Journal of Antimicrobial Chemotherapy

Leading articles:

Jeffrey R. Edwards and Michael J. Betts

Carbapenems: the pinnacle of the ß-lactam antibiotics or room for improvement?
J. Antimicrob. Chemother. 2000 45: 1-4; doi:10.1093/jac/45.1.1 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

S. Ragnar Norrby

Neurotoxicity of carbapenem antibiotics: consequences for their use in bacterial meningitis
J. Antimicrob. Chemother. 2000 45: 5-7; doi:10.1093/jac/45.1.5 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Oana Ciofu, Terry J. Beveridge, Jagath Kadurugamuwa, Jan Walther-Rasmussen, and Niels Høiby

Chromosomal ß-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa
J. Antimicrob. Chemother. 2000 45: 9-13; doi:10.1093/jac/45.1.9 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Pier Carlo Braga, Monica Dal Sasso, and Maria Teresa Sala

Sub-MIC concentrations of cefodizime interfere with various factors affecting bacterial virulence
J. Antimicrob. Chemother. 2000 45: 15-25; doi:10.1093/jac/45.1.15 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. Leclercq, R. Bismuth, I. Casin, J. D. Cavallo, J. Croizé, A. Felten, F. Goldstein, H. Monteil, C. Quentin-Noury, M. Reverdy, M. Vergnaud, and R. Roiron

In vitro activity of fusidic acid against streptococci isolated from skin and soft tissue infections
J. Antimicrob. Chemother. 2000 45: 27-29; doi:10.1093/jac/45.1.27 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. A. A. Hoogkamp-Korstanje and J. Roelofs-Willemse

Comparative in vitro activity of moxifloxacin against Gram-positive clinical isolates
J. Antimicrob. Chemother. 2000 45: 31-39; doi:10.1093/jac/45.1.31 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. Savoia, C. Avanzini, K. Bosio, G. Volpe, D. Carpi, G. Dotti, and M. Zucca

Macrolide resistance in group A streptococci
J. Antimicrob. Chemother. 2000 45: 41-47; doi:10.1093/jac/45.1.41 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Chang-Phone Fung, Bor-Shen Hu, Sai-Cheong Lee, Peter Yuk-Fong Liu, Tsrang-Neng Jang, Hsieh-Shong Leu, Benjamin I. Kuo, Muh-Yung Yen, Cheng-Yi Liu, Yung-Chin Liu, Yeu-Jun Lau, and Kwok-Woon Yu

Antimicrobial resistance of Streptococcus pneumoniae isolated in Taiwan: an island-wide surveillance study between 1996 and 1997
J. Antimicrob. Chemother. 2000 45: 49-55; doi:10.1093/jac/45.1.49 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Khanh Q. Bui, Mary Anne Banevicius, Charles H. Nightingale, Richard Quintiliani, and David P. Nicolau

In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa
J. Antimicrob. Chemother. 2000 45: 57-62; doi:10.1093/jac/45.1.57 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Cynthia M. Gerber, Marianne Cottagnoud, Klaus Neftel, Martin G. Täuber, and Philippe Cottagnoud

Evaluation of cefepime alone and in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro
J. Antimicrob. Chemother. 2000 45: 63-68; doi:10.1093/jac/45.1.63 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Haragopal Thadepalli, Umapathi Reddy, See Kean Chuah, Nancy Hanna, Gary Rana, and Sastry Gollapudi

Evaluation of trovafloxacin in the treatment of Klebsiella pneumoniae lung infection in tumour-bearing mice
J. Antimicrob. Chemother. 2000 45: 69-75; doi:10.1093/jac/45.1.69 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

K. Peters, S. Leitzke, J. E. Diederichs, K. Borner, H. Hahn, R. H. Müller, and S. Ehlers

Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection
J. Antimicrob. Chemother. 2000 45: 77-83; doi:10.1093/jac/45.1.77 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Elizabeth M. Johnson, Karen L. Oakley, Sarah A. Radford, Caroline B. Moore, Peter Warn, David W. Warnock, and David W. Denning

Lack of correlation of in vitro amphotericin B susceptibility testing with outcome in a murine model of Aspergillus infection
J. Antimicrob. Chemother. 2000 45: 85-93; doi:10.1093/jac/45.1.85 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

L. J. Cross, J. Bagg, D. Oliver, and D. Warnock

Serum itraconazole concentrations and clinical responses in Candida-associated denture stomatitis patients treated with itraconazole solution and itraconazole capsules
J. Antimicrob. Chemother. 2000 45: 95-99; doi:10.1093/jac/45.1.95 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

P. Giakkoupi, E. Tzelepi, P. T. Tassios, N. J. Legakis, and L. S. Tzouvelekis

Detrimental effect of the combination of R164S with G238S in TEM-1 ß-lactamase on the extended-spectrum activity conferred by each single mutation
J. Antimicrob. Chemother. 2000 45: 101-104; doi:10.1093/jac/45.1.101 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gioia S. Babini and David M. Livermore

Effect of conalbumin on the activity of Syn 2190, a 1,5 dihydroxy-4-pyridon monobactam inhibitor of AmpC ß-lactamases
J. Antimicrob. Chemother. 2000 45: 105-109; doi:10.1093/jac/45.1.105 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. C. Graham, O. M. Murphy, D. Stewart, A. M. Kearns, A. Galloway, and R. Freeman

Comparison of PCR detection of mecA with methicillin and oxacillin disc susceptibility testing in coagulase-negative staphylococci
J. Antimicrob. Chemother. 2000 45: 111-113; doi:10.1093/jac/45.1.111 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Giovanni Bonfiglio, Carmela Cascone, Cinzia Azzarelli, Viviana Cafiso, Federico Marchetti, and Stefania Stefani

Levofloxacin in vitro activity and time–kill evaluation of Stenotrophomonas maltophilia clinical isolates
J. Antimicrob. Chemother. 2000 45: 115-117; doi:10.1093/jac/45.1.115 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

K. Lagrou, W. E. Peetermans, J. Verhaegen, S. Van Lierde, L. Verbist, and J. Van Eldere

Macrolide resistance in Belgian Streptococcus pneumoniae
J. Antimicrob. Chemother. 2000 45: 119-121; doi:10.1093/jac/45.1.119 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Andrew J. H. Simpson, David A. B. Dance, Vanaporn Wuthiekanun, and Nicholas J. White

Serum bactericidal and inhibitory titres in the management of melioidosis
J. Antimicrob. Chemother. 2000 45: 123-127; doi:10.1093/jac/45.1.123 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Serge Alfandari and Gilles Beaucaire

Comments on the report of the BSAC Working Party (WP) on self-medication of antibacterials without prescription
J. Antimicrob. Chemother. 2000 45: 129-130; doi:10.1093/jac/45.1.129 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Robin A. Howe, Mandy Wootton, Timothy R. Walsh, Peter M. Bennett, and Alasdair P. Macgowan

Heterogeneous resistance to vancomycin in Staphylococcus aureus
J. Antimicrob. Chemother. 2000 45: 130-131; doi:10.1093/jac/45.1.130 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

R. Geisel, F.-J. Schmitz, L. Thomas, H. Labischinsky, and W. Witte

Reply
J. Antimicrob. Chemother. 2000 45: 131-132; doi:10.1093/jac/45.1.131 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Alexander K. Rowe, Benjamin Schwartz, Avril Wasas, and Keith P. Klugman

Evaluation of the Etest as a means of determining the antibiotic susceptibilities of isolates of Streptococcus pneumoniae and Haemophilus influenzae from children in the Central African Republic
J. Antimicrob. Chemother. 2000 45: 132-133; doi:10.1093/jac/45.1.132 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book reviews:

J. P. Leeming

Principles and Practice of Disinfection, Preservation and Sterilization, 3rd edn.
J. Antimicrob. Chemother. 2000 45: 135; doi:10.1093/jac/45.1.135 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

R. C. Spencer

The BAMM Clinical Directors Series Clinical Director of Pathology: Tackling the Role
J. Antimicrob. Chemother. 2000 45: 135; doi:10.1093/jac/45.1.135-a [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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