In vitro selection of Plasmodium falciparum drug-resistant parasite lines
Abstract
The in vitro selection of antimicrobial resistance in important pathogens can provide critical information on the genetic basis of drug resistance, and such information can be used to predict, anticipate and even contain the spread of resistance in clinical practice. For instance, the discovery of the role of pfmdr1 in mefloquine resistance in malaria parasites resulted from in vitro studies. However, the in vitro selection of resistance is difficult, challenging and time consuming. In this review, we discuss the key parameters that impact on the efficiency of the in vitro selection of resistance, and propose strategies to improve and streamline this process.
Key words
- ‘accelerated resistance to multidrug’
- clones
- per-parasite resistant frequency
- mutation rate
- resistance indexes
- © The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This Article
- This article is Open AccessOA
- » AbstractFree
- Full Text (HTML)
- Full Text (PDF)
-
All Versions of this Article:
- dkp449v1
- 65/3/390 most recent
Classifications
Services
Citing Articles
Google Scholar
PubMed
Related Content
Share
- Email this article
-
CiteULike
Connotea
Delicious
Facebook
Google+
Mendeley
Twitter
The Journal
Published on behalf of
Impact factor: 4.659
5-Yr impact factor: 4.480
Alerting Services
Corporate Services
Most
-
Most Read
- Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults: a report of the Working Party of the British Society for Antimicrobial Chemotherapy
- Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact
- Herbal medicines for treatment of bacterial infections: a review of controlled clinical trials
- An analysis of antibiotic prescriptions from general dental practitioners in England
- Antibiotic treatment of Gram-positive bone and joint infections
-
Most Cited
- Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility
- Determination of minimum inhibitory concentrations
- CTX-M: changing the face of ESBLs in Europe
- Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum {beta}-lactamases in the UK
- Synergy, antagonism, and what the chequerboard puts between them
Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.