JAC Advance Access published online on December 19, 2007
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkm484
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Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis
1 Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa 2 Médecins Sans Frontières, Khayelitsha, Cape Town, South Africa 3 Department of Public Health, University of Cape Town, South Africa
Received 26 July 2007; returned 7 October 2007; revised 16 November 2007; accepted 21 November 2007
* Corresponding author. Tel: +27-21-4066293; Fax: +27-21-4481989; E-mail: karen.cohen{at}uct.ac.za
Background and objectives: Nevirapine-containing antiretroviral therapy (ART) and rifampicin-based antitubercular therapy are commonly co-administered in Africa, where nevirapine is often the only available non-nucleoside reverse transcriptase inhibitor. Rifampicin induces the metabolism of nevirapine, but the extent of the reduction in nevirapine concentrations has varied widely in previous studies. We describe the steady-state pharmacokinetics of nevirapine during and after antitubercular therapy in South African patients.
Methods: Sixteen patients receiving ART including standard doses of nevirapine were admitted twice for intensive pharmacokinetic sampling: during and after rifampicin-based antitubercular therapy.
Results: Geometric mean ratios for nevirapine pharmacokinetic parameters during versus after antitubercular therapy were 0.61 [90% confidence interval (CI) 0.49–0.79] for Cmax, 0.64 (90% CI 0.52–0.80) for area under the curve up to 12 h (AUC0–12) and 0.68 (90% CI 0.53–0.86) for Cmin. Nevirapine Cmin was subtherapeutic (<3 mg/L) in six patients during antitubercular therapy (one of whom developed virological failure) and in none afterwards. There was no correlation between rifampicin concentrations and the degree of nevirapine induction assessed by the proportional change in nevirapine concentrations between the two admissions. The ratio of nevirapine AUC0–12 to the AUC0–12 of its 12-hydroxy metabolite was significantly lower in the presence of antitubercular therapy, consistent with induced metabolism.
Conclusions: Nevirapine concentrations were significantly decreased by concomitant rifampicin-based antitubercular therapy and a high proportion of patients had subtherapeutic plasma concentrations. Further study in African patients is required to determine the implications for treatment outcomes.
Key Words: pharmacokinetics , interaction , 12-hydroxynevirapine
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