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JAC Advance Access published online on June 17, 2009

Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkp219
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letter

Toxicokinetics of voriconazole during massive intentional poisoning

Hadrien Rozé1,*, Mathieu Lafargue1, Olivier Joannes-Boyau1, Hélène Batoz1, Claire Dromer2, Dominique Breilh3 and Gérard Janvier1

1 Thoracic Intensive Care Department, Bordeaux University Hospital, Pessac, France 2 Cardio-pulmonary Transplantation Department, Bordeaux University Hospital, Pessac, France 3 Clinical Pharmacokinetics and Pharmacy Department, Bordeaux University Hospital, Pessac, France


* Corresponding author. SAR 2, Hôpital Haut Lévèque, avenue Magellan, 33600 Pessac, France. Tel: +33-5-57-65-68-66; Fax: +33-5-57-65-68-11; E-mail: hadrien.roze@chu-bordeaux.fr

Key Words: invasive pulmonary aspergillosis , pharmacokinetics , drug toxicity , lung transplantation

The first 10% of the full text of this article appears below.

Sir,

We describe the case of a middle-aged man who intentionally poisoned himself with 9.8 g of voriconazole, 60 mg of prednisolone, 4 g of sulfamethoxazole, 2.5 g of azithromycin and 120 mg of bromazepam. This patient with cystic fibrosis had undergone bilateral lung transplantation 7 years previously. He had been . . . [Full Text of this Article]


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