi:10.1093/jac/45.4.467 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wilenes das Graças Silva e Souza, Katia Eliane Santos Avelar, Luis Caetano Martha Antunes, Leandro Araujo Lobo, Regina Maria Cavalcanti Pilotto Domingues, and Maria Candida de Souza Ferreira

Resistance profile of Bacteroides fragilis isolated in Brazil. Do they shelter the cfiA gene?
J. Antimicrob. Chemother. 2000 45: 475-481; doi:10.1093/jac/45.4.475 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Raymond P. Smith, Aldona L. Baltch, Mary A. Franke, Phyllis B. Michelsen, and Lawrence H. Bopp

Levofloxacin penetrates human monocytes and enhances intracellular killing of Staphylococcus aureus and Pseudomonas aeruginosa
J. Antimicrob. Chemother. 2000 45: 483-488; doi:10.1093/jac/45.4.483 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Martin A. Shapiro, Kurt D. Donovan, and Jeffrey W. Gage

Comparative therapeutic efficacy of clinafloxacin in a pneumococcal meningitis mouse model
J. Antimicrob. Chemother. 2000 45: 489-492; doi:10.1093/jac/45.4.489 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

María-Jesús Rodríguez-Hernández, Jerónimo Pachón, Cristina Pichardo, Lucila Cuberos, José Ibáñez-Martínez, Andrés García-Curiel, Francisco J. Caballero, Ignacio Moreno, and M. Enrique Jiménez-Mejías

Imipenem, doxycycline and amikacin in monotherapy and in combination in Acinetobacter baumannii experimental pneumonia
J. Antimicrob. Chemother. 2000 45: 493-501; doi:10.1093/jac/45.4.493 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Ferguson, J. McEwen, H. Al-Ajmi, L. Purkins, P. J. Colman, and S. A. Willavize

A comparison of the photosensitizing potential of trovafloxacin with that of other quinolones in healthy subjects
J. Antimicrob. Chemother. 2000 45: 503-509; doi:10.1093/jac/45.4.503 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gregory I. Snell, Thomas C. Kotsimbos, Bronwyn J. Levvey, Marina Skiba, David M. Rutherford, David C. M. Kong, Trevor J. Williams, and Henry Krum

Pharmacokinetic assessment of oral ganciclovir in lung transplant recipients with cystic fibrosis
J. Antimicrob. Chemother. 2000 45: 511-516; doi:10.1093/jac/45.4.511 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

François Sanschagrin, Esther Thériault, Yves Sabbagh, Normand Voyer, and Roger C. Levesque

Combinatorial biochemistry and shuffling of TEM, SHV and Streptomyces albus omega loops in PSE-4 class A ß-lactamase
J. Antimicrob. Chemother. 2000 45: 517-519; doi:10.1093/jac/45.4.517 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

María del Mar Tavío, Jordi Vila, Joaquím Ruiz, Gianfranco Amicosante, Nicola Franceschini, Antonio M. Martín-Sánchez, and María Teresa Jiménez de Anta

In vitro selected fluoroquinolone-resistant mutants of Citrobacter freundii: analysis of the quinolone resistance acquisition
J. Antimicrob. Chemother. 2000 45: 521-524; doi:10.1093/jac/45.4.521 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lois M. Ednie, Michael R. Jacobs, and Peter C. Appelbaum

Activity of gemifloxacin, a new broad-spectrum quinolone, against 200 pneumococci by four different susceptibility testing methods
J. Antimicrob. Chemother. 2000 45: 525-528; doi:10.1093/jac/45.4.525 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. Paton, J. Arnold, J. Cockburn, and F. X. S. Emmanuel

Susceptibility testing of Haemophilus influenzae to clarithromycin
J. Antimicrob. Chemother. 2000 45: 529-531; doi:10.1093/jac/45.4.529 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Christine Armbruster, B. Robibaro, A. Griesmacher, and H. Vorbach

Endothelial cell compatibility of trovafloxacin and levofloxacin for intravenous use
J. Antimicrob. Chemother. 2000 45: 533-535; doi:10.1093/jac/45.4.533 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

C. de Champs, R. Bonnet, D. Sirot, C. Chanal, and J. Sirot

Clinical relevance of Proteus mirabilis in hospital patients: a two year survey
J. Antimicrob. Chemother. 2000 45: 537-539; doi:10.1093/jac/45.4.537 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lila Rahalison, Annie Guiyoule, Stephane P. Bonacorsi, Ivan Slacanin, Suzanne Chanteau, and Elisabeth Carniel

Failure of oily chloramphenicol depot injection to treat plague in a murine model
J. Antimicrob. Chemother. 2000 45: 541-545; doi:10.1093/jac/45.4.541 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Pio Maria Furneri, Giancarlo Rappazzo, Maria Pia Musumarra, Gianna Tempera, and Lucia Silvana Roccasalva

Genetic basis of natural resistance to erythromycin in Mycoplasma hominis
J. Antimicrob. Chemother. 2000 45: 547-548; doi:10.1093/jac/45.4.547 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Jennifer M. Andrews and Richard Wise

In vitro susceptibility of Neisseria meningitidis
J. Antimicrob. Chemother. 2000 45: 548-549; doi:10.1093/jac/45.4.548 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Robert R. S. Nelson

Selection of resistance to the essential oil of Melaleuca alternifolia in Staphylococcus aureus
J. Antimicrob. Chemother. 2000 45: 549-550; doi:10.1093/jac/45.4.549 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

John. P. Cassella, S. Cassella, and R. L. Ashford

Use of essential oil therapies in immunocompromised patients
J. Antimicrob. Chemother. 2000 45: 550-551; doi:10.1093/jac/45.4.550 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book review:

G. Kudesia

HIV and the New Viruses, 2nd edn
J. Antimicrob. Chemother. 2000 45: 553; doi:10.1093/jac/45.4.553 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Errata:

Michael V. Martin

The use of fluconazole and itraconazole in the treatment of Candida albicans infections: a review
J. Antimicrob. Chemother. 2000 45: 555. [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Margarita M. Navia, Joaquím Ruiz, Anna Ribera, M. Teresa Jiménez de Anta, and Jordi Vila

Analysis of the mechanisms of quinolone resistance in clinical isolates of Citrobacter freundii
J. Antimicrob. Chemother. 2000 45: 556. [Extract] [FREE Full Text] [Request Permissions]  

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