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JAC Advance Access published online on July 12, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl260
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Leading article

Clinical development of anti-tuberculosis drugs

D. A. Mitchison 1 *

1 St George's, University of London, Division of Cellular & Molecular Medicine, Cranmer Terrace, London SW17 0RE, UK

* To whom correspondence should be addressed.
D. A. Mitchison, E-mail: dmitchis{at}sgul.ac.uk


  Abstract

In the clinical development of new anti-tuberculosis drugs, the most important step is efficient Phase II studies to show whether the drug is likely to be able to shorten treatment and with what other drugs it has the greatest sterilizing activity. The use of non-linear mixed effects modelling applied to serial sputum cfu counts appears to be the most effective technique, but we know little about the optimal design of such novel studies. A paper in the current journal reports on the relative efficiencies of various timing patterns in sampling sputum.

Keywords: TB; drug development; treatment.
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