Journal of Antimicrobial Chemotherapy

Leading articles:

Ian Phillips

The use of bacitracin as a growth promoter in animals produces no risk to human health
J. Antimicrob. Chemother. 1999 44: 725-728; doi:10.1093/jac/44.6.725 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Review:

J. M. T. Hamilton-Miller

ß-Lactams: variations on a chemical theme, with some surprising biological results
J. Antimicrob. Chemother. 1999 44: 729-734; doi:10.1093/jac/44.6.729 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

María del Mar Tavío, Jordi Vila, Joaquím Ruiz, José Ruiz, Antonio Manuel Martín-Sánchez, and María Teresa Jiménez de Anta

Mechanisms involved in the development of resistance to fluoroquinolones in Escherichia coli isolates
J. Antimicrob. Chemother. 1999 44: 735-742; doi:10.1093/jac/44.6.735 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Margarita M. Navia, Joaquím Ruiz, Anna Ribera, M. Teresa Jiménez de Anta, and Jordi Vila

Analysis of the mechanisms of quinolone resistance in clinical isolates of Citrobacter freundii
J. Antimicrob. Chemother. 1999 44: 743-748; doi:10.1093/jac/44.6.743 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Clyde Thornsberry, Mark E. Jones, Mary L. Hickey, Yolanda Mauriz, James Kahn, and Daniel F. Sahm

Resistance surveillance of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated in the United States, 1997–1998
J. Antimicrob. Chemother. 1999 44: 749-759; doi:10.1093/jac/44.6.749 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alasdair P. MacGowan, Karen E. Bowker, Mandy Wootton, and H. Alan Holt

Exploration of the in-vitro pharmacodynamic activity of moxifloxacin for Staphylococcus aureus and streptococci of Lancefield Groups A and G
J. Antimicrob. Chemother. 1999 44: 761-766; doi:10.1093/jac/44.6.761 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Akihiko Ohwada, Mitsuaki Sekiya, Hideaki Hanaki, Kyoko Kuwahara Arai, Isao Nagaoka, Satoshi Hori, Shigeru Tominaga, Keiichi Hiramatsu, and Yoshinosuke Fukuchi

DNA vaccination by mecA sequence evokes an antibacterial immune response against methicillin-resistant Staphylococcus aureus
J. Antimicrob. Chemother. 1999 44: 767-774; doi:10.1093/jac/44.6.767 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

José M. Entenza, Isabelle Caldelari, Michel P. Glauser, and Philippe Moreillon

Efficacy of levofloxacin in the treatment of experimental endocarditis caused by viridans group streptococci
J. Antimicrob. Chemother. 1999 44: 775-786; doi:10.1093/jac/44.6.775 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yona Shadkchan and Esther Segal

Antifungal activity of amphotericin B–lipid admixtures in experimental systemic candidosis in naive mice
J. Antimicrob. Chemother. 1999 44: 787-790; doi:10.1093/jac/44.6.787 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Swapna Medda, Sibabrata Mukhopadhyay, and Mukul Kumar Basu

Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms
J. Antimicrob. Chemother. 1999 44: 791-794; doi:10.1093/jac/44.6.791 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nicole van den Braak, Alex van Belkum, Deborah Kreft, René te Witt, Henri A. Verbrugh, and Hubert Ph. Endtz

The prevalence and clonal expansion of high-level gentamicin-resistant enterococci isolated from blood cultures in a Dutch university hospital
J. Antimicrob. Chemother. 1999 44: 795-798; doi:10.1093/jac/44.6.795 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Geddes, M. Thaler, S. Schonwald, M. Härkönen, F. Jacobs, and I. Nowotny

Levofloxacin in the empirical treatment of patients with suspected bacteraemia/sepsis: comparison with imipenem/cilastatin in an open, randomized trial
J. Antimicrob. Chemother. 1999 44: 799-810; doi:10.1093/jac/44.6.799 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Peter P. Sendi, Bruce A. Craig, Gabriela Meier, Dominik Pfluger, Amiram Gafni, Milos Opravil, Manuel Battegay, and Heiner C. Bucher

Cost-effectiveness of azithromycin for preventing Mycobacterium avium complex infection in HIV-positive patients in the era of highly active antiretroviral therapy
J. Antimicrob. Chemother. 1999 44: 811-817; doi:10.1093/jac/44.6.811 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

J. M. Andrews, J. P. Ashby, G. M. Jevons, and R. Wise

Tentative minimum inhibitory concentration and zone diameter breakpoints for moxifloxacin using BSAC criteria
J. Antimicrob. Chemother. 1999 44: 819-822; doi:10.1093/jac/44.6.819 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. Wainwright, D. A. Phoenix, M. Gaskell, and B. Marshall

Photobactericidal activity of methylene blue derivatives against vancomycin-resistant Enterococcus spp.
J. Antimicrob. Chemother. 1999 44: 823-825; doi:10.1093/jac/44.6.823 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mohammad Ashraf Hossain, Shigefumi Maesaki, Kotaro Mitsutake, Hiroshi Kakeya, Eisuke Sasaki, Kazunori Tomono, Takayoshi Tashiro, and Shigeru Kohno

In-vitro and in-vivo activities of SCH56592 against Cryptococcus neoformans
J. Antimicrob. Chemother. 1999 44: 827-829; doi:10.1093/jac/44.6.827 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Chad R. Messick, Keith A. Rodvold, and Susan L. Pendland

Modified time–kill assay against multidrug-resistant Enterococcus faecium with novel antimicrobial combinations
J. Antimicrob. Chemother. 1999 44: 831-834; doi:10.1093/jac/44.6.831 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Soman, D. Honeybourne, J. Andrews, G. Jevons, and R. Wise

Concentrations of moxifloxacin in serum and pulmonary compartments following a single 400 mg oral dose in patients undergoing fibre-optic bronchoscopy
J. Antimicrob. Chemother. 1999 44: 835-838; doi:10.1093/jac/44.6.835 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Antimicrobial practice:

Nana Thrane, Charlotte Olesen, Henrik C. Schønheyder, and Henrik T. Sørensen

Multiple prescriptions of antibiotics for children aged 0 to 5 years in relation to type of antibiotic
J. Antimicrob. Chemother. 1999 44: 839-842; doi:10.1093/jac/44.6.839 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

K. O. Buabeng, A. R. Mackenzie, R. B. S. Laing, I. Cook, B. Jappy, and I. M. Gould

Assessment of the efficacy, safety and quality of gentamicin use in Aberdeen Royal Infirmary
J. Antimicrob. Chemother. 1999 44: 843-845; doi:10.1093/jac/44.6.843 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Franz-Josef Schmitz, Ralf Sadurski, Andre Stattfeld, Angela Kray, Jan Verhoef, and A. C. Fluit

Cross-resistance analyses and molecular typing of Staphylococcus aureus and Streptococcus spp. isolates resistant to quinupristin/dalfopristin
J. Antimicrob. Chemother. 1999 44: 847-849; doi:10.1093/jac/44.6.847 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

J. M. T. Hamilton-Miller

New BSAC sensitivity testing guidelines
J. Antimicrob. Chemother. 1999 44: 850-851; doi:10.1093/jac/44.6.850 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

R. Wise

Reply
J. Antimicrob. Chemother. 1999 44: 851; doi:10.1093/jac/44.6.851 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Albert Sotto, Vincent Foulongne, Danielle Sirot, and Jacques Jourdan

A method using TEM-5-ß-lactamase to assay imipenem
J. Antimicrob. Chemother. 1999 44: 851-852; doi:10.1093/jac/44.6.851-a [Extract] [FREE Full Text] [PDF] [Request Permissions]  

M. Y. Rohani, N. Parasakthi, A. Raudzah, and M. Y. Yasim

In-vitro susceptibilities of Streptococcus pneumoniae strains isolated in Malaysia to six antibiotics
J. Antimicrob. Chemother. 1999 44: 852-853; doi:10.1093/jac/44.6.852 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Henrik Toft Sørensen, Helle Larsen, Elise Snitker Jensen, Ane Marie Thulstrup, Henrik C. Schønheyder, Gunnar Lauge Nielsen, and Andrew Czeizel

Safety of metronidazole during pregnancy: a cohort study of risk of congenital abnormalities, preterm delivery and low birth weight in 124 women
J. Antimicrob. Chemother. 1999 44: 854-856; doi:10.1093/jac/44.6.854 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book reviews:

R. C. Spencer

Of Mice, Men and Microbes: Hantavirus
J. Antimicrob. Chemother. 1999 44: 857; doi:10.1093/jac/44.6.857-a [Extract] [FREE Full Text] [PDF] [Request Permissions]  

R. Jones

Viral Infections in the Respiratory Tract (Lung Biology in Health and Disease Volume 127)
J. Antimicrob. Chemother. 1999 44: 857; doi:10.1093/jac/44.6.857-b [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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