Journal of Antimicrobial Chemotherapy

Leading articles:

I. M. GOULD

Control of antibiotic use in the United Kingdom
J. Antimicrob. Chemother. 1988 22: 395-397; doi:10.1093/jac/22.4.395 [PDF] [Request Permissions]  

A. H. WILLIAMS and R. N. GRÜNEBERG

Teicoplanin revisited
J. Antimicrob. Chemother. 1988 22: 397-401; doi:10.1093/jac/22.4.397 [PDF] [Request Permissions]  

Review:

A. Stanley Tyms, John D. Williamson, and Cyrus J. Bacchi

Polyamine inhibitors in antimicrobial chemotherapy
J. Antimicrob. Chemother. 1988 22: 403-427; doi:10.1093/jac/22.4.403 [PDF] [Request Permissions]  

Original articles:

B. A. Wylie, S. G. B. Amyes, H.-K. Young, and H. J. Koornhof

Identification of a novel plasmid-encoded dihydrofolate reductase mediating high-level resistance to trimethoprim
J. Antimicrob. Chemother. 1988 22: 429-435; doi:10.1093/jac/22.4.429 [Abstract] [PDF] [Request Permissions]  

D. Abeck, A. P. Johnson, Y. Dangor, and R. C. Ballard

Antibiotic susceptibilities and plasmid profiles of Haemophilus ducreyi isolates from southern Africa
J. Antimicrob. Chemother. 1988 22: 437-444; doi:10.1093/jac/22.4.437 [Abstract] [PDF] [Request Permissions]  

A. J. Howard and K. T. Dunkin

Comparative in-vitro activity of a new oral carbacephem, LV163892
J. Antimicrob. Chemother. 1988 22: 445-456; doi:10.1093/jac/22.4.445 [Abstract] [PDF] [Request Permissions]  

B. G. Moffie and R. P. Mouton

Sensitivity and resistance of Legionella pneumophila to some antibiotics and combinations of antibiotics
J. Antimicrob. Chemother. 1988 22: 457-462; doi:10.1093/jac/22.4.457 [Abstract] [PDF] [Request Permissions]  

N. Woodford and C. A. Ison

The effect of media on antimicrobial susceptibility testing of Neisseria gonorrhoeae
J. Antimicrob. Chemother. 1988 22: 463-471; doi:10.1093/jac/22.4.463 [Abstract] [PDF] [Request Permissions]  

F. C. Odds and C. E. Webster

Effects of azole antifungals in vitro on host/parasite interactions relevant to candida infections
J. Antimicrob. Chemother. 1988 22: 473-481; doi:10.1093/jac/22.4.473 [Abstract] [PDF] [Request Permissions]  

Reuben Ramphal, Michel Lhermitte, M. Filliat, and Philippe Roussel

The binding of anti-pseudomonal antibiotics to macromolecules from cystic fibrosis sputum
J. Antimicrob. Chemother. 1988 22: 483-490; doi:10.1093/jac/22.4.483 [Abstract] [PDF] [Request Permissions]  

Marbeth I. Stevenson, Eileen M. Scott, and Paul S. Collier

Effect of ciprofloxacin in an in-vitro pharmacokinetic model against Pseudomonas aeruginosa isolated during cystic fibrosis lung infection
J. Antimicrob. Chemother. 1988 22: 491-498; doi:10.1093/jac/22.4.491 [Abstract] [PDF] [Request Permissions]  

Jacques Berré, Jean-Pierre Thys, Mireille Husson, Diamon Gangji, and Jean Klastersky

Penetration of ciprofloxacin in bronchial secretions after intravenous administration
J. Antimicrob. Chemother. 1988 22: 499-504; doi:10.1093/jac/22.4.499 [Abstract] [PDF] [Request Permissions]  

Cluade Martin, Marie-Noëlle Mallet, Pierre Saux, Bernard Bruguerolle, Viviane Herat, and François Gouin

Tobramycin dosing in mechanically ventilated patients Inaccuracy of a ‘rule of thumb’
J. Antimicrob. Chemother. 1988 22: 505-511; doi:10.1093/jac/22.4.505 [Abstract] [PDF] [Request Permissions]  

M. Nowicki, J. C. Paucod, N. Bornstein, H. Meugnier, P. Isoard, and J. Fleurette

Comparative efficacy of five antibiotics on experimental airborne legionellosis in guinea-pigs
J. Antimicrob. Chemother. 1988 22: 513-519; doi:10.1093/jac/22.4.513 [Abstract] [PDF] [Request Permissions]  

Silvia E. Schliamser, Hans Bolander, Harry Kourtopoulos, Jarl Sigaard, and S. Ragnar Norrby

Neurotoxicity of benzylpenicillin in experimental Escherichia coli meningitis
J. Antimicrob. Chemother. 1988 22: 521-528; doi:10.1093/jac/22.4.521 [Abstract] [PDF] [Request Permissions]  

Arnold S. Bayer, Patrick Lindsay, and Thomas R. Parr, Jr.

In-vitro and in-vivo bacterocodal interactions of clindamycin and ceftazidime, by non-ß-lactamase mechanisms, in experimental Pseudomonas aeruginosa endocarditis caused by a constitutive ß-lactamase overproducing strain
J. Antimicrob. Chemother. 1988 22: 529-539; doi:10.1093/jac/22.4.529 [Abstract] [PDF] [Request Permissions]  

S. R. Norrby, L. Dotevall, M. Eriksson, B. Settergren, P. Larsson, R. Lundholm, L. Å Burman, and K. Alestig

Efficacy and safety of cefpirome (FLR810)
J. Antimicrob. Chemother. 1988 22: 541-547; doi:10.1093/jac/22.4.541 [Abstract] [PDF] [Request Permissions]  

Gregory P. Melcher, Ted L. Hadfield, John K. Gaines, and Richard E. Winn

Comparative efficacy and toxicity of roxithromycin and erythromycin ethylsuccinate in the treatment of streptococcal pharyngitis in adults
J. Antimicrob. Chemother. 1988 22: 549-556; doi:10.1093/jac/22.4.549 [Abstract] [PDF] [Request Permissions]  

Elaine D. Letendre, Renée Mantha, and Pierre L. Turgeon

Selection of resistance by piperacillin during Pseudomonas aeruginosa endocarditis
J. Antimicrob. Chemother. 1988 22: 557-562; doi:10.1093/jac/22.4.557 [Abstract] [PDF] [Request Permissions]  

K. Tullus, B. Berglund, B. Fryklund, I. Kühn, and L. G. Burman

Influence of antibiotic therapy on faecal carriage of P-fimbriated Escherichia coli and other Gram-negative bacteria in neonates
J. Antimicrob. Chemother. 1988 22: 563-568; doi:10.1093/jac/22.4.563 [Abstract] [PDF] [Request Permissions]  

Correspondence:

DAVID J. MORRIS

Antiviral chemoprophylaxis for cytomegalovirus infection
J. Antimicrob. Chemother. 1988 22: 569; doi:10.1093/jac/22.4.569 [PDF] [Request Permissions]  

B. CHATTOPADHYAY

The continuing problem of pneumococcal infection
J. Antimicrob. Chemother. 1988 22: 569-570; doi:10.1093/jac/22.4.569-a [PDF] [Request Permissions]  

OLE E. CHRISTENSEN, KJELD K. TUXEN, and PAUL MENDAY

Treatment of travellers' diarrhoea with pivmecillinam
J. Antimicrob. Chemother. 1988 22: 570-571; doi:10.1093/jac/22.4.570 [PDF] [Request Permissions]  

ARN ELIASSON, J. BRUCE MCCLAIN, SARA ROTHMAN, ARTHUR DOBEK, JAMES MALCOLM, and ALAN CROSS

A survey of faecal cytotoxin in cefoperazone induced diarrhoea
J. Antimicrob. Chemother. 1988 22: 571-573; doi:10.1093/jac/22.4.571 [PDF] [Request Permissions]  

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