Skip Navigation


JAC Advance Access first published online on March 5, 2007
This version published online on March 6, 2007
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkm007
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
59/4/633    most recent
dkm007v2
dkm007v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lee, J. H.
Right arrow Articles by Lee, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lee, J. H.
Right arrow Articles by Lee, J. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Differences in phenotypic and genotypic traits against antimicrobial agents between Acinetobacter baumannii and Acinetobacter genomic species 13TU

Jung Hoon Lee1, Chul Hee Choi1, Hee Young Kang1, Ji Young Lee1, Jungmin Kim1, Yoo Chul Lee1, Sung Yong Seol1, Dong Taek Cho1, Kun Woo Kim2, Do Young Song3 and Je Chul Lee1,*

1 Department of Microbiology, Kyungpook National University School of Medicine, Daegu 700-422, Republic of Korea 2 Department of Internal Medicine, Daegu Fatima Hospital, Daegu 701-600, Republic of Korea 3 Department of Clinical Pathology, Daegu Fatima Hospital, Daegu 701-600, Republic of Korea

Received 19 October 2006; returned 15 December 2006; revised 11 January 2007; accepted 12 January 2007

* Corresponding author. Tel: +82-53-420-4844; Fax: +82-53-427-5664; E-mail: leejc{at}knu.ac.kr

Objectives: To investigate the differences in antimicrobial susceptibility and resistance mechanisms against imipenem between Acinetobacter baumannii and Acinetobacter genomic species 13TU.

Methods: A total of 232 non-duplicate Acinetobacter species were consecutively collected from two Korean hospitals in Daegu, Republic of Korea, between November 2004 and November 2005. Antimicrobial susceptibility was determined by agar dilution methods. Resistance to imipenem was characterized by a carbapenemase activity test and PCR amplification. PFGE was performed to determine the clonal relatedness of imipenem-resistant Acinetobacter species.

Results: A. baumannii was the most prevalent species (61.2%), followed by Acinetobacter genomic species 13TU (25.9%). The resistance rates of A. baumannii to most antimicrobial agents were higher than those of other Acinetobacter species, while the resistance rate to imipenem was the highest in Acinetobacter genomic species 13TU. Imipenem-resistant Acinetobacter genomic species 13TU isolates produced VIM-2 metallo-ß-lactamase, while imipenem-resistant A. baumannii isolates produced OXA-23 and/or OXA-51 ß-lactamase. Imipenem-resistant Acinetobacter strains originated from different clones in each hospital.

Conclusions: Two prevalent Acinetobacter species, A. baumannii and Acinetobacter genomic species 13TU, possess distinct phenotypic and genotypic traits against antimicrobials.

Key Words: carbapenem resistance , metallo-ß-lactamases , ß-lactamases , A. baumannii


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Med MicrobiolHome page
R. Uma Karthika, R. Srinivasa Rao, S. Sahoo, P. Shashikala, R. Kanungo, S. Jayachandran, and K. Prashanth
Phenotypic and genotypic assays for detecting the prevalence of metallo-{beta}-lactamases in clinical isolates of Acinetobacter baumannii from a South Indian tertiary care hospital
J. Med. Microbiol., April 1, 2009; 58(4): 430 - 435.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
T.-L. Chen, R. C.-C. Wu, M.-F. Shaio, C.-P. Fung, and W.-L. Cho
Acquisition of a Plasmid-Borne blaOXA-58 Gene with an Upstream IS1008 Insertion Conferring a High Level of Carbapenem Resistance to Acinetobacter baumannii
Antimicrob. Agents Chemother., July 1, 2008; 52(7): 2573 - 2580.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
W.-C. Ko, N.-Y. Lee, S. C. Su, L. Dijkshoorn, M. Vaneechoutte, L.-R. Wang, J.-J. Yan, and T. C. Chang
Oligonucleotide Array-Based Identification of Species in the Acinetobacter calcoaceticus-A. baumannii Complex in Isolates from Blood Cultures and Antimicrobial Susceptibility Testing of the Isolates
J. Clin. Microbiol., June 1, 2008; 46(6): 2052 - 2059.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
Y.-C. Lin, W.-H. Sheng, S.-C. Chang, J.-T. Wang, Y.-C. Chen, R.-J. Wu, K.-C. Hsia, and S.-Y. Li
Application of a Microsphere-Based Array for Rapid Identification of Acinetobacter spp. with Distinct Antimicrobial Susceptibilities
J. Clin. Microbiol., February 1, 2008; 46(2): 612 - 617.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
S. A. Shelburne III, K. V. Singh, A. C. White Jr., L. Byrne, A. Carmer, C. Austin, E. Graviss, C. Stager, B. E. Murray, and R. L. Atmar
Sequential Outbreaks of Infections by Distinct Acinetobacter baumannii Strains in a Public Teaching Hospital in Houston, Texas
J. Clin. Microbiol., January 1, 2008; 46(1): 198 - 205.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.