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JAC Advance Access published online on December 21, 2007
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkm501
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Correspondence

Treatment of external ventricular drain-associated ventriculitis caused by Enterococcus faecalis with intraventricular daptomycin

Juliet Elvy1, David Porter2 and Erwin Brown1,*

1 Department of Medical Microbiology, Frenchay Hospital, Bristol BS16 1LE, UK 2 Department of Neurosurgery, Frenchay Hospital, Bristol BS16 1LE, UK

* Corresponding author. Tel: +44-117-9186590; Fax: +44-117-9571866; E-mail: erwin.brown@nbt.nhs.uk

Key Words: neurosurgical infections , ventricular access device , intrathecal

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Sir,

External ventricular drains (EVDs) are essential monitoring devices in neurosurgery, and direct portals for the removal of cerebrospinal fluid (CSF), including the temporary control of raised intracranial pressure, and for the instillation of therapeutic agents. Their benefits must be balanced against the complications associated with their use, the most important of which is infection (ventriculitis). Most patients with EVD-associated ventriculitis can be cured by instilling antibiotics directly into the ventricles.1 We describe here a patient with such an infection treated by administering daptomycin using . . . [Full Text of this Article]

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