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JAC Advance Access published online on August 10, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl338
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Received May 26, 2006
Revised July 8, 2006
Accepted July 26, 2006

Original article

In vitro activity of linezolid against clinical isolates of Fusobacterium spp

G. Daeschlein 1, C. Hoehne 1, O. Assadian 2 *, F. Daxboeck 2, C. Meinl 2, A. Kramer 3, and A. S. Kekulé 1

1 Institute for Medical Microbiology, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany
2 Department for Hygiene and Medical Microbiology, Medical University of Vienna, Vienna, Austria
3 Institute for Hygiene and Environmental Medicine, Ernst-Moritz-Arndt University, Greifswald, Germany

* To whom correspondence should be addressed.
O. Assadian, E-mail: ojan.assadian{at}meduniwien.ac.at


  Abstract

Objectives: Although most susceptibility studies for linezolid have investigated aerobic bacteria, only a few have investigated anaerobe isolates. The aim of the present study was to determine the antibacterial activity of linezolid against a larger sample of clinical isolates of Fusobacterium spp. and to report on the detailed susceptibility, stratified by species.

Methods: The in vitro susceptibility of 80 clinical isolates of Fusobacterium (Fusobacterium necrophorum, n = 34; Fusobacterium nucleatum, n = 20; Fusobacterium varium, n = 18; Fusobacterium mortiferum; n = 8) was tested and compared with the activity of the older compounds amoxicillin and amoxicillin/clavulanic acid.

Results: The MIC of linezolid ranged from 0.016 to 1.0 mg/L, with the MIC90 being 0.5 mg/L. The highest MIC obtained for linezolid (1.0 mg/L) was measured for an F. varium isolate. The MIC90 for both, amoxicillin (range: 0.016-0.75 mg/L) and amoxicillin/clavulanic acid (range: 0.047-0.75 mg/L), was 0.5 mg/L. Overall, no resistant strains were found in the study.

Conclusions: Compared with amoxicillin and amoxicillin/clavulanic acid, linezolid was less active against F. necrophorum (MIC90 0.25 mg/L) and F. nucleatum (MIC90 0.25 mg/L), equally active against F. varium (MIC90 0.75 mg/L) and slightly more active against F. mortiferum (MIC90 0.19 mg/L).

Keywords: anaerobic bacteria; susceptibility; MIC; resistance; amoxicillin; amoxicillin/clavulanic acid.
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