Skip Navigation



JAC Advance Access published online on October 25, 2007
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkm410
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
61/1/1    most recent
dkm410v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Millar, B. C.
Right arrow Articles by Moore, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Millar, B. C.
Right arrow Articles by Moore, J. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Leading article

Community-associated MRSA (CA-MRSA): an emerging pathogen in infective endocarditis

B. Cherie Millar1, Bernard D. Prendergast2 and John E. Moore1,*

1 Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Lisburn Road, Belfast BT9 7AD, Northern Ireland, UK 2 Department of Cardiology, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK

* Corresponding author. Tel: +44-28-9026-3554; Fax: +44-28-9026-3991; E-mail: jemoore{at}niphl.dnet.co.uk

Over the last decade, a novel methicillin-resistant Staphylococcus aureus (MRSA) has emerged, primarily associated with healthy individuals within the community. This organism is distinct from healthcare-associated MRSA (HA-MRSA) in terms of epidemiology, microbiology and clinical manifestation and as such has been defined as community-associated MRSA (CA-MRSA). Given that S. aureus is a major aetiological agent of infective endocarditis (IE), particularly associated with the iv drug user population, reports of IE attributed to CA-MRSA are now emerging in the literature. The aims of this article are to (i) define and contrast CA-MRSA with HA-MRSA; (ii) review the published cases of CA-MRSA IE to date; and (iii) evaluate the current international recommendations for antibiotic prophylaxis and treatment regimens for IE in relation to CA-MRSA.

Key Words: community-acquired MRSA , PVL , Panton-Valentine leucocidin


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
L. I. Llarrull, J. F. Fisher, and S. Mobashery
Molecular Basis and Phenotype of Methicillin Resistance in Staphylococcus aureus and Insights into New {beta}-Lactams That Meet the Challenge
Antimicrob. Agents Chemother., October 1, 2009; 53(10): 4051 - 4063.
[Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J. Meng, H. Wang, Z. Hou, T. Chen, J. Fu, X. Ma, G. He, X. Xue, M. Jia, and X. Luo
Novel Anion Liposome-Encapsulated Antisense Oligonucleotide Restores Susceptibility of Methicillin-Resistant Staphylococcus aureus and Rescues Mice from Lethal Sepsis by Targeting mecA
Antimicrob. Agents Chemother., July 1, 2009; 53(7): 2871 - 2878.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
V. Dubois, C. Arpin, V. Dupart, A. Scavelli, L. Coulange, C. Andre, I. Fischer, F. Grobost, J.-P. Brochet, I. Lagrange, et al.
{beta}-Lactam and aminoglycoside resistance rates and mechanisms among Pseudomonas aeruginosa in French general practice (community and private healthcare centres)
J. Antimicrob. Chemother., August 1, 2008; 62(2): 316 - 323.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
S. Wolff, H. Hahne, M. Hecker, and D. Becher
Complementary Analysis of the Vegetative Membrane Proteome of the Human Pathogen Staphylococcus aureus
Mol. Cell. Proteomics, August 1, 2008; 7(8): 1460 - 1468.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
H.-C. Tsai, Y.-S. Chen, S. S.-J. Lee, and Y.-C. Liu
Comment on: Community-associated MRSA (CA-MRSA): an emerging pathogen in infective endocarditis
J. Antimicrob. Chemother., April 1, 2008; 61(4): 966 - 967.
[Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
B. C. Millar, B. D. Prendergast, and J. E. Moore
Community-associated MRSA (CA-MRSA): an emerging pathogen in infective endocarditis--authors' response
J. Antimicrob. Chemother., April 1, 2008; 61(4): 967 - 968.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.