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JAC Advance Access published online on October 27, 2008
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkn426
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

Emergence of Qnr determinants in human Salmonella isolates in Taiwan

Jiunn-Jong Wu1, Wen-Chien Ko2, Chien-Shun Chiou3, Hung-Mo Chen4, Li-Ron Wang1,4 and Jing-Jou Yan4,*

1 Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University Medical College, Tainan 70101, Taiwan 2 Department of Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan 70428, Taiwan 3 The Central Branch Office, Center for Disease Control, Taichung 40855, Taiwan 4 Department of Pathology, National Cheng Kung University Medical College and Hospital, Tainan 70428, Taiwan

Received 17 May 2008; returned 21 July 2008; revised 18 August 2008; accepted 18 September 2008

* Corresponding author. Tel: +886-6-235-3535; Fax: +886-6-276-6195; E-mail: jingjou{at}mail.ncku.edu.tw

Objectives: The aim of this study was to determine the prevalence and characteristics of qnr-carrying Salmonella isolates from humans in southern Taiwan.

Methods: A total of 446 Salmonella isolates collected between 2003 and 2006 were screened for qnrA, qnrB and qnrS by PCR experiments. Genetic structures of qnr were determined by PCR-based methods or direct sequencing of plasmid DNA.

Results: qnrB2 and qnrS1 were detected in two serovar Enteritidis isolates and two serovar Typhimurium isolates, respectively. One qnrS1-positive isolate was found to produce the CMY-2 AmpC enzyme. qnrS1 was identified on a 10 kb plasmid, which exhibited >99% nucleotide sequence identity with plasmid TPqnrS-1a reported from the UK. qnrB2 was found in a complex sul1-type class 1 integron on a >100 kb plasmid.

Conclusions: This study demonstrated the occurrence of qnrB2 and qnrS1 in Salmonella for the first time in Taiwan and characterized their genetic structures.

Key Words: quinolones , cephalosporinases , plasmid-mediated quinolone resistance


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