Journal of Antimicrobial Chemotherapy

Leading articles:

Issam Raad

Management of intravascular catheter-related infections
J. Antimicrob. Chemother. 2000 45: 267-270; doi:10.1093/jac/45.3.267 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Rie Nagano, Yuka Adachi, Terutaka Hashizume, and Hajime Morishima

In vitro antibacterial activity and mechanism of action of J-111,225, a novel 1ß-methylcarbapenem, against transferable IMP-1 metallo-ß-lactamase producers
J. Antimicrob. Chemother. 2000 45: 271-276; doi:10.1093/jac/45.3.271 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Papaparaskevas, A. Vatopoulos, P. T. Tassios, A. Avlami, N. J. Legakis, and V. Kalapothaki

Diversity among high-level aminoglycoside-resistant enterococci
J. Antimicrob. Chemother. 2000 45: 277-283; doi:10.1093/jac/45.3.277 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Andrews, J. Ashby, G. Jevons, T. Marshall, N. Lines, and R. Wise

A comparison of antimicrobial resistance rates in Gram-positive pathogens isolated in the UK from October 1996 to January 1997 and October 1997 to January 1998
J. Antimicrob. Chemother. 2000 45: 285-293; doi:10.1093/jac/45.3.285 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ana C. Gales, Ronald N. Jones, Kelley A. Gordon, Hélio S. Sader, Werner W. Wilke, Mondell L. Beach, Michael A. Pfaller, Gary V. Doern, and the SENTRY Study Group (Latin America)

Activity and spectrum of 22 antimicrobial agents tested against urinary tract infection pathogens in hospitalized patients in Latin America: report from the second year of the SENTRY Antimicrobial Surveillance Program (1998)
J. Antimicrob. Chemother. 2000 45: 295-303; doi:10.1093/jac/45.3.295 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Timothy J. Ives, Eric L. Marston, Russell L. Regnery, John D. Butts, and Thomas C. Majerus

In vitro susceptibilities of Rickettsia and Bartonella spp. to 14-hydroxy-clarithromycin as determined by immunofluorescent antibody analysis of infected Vero cell monolayers
J. Antimicrob. Chemother. 2000 45: 305-310; doi:10.1093/jac/45.3.305 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ritsuko Hori, Harumi Araki, Minoru Yonezawa, Shinzaburo Minami, and Yasuo Watanabe

Therapeutic effects of parenteral ß-lactam antibiotics on experimental otitis media caused by penicillin-resistant Streptococcus pneumoniae in guinea-pigs
J. Antimicrob. Chemother. 2000 45: 311-314; doi:10.1093/jac/45.3.311 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

C. Cabellos, J. Martínez-Lacasa, F. Tubau, A. Fernández, P. F. Viladrich, J. Liñares, and F. Gudiol

Evaluation of combined ceftriaxone and dexamethasone therapy in experimental cephalosporin-resistant pneumococcal meningitis
J. Antimicrob. Chemother. 2000 45: 315-320; doi:10.1093/jac/45.3.315 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

María M. Sánchez-Recio, Clara-Isabel Colino, and Amparo Sánchez-Navarro

A retrospective analysis of pharmacokinetic/pharmacodynamic indices as indicators of the clinical efficacy of ciprofloxacin
J. Antimicrob. Chemother. 2000 45: 321-328; doi:10.1093/jac/45.3.321 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Federico Pea, Lorenzo Porreca, Massimo Baraldo, and Mario Furlanut

High vancomycin dosage regimens required by intensive care unit patients cotreated with drugs to improve haemodynamics following cardiac surgical procedures
J. Antimicrob. Chemother. 2000 45: 329-335; doi:10.1093/jac/45.3.329 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Esteban Varela, Stephen M. Cohn, Margaret Brown, C. Gillon Ward, Nicholas Namias, and Paul B. Spalding

Pharmacokinetics and burn eschar penetration of intravenous ciprofloxacin in patients with major thermal injuries
J. Antimicrob. Chemother. 2000 45: 337-342; doi:10.1093/jac/45.3.337 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. B. Regazzi, P. Villani, R. Maserati, E. Seminari, A. Pan, F. LoCaputo, E. Gambarana, and C. Fiocchi

Clinical pharmacokinetics of nelfinavir combined with efavirenz and stavudine during rescue treatment of heavily pretreated HIV-infected patients
J. Antimicrob. Chemother. 2000 45: 343-347; doi:10.1093/jac/45.3.343 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Younes Laksai, Monica Severino, Mariagrazia Perilli, Gianfranco Amicosante, Giovanni Bonfiglio, and Stefania Stefani

First identification of an SHV-12 extended-spectrum ß-lactamase in Klebsiella pneumoniae isolated in Italy
J. Antimicrob. Chemother. 2000 45: 349-351; doi:10.1093/jac/45.3.349 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mark E. Jones, Nienke M. Boenink, Jan Verhoef, Karl Köhrer, and Franz-Josef Schmitz

Multiple mutations conferring ciprofloxacin resistance in Staphylococcus aureus demonstrate long-term stability in an antibiotic-free environment
J. Antimicrob. Chemother. 2000 45: 353-356; doi:10.1093/jac/45.3.353 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Naoki Kato, Kaori Tanaka, Haru Kato, and Kunitomo Watanabe

In vitro activity of R-95867, the active metabolite of a new oral carbapenem, CS-834, against anaerobic bacteria
J. Antimicrob. Chemother. 2000 45: 357-361; doi:10.1093/jac/45.3.357 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Karl Weiss, Christiane Restieri, Emidio De Carolis, Michel Laverdière, and Hélène Guay

Comparative activity of new quinolones against 326 clinical isolates of Stenotrophomonas maltophilia
J. Antimicrob. Chemother. 2000 45: 363-365; doi:10.1093/jac/45.3.363 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Peter C. T. Hannan and Gary Woodnutt

In vitro activity of gemifloxacin (SB 265805; LB20304a) against human mycoplasmas
J. Antimicrob. Chemother. 2000 45: 367-369; doi:10.1093/jac/45.3.367 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

F. C. Odds and H. Vanden Bossche

Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro
J. Antimicrob. Chemother. 2000 45: 371-373; doi:10.1093/jac/45.3.371 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Giacometti, O. Cirioni, F. Barchiesi, and G. Scalise

Anticryptosporidial activity of ranalexin, lasalocid and azithromycin alone and in combination in cell lines
J. Antimicrob. Chemother. 2000 45: 375-377; doi:10.1093/jac/45.3.375 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kaneyoshi Shibata, Rie Nagano, Terutaka Hashizume, and Hajime Morishima

Therapeutic efficacy of J-111,225, a novel trans-3,5-disubstituted pyrrolidinylthio-1ß-methylcarbapenem, against experimental murine systemic infections
J. Antimicrob. Chemother. 2000 45: 379-382; doi:10.1093/jac/45.3.379 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Fatima El Bakri, A. Pallett, A. G. Smith, and A. S. Duncombe

Once-daily versus multiple-daily gentamicin in empirical antibiotic therapy of febrile neutropenia following intensive chemotherapy
J. Antimicrob. Chemother. 2000 45: 383-386; doi:10.1093/jac/45.3.383 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Antimicrobial practice:

Fahad A. Al-Eidan, James C. McElnay, M. G. Scott, M. P. Kearney, J. Corrigan, and J. B. McConnell

Use of a treatment protocol in the management of community-acquired lower respiratory tract infection
J. Antimicrob. Chemother. 2000 45: 387-394; doi:10.1093/jac/45.3.387 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Ruiz Bremón, M. Ruiz-Tovar, B. Pérez Gorricho, P. Díaz de Torres, and R. López Rodríguez

Non-hospital consumption of antibiotics in Spain: 1987–1997
J. Antimicrob. Chemother. 2000 45: 395-400; doi:10.1093/jac/45.3.395 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Emilio Pérez-Trallero

Pneumococcal macrolide resistance—not a myth
J. Antimicrob. Chemother. 2000 45: 401-402; doi:10.1093/jac/45.3.401 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Guy W. Amsden

Reply
J. Antimicrob. Chemother. 2000 45: 402-403; doi:10.1093/jac/45.3.402 [Extract] [FREE Full Text] [Request Permissions]  

M. J. Weinbren, A. P. Johnson, and N. Woodford

Defining high-level gentamicin resistance in enterococci
J. Antimicrob. Chemother. 2000 45: 404-405; doi:10.1093/jac/45.3.404 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

N. C. Weightman and M. Barnham

Effect of the incubation atmosphere on the susceptibilities of Haemophilus influenzae isolates to macrolides and amoxycillin as determined by the Etest
J. Antimicrob. Chemother. 2000 45: 405-406; doi:10.1093/jac/45.3.405 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

J. R. Hernández, L. Martínez-Martínez, A. Pascual, A. I. Suárez, and E. J. Perea

Trends in the susceptibilities of Proteus mirabilis isolates to quinolones
J. Antimicrob. Chemother. 2000 45: 407-408; doi:10.1093/jac/45.3.407 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

F. Barchiesi, D. Arzeni, F. Caselli, and G. Scalise

Primary resistance to flucytosine among clinical isolates of Candida spp.
J. Antimicrob. Chemother. 2000 45: 408-409; doi:10.1093/jac/45.3.408 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

J. H. Sloos, L. Dijkshoorn, and C. P. A. van Boven

Septicaemias caused by a strain of Staphylococcus haemolyticus exhibiting intermediate susceptibility to teicoplanin in multiple intensive care unit patients
J. Antimicrob. Chemother. 2000 45: 410-411; doi:10.1093/jac/45.3.410 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

F. Frippiat, G. Derue, F. Heller, P. Honore, M. Moreau, and B. Vandercam

Acute pancreatitis associated with severe lactic acidosis in human immunodeficiency virus-infected patients receiving triple therapy
J. Antimicrob. Chemother. 2000 45: 411-412; doi:10.1093/jac/45.3.411 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book review:

Helen M. Palmer

Using Antibodies: A Laboratory Manual
J. Antimicrob. Chemother. 2000 45: 413; doi:10.1093/jac/45.3.413 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Errata:

Christopher T. D. Price, Frances G. O'Brien, Bradley P. Shelton, John R. Warmington, Warren B. Grubb, and John E. Gustafson

Effects of salicylate and related compounds on fusidic acid MICs in Staphylococcus aureus
J. Antimicrob. Chemother. 2000 45: 415; doi:10.1093/jac/45.3.415 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Richard Ellis

Microbiology in Clinical Practice, 3rd edn (Book review)
J. Antimicrob. Chemother. 2000 45: 415. [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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