Journal of Antimicrobial Chemotherapy

Leading articles:

Joanne M. Legg and Adrian J. Bint

Will pneumococci put quinolones in their place?
J. Antimicrob. Chemother. 1999 44: 425-427; doi:10.1093/jac/44.4.425 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Reviews:

Michael V. Martin

The use of fluconazole and itraconazole in the treatment of Candida albicans infections: a review
J. Antimicrob. Chemother. 1999 44: 429-437; doi:10.1093/jac/44.4.429 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Original articles:

Helene Carsenti-Etesse, Pierre-Marie Roger, Brigitte Dunais, Sophie Durgeat, G. Mancini, M. Bensoussan, and Pierre Dellamonica

Gradient plate method to induce Streptococcus pyogenes resistance
J. Antimicrob. Chemother. 1999 44: 439-443; doi:10.1093/jac/44.4.439 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. Wootton, K. E. Bowker, A. Janowska, H. A. Holt, and A. P. MacGowan

In-vitro activity of HMR 3647 against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and ß-haemolytic streptococci
J. Antimicrob. Chemother. 1999 44: 445-453; doi:10.1093/jac/44.4.445 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kyoichi Totsuka, Masayuki Shiseki, Ken Kikuchi, and Yuka Matsui

Combined effects of vancomycin and imipenem against methicillin-resistant Staphylococcus aureus (MRSA) in vitro and in vivo
J. Antimicrob. Chemother. 1999 44: 455-460; doi:10.1093/jac/44.4.455 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Marchese, E. Tonoli, E. A. Debbia, and G. C. Schito

Macrolide resistance mechanisms and expression of phenotypes among Streptococcus pneumoniae circulating in Italy
J. Antimicrob. Chemother. 1999 44: 461-464; doi:10.1093/jac/44.4.461 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. Hofbauer, D. Moser, B. Gmeiner, A. D. Kaye, S. Kapiotis, O. Wagner, and M. Frass

Amoxycillin/clavulanic acid combinations increase transmigration of leucocytes through endothelial cell monolayers: endothelial cells play a key role
J. Antimicrob. Chemother. 1999 44: 465-469; doi:10.1093/jac/44.4.465 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kate A. Cholewka, Lisa L. Ioannides-Demos, Lisa Liolios, Phillip Paull, W. John Spicer, and Allan J. McLean

Cephalosporin clinical concentration–time profile modelling and in-vitro bactericidal effects on Escherichia coli
J. Antimicrob. Chemother. 1999 44: 471-476; doi:10.1093/jac/44.4.471 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Melinda K. Lacy, David P. Nicolau, Mary Anne Banevicius, Charles H. Nightingale, and Richard Quintiliani

Protective effect of trovafloxacin, ciprofloxacin and ampicillin against Streptococcus pneumoniaein a murine sepsis model
J. Antimicrob. Chemother. 1999 44: 477-481; doi:10.1093/jac/44.4.477 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. Vanhoof, H. J. Nyssen, E. Van Bossuyt, and E. Hannecart-Pokorni

Aminoglycoside resistance in Gram-negative blood isolates from various hospitals in Belgium and the Grand Duchy of Luxembourg
J. Antimicrob. Chemother. 1999 44: 483-488; doi:10.1093/jac/44.4.483 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Andrzej Palucha, Barbara Mikiewicz, Waleria Hryniewicz, and Marek Gniadkowski

Concurrent outbreaks of extended-spectrum ß-lactamase-producing organisms of the family Enterobacteriaceae in a Warsaw hospital
J. Antimicrob. Chemother. 1999 44: 489-499; doi:10.1093/jac/44.4.489 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Robert Wilson, Rolf Kubin, Ian Ballin, Karl-Matthias Deppermann, Harry P. Bassaris, Paul Leophonte, Ad J. M. Schreurs, Antonio Torres, and Bernd Sommerauer

Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis
J. Antimicrob. Chemother. 1999 44: 501-513; doi:10.1093/jac/44.4.501 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

C. E. Langan, P. Zuck, F. Vogel, A. McIvor, W. Pierzchala, M. Smakal, H. Staley, and C. Marr

Randomized, double-blind study of short-course (5 day) grepafloxacin versus 10 day clarithromycin in patients with acute bacterial exacerbations of chronic bronchitis
J. Antimicrob. Chemother. 1999 44: 515-523; doi:10.1093/jac/44.4.515 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Philippe Saiag, Danielle Praindhui, and Claude Chastang

A double-blind, randomized study assessing the equivalence of valacyclovir 1000 mg once daily versus 500 mg twice daily in the episodic treatment of recurrent genital herpes
J. Antimicrob. Chemother. 1999 44: 525-531; doi:10.1093/jac/44.4.525 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brief reports:

Yoshikuni Onodera, Yoko Uchida, Mayumi Tanaka, and Kenichi Sato

Dual inhibitory activity of sitafloxacin (DU-6859a) against DNA gyrase and topoisomerase IV of Streptococcus pneumoniae
J. Antimicrob. Chemother. 1999 44: 533-536; doi:10.1093/jac/44.4.533 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ramakrishnan Srikumar, Eric Tsang, and Keith Poole

Contribution of the MexAB-OprM multidrug efflux system to the ß-lactam resistance of penicillin-binding protein and ß-lactamase-derepressed mutants of Pseudomonas aeruginosa
J. Antimicrob. Chemother. 1999 44: 537-540; doi:10.1093/jac/44.4.537 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mari Morgan, Roland Salmon, Dafydd Evans-Williams, Ian Hosein, and D. Nicholas Looker

Resistance to methicillin in isolates of Staphylococcus aureus from blood and cerebrospinal fluid in Wales, 1993–1997
J. Antimicrob. Chemother. 1999 44: 541-544; doi:10.1093/jac/44.4.541 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. M. Blondeau, R. Laskowski, and S. Borsos

In-vitro activity of cefepime and seven other antimicrobial agents against 1518 non-fermentative Gram-negative bacilli collected from 48 Canadian health care facilities
J. Antimicrob. Chemother. 1999 44: 545-548; doi:10.1093/jac/44.4.545 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Patricia M. Roblin and Margaret R. Hammerschlag

In-vitro activity of gatifloxacin against Chlamydia trachomatis and Chlamydia pneumoniae
J. Antimicrob. Chemother. 1999 44: 549-551; doi:10.1093/jac/44.4.549 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Eric Dannaoui, Florence Persat, Marie-France Monier, Elisabeth Borel, Marie-Antoinette Piens, and Stéphane Picot

In-vitro susceptibility of Aspergillus spp. isolates to amphotericin B and itraconazole
J. Antimicrob. Chemother. 1999 44: 553-555; doi:10.1093/jac/44.4.553 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Josep Guarro, Carme Aguilar, and Isabel Pujol

In-vitro antifungal susceptibilities of Basidiobolus and Conidiobolus spp. strains
J. Antimicrob. Chemother. 1999 44: 557-560; doi:10.1093/jac/44.4.557 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Elena Ortega, Manuel A. de Pablo, Aurelia M. Gallego, José Juan Gaforio, Carmen Alvarez, Alfonso Ruiz-Bravo, and Gerardo Alvarez de Cienfuegos

Modification of acquired immunity in mice by imipenem/cilastatin
J. Antimicrob. Chemother. 1999 44: 561-564; doi:10.1093/jac/44.4.561 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Stéphane Blanot, Claire Boumaila, and Patrick Berche

Intracerebral activity of antibiotics against Listeria monocytogenes during experimental rhombencephalitis
J. Antimicrob. Chemother. 1999 44: 565-568; doi:10.1093/jac/44.4.565 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rodrigo Martino, Maricel Subirá, Anna Sureda, and Jorge Sierra

Amphotericin B lipid complex at 3 mg/kg/day for treatment of invasive fungal infections in adults with haematological malignancies
J. Antimicrob. Chemother. 1999 44: 569-572; doi:10.1093/jac/44.4.569 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Giovanni Di Perri, Piero Olliaro, Stephen Ward, Benedetta Allegranzi, Stefano Bonora, and Ercole Concia

Rapid absorption and clinical effectiveness of intragastric mefloquine in the treament of cerebral malaria in African children
J. Antimicrob. Chemother. 1999 44: 573-576; doi:10.1093/jac/44.4.573 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Correspondence:

Derek Law, Caroline B. Moore, and David W. Denning

Discrepancies associated with the measurement of itraconazole serum concentrations by bioassays
J. Antimicrob. Chemother. 1999 44: 577-578; doi:10.1093/jac/44.4.577 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Vicki A. Luna and Marilyn C. Roberts

In-vitro activities of 11 antibiotics against 75 strains of Streptococcus pneumoniae with reduced susceptibilities to penicillin isolated from patients in Washington State
J. Antimicrob. Chemother. 1999 44: 578-580; doi:10.1093/jac/44.4.578 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Jon S. Brazier, Simon L. J. Stubbs, and Brian I. Duerden

Metronidazole resistance among clinical isolates belonging to the Bacteroides fragilis group: time to be concerned?
J. Antimicrob. Chemother. 1999 44: 580-581; doi:10.1093/jac/44.4.580 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Stavroula Panagea, John D. Perry, and F. Kate Gould

Should clindamycin be used as treatment of patients with infections caused by erythromycin-resistant staphylococci?
J. Antimicrob. Chemother. 1999 44: 581-582; doi:10.1093/jac/44.4.581 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Book reviews:

Giles C. Hartman

Urinary Tract Infections
J. Antimicrob. Chemother. 1999 44: 583; doi:10.1093/jac/44.4.583 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Corrigendum:

Ronald L. Nichols, Donald R. Graham, Steven L. Barriere, Anthony Rodgers, Samuel E. Wilson, Marcus Zervos, David L. Dunn, and Bruce Kreter

Treatment of hospitalized patients with complicated Gram- positive skin and skin structure infections: two randomized, multicentre studies of quinupristin/dalfopristin versus cefazolin, oxacillin or vancomycin
J. Antimicrob. Chemother. 1999 44: 585. [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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