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JAC Advance Access published online on April 19, 2008
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkn124
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

In vitro activity of telavancin against recent Gram-positive clinical isolates: results of the 2004–05 Prospective European Surveillance Initiative

Deborah C. Draghi1, Bret M. Benton2, Kevin M. Krause2, Clyde Thornsberry1, Chris Pillar1 and Daniel F. Sahm1,*

1 Eurofins Medinet, Inc., 13665 Dulles Technology Drive, Suite 200, Herndon, VA, USA 2 Theravance, Inc., 901 Gateway Boulevard, South San Francisco, CA, USA

Received 20 December 2007; returned 20 February 2008; revised 21 January 2008; accepted 27 February 2008

* Corresponding author. Tel: +1-703-480-2536; Fax: +1-703-480-2654; E-mail: daniel.sahm{at}eurofinsmedinet.com

Objectives: Telavancin is a novel semi-synthetic lipoglycopeptide currently in late-stage clinical development for the treatment of serious infections due to Gram-positive bacteria. The objective of this study was to provide a baseline prospective assessment of its in vitro activity against a large and diverse collection of Gram-positive clinical isolates from Europe and Israel.

Methods: Gram-positive clinical isolates, collected between October 2004 and December 2005 from 36 hospital laboratories in 15 countries, were tested by broth microdilution using CLSI methodology.

Results: In total, 3206 isolates were collected. Telavancin had potent activity against Staphylococcus aureus and coagulase-negative staphylococci (MIC range ≤0.015 to 2 mg/L), independent of resistance to methicillin or to multiple drugs. Telavancin had particularly strong activity against streptococcal isolates (MIC range ≤0.001 to 0.5 mg/L), including penicillin-resistant and multiple drug-resistant Streptococcus pneumoniae and erythromycin non-susceptible β-haemolytic and viridans group streptococci. Telavancin also had excellent activity against vancomycin-susceptible enterococci (MIC90 0.5 mg/L), and although its MICs were elevated against VanA strains (Enterococcus faecalis MIC90 8 mg/L and Enterococcus faecium MIC90 4 mg/L), its MIC90 was substantially lower than observed with available glycopeptides.

Conclusions: Telavancin has potent in vitro activity against contemporary Gram-positive clinical isolates from diverse geographic areas in Europe and Israel.

Key Words: susceptibility tests , Staphylococcus aureus , enterococci , Streptococcus spp.


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