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JAC Advance Access published online on September 28, 2008
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkn414
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letter

An HPLC assay for daptomycin in serum

C. M. Tobin*, J. M. Darville, A. M. Lovering and A. P. MacGowan

Bristol Centre for Antimicrobial Research and Evaluation, Microbiology Department, Southmead Hospital, North Bristol NHS Trust, Bristol BS10 5NB, UK

* Corresponding author. Tel: +44-117-9505050, ext. 4311; Fax: +44-117-9592317; E-mail: caroline.tobin@nbt.nhs.uk

Key Words: therapeutic drug monitoring , antibiotics , pharmacokinetics

The first 10% of the full text of this article appears below.

Sir,

The lipopeptides have a unique mode of action.1 Although they are active against all clinically important Gram-positive bacteria,2 they display no activity against Gram-negative organisms.3,4 Daptomycin has been licensed for the treatment of complicated skin and skin structure infections, and for right-sided endocarditis. The approved dosage in the UK is 4 mg/kg daily. For Staphylococcus aureus bacteraemia and endocarditis, a dosage of 6 mg/kg daily is advised (British National Formulary 55, March . . . [Full Text of this Article]


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