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JAC Advance Access published online on July 30, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl314
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Received April 24, 2006
Revised July 7, 2006
Accepted July 7, 2006

Original article

In vitro activity of a new antibacterial rhodanine derivative against Staphylococcus epidermidis biofilms

Maxime Gualtieri 1, Lionel Bastide 2, Philippe Villain-Guillot 1, Sylvie Michaux-Charachon 3, Jaqueline Latouche 1, and Jean-Paul Leonetti 1 *

1 CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Santé, Faculté de Pharmacie, Montpellier, France
2 Selectbiotics, Nîmes, France
3 INSERM U-431, Faculté de Médecine, Nîmes, France; Laboratoire de Bactériologie, CHU de Nîmes, Nîmes, France

* To whom correspondence should be addressed.
Jean-Paul Leonetti, E-mail: jp.leonetti{at}cpbs.univ-montp1.fr


  Abstract

Objectives: Staphylococcus epidermidis biofilms form at the surface of implants and prostheses and are responsible for the failure of many antibiotic therapies. Only a few antibiotics are relatively active against biofilms, and rifampicin, a transcription inhibitor, is among the most effective molecules for treating biofilm-related infections. Having recently selected a new potential transcription inhibitor, we attempted to evaluate its efficacy against S. epidermidis biofilms.

Methods: Biofilm-forming S. epidermidis strains were grown planktonically or as biofilms and their susceptibility to this transcription inhibitor was compared with reference antibiotics with different mechanisms of action.

Conclusions: Our results demonstrate that this new molecule is active; its effects are fast and kinetically related to those of rifampicin, but unlike rifampicin it does not select for resistant bacteria.

Keywords: RNA polymerase; inhibitors; antibiotics.
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P. Villain-Guillot, M. Gualtieri, L. Bastide, and J.-P. Leonetti
In Vitro Activities of Different Inhibitors of Bacterial Transcription against Staphylococcus epidermidis Biofilm
Antimicrob. Agents Chemother., September 1, 2007; 51(9): 3117 - 3121.
[Abstract] [Full Text] [PDF]


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