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JAC Advance Access published online on July 5, 2007
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkm252
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Evaluation of the BacT/ALERT PZA kit in comparison with the BACTEC 460TB PZA for testing Mycobacterium tuberculosis susceptibility to pyrazinamide

Lina Marcela Aragón1, Montserrat Garrigó1,2, Carmen Moreno1, Montserrat Español1 and Pere Coll1,2,*

1 Servei de Microbiología, Hospital de la Santa Creu i Sant Pau, Av. Sant Antoni Ma Claret, 167, 08025 Barcelona, Spain 2 Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain

Received 3 May 2007; returned 6 June 2007; revised 13 June 2007; accepted 15 June 2007

* Corresponding author. Tel: +34-93-2919069; Fax: +34-93-2919070; E-mail: pcoll{at}santpau.es

Objectives: To compare the performance of the BacT/ALERT PZA kit (BioMerieux, Marcy l'Etoile, France) with the radiometric BACTEC 460TB PZA test (Becton–Dickinson method) for testing Mycobacterium tuberculosis susceptibility to pyrazinamide.

Methods: A total of 50 M. tuberculosis strains were tested. Thirty of these strains had been previously considered pyrazinamide-susceptible and 20 pyrazinamide-resistant by BACTEC 460TB.

Results: Final overall agreement was 100%. Time needed for the susceptibility test was 6.69 days for the BacT/ALERT PZA kit versus 8.07 days for the BACTEC 460TB PZA test.

Conclusions: BacT/ALERT PZA test is an excellent alternative to BACTEC 460TB for pyrazinamide susceptibility testing.

Key Words: susceptibility testing , resistance , tuberculosis


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