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JAC Advance Access published online on February 8, 2008
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkn022
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

Antifungal susceptibility profile of clinical Fusarium spp. isolates identified by molecular methods

Ana Alastruey-Izquierdo, Manuel Cuenca-Estrella, Araceli Monzón, Emilia Mellado and Juan Luís Rodríguez-Tudela*

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain

Received 20 July 2007; returned 3 December 2007; revised 30 October 2007; accepted 3 January 2008

* Corresponding author. Tel: +34-918223919; Fax: +34-915097966; E-mail: jlrtudela{at}isciii.es

Objectives: To analyse the susceptibility pattern of a collection of Fusarium clinical isolates.

Methods: The antifungal susceptibility pattern of 67 isolates of Fusarium was analysed. Strains were identified by morphological and molecular methods by means of sequencing elongation factor {alpha}.

Results and conclusions: Six different species were identified. Fusarium solani was the most frequently isolated, followed by Fusarium oxysporum, Fusarium proliferatum and Fusarium verticilloides. Amphotericin B was the only drug with in vitro activity (range: 0.015–32 mg/L). The rest of the antifungals tested (itraconazole, voriconazole, ravuconazole, posaconazole and terbinafine) showed very poor activity against Fusarium, confirming the multiresistant nature of this genus.

Key Words: elongation factor {alpha} , antifungal resistance , emerging moulds


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