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JAC Advance Access published online on October 26, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl401
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Received May 30, 2006
Revised September 6, 2006
Accepted September 7, 2006

Brief report

Evaluation of anti-pneumococcal capsular antibodies as adjunctive therapy in experimental pneumococcal meningitis

Christian T. Brandt 1 *, Niels Frimodt-Møller 1, Jens D. Lundgren 2, Michael Pedersen 3, Ian C. Skovsted 1, Ian J. Rowland 4, and Christian Østergaard 5

1 National Center for Antimicrobials and Infection Control, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
2 CHIP, Copenhagen University Hospital Hvidovre, Kettegaard Allé 30, 2650 Hvidovre, Denmark
3 Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, 2100 Copenhagen, Denmark
4 Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Kettegaard Allé 30, 2650 Hvidovre, Denmark
5 National Center for Antimicrobials and Infection Control, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark; Department of Clinical Microbiology, Copenhagen University Hospital Herlev, Herlev Ringvej, 2730 Herlev, Denmark

* To whom correspondence should be addressed.
Christian T. Brandt, E-mail: ctb{at}ssi.dk


  Abstract

Objective: Bacteraemia concomitant with meningitis has been shown to greatly affect outcome. Consequently, the efficacy of serotype-specific anti-pneumococcal antiserum (APAS) was investigated in a rat model of pneumococcal meningitis.

Methods: Rats were infected with Streptococcus pneumoniae serotype 3. All rats received ceftriaxone starting 26 h post-infection. APAS was administered either at the time of infection or 26 h post-infection and effects were compared with rats treated with antibiotics only.

Results and conclusion: A significant clinical benefit was found when APAS was given at the time of infection whereas no effect was found when administered 26 h after infection. This work indicates that the clinical value of using APAS in pneumococcal meningitis may be limited.

Keywords: Experimental meningitis; pneumococcal anti-serum; sepsis; outcome.
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