Skip Navigation



JAC Advance Access published online on May 19, 2008
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkn213
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Data
Right arrow All Versions of this Article:
62/3/617    most recent
dkn213v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Moulin, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moulin, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

A comparison of antimicrobial usage in human and veterinary medicine in France from 1999 to 2005

Gérard Moulin1, Philippe Cavalié2, Isabelle Pellanne2, Anne Chevance1, Arlette Laval3, Yves Millemann4, Pierre Colin5, Claire Chauvin on behalf of the ‘Antimicrobial Resistance’ ad hoc Group of the French Food Safety Agency6,*,{dagger}

1 AFSSA ANMV French Agency for Veterinary Medicinal Products, Fougères, France 2 AFSSAPS French Health Products Safety Agency, St Denis, France 3 National Veterinary School of Nantes, Nantes, France 4 National Veterinary School of Alfort, Maisons-Alfort, France 5 ESMISAB, University of Brest, Plouzané, France 6 AFSSA French Food Safety Agency, Ploufragan, France

Received 10 January 2008; returned 21 April 2008; revised 22 February 2008; accepted 27 April 2008

* Correspondence address. AFSSA French Food Safety Agency, LERAP, BP 53, Zoopole, 22440 Ploufragan, France. Tel: +33-2-96-01-62-66; Fax: +33-2-96-01-62-95; E-mail: c.chauvin{at}afssa.fr

Objectives: The antimicrobials allowed and amounts sold in veterinary and human medicine in France were compared to see if the same antimicrobial drugs are used in veterinary and human medicine, and to the same extent.

Methods: Registers of all approved antimicrobial commercial products, kept by the French Agency for Veterinary Medicinal Products (AFSSA ANMV) for animals and the French Health Products Safety Agency (AFSSAPS) for humans, were compared to determine whether the same antimicrobials were approved in 2007 for use in both human and animal populations. Sales data were collected from pharmaceutical companies between 1999 and 2005 by the AFSSA ANMV and AFSSAPS. Usage of the different antimicrobial anatomical therapeutic chemical (ATC) classes in human and veterinary medicines was recorded. Data were expressed in tonnes of active ingredients and were then related to the animal and human biomasses to compare usages expressed in mg/kg.

Results: All antimicrobial ATC classes were used in both human and veterinary medicine. Tetracyclines accounted for the most sales in veterinary medicine. β-Lactams predominated in human medicine. A decrease in the amounts consumed by both human and animal populations was observed during the study. In 2005, 760 tonnes were used in human medicine and 1320 tonnes in veterinary medicine, corresponding to 199 and 84 mg/kg of live weight in human and animal populations, respectively.

Conclusions: The same antimicrobial drugs were used in human and veterinary medicines but the quantitative patterns of use were different. Expression of antimicrobial usage is a key point to address when comparing usage trends.

Key Words: anti-infectives , drug use surveillance , data collection , measurement unit

{dagger} Members are listed in the Acknowledgements section.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.