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JAC Advance Access published online on September 8, 2008
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkn380
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

UK epidemic Escherichia coli strains A–E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone

Siu Ha Lau1,2, Mary E. Kaufmann3, David M. Livermore3, Neil Woodford3, Geraldine A. Willshaw3, Tom Cheasty3, Katie Stamper4, Suganya Reddy5, John Cheesbrough5, Frederick J. Bolton2, Andrew J. Fox2 and Mathew Upton1,*

1 Department of Medical Microbiology, School of Medicine, University of Manchester, Clinical Sciences Building, Manchester Royal Infirmary, Manchester M13 9WL, UK 2 Health Protection Agency North West Laboratory, Clinical Science Building, Manchester Royal Infirmary, Manchester M13 9WZ, UK 3 Health Protection Agency, Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK 4 The Microbiology Department, Stepping Hill Hospital, Poplar Grove, Hazel Grove, Stockport NHS Foundation Trust, Stockport SK2 7JE, UK 5 Preston Microbiology Services, Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust, Sharoe Green Lane, Preston, Lancashire PR2 9HT, UK

Received 30 June 2008; accepted 13 August 2008

* Corresponding author. Tel: +44-161-276-8828; Fax: +44-161-276-8826; E-mail: mat.upton{at}manchester.ac.uk

Objectives: Uropathogenic and invasive Escherichia coli O25:H4-ST131 isolates producing CTX-M-15 extended-spectrum β-lactamase (ESBL) enzymes have recently been shown to be disseminated across the globe. In the UK, many CTX-M-15 ESBL-producing E. coli strains have been previously defined as belonging to the epidemic strains A–E, as determined by PFGE. The present study was carried out to define the relationship between these two groups of pathogenic E. coli.

Methods: Multilocus sequence typing and PFGE were used for molecular characterization of a collection of 61 ESBL-producing E. coli isolates from across the UK.

Results: Strains A to E all belonged to the ST131 clone, further underscoring the epidemiological importance of this lineage.

Conclusions: The future spread of the ST131 clone, and its UK variants, should be monitored closely and the pathogenic mechanisms explaining their success should be investigated.

Key Words: multilocus sequence typing , MLST , molecular epidemiology , uropathogenic Escherichia coli , UPEC , extended-spectrum β-lactamases , PFGE


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