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JAC Advance Access published online on March 3, 2008
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkn083
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letter

Antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis isolates in eight Central, East and Baltic European countries in 2005–06: results of the Cefditoren Surveillance Study

M. Gracia1, C. Díaz1, P. Coronel2, M. Gimeno2, R. García-Rodas1, G. del Prado1, L. Huelves1, V. Ruiz1, P. L. Naves1, M. C. Ponte1, J. J. Granizo3 and F. Soriano1,*

1 Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundación Jiménez Díaz, Avenida de Reyes Católicos 2, 28040 Madrid, Spain 2 Scientific Department, Tedec-Meiji Farma, S.A., Madrid, Spain 3 Granadata, Madrid, Spain

* Corresponding author. Tel: +34-915447387; Fax: +34-915494764; E-mail: fsoriano@fjd.es

Key Words: ampicillin resistance , amoxicillin/clavulanic acid , cefditoren , β-lactamases

The first 10% of the full text of this article appears below.

Sir,

Cefditoren pivoxil is an aminothiazolyl oral cephalosporin with a broad spectrum of activity against Gram-positive and Gram-negative pathogens and is stable to hydrolysis by many common β-lactamases.1 It has been shown to be active in vitro against many respiratory tract pathogens including Haemophilus influenzae and Moraxella catarrhalis.1 Resistance of both organisms to β-lactam antibiotics is generally conferred by either the presence of β-lactamase or as a result of alterations in penicillin-binding protein 3.

In this study, we compare the in vitro activity of cefditoren with that of nine other . . . [Full Text of this Article]


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