Limitations of antibiotic options for invasive infections caused by methicillin-resistant Staphylococcus aureus: is combination therapy the answer?
Abstract
Invasive infections caused by methicillin-resistant Staphylococcus aureus (MRSA), particularly those involving persistent bacteraemia, necrotizing pneumonia, osteomyelitis and other deep-seated sites of infections, are associated with high mortality and are often difficult to treat. The response to treatment of severe MRSA infection with currently available antibiotics active against MRSA is often unsatisfactory, leading some physicians to resort to combination antibiotic therapy. Now, with the emergence of community-associated MRSA (CA-MRSA) clones that display enhanced virulence potentially related to up-regulated toxin production, the use of adjuvant protein synthesis-inhibiting antibiotics to reduce toxin production also has been advocated by some experts. In this review, we discuss the limitations of antibiotics currently available for the treatment of serious invasive MRSA infections and review the existing literature that examines the potential role of combination therapy in these infections.
Key words
- Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy 2009. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
This Article
- » AbstractFree
- Full Text (HTML)Free
- Full Text (PDF)Free
-
All Versions of this Article:
- dkp377v1
- 65/1/24 most recent
Classifications
Services
Citing Articles
Google Scholar
PubMed
Related Content
Share
- Email this article
-
CiteULike
Connotea
Delicious
Facebook
Google+
Mendeley
Twitter
The Journal
Published on behalf of
Impact factor: 4.659
5-Yr impact factor: 4.480
Alerting Services
Corporate Services
Most
-
Most Read
- Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults: a report of the Working Party of the British Society for Antimicrobial Chemotherapy
- Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact
- Herbal medicines for treatment of bacterial infections: a review of controlled clinical trials
- An analysis of antibiotic prescriptions from general dental practitioners in England
- Antibiotic treatment of Gram-positive bone and joint infections
-
Most Cited
- Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility
- Determination of minimum inhibitory concentrations
- CTX-M: changing the face of ESBLs in Europe
- Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum {beta}-lactamases in the UK
- Synergy, antagonism, and what the chequerboard puts between them
Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.