Journal of Antimicrobial Chemotherapy

Leading articles:

I. CHOPRA

The magainins: antimicrobial peptides with potential for topical application
J. Antimicrob. Chemother. 1993 32: 351-353; doi:10.1093/jac/32.3.351 [PDF] [Request Permissions]  

Review:

Helena Cederlund and Per-Anders Mårdh

Antibacterial activities of non-antibiotic drugs
J. Antimicrob. Chemother. 1993 32: 355-365; doi:10.1093/jac/32.3.355 [Abstract] [PDF] [Request Permissions]  

Original articles:

Peter Heisig

High-level fluoroquinolone resistance in a Salmonella typhimurium isolate due to alterations in both gyrA and gyrB genes
J. Antimicrob. Chemother. 1993 32: 367-377; doi:10.1093/jac/32.3.367 [Abstract] [PDF] [Request Permissions]  

A. Denis and N. J. Moreau

Mechanisms of quinolone resistance in clinical isolates: accumulation of sparfloxacin and of fluoroquinolones of various hydrophobicity, and analysis of membrane composition
J. Antimicrob. Chemother. 1993 32: 379-392; doi:10.1093/jac/32.3.379 [Abstract] [PDF] [Request Permissions]  

S. L. Lacey, S. F. Moss, and G. W. Taylor

Metronidazole uptake by sensitive and resistant isolates of Helicobacter pylori
J. Antimicrob. Chemother. 1993 32: 393-400; doi:10.1093/jac/32.3.393 [Abstract] [PDF] [Request Permissions]  

J. J. S. Snell, D. F. J. Brown, S. F. Perry, and R. George

Antimicrobial susceptibility testing of enterococci: results of a survey conducted by the United Kingdom National External Quality Assessment Scheme for Microbiology
J. Antimicrob. Chemother. 1993 32: 401-411; doi:10.1093/jac/32.3.401 [Abstract] [PDF] [Request Permissions]  

R. Zemelman, H. Bello, M. Dominguez, G. Gonzalez, S. Mella, and A. Garcia

Activity of imipenem, third-generation cephalosporins, aztreonam and ciprofloxacin against multi-resistant Gram-negative bacilli isolated from Chilean hospitals
J. Antimicrob. Chemother. 1993 32: 413-419; doi:10.1093/jac/32.3.413 [Abstract] [PDF] [Request Permissions]  

Tetsuro Muratani, Eisaku Yokota, Tamiko Nakane, Eiko Inoue, and Susumu Mitsuhashi

In-vitro evaluation of the four ß-lactamase inhibitors: BRL42715, clavulanic acid, sulbactam, and tazobactam
J. Antimicrob. Chemother. 1993 32: 421-429; doi:10.1093/jac/32.3.421 [Abstract] [PDF] [Request Permissions]  

G. Bonfigilo and D. M. Livermore

Behaviour of ß-lactamase-positive and -negative Staphylococcus aureus isolates in susceptibility tests with piperacillin/tazobactam and other ß-lactam/ß-lactamase inhibitor combinations
J. Antimicrob. Chemother. 1993 32: 431-444; doi:10.1093/jac/32.3.431 [Abstract] [PDF] [Request Permissions]  

Arvind M. Dhople and Maria A. Ibanez

In-vitro activity of three new fluoroquinolones and synergy with ansamycins against Mycobacterium leprae
J. Antimicrob. Chemother. 1993 32: 445-451; doi:10.1093/jac/32.3.445 [Abstract] [PDF] [Request Permissions]  

Henry F. Chambers and Michael A. Fournier

Efficacy of cefoperazone in combination with sulbactam in experimental Staphylococcus aureus endocarditis in rabbits
J. Antimicrob. Chemother. 1993 32: 453-458; doi:10.1093/jac/32.3.453 [Abstract] [PDF] [Request Permissions]  

John S. Hostetler, Linda H. Hanson, and David A. Stevens

Effect of hydroxypropyl-ß-cyclodextrin on efficacy of oral itraconazole in disseminated murine cryptococcosis
J. Antimicrob. Chemother. 1993 32: 459-463; doi:10.1093/jac/32.3.459 [Abstract] [PDF] [Request Permissions]  

Karl V. Clemons and David A. Stevens

Therapeutic efficacy of a liposomal formulation of amphotericin B (AmBisome) against murine blastomycosis
J. Antimicrob. Chemother. 1993 32: 465-472; doi:10.1093/jac/32.3.465 [Abstract] [PDF] [Request Permissions]  

B. Veber, E. Vallée, J. M. Desmonts, J. J. Pocidalo, and E. Azoulay-Dupuis

Correlation between macrolide lung pharmacokinetics and therapeutic efficacy in a mouse model of pneumococcal pneumonia
J. Antimicrob. Chemother. 1993 32: 473-482; doi:10.1093/jac/32.3.473 [Abstract] [PDF] [Request Permissions]  

A. Pargal, C. Rao, K. K. Bhopale, K. S. Pradhan, K. B. Masani, and C. L. Kaul

Comparative pharmacokinetics and amoebicidal activity of metronidazole and satranidazole in the golden hamster, Mesocricetus auratus
J. Antimicrob. Chemother. 1993 32: 483-489; doi:10.1093/jac/32.3.483 [Abstract] [PDF] [Request Permissions]  

Hans G. W. de Groot, Paul A. Hustinx, Anno S. Lampe, and Willem M. Oosterwijk

Comparison of imipenem/cilastatin with the combination of aztreonam and clindamycin in the treatment of intra-abdominal infections
J. Antimicrob. Chemother. 1993 32: 491-500; doi:10.1093/jac/32.3.491 [Abstract] [PDF] [Request Permissions]  

For debate:

A. M. HARRIS

National and international aspects of susceptibility testing
J. Antimicrob. Chemother. 1993 32: 501-503; doi:10.1093/jac/32.3.501 [PDF] [Request Permissions]  

Correspondence:

KEITH J. WILLIAMS

Origins of chemotherapy
J. Antimicrob. Chemother. 1993 32: 505-507; doi:10.1093/jac/32.3.505 [PDF] [Request Permissions]  

D. M. MACLAREN

Antimicrobial prophylaxis in surgery: microbiological factors
J. Antimicrob. Chemother. 1993 32: 507; doi:10.1093/jac/32.3.507 [PDF] [Request Permissions]  

F. SCAGLIONE, S. DUGNANI, G. DEMARTINI, M. SAUDELLI, G. GALMOZZI, and F. FRASCHINI

The postantibiotic effect of clarithromycin and its major human metabolite, 14-hydroxyclarithromycin
J. Antimicrob. Chemother. 1993 32: 507-509; doi:10.1093/jac/32.3.507-a [PDF] [Request Permissions]  

KHALEDA HAIDER, M. A. MALEK, and M. JOHN ALBERT

Occurrence of drug resistance in Shigella species isolated from patients with diarrhoea in Bangladesh
J. Antimicrob. Chemother. 1993 32: 509-511; doi:10.1093/jac/32.3.509 [PDF] [Request Permissions]  

Book review:

DAVID GREENWOOD

Book review
J. Antimicrob. Chemother. 1993 32: 513; doi:10.1093/jac/32.3.513 [PDF] [Request Permissions]  

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