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JAC Advance Access published online on December 1, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl482
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Received August 9, 2006
Revised October 24, 2006
Accepted November 3, 2006

Brief report

Differences in biofilm development and antibiotic susceptibility among Streptococcus pneumoniae isolates from cystic fibrosis samples and blood cultures

María García-Castillo 1, María Isabel Morosini 1, Aránzazu Valverde 1, Felisa Almaraz 1, Fernando Baquero 1, Rafael Cantón 1, and Rosa del Campo 1 *

1 Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Ctra. Colmenar Km 9.1, Madrid 28034, Spain

* To whom correspondence should be addressed.
Rosa del Campo, E-mail: rosacampo{at}yahoo.com


  Abstract

Objectives: To compare the capability of biofilm development between Streptococcus pneumoniae isolates from cystic fibrosis (CF) respiratory samples and those from non-CF blood cultures. Antibiotic susceptibility of biofilm-forming isolates, as well as differences between antibiotic susceptibility of sessile cells [minimum biofilm inhibitory concentration (MBIC)] and their planktonic counterparts (conventional MIC), were also assessed.

Methods: Biofilm formation was performed using a microtitre method in 20 CF and 22 non-CF blood culture S. pneumoniae isolates.

Results and conclusions: Biofilm formation occurs more frequently among S. pneumoniae isolates from CF (80%) than among non-CF blood culture isolates (50%) (P = 0.04). Moreover MBICs were significantly higher than conventional planktonic MICs among CF but not among non-CF blood isolates, suggesting a high adaptability of CF strains to form biofilms in adverse conditions.

Keywords: S. pneumoniae; minimum biofilm inhibitory concentrations; CF.
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