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JAC Advance Access published online on July 11, 2007
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkm257
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Antimicrobial resistance of Vibrio cholerae O1 serotype Ogawa isolated in Manhiça District Hospital, southern Mozambique

Inácio Mandomando1,2,*, Mateu Espasa1, Xavier Vallès1, Jahit Sacarlal1,3, Betuel Sigaúque1,2, Joaquim Ruiz4 and Pedro Alonso1,4

1 Centro de Investigação em Saúde da Manhiça (CISM), Maputo, Mozambique 2 Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique 3 Faculdade de Medicine, Universidade Eduardo Mondlane, Maputo, Mozambique 4 Centre for International Health Research (CRESIB), Hospital Clinic/IDIBAPS, Universitat de Barcelona, Spain

Received 20 March 2007; returned 27 April 2007; revised 4 June 2007; accepted 20 June 2007

* Correspondence address. Manhiça Health Research Centre, Street 12, Manhiça Village, PO Box 1929, Maputo, Mozambique. Tel: +258-21-810-002; Fax: +258-21-810-181; E-mail: inacio.mandomando{at}manhica.net, imandomando2004@yahoo.com.br

Objectives: To describe the antimicrobial susceptibility profile of isolated Vibrio cholerae O1 serotype Ogawa recovered from patients admitted to the cholera facility in the Manhiça District Hospital (MDH), Mozambique.

Methods: Rectal swabs were collected from patients with complaints symptomatic of cholera admitted to the MDH cholera facility. Samples were processed for V. cholerae isolation at the Centro de Investigação em Saúde da Manhiça (CISM) and identified by biochemical reaction. Serotypes were determined by slide-agglutination antisera. Susceptibilities were determined by disc diffusion.

Results: Seventy-seven isolates were examined for their resistance profile. High incidences of antimicrobial resistance were found for chloramphenicol (57.9%), co-trimoxazole (96.6%) and tetracycline (97.3%). Quinolone resistance remained low (4.2%).

Conclusions: Although V. cholerae infections in Africa do not usually require antimicrobial treatment, strains in rural Mozambique show high incidences of resistance to readily available drugs. When appropriate, quinolones or third-generation cephalosporins can be used as treatment options.

Key Words: susceptibility profile , cholera , diarrhoea


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